Abstract:
OBJECTIVES:To investigate the role of beta oscillations in urinary voiding and their association with lower urinary tract symptoms in Parkinson disease (PD). METHODS:We used surgically implanted deep brain stimulation electrodes to record local field potential signals from the subthalamic nucleus (STN) and globus pallidus interna (GPi) of patients with PD during urinary voiding. Five patients with STN electrodes and 5 patients with GPi electrodes were tested. We also explored correlations between beta oscillatory power and urinary symptoms assessed by the International Consultation on Incontinence Lower Urinary Tract Symptoms questionnaire. RESULTS:Beta suppression occurred during urinary voiding in the GPi (p < 0.05) but not the STN. Furthermore, the beta signal in the GPi during voiding correlated significantly with severity of incontinence and urinary frequency (p < 0.05). CONCLUSIONS:In this study, we have demonstrated that local field potentials can provide information about the neural control of the bladder. Our findings suggest that the GPi is implicated in the process of urinary voiding and that its mechanism of action is linked to signals in the beta frequency band. Moreover, our correlational analyses show that beta oscillations may be implicated more generally in the pathophysiology of lower urinary tract symptoms in PD.
journal_name
Neurologyjournal_title
Neurologyauthors
Roy HA,Aziz TZ,Fitzgerald JJ,Green ALdoi
10.1212/WNL.0000000000005355subject
Has Abstractpub_date
2018-04-24 00:00:00pages
e1530-e1534issue
17eissn
0028-3878issn
1526-632Xpii
WNL.0000000000005355journal_volume
90pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::Mitoxantrone is the first drug approved for the treatment of secondary progressive multiple sclerosis (SPMS) in the United States. This assessment considers use of mitoxantrone in the treatment of MS. Mitoxantrone probably reduces the clinical attack rate and reduces attack-related MRI outcomes in patients with relaps...
journal_title:Neurology
pub_type: 指南,杂志文章,实务指引,评审
doi:10.1212/01.wnl.0000095425.84407.39
更新日期:2003-11-25 00:00:00
abstract:OBJECTIVES:To investigate longitudinally the profile of cognitive impairment in nondemented patients with ALS. METHODS:Twenty nondemented patients with ALS and 18 controls were interviewed at two time points separated by a 6-month interval. The extensive battery was designed to accommodate the range of physical disabi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000156519.41681.27
更新日期:2005-04-12 00:00:00
abstract:BACKGROUND:Given that vagal afferents project to brainstem regions that promote alertness, the authors tested the hypothesis that vagus nerve stimulation (VNS) would improve daytime sleepiness in patients with epilepsy. METHODS:Sixteen subjects with medically refractory seizures underwent polysomnography and multiple ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.5.879
更新日期:2001-09-11 00:00:00
abstract:OBJECTIVE:To determine whether blood-based biomarkers can differentiate older veterans with and without traumatic brain injury (TBI) and cognitive impairment (CogI). METHODS:We enrolled 155 veterans from 2 veterans' retirement homes: 90 without TBI and 65 with TBI history. Participants were further separated into CogI...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000010087
更新日期:2020-09-01 00:00:00
abstract::The association of the STH gene polymorphism with Alzheimer disease (AD) is debated. In the analysis of two genetically and diagnostically distinct groups of Alzheimer patients from the USA and Italy, the authors did not find an association with the STH polymorphism. However, the APOE-4-associated risk of AD greatly i...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000125693.59817.31
更新日期:2004-05-11 00:00:00
abstract:OBJECTIVE:To investigate botulinum toxin (BTX) effects on central and peripheral motor excitability in writer's cramp. METHODS:Using transcranial magnetic stimulation over the motor cortex and brainstem and peripheral electrical stimulation, the authors investigated measures of motor cortical and peripheral motor exci...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000095965.36574.0f
更新日期:2003-12-09 00:00:00
abstract:OBJECTIVE:We developed the Recurrence and Recovery Questionnaire (RRQ) by converting the Pediatric Stroke Outcome Measure (PSOM) to a questionnaire for telephone interview and sought to validate the RRQ in a large cohort. METHOD:We analyzed parents' RRQ responses and same-day PSOM assessments for 232 children who had ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318266fc9a
更新日期:2012-08-28 00:00:00
abstract::Glucocorticoid therapy slows the progression of Duchenne muscular dystrophy. In muscle cultures, the addition of the glucocorticoid methylprednisolone increases myogenesis in most normal mixed and clonal cultures. Conversely, in some normal clonal and most dystrophic cultures, methylprednisolone inhibits fusion. Howev...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.2.342
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:Mild parkinsonian signs (MPS) are associated with prevalent and incident dementia but it is not known whether they are associated with mild cognitive impairment (MCI). OBJECTIVE:To determine whether MPS and specific MPS (changes in axial function, rigidity, tremor) are associated with MCI in nondemented com...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000156157.97411.5E
更新日期:2005-04-12 00:00:00
abstract::Resources of the Rochester Epidemiology Project were used to estimate prevalence rates for dementia on January 1, 1975, 1980, and 1985, and to evaluate trends over time. Prevalence rates increased with age for both men and women. There was no difference in the prevalence rates for January 1, 1975, and January 1, 1980,...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.1.75
更新日期:1995-01-01 00:00:00
abstract::Compressive neuropathy due to tight application of handcuffs occurred in 5 patients. The superficial radial nerve was affected in 8 hands and the median nerve in two. Neurologic deficits persisted as long as 3 years after handcuffing. Nerve conduction studies helped to exclude malingering and other diagnoses. All pati...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.1.145
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVES:To study the behavioral and neuroanatomic characteristics of perseverative behavior encountered on a target cancellation task in patients with neglect. METHODS:Motor perseverative behavior during line cancellation task was evaluated retrospectively in 60 patients with left hemispatial neglect from right hem...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.8.1569
更新日期:1999-05-12 00:00:00
abstract::A term neonate was being treated with intravenous phenytoin. To maintain a serum level above 10 micrograms per milliliter and abolish seizure activity, it was necessary to carry out repeated serum concentration measurements, administer several loading doses, and administer an unusually large maintenance dose (25 mg pe...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.1.106
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVE:Paroxysmal kinesigenic dyskinesia (PKD) is a rare disorder characterized by recurrent attacks of hyperkinetic movements. PKD can be isolated or associated with benign infantile seizures as part of the infantile convulsions with choreoathetosis (ICCA) syndrome. Mutations in the PRRT2 gene were recently identif...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31825f06c3
更新日期:2012-07-10 00:00:00
abstract::The effect of bilateral frontal leukotomy on motor function was evaluated by neurologic examination, tests of praxis, and appropriate neuropsychologic tests administered to five groups of subjects. Postleukotomy schizophrenic patients were subdivided into three degrees of recovery. Two nonleukotomized groups served as...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.12.1353
更新日期:1982-12-01 00:00:00
abstract:OBJECTIVE:The study aims to examine α-synuclein in the CSF of patients with severe traumatic brain injury (TBI) and its relationship with clinical characteristics and long-term outcomes. METHODS:This prospective case-control study enrolled patients with severe TBI (Glasgow Coma Score ≤ 8) who underwent ventriculostomy...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182904d43
更新日期:2013-04-30 00:00:00
abstract:OBJECTIVE:To investigate residual function of the motor cortex corresponding to the hand of the amputated arm (MCamp). METHODS:Focal transcranial magnetic stimulation (TMS) of MCamp was performed in 10 patients 22 to 52 years after arm amputation to inhibit tonic muscle contraction in the intact hand ipsilateral to co...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.4.984
更新日期:2000-02-22 00:00:00
abstract::To assess the possible role of amine neurotransmitters in human epilepsy, we measured metabolites of serotonin (5-hydroxyindoleacetic acid [5-HIAA]), dopamine (homovanillic acid [HVA]), and norepinephrine (3-methoxy-4-hydroxyphenylethylene glycol [MHPG]) in the lumbar cerebrospinal fluid (CSF) of patients with partial...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.8.1157
更新日期:1979-08-01 00:00:00
abstract::Pure alexia, following an infarction in the distribution of the left posterior cerebral artery, is attributed to damage of the left occipital lobe and the splenium of the corpus callosum. We describe a case of pure alexia in a 57-year-old woman with infarction of the left lateral geniculate body and the splenium of th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.4.587
更新日期:1991-04-01 00:00:00
abstract::We studied acetaminophen sulfation, plasma sulfate levels, and the activity of sulfotransferase in blood platelets in patients with Parkinson's disease, Huntington's disease, and in controls and did not find any abnormality in the patient groups, independent of the use of medication. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.7.1373
更新日期:1993-07-01 00:00:00
abstract::Neurogenic left ventricular dysfunction is a recognized complication of subarachnoid hemorrhage, but this condition has not been reported after seizure activity. The authors present two cases of neurogenic stunned myocardium after convulsive seizures, suggesting that ictal activity can lead to sympathetically mediated...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000163858.77494.7A
更新日期:2005-06-14 00:00:00
abstract:OBJECTIVES:To test the hypothesis that neuropsychiatric symptomatology is predictive of the success of seizure control in patients newly treated with antiepileptic drugs (AEDs), and that this predictive value adds to that provided by other clinical, imaging, and genomic factors in a multivariate model. METHODS:One hun...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181f25b16
更新日期:2010-09-14 00:00:00
abstract:BACKGROUND:Bapineuzumab, a humanized anti-amyloid-beta (Abeta) monoclonal antibody for the potential treatment of Alzheimer disease (AD), was evaluated in a multiple ascending dose, safety, and efficacy study in mild to moderate AD. METHODS:The study enrolled 234 patients, randomly assigned to IV bapineuzumab or place...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0b013e3181c67808
更新日期:2009-12-15 00:00:00
abstract::Children with epilepsy have more behavioral and cognitive problems than children with other chronic illnesses and children in the general population. Risk factors are multiple, probably involving a combination of neurological, seizure, family, and child variables. Problems with attention and symptoms of depression occ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00
abstract::The authors evaluated education attainment and neuropsychological deficits in children with sickle cell disease (SCD) and silent cerebral infarcts. Children with silent infarcts had twice the rate of school difficulties as children without infarcts. Eighty percent of silent infarct cases had clinically significant cog...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.8.1109
更新日期:2001-04-24 00:00:00
abstract::Episodic paroxysmal hemicrania (EPH) is a rare disorder characterized by discrete bouts of hemicranial headache separated by headache-free remissions. Although EPH resembles episodic cluster headache in the location and quality of pain as well as the pattern of associated autonomic features, it is distinguished by the...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.42.5.964
更新日期:1992-05-01 00:00:00
abstract::Lymphocytic meningoradiculitis (Bannwarth's syndrome) is a radicular neuralgia associated with a chronic lymphocytic pleocytosis in cerebrospinal fluid and frequently with unilateral or bilateral peripheral facial weakness. Most reported cases have occurred during the summer among adults living in central Europe. Lymp...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.11.1476
更新日期:1983-11-01 00:00:00
abstract::Dialysis encephalopathy is a progressive, fatal condition that occurs in patients receiving hemodialysis. It is characterized by abnormalities in speech, myoclonic jerks, and striking changes on the electroencephalogram. We observed dramatic reversal of the clinical symptoms and electroencephalographic abnormalities i...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.12.1130
更新日期:1976-12-01 00:00:00
abstract::We report the cases of three siblings homozygous for a mutated transthyretin (TTR) gene that causes type I familial amyloidotic polyneuropathy (FAP), in whom we made the diagnosis by identifying both the mutated TTR gene and a variant TTR in their sera. Their serum levels for the variant TTR are twice those of patient...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.10.2045
更新日期:1992-10-01 00:00:00
abstract::We measured monoamine metabolites and biopterin in the CSF of 37 patients with dementia of the Alzheimer type (DAT), with or without extrapyramidal signs, and in 14 age-matched healthy controls. Compared with concentrations in DAT and controls, the concentrations of homovanillic acid (HVA) and biopterin were significa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.4.554
更新日期:1988-04-01 00:00:00