Abstract:
:We report cerebral vasculitis in 2 cocaine users who developed symptoms (transient blindness and persistent headache) while smoking "crack," followed by progressive widespread cerebral dysfunction with focal signs over the next few weeks. One patient had smoked crack exclusively, and the other also used cocaine intravenously. Sedimentation rates were elevated and HIV titers negative. Arteriography was normal in 1 patient and in the other showed multiple large-vessel occlusions without beading. Brain biopsy showed vasculitis involving small vessels in both patients. Multinucleated cells were present in the neuropil, but there were no granulomas or evidence of infection. One patient improved significantly with corticosteroid treatment, and made a good recovery. The other died despite corticosteroid and cyclophosphamide treatment.
journal_name
Neurologyjournal_title
Neurologyauthors
Krendel DA,Ditter SM,Frankel MR,Ross WKdoi
10.1212/wnl.40.7.1092subject
Has Abstractpub_date
1990-07-01 00:00:00pages
1092-4issue
7eissn
0028-3878issn
1526-632Xjournal_volume
40pub_type
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