Plasma tau correlates with basal forebrain atrophy rates in people at risk for Alzheimer disease.

abstract：:The majority of patients with traumatic brain injury (TBI) are classified as having a mild TBI. Despite being categorized as mild, these individuals report ongoing and complex symptoms, which negatively affect their ability to complete activities of daily living and overall quality of life. Some of the major symptoms ...

journal_title：Neurology

authors： Elenberger J,Kim B,de Castro-Abeger A,Rex TS

更新日期：2020-11-03 00:00:00

abstract：OBJECTIVE:To compare the efficacy and safety of oral anticoagulants vs antiplatelets in patients with stroke and atherosclerotic plaques in the aortic arch or cervical or intracranial arteries, collectively described as supracardiac atherosclerosis. METHODS:We searched PubMed and Scopus until August 28, 2019, for rand...

journal_title：Neurology

authors： Sagris D,Georgiopoulos G,Leventis I,Pateras K,Pearce LA,Korompoki E,Makaritsis K,Vemmos K,Milionis H,Ntaios G

更新日期：2020-08-04 00:00:00

abstract：:The syndrome of increased intracranial pressure without hydrocephalus or mass lesion and with normal CSF composition, previously referred to as pseudotumor cerebri, is a diagnosis of exclusion now termed idiopathic intracranial hypertension (IIH). Diagnostic criteria of this disorder have not been updated since the Mo...

journal_title：Neurology

authors： Friedman DI,Jacobson DM

更新日期：2002-11-26 00:00:00

abstract：:The "modified host protein" model of scrapie proposes that the transmissible agent is composed of the degradation-resistant protein, Sp33-37, and that clinical and pathologic signs result from neurotoxic accumulations of this protein. Sp33-37 is an abnormal, amyloidogenic isoform of the normally occurring cellular pro...

journal_title：Neurology

authors： Bendheim PE,Brown HR,Rudelli RD,Scala LJ,Goller NL,Wen GY,Kascsak RJ,Cashman NR,Bolton DC

更新日期：1992-01-01 00:00:00

abstract：:Restless legs syndrome (RLS) is a common neurologic disorder that affects 5 to 10% of the population and increases in prevalence with aging. The clinical hallmarks of RLS include dysesthesias or paresthesias in the legs and sometimes the arms, occurring primarily at rest, which are usually worse in the evening and are...

journal_title：Neurology

authors： Comella CL

更新日期：2002-02-26 00:00:00

abstract：BACKGROUND:Mild parkinsonian signs (MPS) are associated with prevalent and incident dementia but it is not known whether they are associated with mild cognitive impairment (MCI). OBJECTIVE:To determine whether MPS and specific MPS (changes in axial function, rigidity, tremor) are associated with MCI in nondemented com...

journal_title：Neurology

authors： Louis ED,Schupf N,Manly J,Marder K,Tang MX,Mayeux R

更新日期：2005-04-12 00:00:00

abstract：:Thyrotropin-releasing hormone has been reported to increase strength in patients with amyotrophic lateral sclerosis (ALS). DN-1417 is an analog of thyrotropin-releasing hormone, which has less endocrinologic activity, but more anterior horn cell stimulating effect (with no "autorefractory state"). However, 2 mg DN-141...

journal_title：Neurology

authors： Hawley RJ,Kratz R,Goodman RR,McCutchen CB,Sirdofsky M,Hanson PA

更新日期：1987-04-01 00:00:00

abstract：:We studied 13 patients with severe drug-induced parkinsonism (DIP) using L-6-[18F]fluorodopa positron emission tomography (18F-dopa PET) to investigate the integrity of their dopaminergic nigrostriatal projections. Twelve of these patients were subsequently followed clinically for a median of 23.5 months (range, 6 to ...

journal_title：Neurology

authors： Burn DJ,Brooks DJ

更新日期：1993-03-01 00:00:00

abstract：:A 4-year-old girl presented to our tertiary care hospital with a complaint of lower extremity weakness and unsteady gait for 2 days. She was able to pull herself to stand, but could not stand unsupported. She had no sensory symptoms or pain. She did not complain of any weakness in her arms, trunk, face, or neck. She h...

journal_title：Neurology

authors： Chagnon SL,Naik M,Abdel-Hamid H

更新日期：2014-03-18 00:00:00

abstract：OBJECTIVE:To estimate whole-brain microinfarct burden from microinfarct counts in routine postmortem examination. METHODS:We developed a simple mathematical method to estimate the total number of cerebral microinfarcts from counts obtained in the small amount of tissue routinely examined in brain autopsies. We derived...

journal_title：Neurology

authors： Westover MB,Bianchi MT,Yang C,Schneider JA,Greenberg SM

更新日期：2013-04-09 00:00:00

abstract：:Many studies of monozygotic (MZ) twins have revealed evidence of genetic influences on intellectual functions and their derangement in certain neurologic and psychiatric diseases afflicting the forebrain. Relatively little is known about genetic influences on the size and shape of the human forebrain and its gross mor...

journal_title：Neurology

authors： Tramo MJ,Loftus WC,Stukel TA,Green RL,Weaver JB,Gazzaniga MS

更新日期：1998-05-01 00:00:00

abstract：:In 64 patients with Parkinson's disease (PD), the basal level of prolactin (PRL) was normal. Bromocriptine (BCT) caused a significant suppression of PRL in all parkinsonian patients and controls. When given after BCT treatment, thyrotropin-releasing hormone (TRH) induced a significantly lower PRL rise in recent-onset ...

journal_title：Neurology

authors： Laihinen A,Rinne UK

更新日期：1986-03-01 00:00:00

abstract：:Mutations in NOTCH3 are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a hereditary angiopathy causing stroke and vascular dementia. All CADASIL mutations identified so far result in the loss or gain of one cysteine residue within epidermal growth fac...

journal_title：Neurology

authors： Dichgans M,Herzog J,Gasser T

更新日期：2001-11-13 00:00:00

abstract：:Mitoxantrone is the first drug approved for the treatment of secondary progressive multiple sclerosis (SPMS) in the United States. This assessment considers use of mitoxantrone in the treatment of MS. Mitoxantrone probably reduces the clinical attack rate and reduces attack-related MRI outcomes in patients with relaps...

journal_title：Neurology

authors： Goodin DS,Arnason BG,Coyle PK,Frohman EM,Paty DW,Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.

更新日期：2003-11-25 00:00:00

abstract：BACKGROUND:X-linked adrenoleukodystrophy (X-ALD) has variants with widely different outcomes, hampering clinical counseling and evaluation of therapies. OBJECTIVE:To evaluate the degree to which MRI patterns can predict lesion progression. METHODS:Two hundred six boys and men with cerebral X-ALD (median age 12.2 year...

journal_title：Neurology

authors： Loes DJ,Fatemi A,Melhem ER,Gupte N,Bezman L,Moser HW,Raymond GV

更新日期：2003-08-12 00:00:00

abstract：OBJECTIVE:To identify independent predictors of clinical or cerebral lesion progression in a large sample of adult patients with moyamoya angiopathy (MMA) prior to decisions regarding revascularization surgery. METHODS:Ninety participants (median age, 37.5 years) were assessed at baseline and followed for a median tim...

journal_title：Neurology

authors： Hervé D,Ibos-Augé N,Calvière L,Rogan C,Labeyrie MA,Guichard JP,Godin O,Kossorotoff M,Habert MO,Lasserve ET,Chevret S,Chabriat H

更新日期：2019-07-23 00:00:00

abstract：OBJECTIVE:To determine whether whole-brain, event-related fMRI can distinguish healthy older adults with known Alzheimer disease (AD) risk factors (family history, APOE epsilon4) from controls using a semantic memory task involving discrimination of famous from unfamiliar names. METHODS:Sixty-nine cognitively asymptom...

journal_title：Neurology

authors： Seidenberg M,Guidotti L,Nielson KA,Woodard JL,Durgerian S,Antuono P,Zhang Q,Rao SM

更新日期：2009-08-25 00:00:00

abstract：BACKGROUND:To assess the temporal trend in multiple sclerosis (MS) onset during the last 50 years in Sardinia, Italy. METHODS:The authors used a cohort study to assess age at onset in 1,513 MS patients at the MS clinic in Cagliari, all born and living in Sardinia. They also assessed age at onset in 41 pairs of familia...

journal_title：Neurology

authors： Cocco E,Sardu C,Lai M,Spinicci G,Contu P,Marrosu MG

更新日期：2004-05-25 00:00:00

abstract：:There are multiple difficulties in evaluating new treatments for multiple sclerosis (MS). The clinical diagnosis is imprecise, and the correlation between lesion and clinical dysfunction is incomplete. The neurologic evaluation is complex and lacks full precision. The course of MS is complex and has limited predictabi...

journal_title：Neurology

authors： Brown JR

更新日期：1980-07-01 00:00:00

abstract：BACKGROUND:HIV infection is associated with a painful distal sensory polyneuropathy (DSP) that can severely limit the quality of life of affected subjects. The pathogenesis of DSP is unknown, although both HIV proteins and products of immune activation triggered by HIV infection have been implicated. OBJECTIVE:To asse...

journal_title：Neurology

authors： Schifitto G,McDermott MP,McArthur JC,Marder K,Sacktor N,McClernon DR,Conant K,Cohen B,Epstein LG,Kieburtz K,NEAD Consortium.

更新日期：2005-03-08 00:00:00

abstract：:Whether autoimmune mechanisms play a role in the pathogenesis of inclusion body myositis (IBM) is unknown. Human leukocyte antigen (HLA) analysis in 52 patients, including 17 with autoimmune disorders (AIDs), showed that patients were more likely to have antigens from the autoimmune-prone HLA-B8-DR3 ancestral haplotyp...

journal_title：Neurology

authors： Badrising UA,Schreuder GM,Giphart MJ,Geleijns K,Verschuuren JJ,Wintzen AR,Maat-Schieman ML,van Doorn P,van Engelen BG,Faber CG,Hoogendijk JE,de Jager AE,Koehler PJ,de Visser M,van Duinen SG,Dutch IBM Study Group.

更新日期：2004-12-28 00:00:00

abstract：:We studied electrically elicited blink reflex responses in patients with hemifacial spasm (HFS) by applying single isolated, as well as paired (conditioning and test), stimuli at both sides of the face. Responses after single stimuli were of larger size on the side of the spasm compared with the uninvolved side and co...

journal_title：Neurology

authors： Valls-Sole J,Tolosa ES

更新日期：1989-08-01 00:00:00

abstract：OBJECTIVE:To investigate the feasibility, safety, and efficacy of a ketogenic diet (KD) for superrefractory status epilepticus (SRSE) in adults. METHODS:We performed a prospective multicenter study of patients 18 to 80 years of age with SRSE treated with a KD treatment algorithm. The primary outcome measure was signif...

journal_title：Neurology

authors： Cervenka MC,Hocker S,Koenig M,Bar B,Henry-Barron B,Kossoff EH,Hartman AL,Probasco JC,Benavides DR,Venkatesan A,Hagen EC,Dittrich D,Stern T,Radzik B,Depew M,Caserta FM,Nyquist P,Kaplan PW,Geocadin RG

更新日期：2017-03-07 00:00:00

abstract：:In a retrospective study of 103 corticosteroid-treated MS patients, the average rate of fracture events was 3.2% of the patients per year over 7.1 (+/- 5.7 SD) years at risk. Fractures of the ribs, pelvis, hip, or vertebrae occurred in 11 patients and became most common 5 years after starting steroids. Relatively high...

journal_title：Neurology

authors： Troiano RA,Jotkowitz A,Cook SD,Bansil S,Zito G

更新日期：1992-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the effects of mitoxantrone (Mx) in progressive multiple sclerosis (MS) on MRI. METHODS:A total of 194 patients with worsening relapsing-remitting or secondary progressive MS were treated with Mx 12 mg/m2 (n = 34), Mx 5 mg/m2 (n = 40), or placebo (n = 36) at 3-month intervals IV over a 2-year per...

journal_title：Neurology

authors： Krapf H,Morrissey SP,Zenker O,Zwingers T,Gonsette R,Hartung HP,MIMS Study Group.

更新日期：2005-09-13 00:00:00

abstract：:Previous studies have suggested that an abnormal release of potassium from muscle may accompany attacks of paramyotonic weakness. We investigated 3 patients with paramyotonia congenita before and after the induction of forearm muscle weakness by exercise in cold water. Two of these patients had paralysis periodica par...

journal_title：Neurology

authors： Moxley RT 3rd,Ricker K,Kingston WJ,Böhlen R

更新日期：1989-07-01 00:00:00

abstract：OBJECTIVE:To investigate whether repetitive transcranial magnetic stimulation (rTMS) can modify spasticity. METHODS:We used high-frequency (5 Hz) and low-frequency (1 Hz) rTMS protocols in 19 remitting patients with relapsing-remitting multiple sclerosis and lower limb spasticity. RESULTS:A single session of 1 Hz rTM...

journal_title：Neurology

authors： Centonze D,Koch G,Versace V,Mori F,Rossi S,Brusa L,Grossi K,Torelli F,Prosperetti C,Cervellino A,Marfia GA,Stanzione P,Marciani MG,Boffa L,Bernardi G

更新日期：2007-03-27 00:00:00

abstract：:Serum levels of creatine phosphokinase (CPK) and pyruvic kinase (PK) were determined in 42 controls, 57 patients with various neuromuscular disorders, and 23 female relatives of Duchenne dystrophy patients. CPK and PK enzyme activities were increased in comparable numbers of muscle disease patients and female carriers...

journal_title：Neurology

authors： Seay AR,Ziter FA,Wu LH,Wu JT

更新日期：1978-10-01 00:00:00

abstract：:Factors affecting osmotic fragility were studied in red blood cells of patients with Duchenne muscular dystrophy. The mean osmotic fragility (MOF), operationally defined as the NaCl concentration for 50% hemolysis, was found to be higher by 3.63 +/- 0.51 mM in Duchenne cells than in normal cells having an MOF of 60.1 ...

journal_title：Neurology

authors： Kim HD,Luthra MG,Watts RP,Stern LZ

更新日期：1980-07-01 00:00:00

abstract：OBJECTIVE:To examine the association between Miller Fisher syndrome (MFS) and antecedent Haemophilus influenzae infection. BACKGROUND:Little is known about agents in prior respiratory tract infection of MFS, whereas antecedent upper respiratory symptoms are frequent. H. influenzae is a major pathogen that can cause hu...

journal_title：Neurology

authors： Koga M,Yuki N,Tai T,Hirata K

更新日期：2001-08-28 00:00:00