Abstract:
OBJECTIVE:Using interictal alpha-[11C]methyl-l-tryptophan ([11C]AMT) PET scan, the authors have undertaken a quantitative analysis of all tubers visible on MRI or 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) PET, to determine the relationship between [11C]AMT uptake and epileptic activity on EEG. BACKGROUND:Tuberous sclerosis complex (TSC) is an autosomal dominant disorder, often associated with cortical tubers and intractable epilepsy. The authors have shown previously that [11C]AMT PET scans show high tracer uptake in some epileptogenic tubers and low uptake in the remaining tubers. METHODS:Eighteen children, age 7 months to 16 years, were studied. Patients underwent video-EEG monitoring, PET scans of [11C]AMT and [18F]FDG, and T2-weighted or fluid-attenuated inversion recovery (FLAIR) MRI. [11C]AMT uptake values were measured in 258 cortical tubers delineated with coregistered MRI or [18F]FDG scans. Uptake ratios were calculated between the [11C]AMT uptake in tubers and those for normal cortex (tuber/normal cortex). Using the region of epileptiform activity, the authors performed receiver operator characteristics (ROC) analysis and determined the optimal uptake ratio for detecting presumed epileptogenic tubers. RESULTS:Tuber uptake ratios ranged from 0.6 to 2.0. Tuber uptake ratios in the epileptic lobes were higher than those in the nonepileptic lobes (p < 0.0001). All 15 patients with focal seizure activity showed one or more lesions with uptake ratio above 0.98 in the epileptic lobe. ROC analysis showed that a tuber uptake ratio of 0.98 resulted in a specificity of 0.91. CONCLUSIONS:Cortical tubers with [11C]AMT uptake greater than or equal to normal cortex are significantly related to epileptiform activity in that lobe. Together, interictal [11C]AMT PET and FLAIR MRI improve the detection of potentially epileptogenic tubers in patients with TSC being evaluated for epilepsy surgery.
journal_name
Neurologyjournal_title
Neurologyauthors
Asano E,Chugani DC,Muzik O,Shen C,Juhász C,Janisse J,Ager J,Canady A,Shah JR,Shah AK,Watson C,Chugani HTdoi
10.1212/wnl.54.10.1976subject
Has Abstractpub_date
2000-05-23 00:00:00pages
1976-84issue
10eissn
0028-3878issn
1526-632Xjournal_volume
54pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:To determine the diagnostic accuracy of confrontation visual field testing and to compare the accuracy of confrontation tests both individually and in combination. METHODS:Patients were prospectively recruited from ophthalmology clinics over a 6-month period. All patients underwent SITA-standard 24-2 Humphre...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181d90017
更新日期:2010-04-13 00:00:00
abstract::We treated 64 emergency room patients with a primary vascular headache with dihydroergotamine (DHE), meperidine, or butorphanol. Post-treatment pain scores were lowest in the DHE group (p less than 0.01). Eight of 21 patients receiving DHE had greater than 90% reduction in pain compared with three of 19 patients recei...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.39.4.590
更新日期:1989-04-01 00:00:00
abstract::Fourteen patients with Alzheimer's disease were evaluated by psychometric testing, fluorodeoxyglucose positron emission tomography (PET), and EEG. They were divided into two groups according to the EEG findings. Group A (seven patients) had normal alpha backgrounds and group B (seven patients) had decreased alpha back...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.5.747
更新日期:1988-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the production rate of CSF in patients with differing disease states. METHODS:The authors measured the production rate of CSF in three groups of patients: five patients with PD below age 60 (aged 51 +/- 4 years, mean +/- SD), nine with PD over age 60 (aged 69 +/- 6 years, mean +/- SD), and seven ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.10.1763
更新日期:2001-11-27 00:00:00
abstract:BACKGROUND:Co-occurrence of Parkinson disease (PD) and melanoma has been reported in numerous studies. If this was due to common genetic mechanisms, a positive family history of melanoma would be associated with an excessive PD risk, independent of environmental risk factors for PD. METHODS:We prospectively examined a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181bd13a1
更新日期:2009-10-20 00:00:00
abstract::To assess reversibility of focal cerebral ischemia, we performed a neurologic and pathologic study of 27 monkeys subjected to temporary middle cerebral artery occlusion. An implanted snare ligature occluded the artery in awake monkeys for 30 minutes, 4 hours, 8 hours, 16 hours, 24 hours, or permanently. Serial neurolo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.10.1295
更新日期:1981-10-01 00:00:00
abstract:OBJECTIVE:To determine whether physical activity and body mass index (BMI) predict instrumental or basic activities of daily living (I/ADL) trajectories before or after stroke compared to individuals who remained stroke-free. METHODS:Using a prospective cohort, the Health and Retirement Study, we followed adults witho...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003888
更新日期:2017-05-02 00:00:00
abstract::Intracranial EEG recording is often required to identify an area of the brain for resective surgery for intractable epilepsy. We simultaneously compared bilaterally placed depth and limited subdural electrode EEG to determine the most effective method of recording seizures from the temporal lobes. Localized complex pa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.11.1497
更新日期:1989-11-01 00:00:00
abstract::Seven patients had pendular, vertical, isolated movements of the eyes soon after severe pontine strokes. The movements had a frequency of about 2 Hz and amplitudes of 3 to 40 degrees. Other rhythmic body movements at similar frequencies occurred in four patients after a delay of 6 weeks to 9 months. The character and ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.1.86
更新日期:1986-01-01 00:00:00
abstract::We studied 60 patients with idiopathic Parkinson disease with motor and neuropsychologic tests to ascertain whether the severity of motor symptoms was associated with the degree of neuropsychologic deficity. Significant correlations were found between the severity of brady kinesia and impaired performance on tests ass...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.2.133
更新日期:1982-02-01 00:00:00
abstract::Sphingosine 1-phosphate receptors (S1PRs) are G protein-coupled receptors expressed by many cell types, including immune and neural cells. These receptors are promising targets for immunomodulatory and possibly neuromodulatory therapies. Fingolimod (FTY720) is a sphingosine analog that, when phosphorylated, becomes a ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31820d9507
更新日期:2011-02-22 00:00:00
abstract:OBJECTIVE:To investigate recovery of medical decision-making capacity (MDC) over the first year following traumatic brain injury (TBI). METHODS:A total of 177 participants (111 persons with TBI and 66 healthy controls) were recruited from an inpatient/outpatient TBI rehabilitation unit and outpatient neurology departm...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003079
更新日期:2016-09-06 00:00:00
abstract:OBJECTIVE:To determine whether there is a relationship between aortic plaques and intracranial (IC) atherosclerosis. METHODS:We reviewed 922 patients with stroke who had both transesophageal echocardiography and cerebral angiography. The plaques of these patients were classified as either complex aortic plaques (CAP),...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000238511.72927.3c
更新日期:2006-10-10 00:00:00
abstract::Despite a paucity of controlled data, stereotactic pallidotomy is increasingly used for the treatment of advanced Parkinson's disease (PD). To study the efficacy of the procedure on the cardinal PD features of rigidity, tremor, bradykinesia, and postural instability, we blindly rated randomized videos of 34 patients r...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.1.266
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of AD and other dementias in a rural elderly Hindi-speaking population in Ballabgarh in northern India. DESIGN:The authors performed a community survey of a cohort of 5,126 individuals aged 55 years and older, 73.3% of whom were illiterate. Hindi cognitive and functional screening...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.4.1000
更新日期:1998-10-01 00:00:00
abstract::We report cerebral vasculitis in 2 cocaine users who developed symptoms (transient blindness and persistent headache) while smoking "crack," followed by progressive widespread cerebral dysfunction with focal signs over the next few weeks. One patient had smoked crack exclusively, and the other also used cocaine intrav...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.7.1092
更新日期:1990-07-01 00:00:00
abstract::About one-third of patients with acoustic tumor (AT) initially seek medical attention for nonaudiologic complaints. The nonspecific early symptoms of AT require the inclusion of AT in many neurologic differential diagnoses. Advances in electrophysiologic and radiographic tests have allowed earlier diagnosis of AT at a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.2.211
更新日期:1983-02-01 00:00:00
abstract::We report the cases of 5 patients from 2 sibships with the "adult" or chronic form of GM2 gangliosidosis and 2 patients from another sibship with the juvenile form. We demonstrated hexosaminidase A deficiency in all cases but in 1 sibship the enzymatic profile was identical to that in Tay-Sachs disease, whereas in the...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.1.145
更新日期:1990-01-01 00:00:00
abstract::The motor effects of direct agonists which act selectively on certain dopamine receptors were studied in monkeys rendered hemiparkinsonian by unilateral intracarotid injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The D-2 dopamine agonist, LY 171555, but not the D-1 agonist, SKF 38393, reduced parkin...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.10.1592
更新日期:1987-10-01 00:00:00
abstract::Hippocampal formation atrophy (HFA) developed in an adult, who did not have epilepsy previously, after the occurrence of new-onset partial seizures from acute thrombosis of an ipsilateral parietal venous angioma. There was no evidence of hippocampal injury, and the patient had only one brief, generalized tonic-clonic ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.10.1553
更新日期:2002-05-28 00:00:00
abstract::Patients, clinicians, and hospitals have undergone monumental changes during the coronavirus disease 2019 (COVID-19) pandemic. This crisis has forced us to consider the obligations that we neurologists have to our individual patients as well as the greater community. By returning to our fundamental understanding of th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009744
更新日期:2020-07-28 00:00:00
abstract::The authors describe diffusion-weighted imaging (DWI) and magnetic resonance spectroscopy (MRS) changes in the hippocampus within 48 hours of acute symptomatic seizures or status epilepticus in 12 patients. DWI showed increased signal and a decreased apparent diffusion coefficient (ADC) in all patients, with correspon...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000218207.18707.f4
更新日期:2006-06-13 00:00:00
abstract::Fatigue is a common but poorly understood symptom in Parkinson's disease (PD). Using previously validated scales, we asked 58 nondemented PD patients and 58 controls to fill out questionnaires assessing fatigue and depression and found that PD patients were more depressed and more fatigued than age-matched controls. A...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.10.2016
更新日期:1993-10-01 00:00:00
abstract:OBJECTIVE:To critically re-evaluate cases diagnosed as adult neuronal ceroid lipofuscinosis (ANCL) in order to aid clinicopathologic diagnosis as a route to further gene discovery. METHODS:Through establishment of an international consortium we pooled 47 unsolved cases regarded by referring centers as ANCL. Clinical a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002943
更新日期:2016-08-09 00:00:00
abstract::Previous anatomic and physiologic studies suggest brainstem dysfunction in cranial-cervical dystonia. To further explore this, we studied suprathreshold acoustic reflex waveforms in 15 such patients. A unique feature of this technique is its ability to reject movement artifacts before averaging the acoustic reflex wav...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.3.594
更新日期:1992-03-01 00:00:00
abstract::Coenzyme Q10 (CoQ10) transfers electrons from complexes I and II of the mitochondrial respiratory chain to complex III. There is one published report of human CoQ10 deficiency describing two sisters with encephalopathy, proximal weakness, myoglobinuria, and lactic acidosis. We report a patient who had delayed motor mi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.5.1238
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:To assess safety and feasibility of real-time (RT) MRI for evaluation of dysphagia and to compare this technique to standard assessment by flexible endoscopic evaluation of swallowing (FEES) and videofluoroscopy (VF) in a cohort of patients with inclusion body myositis (IBM). METHODS:Using RT-MRI, FEES, and ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003337
更新日期:2016-11-15 00:00:00
abstract::The effects of lysine vasopressin on memory and cognitive deficits in Alzheimer disease was investigated. In a double-blind study, seven patients were given 16 units of lysine vasopressin per day for 10 days and were compared with seven different patients receiving placebo. No significant difference in performance bet...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.32.6.674
更新日期:1982-06-01 00:00:00
abstract::Rosenthal fibers are present in several neurologic disorders. Their occurrence in widespread subependymal, subpial, and perivascular locations is thought to be diagnostic of Alexander's disease, but they have also been reported in rare adult cases. Some of these patients were neurologically intact with severe systemic...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.9.1733
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND:In patients with active epilepsy, adverse medication effects and severity of depression are correlated with health-related quality of life, but seizure frequency is not. We sought to examine if the same pattern exists in patients with psychogenic nonepileptic seizures (PNES). METHODS:We administered seizure...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181b04c83
更新日期:2009-08-04 00:00:00