Beta oscillations and urinary voiding in Parkinson disease.

Abstract:

OBJECTIVES:To investigate the role of beta oscillations in urinary voiding and their association with lower urinary tract symptoms in Parkinson disease (PD). METHODS:We used surgically implanted deep brain stimulation electrodes to record local field potential signals from the subthalamic nucleus (STN) and globus pallidus interna (GPi) of patients with PD during urinary voiding. Five patients with STN electrodes and 5 patients with GPi electrodes were tested. We also explored correlations between beta oscillatory power and urinary symptoms assessed by the International Consultation on Incontinence Lower Urinary Tract Symptoms questionnaire. RESULTS:Beta suppression occurred during urinary voiding in the GPi (p < 0.05) but not the STN. Furthermore, the beta signal in the GPi during voiding correlated significantly with severity of incontinence and urinary frequency (p < 0.05). CONCLUSIONS:In this study, we have demonstrated that local field potentials can provide information about the neural control of the bladder. Our findings suggest that the GPi is implicated in the process of urinary voiding and that its mechanism of action is linked to signals in the beta frequency band. Moreover, our correlational analyses show that beta oscillations may be implicated more generally in the pathophysiology of lower urinary tract symptoms in PD.

journal_name

Neurology

journal_title

Neurology

authors

Roy HA,Aziz TZ,Fitzgerald JJ,Green AL

doi

10.1212/WNL.0000000000005355

subject

Has Abstract

pub_date

2018-04-24 00:00:00

pages

e1530-e1534

issue

17

eissn

0028-3878

issn

1526-632X

pii

WNL.0000000000005355

journal_volume

90

pub_type

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