Abstract:
:Hippocampal formation atrophy (HFA) developed in an adult, who did not have epilepsy previously, after the occurrence of new-onset partial seizures from acute thrombosis of an ipsilateral parietal venous angioma. There was no evidence of hippocampal injury, and the patient had only one brief, generalized tonic-clonic seizure. Although HFA progressed rapidly over 5.5 months, the partial seizures did not become prolonged or secondarily generalized. Evidence from the patient indicates that partial seizure activity can cause rapid and progressive hippocampal atrophy.
journal_name
Neurologyjournal_title
Neurologyauthors
Worrell GA,Sencakova D,Jack CR,Flemming KD,Fulgham JR,So ELdoi
10.1212/wnl.58.10.1553subject
Has Abstractpub_date
2002-05-28 00:00:00pages
1553-6issue
10eissn
0028-3878issn
1526-632Xjournal_volume
58pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::Mapping eloquent language cortex in presurgical patients typically is accomplished using highly invasive direct cortical stimulation techniques. Functional imaging during language activation using positron emission tomography (PET) is a promising, noninvasive alternative that requires validation. In seven patients und...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.4.1056
更新日期:1997-04-01 00:00:00
abstract:OBJECTIVE:To make evidence-based treatment recommendations for patients with Parkinson disease (PD) with dementia, depression, and psychosis based on these questions: 1) What tools are effective to screen for depression, psychosis, and dementia in PD? 2) What are effective treatments for depression and psychosis in PD?...
journal_title:Neurology
pub_type: 杂志文章,实务指引
doi:10.1212/01.wnl.0000215428.46057.3d
更新日期:2006-04-11 00:00:00
abstract::Intracerebral hemorrhage (ICH) represents 8 to 15% of all strokes in the United States and 20 to 30% of all strokes in Japan and China. Although ICH represents a relatively small fraction of total strokes, it is a formidable disease, with a 30-day mortality rate two- to sixfold higher than that for ischemic stroke. Fu...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.51.3_suppl_3.s69
更新日期:1998-09-01 00:00:00
abstract::Thirty-one individuals awaiting trial or sentencing for murder or undergoing an appeal process requested a neurologic examination through legal counsel. We attempted in each instance to obtain EEG, MRI or CT, and neuropsychological testing. Neurologic examination revealed evidence of "frontal" dysfunction in 20 (64.5%...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.9.1641
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVE:To describe the detection frequency and clinical associations of immunoglobulin G (IgG) targeting dipeptidyl-peptidase-like protein-6 (DPPX), a regulatory subunit of neuronal Kv4.2 potassium channels. METHODS:Specimens from 20 patients evaluated on a service basis by tissue-based immunofluorescence yielded a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000991
更新日期:2014-11-11 00:00:00
abstract:OBJECTIVE:To assess the evidence demonstrating efficacy, tolerability, and safety of seven new antiepileptic drugs (AEDs) (gabapentin, lamotrigine, topiramate, tiagabine, oxcarbazepine, levetiracetam, and zonisamide) in the treatment of children and adults with refractory partial and generalized epilepsies. METHODS:A ...
journal_title:Neurology
pub_type: 指南,杂志文章,实务指引,评审
doi:10.1212/01.wnl.0000123695.22623.32
更新日期:2004-04-27 00:00:00
abstract::Valproic acid (VPA) has been postulated to exert its anticonvulsant effects by interaction with the postsynaptic GABA receptor. To test that hypothesis, we applied VPA in clinically appropriate concentrations to cortical neurons in dissociated cell culture. VPA did not enhance the postsynaptic effect of GABA, but did ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.2.259
更新日期:1986-02-01 00:00:00
abstract:OBJECTIVE:To determine the association between hypertensive disorders of pregnancy (HDP) and cognitive impairment 15 years after pregnancy, we measured cognitive performance in 115 women with a history of HDP and in 481 women with a previous normotensive pregnancy. METHODS:This was a nested cohort study embedded in a ...
journal_title:Neurology
pub_type: 评论,杂志文章
doi:10.1212/WNL.0000000000011363
更新日期:2021-02-02 00:00:00
abstract:OBJECTIVE:To evaluate trends in atrial fibrillation (AF) prevalence in acute ischemic stroke (AIS) and TIA in the United States. METHODS:We used the Nationwide Inpatient Sample to retrospectively compute weighted prevalence of AF in AIS (n = 4,355,140) and TIA (n = 1,816,459) patients admitted to US hospitals from 200...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003321
更新日期:2016-11-08 00:00:00
abstract:BACKGROUND:Genetic studies of PD frequently rely on family history interviews (FHI), yet the accuracy of data obtained in this way is unclear. OBJECTIVE:To assess the interinformant reliability and validity of family history information on PD in first-degree relatives of PD cases and controls. METHODS:A structured FH...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000074784.35961.c0
更新日期:2003-07-08 00:00:00
abstract:OBJECTIVE:To study the presenting features and value of routine diagnostic procedures in patients with leptomeningeal metastases (LMM) related to the primary malignancy to improve diagnostic assessment. METHODS:The authors studied the presenting features and value of routine diagnostic procedures in relation to the hi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.2.382
更新日期:1999-07-22 00:00:00
abstract::Cerebral cholesterol metabolism has been linked with production of amyloid peptide (Abeta) crucial in AD. The association between use of cholesterol-lowering drugs (statins) and AD disease is currently being intensely discussed. In this case-control study on elderly nondemented subjects, the authors provide the first ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.59.8.1257
更新日期:2002-10-22 00:00:00
abstract:OBJECTIVE:To determine the role of oxidative stress in mediating HIV dementia and to identify novel therapeutic compounds that may block this oxidative stress. METHODS:Brain tissue from patients with HIV encephalitis and macaques with simian immune deficiency virus encephalitis was immunostained for lipid peroxidation...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000042048.85204.3d
更新日期:2003-01-28 00:00:00
abstract::Kuru plaques are the pathologic hallmark in Gerstmann-Sträussler syndrome (GSS). To demonstrate that prion protein (PrP) is a component of kuru plaque cores, we fractionated and sequenced kuru plaque core derived peptides, following digestion with Achromobacter lyticus protease I. We identified 3 PrP-derived peptides ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.2_part_1.306
更新日期:1991-02-01 00:00:00
abstract::The term "Wernicke's area" is most often used as an anatomical label for the gyri forming the lower posterior left sylvian fissure. Although traditionally this region was held to support language comprehension, modern imaging and neuropsychological studies converge on the conclusion that this region plays a much large...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0000000000002219
更新日期:2015-12-15 00:00:00
abstract:PURPOSE:To understand the role of the angiopoietin-like 6 gene (ANGPTL6) in intracranial aneurysms (IAs), we investigated its role in a large cohort of familial IAs. METHODS:Individuals with family history of IA were recruited to the Genetic and Observational Subarachnoid Haemorrhage (GOSH) study. The ANGPTL6 gene was...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000011125
更新日期:2020-10-26 00:00:00
abstract::Epilepsy is common in people with intellectual and developmental disabilities (IDD). In adulthood, patients with IDD and epilepsy (IDD-E) have neurologic, psychiatric, medical, and social challenges compounded by fragmented and limited care. With increasing neurologic disability, there is a higher frequency of epileps...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0000000000002060
更新日期:2015-10-27 00:00:00
abstract::Anti-Leu 7 antibody reacts with determinants on a subset of natural killer (NK) cells and myelin-associated glycoprotein (MAG). In a patient patient with peripheral neuropathy and IgM autoantibodies against MAG, we found the distribution and functions of NK cells to be normal. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.4.566
更新日期:1986-04-01 00:00:00
abstract:OBJECTIVE:To determine black-white differences in 1-year recurrent stroke and 30-day case fatality after a recurrent stroke in older US adults. METHODS:We conducted a retrospective cohort study using a 5% random sample of Medicare beneficiaries with fee-for-service health insurance coverage who were hospitalized for i...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006467
更新日期:2018-11-06 00:00:00
abstract::We report a family with an X-linked recessive disorder characterized by muscle cramps and myalgia. Nine affected male family members had high resting serum levels of creatine kinase, and well-developed musculature with calf hypertrophy but no evidence of muscular weakness. Symptoms began in childhood and did not progr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.10.1277
更新日期:1989-10-01 00:00:00
abstract::Patients with mild cognitive impairment (MCI) were assessed, and a metabolic profile associated with conversion to AD at 18-month follow-up was sought. As compared with nonconverters (n = 10), converters (n = 7) had lower fluorodeoxyglucose uptake in the right temporoparietal cortex (p = 0.02, corrected for cluster si...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000055847.17752.e6
更新日期:2003-04-22 00:00:00
abstract::Most gliomas in neurofibromatosis type 1 (NF1) are pilocytic astrocytomas (PAs) of the optic pathway occurring in young children. However, some individuals develop gliomas that lack the typical NF1-associated clinical features or radiographic appearance. We identified 17 atypical presentations from a review of 100 pat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000240076.31298.47
更新日期:2006-10-24 00:00:00
abstract::To study the incidence of abnormalities of the pyruvate (PDH) or ketoglutarate (KGDH) dehydrogenase complexes in patients with spinocerebellar degenerations, we measured the activities of PDH and KGDH in platelet-enriched preparations from the blood of 14 patients. Low PDH was found in 6 of the 14 patients; low KGDH w...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.1.126
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVE:Brain changes occurring early in HIV infection are not well characterized. The Chicago Early HIV Infection Study aimed to evaluate the presence and extent of structural brain alterations using quantitative MRI. METHODS:Forty-three HIV and 21 control subjects were enrolled. Mean length of infection was estima...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318278b5b4
更新日期:2012-12-11 00:00:00
abstract:OBJECTIVE:To investigate the cognitive decline in dementia with Lewy bodies (DLBs) and characterize the contribution of Lewy bodies (LBs) to cognitive impairment in the presence of concurrent Alzheimer disease (AD). METHODS:Cognitive deficits and rates of progression attributable to DLB and AD neuropathology were inve...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000180964.60708.c2
更新日期:2005-10-25 00:00:00
abstract::In a previously unreported family with olivopontocerebellar atrophy, the kindred contained over 600 individuals in five generations. Of 83 offsping of affected individuals who over over 38.8 years of age (the mean age of the onset of disease in this family), 47 had ataxia; there was autosomal dominant transmission. Cl...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.1.12
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVE:To investigate whether patients with moyamoya angiopathy without obvious retinal pathologies such as retinal infarctions or the congenital morning glory anomaly may have subtle subclinical retinal changes. METHODS:In this cross-sectional study, spectral domain optical coherence tomography was used to analyze...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001832
更新日期:2015-08-11 00:00:00
abstract:BACKGROUND:In acute cerebral ischemia, two variables characterize the extent of hypoperfusion: the volume of hypoperfused tissue and the intensity of hypoperfusion within these regions. We evaluated the determinants of the intensity of hypoperfusion within oligemic regions among patients who were eligible for recanaliz...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000335929.06390.d3
更新日期:2008-11-25 00:00:00
abstract::Plasma levels of six short-chain fatty acids (SCFA) were measured in 23 Reye's syndrome patients. In sequential measurements, only propionic acid correlated closely with neurologic severity. Although admission SCFA levels were slightly elevated, there were no significant differences between patients grouped by severit...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.6.831
更新日期:1984-06-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between baseline hypertension and severity of white matter hyperintensities (WMH) at 4-year follow-up in a sample of subjects aged 59 to 71 years old at entry. METHODS:Subjects were participants in the Epidemiology of Vascular Ageing study, a longitudinal study on vascular agi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.7.921
更新日期:2001-04-10 00:00:00