Topographic Distribution of Amyloid-β, Tau, and Atrophy in Patients With Behavioral/Dysexecutive Alzheimer Disease.

abstract：OBJECTIVE:To determine the diagnostic accuracy of confrontation visual field testing and to compare the accuracy of confrontation tests both individually and in combination. METHODS:Patients were prospectively recruited from ophthalmology clinics over a 6-month period. All patients underwent SITA-standard 24-2 Humphre...

journal_title：Neurology

authors： Kerr NM,Chew SS,Eady EK,Gamble GD,Danesh-Meyer HV

更新日期：2010-04-13 00:00:00

abstract：BACKGROUND:Inherited and de novo mutations in sodium channel genes underlie a variety of channelopathies. Mutations in SCN2A, encoding the brain sodium channel Na(V)1.2, have previously been reported to be associated with benign familial neonatal infantile seizures, febrile seizures plus, and intractable epilepsy of in...

journal_title：Neurology

authors： Liao Y,Anttonen AK,Liukkonen E,Gaily E,Maljevic S,Schubert S,Bellan-Koch A,Petrou S,Ahonen VE,Lerche H,Lehesjoki AE

更新日期：2010-10-19 00:00:00

abstract：OBJECTIVE:To test the hypothesis that concussion-related brain alterations seen at symptomatic injury and medical clearance to return to play (RTP) will have dissipated by 1 year after RTP. METHODS:For this observational study, 24 athletes with concussion were scanned longitudinally within 1 week after injury, at RTP,...

journal_title：Neurology

authors： Churchill NW,Hutchison MG,Graham SJ,Schweizer TA

更新日期：2019-11-19 00:00:00

abstract：:The predictive value of CSF oligoclonal banding for the development of clinically definite MS (CDMS) within 5 years after optic neuritis was assessed in 76 patients enrolled in the Optic Neuritis Treatment Trial. The presence of oligoclonal bands was associated with the development of CDMS (p = 0.02). However, the res...

journal_title：Neurology

authors： Cole SR,Beck RW,Moke PS,Kaufman DI,Tourtellotte WW

更新日期：1998-09-01 00:00:00

abstract：:Four patients with disabling action tremor in the setting of MS were treated with isoniazid (800 to 1200 mg per day). All patients showed significant improvement of the tremor, allowing more functional use of their extremities. To the best of our knowledge, this is the only medical treatment for this type of tremor. ...

journal_title：Neurology

authors： Sabra AF,Hallett M,Sudarsky L,Mullally W

更新日期：1982-08-01 00:00:00

abstract：:Early, intravenous administration of hematin in a patient with acute intermittent porphyria and severe quadriparesis may have produced partial but remarkable improvement of neuropathy, and resulted in simultaneous decline of porphyrin precursors in the blood. Intermittent, biweekly hematin infusions given 1 month afte...

journal_title：Neurology

authors： Bosch EP,Pierach CA,Bossenmaier I,Cardinal R,Thorson M

更新日期：1977-11-01 00:00:00

abstract：:A 12-year-old girl who had zoster ophthalmicus 10 months earlier presented with hemiparesis and corresponding basal ganglionic infarction related to middle cerebral artery branch thrombosis ipsilateral to the zoster. Hematologic evaluation disclosed protein C deficiency. This represents the first zoster-associated str...

journal_title：Neurology

authors： Cadavid D,Pearl PL,Dubovsky EC,Angiolillo A,Vezina LG

更新日期：1999-09-22 00:00:00

abstract：OBJECTIVE:To study the attributes of quantitative strength testing using hand-held dynamometry (HHD) as an efficacy measure in 2 large phase 3 amyotrophic lateral sclerosis (ALS) trials. METHODS:In the phase 3 trials of ceftriaxone and dexpramipexole, 513 and 943 patients, respectively, were enrolled in double-blind, ...

journal_title：Neurology

authors： Shefner JM,Liu D,Leitner ML,Schoenfeld D,Johns DR,Ferguson T,Cudkowicz M

更新日期：2016-08-09 00:00:00

abstract：:In a series of 44 consecutive patients with Charcot-Marie-Tooth disease (CMT), we found restless legs syndrome (RLS) in 10 of 27 CMT type 2 (CMT2) patients (37%) and in none of 17 CMT type 1 patients (p = 0.004). In the CMT2 patients, RLS was associated with positive sensory symptoms (10/10 versus 10/17; p = 0.026). T...

journal_title：Neurology

authors： Gemignani F,Marbini A,Di Giovanni G,Salih S,Terzano MG

更新日期：1999-03-23 00:00:00

abstract：OBJECTIVE:We determined whether Gram-negative bacterial molecules are associated with Alzheimer disease (AD) neuropathology given that previous studies demonstrate Gram-negative Escherichia coli bacteria can form extracellular amyloid and Gram-negative bacteria have been reported as the predominant bacteria found in no...

journal_title：Neurology

authors： Zhan X,Stamova B,Jin LW,DeCarli C,Phinney B,Sharp FR

更新日期：2016-11-29 00:00:00

abstract：:IgM anti-GM1 antibodies occur with increased frequency in the serum of patients with multifocal motor neuropathy (MMN). We tested the ability of serum IgM from patients with MMN to bind to GM1 ganglioside covalently bound to secondary amino groups on ELISA plates (Co-GM1). The Co-GM1 technique detected high titer (> 1...

journal_title：Neurology

authors： Pestronk A,Choksi R

更新日期：1997-11-01 00:00:00

abstract：:Patients, clinicians, and hospitals have undergone monumental changes during the coronavirus disease 2019 (COVID-19) pandemic. This crisis has forced us to consider the obligations that we neurologists have to our individual patients as well as the greater community. By returning to our fundamental understanding of th...

journal_title：Neurology

authors： Rubin MA,Bonnie RJ,Epstein L,Hemphill C,Kirschen M,Lewis A,Suarez JI,Ethics, Law, and Humanities Committee, a joint committee of the American Academy of Neurology, American Neurological Association, and Child Neurology Society; in collabor

更新日期：2020-07-28 00:00:00

abstract：OBJECTIVE:To determine if progressive brain atrophy could be detected over 1- and 2-year intervals in relapsing MS, based on annual MR studies from the Multiple Sclerosis Collaborative Research Group (MSCRG) trial of interferon beta-1a (Avonex). METHODS:All subjects had mild to moderate disability, with baseline expan...

journal_title：Neurology

authors： Simon JH,Jacobs LD,Campion MK,Rudick RA,Cookfair DL,Herndon RM,Richert JR,Salazar AM,Fischer JS,Goodkin DE,Simonian N,Lajaunie M,Miller DE,Wende K,Martens-Davidson A,Kinkel RP,Munschauer FE 3rd,Brownscheidle CM

更新日期：1999-07-13 00:00:00

abstract：:The authors studied immunoglobulin G (IgG) Fc receptor (FcgammaR) IIA, IIIA, and IIIB polymorphisms in 62 patients with Guillain-Barré syndrome (GBS) and in 89 healthy controls. The FcgammaR genotypes and allele frequencies did not differ significantly between the patients with GBS and the controls. Patients homozygou...

journal_title：Neurology

authors： Vedeler CA,Raknes G,Myhr KM,Nyland H

更新日期：2000-09-12 00:00:00

abstract：:All Olmsted County, Minnesota, residents who experienced brain injury from 1935 through 1979 were identified and their medical records reviewed for survival and neurologic outcome. Minimum inclusion criteria included loss of consciousness or post-traumatic amnesia or neurologic evidence of brain injury or skull fractu...

journal_title：Neurology

authors： Wiederholt WC,Melton LJ 3rd,Annegers JF,Grabow JD,Laws ER Jr,Ilstrup DM

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:To investigate the role of blocking antibodies in neonatal Guillain-Barré syndrome (GBS) occurring 12 days postpartum in a child born to a mother with ongoing GBS. METHODS:We studied plasma filtrate, purified IgG, and monovalent Fab fragments from the affected mother and serum from the neonate as well as ser...

journal_title：Neurology

authors： Buchwald B,de Baets M,Luijckx GJ,Toyka KV

更新日期：1999-10-12 00:00:00

abstract：:A 51-year-old man had a 4-month history of progressive headache and gradual onset of somnolence. MRI suggested spontaneous intracranial hypotension (SIH) with diencephalic compression, but he did not improve after three epidural blood patches. He became alert following intrathecal saline infusion that normalized his C...

journal_title：Neurology

authors： Pleasure SJ,Abosch A,Friedman J,Ko NU,Barbaro N,Dillon W,Fishman RA,Poncelet AN

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Benefit from carotid endarterectomy is greatest when performed within 2 weeks of a presenting TIA or stroke and decreases rapidly thereafter. OBJECTIVE:To determine the delays to carotid imaging and endarterectomy in Oxfordshire, UK, and the consequences for the effectiveness of stroke prevention. METHODS:...

journal_title：Neurology

authors： Fairhead JF,Mehta Z,Rothwell PM

更新日期：2005-08-09 00:00:00

abstract：BACKGROUND:HIV infection is associated with a painful distal sensory polyneuropathy (DSP) that can severely limit the quality of life of affected subjects. The pathogenesis of DSP is unknown, although both HIV proteins and products of immune activation triggered by HIV infection have been implicated. OBJECTIVE:To asse...

journal_title：Neurology

authors： Schifitto G,McDermott MP,McArthur JC,Marder K,Sacktor N,McClernon DR,Conant K,Cohen B,Epstein LG,Kieburtz K,NEAD Consortium.

更新日期：2005-03-08 00:00:00

abstract：:We studied three patients with Leigh's syndrome (LS) and cytochrome c oxidase (COX) deficiency. Biochemical studies in brain, muscle, heart, liver, kidney, and fibroblasts disclosed a generalized COX deficiency. Kinetic studies of COX activity in brain mitochondria showed a low Vmax and a normal Km for reduced cytochr...

journal_title：Neurology

authors： Lombes A,Nakase H,Tritschler HJ,Kadenbach B,Bonilla E,DeVivo DC,Schon EA,DiMauro S

更新日期：1991-04-01 00:00:00

abstract：:We performed an open-label study testing the effects of GM1 ganglioside on 10 Parkinson's disease (PD) patients. Patients received 1,000 mg of GM1 by IV infusion after the last of three baseline functional assessments. Patients then self-administered GM1 at a dose of 200 mg/d, by subcutaneous injection, for 18 weeks. ...

journal_title：Neurology

authors： Schneider JS,Roeltgen DP,Rothblat DS,Chapas-Crilly J,Seraydarian L,Rao J

更新日期：1995-06-01 00:00:00

abstract：OBJECTIVE:To compare effects of immediate-release (IR) and sustained-release (CR) carbidopa/levodopa in levodopa-naive PD patients. BACKGROUND:It was hypothesized that the long-acting preparation would be associated with fewer long-term complications. METHODS:A total of 618 patients were studied in 36 centers worldwi...

journal_title：Neurology

authors： Koller WC,Hutton JT,Tolosa E,Capilldeo R

更新日期：1999-09-22 00:00:00

abstract：OBJECTIVE:This study investigated the sex difference in prevalence of depression at 90 days after first-ever stroke. METHODS:Patients with first-ever stroke (n = 786) were identified from the population-based Brain Attack Surveillance in Corpus Christi project (2011-2016). Poststroke depressive symptoms were assessed ...

journal_title：Neurology

authors： Dong L,Sánchez BN,Skolarus LE,Stulberg E,Morgenstern LB,Lisabeth LD

更新日期：2020-05-12 00:00:00

abstract：:This study was undertaken to determine the amount and histologic appearance of the persistent thymic tissue removed post mortem from 20 patients over 60 years of age with myasthenia gravis. One patient died several days after thymectomy. No recognizable thymic tissue on gross examination was seen in any patient. On mi...

journal_title：Neurology

authors： Perlo VP,Arnason B,Castleman B

更新日期：1975-03-01 00:00:00

abstract：:Previous research has shown that the Mini-Mental State Examination (MMS) is biased as a measure of cognitive impairment in minority and low-education patients. The purpose of this study was to (1) develop a statistical correction for effects of age and education and (2) test the efficacy of the statistically adjusted ...

journal_title：Neurology

authors： Mungas D,Marshall SC,Weldon M,Haan M,Reed BR

更新日期：1996-03-01 00:00:00

abstract：OBJECTIVES:This study aims to investigate if patients with inflammatory neuropathies and tremor have evidence of dysfunction in the cerebellum and interactions in sensorimotor cortex compared to nontremulous patients and healthy controls. METHODS:A prospective data collection study investigating patients with inflamma...

journal_title：Neurology

authors： Schwingenschuh P,Saifee TA,Katschnig-Winter P,Reilly MM,Lunn MP,Manji H,Aguirregomozcorta M,Schmidt R,Bhatia KP,Rothwell JC,Edwards MJ

更新日期：2013-05-14 00:00:00

abstract：:We investigated the association of PD with a recently reported I93M mutation of the ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene, and with a new and common polymorphic variant S18Y of the same gene. We did not identify the I93M mutation in any of 139 unrelated PD cases or 113 controls. However, S18Y polymorph...

journal_title：Neurology

authors： Maraganore DM,Farrer MJ,Hardy JA,Lincoln SJ,McDonnell SK,Rocca WA

更新日期：1999-11-10 00:00:00

abstract：OBJECTIVE:To describe the clinical, genetic and MR characteristics of patients with familial mesial temporal lobe epilepsy (MTLE). DESIGN/METHODS:The familial occurrence of MTLE was identified by a systematic search of family history of seizures in patients followed in the authors' epilepsy clinic. All probands and, w...

journal_title：Neurology

authors： Kobayashi E,Lopes-Cendes I,Guerreiro CA,Sousa SC,Guerreiro MM,Cendes F

更新日期：2001-01-23 00:00:00

abstract：:A comprehensive sequence analysis of 29 exons that code for the functional domains of LRRK2 in 160 nondominant Parkinson disease (PD) patients was performed. Novel variant screening in a further 470 sporadic PD patients and 630 controls revealed two novel variants (R1067Q and IVS33 + 6 T>A), which are likely to be pat...

journal_title：Neurology

authors： Skipper L,Shen H,Chua E,Bonnard C,Kolatkar P,Tan LC,Jamora RD,Puvan K,Puong KY,Zhao Y,Pavanni R,Wong MC,Yuen Y,Farrer M,Liu JJ,Tan EK

更新日期：2005-10-25 00:00:00

abstract：:We report two conjugal cases of amyotrophic lateral sclerosis (ALS) occurring between 1977 and 1991 in southern France (Languedoc-Roussillon). Although conjugal ALS may occur by chance, the description of two cases in the same area points to a role of environmental or genetic factors in the etiology of the disease. ...

journal_title：Neurology

authors： Camu W,Cadilhac J,Billiard M

更新日期：1994-03-01 00:00:00