Abstract:
OBJECTIVE:To determine the incidence and clinical effects of antibodies that develop during treatment with natalizumab.
METHODS:In two randomized, double-blind, placebo-controlled studies (natalizumab safety and efficacy in relapsing remitting multiple sclerosis [MS, AFFIRM] and safety and efficacy of natalizumab in combination with interferon beta-1a [INF beta]1a] in patients with relapsing remitting MS [SENTINEL]) of patients with relapsing multiple sclerosis, blood samples were obtained at baseline and every 12 weeks to determine the presence of antibodies against natalizumab. Antibodies to natalizumab were measured using an ELISA. Patients were categorized as "transiently positive" if they had detectable antibodies (>or=0.5 microg/mL) at a single time point or "persistently positive" if they had antibodies at two or more time points >or=6 weeks apart.
RESULTS:In the AFFIRM study, antibodies were detected in 57 of 625 (9%) of natalizumab-treated patients: Twenty (3%) were transiently positive and 37 (6%) were persistently positive. Persistently positive patients showed a loss of clinical efficacy as measured by disability progression (p journal_name journal_title authors doi subject pub_date pages issue eissn issn pii journal_volume pub_type
相关文献
NEUROLOGY文献大全abstract::Regional cerebral glucose metabolism was studied in 16 patients with idiopathic torticollis, using positron emission tomography. Analysis of subcortical regions revealed no consistent focal abnormality of cerebral metabolic rate for glucose, but there was a bilateral breakdown of the normal relationships between the t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.5.653
更新日期:1986-05-01 00:00:00
abstract:OBJECTIVE:To investigate whether arginine methylation is altered in patients with amyotrophic lateral sclerosis (ALS) and how it affects disease severity, progression, and prognosis. METHODS:We compared the immunoreactivity of protein arginine methyltransferase 1 (PRMT1) and its products, asymmetric dimethylated prote...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007311
更新日期:2019-04-16 00:00:00
abstract:OBJECTIVE:To investigate the genetic and physiologic basis of the neuromuscular symptoms of hypotonia-cystinuria syndrome (HCS) and isolated PREPL deficiency, and their response to therapy. METHODS:We performed molecular genetic, histochemical, immunoblot, and ultrastructural studies, investigated neuromuscular transm...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000295
更新日期:2014-04-08 00:00:00
abstract:OBJECTIVE:We endeavored to develop an unruptured intracranial aneurysm (UIA) treatment score (UIATS) model that includes and quantifies key factors involved in clinical decision-making in the management of UIAs and to assess agreement for this model among specialists in UIA management and research. METHODS:An internat...
journal_title:Neurology
pub_type: 共识发展会议,杂志文章
doi:10.1212/WNL.0000000000001891
更新日期:2015-09-08 00:00:00
abstract:BACKGROUND:Hypothalamic hamartomas (HHs), rare developmental abnormalities of the inferior hypothalamus, often cause refractory, symptomatic, mixed epilepsy, including gelastic seizures. We present 37 patients with HH who underwent transcortical transventricular endoscopic resection. METHODS:Between October 2003 and A...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000310644.40767.aa
更新日期:2008-04-22 00:00:00
abstract::The authors studied the association of an exon 4 (E4*epsilon2/3/4) and three promoter polymorphisms of APOE with disease course and severity stratified by gender in 221 patients with multiple sclerosis from two overlapping population-based prevalence cohorts. Women carriers of the E4*epsilon2 allele took longer to att...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000113721.83287.83
更新日期:2004-03-09 00:00:00
abstract:BACKGROUND:The authors previously reported on the development of thyroid dysfunction and autoimmunity during 1-year treatment of patients with MS with interferon-beta 1b (IFN beta-1b). OBJECTIVE:To evaluate the evolution of incident thyroid disease and the possible development of more thyroid disease during longer ter...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.55.4.549
更新日期:2000-08-22 00:00:00
abstract:OBJECTIVE:Precise genetic analyses were conducted with ring finger protein 213 (RNF213) in relation to a particular clinical phenotype in Chinese patients with moyamoya disease (MMD) to determine whether heterozygosity is responsible for the early-onset and severe form of this disease. METHODS:A case-control study for...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008901
更新日期:2020-02-18 00:00:00
abstract::X-linked spinal and bulbar muscular atrophy (SBMA) is usually associated with feminization and hypogonadism. We were unable to find androgen receptor (AR) in the scrotal skin of three patients with SBMA, and propose that AR abnormality is the cause of the disease. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.9.1724
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND:Infection with HIV can result in a debilitating CNS disorder known as HIV dementia (HIV-D). Since the advent of highly active antiretroviral therapy (HAART), the incidence of HIV-D has declined, but the prevalence continues to increase. In this new era of HIV-D, traditional biomarkers such as CSF viral load ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000260610.79853.47
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:To determine the rate of relapse occurrence during pregnancy and postpartum. METHODS:In a cross-sectional study using the national multiple sclerosis (MS) registry, pregnant women with relapsing MS were identified. Data on demographics, clinical characteristics, and disease-modifying therapies (DMTs), includ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000005065
更新日期:2018-03-06 00:00:00
abstract:OBJECTIVE:To assess cerebrovascular reactivity in response to a visual task in participants with cerebral amyloid angiopathy (CAA), Alzheimer disease (AD), and mild cognitive impairment (MCI) using fMRI. METHODS:This prospective cohort study included 40 patients with CAA, 22 with AD, 27 with MCI, and 25 healthy contro...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000010201
更新日期:2020-09-08 00:00:00
abstract::Juvenile myoclonic epilepsy (JME) is a distinct subform of idiopathic generalized epilepsy of adolescence. Linkage studies with Bf and serologic HLA markers in families of JME patients have shown a tight linkage on chromosome 6. We present a linkage analysis with HLA-DQ restriction fragment length polymorphisms on mor...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.10.1651
更新日期:1991-10-01 00:00:00
abstract:OBJECTIVE:APOE epsilon4 has been associated with late-onset familial and sporadic AD and delayed recovery from head injury. The authors examined the relationship between functional recovery of patients with head injury and the APOE alleles. METHODS:Thirty-one patients with head injury who had completed the Acute Neuro...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.10.1536
更新日期:2000-11-28 00:00:00
abstract:BACKGROUND:Benefit from carotid endarterectomy is greatest when performed within 2 weeks of a presenting TIA or stroke and decreases rapidly thereafter. OBJECTIVE:To determine the delays to carotid imaging and endarterectomy in Oxfordshire, UK, and the consequences for the effectiveness of stroke prevention. METHODS:...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000170368.82460.b4
更新日期:2005-08-09 00:00:00
abstract:BACKGROUND:Antiretroviral therapy has improved survival for HIV-1-infected individuals. The neuroepidemiologic implications of HIV-1 in an aging population are not well known, particularly the prevalence of HIV-associated dementia (HAD). METHODS:The authors report a baseline cross-sectional analysis of 202 HIV-1-serop...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000134665.58343.8d
更新日期:2004-09-14 00:00:00
abstract::Two siblings and a third child exhibited a syndrome of progressive muscular weakness and wasting, closely resembling Werdnig-Hoffmann's disease. Autopsy of one of the siblings and the third child showed nearly total absence of myelin sheaths in the cranial and spinal nerve roots, relative preservation of axons, and no...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.6.565
更新日期:1976-06-01 00:00:00
abstract::Several controlled-release carbidopa/levodopa preparations have been formulated to achieve a more stable and extended antiparkinsonian action. The most effective is Sinemet CR (Sinemet CR4), with an erodible polymer matrix that retards release of levodopa. In 19 parkinsonians with prominent dose-by-dose fluctuations, ...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:
更新日期:1989-11-01 00:00:00
abstract:OBJECTIVE:To analyze the frequency of neurologic events during commercial airline flights and to assess whether onboard emergency medical kits are adequate for in-flight neurologic emergencies. METHODS:Collaboration of the Mayo Clinic's Departments of Emergency Medicine and Medical Transportation Service and the Divis...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.58.12.1739
更新日期:2002-06-25 00:00:00
abstract:BACKGROUND:The topodiagnostic value and specificity of nystagmus in patients with mesencephalic lesions and its relation to tonic torsional deficits and vertical saccade deficits is controversial and anecdotal. METHODS:The authors examined 11 patients with vascular MRI-identified mesencephalic lesions and clinical evi...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000038387.90128.8d
更新日期:2002-12-24 00:00:00
abstract:OBJECTIVE:To examine associations of orthostatic hypotension (OH) with dementia and long-term cognitive decline and to update previously published results in the same cohort for stroke with an additional 16 years of follow-up. METHODS:We analyzed data from 11,709 participants without a history of coronary heart diseas...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006027
更新日期:2018-08-21 00:00:00
abstract:OBJECTIVE:We aimed to create an index to stratify cryptogenic stroke (CS) patients with patent foramen ovale (PFO) by their likelihood that the stroke was related to their PFO. METHODS:Using data from 12 component studies, we used generalized linear mixed models to predict the presence of PFO among patients with CS, a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182a08d59
更新日期:2013-08-13 00:00:00
abstract:OBJECTIVE:To examine the severity of impairments in the decision-making abilities (understanding, appreciation, reasoning, and choice) and competency to make a decision to use an Alzheimer disease (AD)-slowing medication in patients with AD and the relationships between these impairments, insight, and overall cognition...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000160000.01742.9D
更新日期:2005-05-10 00:00:00
abstract::Although referrals for narcolepsy are increasing, physicians continue to confront obstacles in diagnosing and treating this condition. Patients with narcolepsy also face challenges at work, at school, and at home. One of the more disturbing problems is the lack of public awareness of the disorder and its potential the...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.50.2_suppl_1.s27
更新日期:1998-02-01 00:00:00
abstract:BACKGROUND:Ullrich congenital muscular dystrophy (UCMD) is a form of merosin-positive congenital muscular dystrophy characterized by proximal contractures, distal laxity, rigidity of the spine, and respiratory complications. Recently, a deficiency of collagen VI on muscle and skin biopsy together with recessive mutatio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.9.1354
更新日期:2002-05-14 00:00:00
abstract::A 32-year-old patient with seizures experienced decreased right-ear hearing during electrocortical stimulation mapping of the left lateral superior temporal gyrus. Audiometric testing under headphones confirmed a reversible, moderate unilateral hearing loss. Under binaural listening conditions, auditory comprehension ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000149524.11371.B1
更新日期:2005-01-25 00:00:00
abstract:OBJECTIVES:Laminin alpha2 deficiency presents at birth with muscle weakness, hypotonia, and usually asymptomatic white matter signal on MRI. Few patients with laminin alpha2 deficiency have been described with seizures and structural brain abnormalities. The reason for the variation in the severity of the clinical phen...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.8.1128
更新日期:2000-10-24 00:00:00
abstract:BACKGROUND AND PURPOSE:Persistently elevated intracranial pressure (ICP) has been associated with poor clinical outcome after severe brain injury, such as neurotrauma, intracerebral hemorrhage, and subarachnoidal hemorrhage. Although ICP monitoring is increasingly being used in intensive care treatment of patients with...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.2.393
更新日期:1996-08-01 00:00:00
abstract:OBJECTIVE:To critically re-evaluate cases diagnosed as adult neuronal ceroid lipofuscinosis (ANCL) in order to aid clinicopathologic diagnosis as a route to further gene discovery. METHODS:Through establishment of an international consortium we pooled 47 unsolved cases regarded by referring centers as ANCL. Clinical a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002943
更新日期:2016-08-09 00:00:00
abstract::Significant evidence has accrued suggesting that antibodies to voltage-gated calcium channel are observed in at least some patients with sporadic ALS (SALS) and that such antibodies alter the function of these ion channels in vitro and in vivo. Further, passive transfer of these immunoglobulin-containing fractions int...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.47.4_suppl_2.40s
更新日期:1996-10-01 00:00:00