Effects of valproic acid in cultured mammalian neurons.

abstract：:A 32-year-old patient with seizures experienced decreased right-ear hearing during electrocortical stimulation mapping of the left lateral superior temporal gyrus. Audiometric testing under headphones confirmed a reversible, moderate unilateral hearing loss. Under binaural listening conditions, auditory comprehension ...

journal_title：Neurology

authors： Sinha SR,Crone NE,Fotta R,Lenz F,Boatman DF

更新日期：2005-01-25 00:00:00

abstract：:Oligoclonal bands ( OCBs ) were examined in CSF from 23 normal controls, 8 cases of inflammatory neurologic diseases, 24 cases of noninflammatory neurologic diseases, 27 sporadic cases of MS, and the 29 MS twin pairs, by isoelectric focusing followed by silver staining or western transblotting and immunoperoxidase sta...

journal_title：Neurology

authors： Xu XH,McFarlin DE

更新日期：1984-06-01 00:00:00

abstract：:We retrospectively studied the effects of changing antiepileptic drug levels on patterns of seizure discharge in 8 patients investigated with intracerebral electrodes during presurgical evaluation. We compared seizures recorded at high levels of medication to seizures recorded at low levels for changes in seizure dura...

journal_title：Neurology

authors： So N,Gotman J

更新日期：1990-03-01 00:00:00

abstract：:We report the cases of 5 patients from 2 sibships with the "adult" or chronic form of GM2 gangliosidosis and 2 patients from another sibship with the juvenile form. We demonstrated hexosaminidase A deficiency in all cases but in 1 sibship the enzymatic profile was identical to that in Tay-Sachs disease, whereas in the...

journal_title：Neurology

authors： Specola N,Vanier MT,Goutières F,Mikol J,Aicardi J

更新日期：1990-01-01 00:00:00

abstract：:We report of a woman aged 52 years born to consanguineous parents and seeking treatment for progressive dementia and delusion. Neurologic examination revealed dementia and emotional instability, indifference, and confabulation. There was also mild spasticity of the bilateral lower limbs. MRI revealed diffuse white mat...

journal_title：Neurology

authors： Ohtake H,Shimohata T,Terajima K,Kimura T,Jo R,Kaseda R,Iizuka O,Takano M,Akaiwa Y,Goto H,Kobayashi H,Sugai T,Muratake T,Hosoki T,Shioiri T,Okamoto K,Onodera O,Tanaka K,Someya T,Nakada T,Tsuji S

更新日期：2004-05-11 00:00:00

abstract：:The incidence of new-onset epilepsy is higher among the elderly, the most rapidly growing segment of the population, than in any other age group. New-onset seizures in elderly patients are typically cryptogenic or symptomatic partial seizures that require long-term treatment. Because seizures in the elderly are often ...

journal_title：Neurology

authors： Bergey GK

更新日期：2004-11-23 00:00:00

abstract：OBJECTIVES:More than 30 different rare mutations, including copy number variants (CNVs), in the amyloid precursor protein gene (APP) cause early-onset familial Alzheimer disease (EOFAD), whereas the contribution of common APP variants to disease risk remains controversial. In this study we systematically assessed the r...

journal_title：Neurology

authors： Hooli BV,Mohapatra G,Mattheisen M,Parrado AR,Roehr JT,Shen Y,Gusella JF,Moir R,Saunders AJ,Lange C,Tanzi RE,Bertram L

更新日期：2012-04-17 00:00:00

abstract：BACKGROUND:The Vietnam Head Injury Study (VHIS) is a prospective, longitudinal follow-up of 1,221 Vietnam War veterans with mostly penetrating head injuries (PHIs). The high prevalence (45%-53%) of posttraumatic epilepsy (PTE) in this unique cohort makes it valuable for study. METHODS:A standardized multidisciplinary ...

journal_title：Neurology

authors： Raymont V,Salazar AM,Lipsky R,Goldman D,Tasick G,Grafman J

更新日期：2010-07-20 00:00:00

abstract：OBJECTIVE:To describe and evaluate the incidence and risk factors of severe neurologic events (SNE) in pediatric recipients of allogeneic or autologous hematopoietic stem cell transplantation (HSCT) for hematologic or nonhematologic diseases. METHODS:Retrospective analysis of 272 consecutive children admitted to the G...

journal_title：Neurology

authors： Faraci M,Lanino E,Dini G,Fondelli MP,Morreale G,Dallorso S,Manzitti C,Calevo MG,Gaggero R,Castagnola E,Haupt R

更新日期：2002-12-24 00:00:00

abstract：:We studied performance on tests of visual neglect and left lateral gaze after caloric stimulation in 18 patients with left-sided visual neglect after strokes. Except for one patient with absent vestibulo-ocular responses, all improved during caloric stimulation on the left by cold (LC) or on the right by warm water (R...

journal_title：Neurology

authors： Rubens AB

更新日期：1985-07-01 00:00:00

abstract：:The authors correlated neurologic features of rostral lateral pontine infarct (rLPI) with lesion location on MRI. rLPI is a motor-sensory stroke presenting as crural monoparesis or crural dominant hemiparesis and segmental superficial or deep sensory disturbances. The dorsolateral pontine base causes crural paresis wi...

journal_title：Neurology

authors： Kataoka S,Miaki M,Saiki M,Saiki S,Yamaya Y,Hori A,Hirose G

更新日期：2003-07-08 00:00:00

abstract：:In seven of eight patients with progressive multiple sclerosis subjected to long-term plasmapheresis in combination with azathioprine and pulsed prednisone therapy, we found modest improvement of neurologic function. There was no change in auditory and visual evoked responses or serum demyelinating activity. In six of...

journal_title：Neurology

authors： Dau PC,Petajan JH,Johnson KP,Panitch HS,Bornstein MB

更新日期：1980-10-01 00:00:00

abstract：:We identified 53 patients with non-neoplastic cysts of the pineal gland. In contrast to patients with pineal neoplasms, pineal cysts are usually asymptomatic. They infrequently obstruct the aqueduct to cause hydrocephalus or compress the tectum to produce the neuro-ophthalmologic signs of dorsal midbrain dysfunction. ...

journal_title：Neurology

authors： Fetell MR,Bruce JN,Burke AM,Cross DT,Torres RA,Powers JM,Stein BM

更新日期：1991-07-01 00:00:00

abstract：:We compared the neurologic and cognitive performance of 15 young veterans who suffered unilateral penetrating missile wounds to the basal forebrain 15 years ago in the Vietnam War with uninjured controls and patients with lesions elsewhere in the brain. The subjects performed worse on tests of episodic memory, reasoni...

journal_title：Neurology

authors： Salazar AM,Grafman J,Schlesselman S,Vance SC,Mohr JP,Carpenter M,Pevsner P,Ludlow C,Weingartner H

更新日期：1986-04-01 00:00:00

abstract：BACKGROUND:A large proportion of survivors of traumatic brain injury (TBI) have persistent cognitive impairments, the profile of which does not always correspond to the size and location of injuries. One possible explanation could be that TBI-induced damage extends beyond obvious lesion sites to affect remote brain net...

journal_title：Neurology

authors： Kasahara M,Menon DK,Salmond CH,Outtrim JG,Taylor Tavares JV,Carpenter TA,Pickard JD,Sahakian BJ,Stamatakis EA

更新日期：2010-07-13 00:00:00

abstract：OBJECTIVE:To investigate whether tactile extinction alters the cortical somatosensory activations induced by hand vibration. BACKGROUND:Tactile extinction occurs mainly after right-brain lesions and consists of the inability to perceive a contralesional cutaneous stimulation when a similar stimulus is applied to the m...

journal_title：Neurology

authors： Remy P,Zilbovicius M,Degos JD,Bachoud-Lévi AC,Rancurel G,Cesaro P,Samson Y

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:In the setting of severe immunosuppression, the polyomavirus JC (JCV) can cause a lytic infection of oligodendrocytes. This demyelinating disease of the CNS white matter (WM) is called progressive multifocal leukoencephalopathy (PML). JCV has a very narrow host-cell range and productive infection of neurons ...

journal_title：Neurology

authors： Du Pasquier RA,Corey S,Margolin DH,Williams K,Pfister LA,De Girolami U,Mac Key JJ,Wüthrich C,Joseph JT,Koralnik IJ

更新日期：2003-09-23 00:00:00

abstract：BACKGROUND:Frontotemporal dementia associated with motor neuron disease (FTD-MND) is a rare neurodegenerative disorder that may be inherited by autosomal dominant trait. No major gene has been identified but a locus was mapped on chromosome 9 (9p21.3-p13.3). METHODS:Ten French families with FTD-MND were tested for lin...

journal_title：Neurology

authors： Le Ber I,Camuzat A,Berger E,Hannequin D,Laquerrière A,Golfier V,Seilhean D,Viennet G,Couratier P,Verpillat P,Heath S,Camu W,Martinaud O,Lacomblez L,Vercelletto M,Salachas F,Sellal F,Didic M,Thomas-Anterion C,Puel M

更新日期：2009-05-12 00:00:00

abstract：OBJECTIVE:To develop a scientifically sound and clinically relevant evidence-based guideline for the treatment of painful diabetic neuropathy (PDN). METHODS:We performed a systematic review of the literature from 1960 to August 2008 and classified the studies according to the American Academy of Neurology classificati...

journal_title：Neurology

authors： Bril V,England J,Franklin GM,Backonja M,Cohen J,Del Toro D,Feldman E,Iverson DJ,Perkins B,Russell JW,Zochodne D,American Academy of Neurology.,American Association of Neuromuscular and Electrodiagnostic Medicine.,American Acade

更新日期：2011-05-17 00:00:00

abstract：BACKGROUND:Basic issues regarding factors influencing progressive supranuclear palsy (PSP) patient caregiver burden remain unresolved, including whether and how disease severity and duration influence caregiver burden. OBJECTIVE:To examine the relation between PSP patient caregiver burden and disease severity, describ...

journal_title：Neurology

authors： Uttl B,Santacruz P,Litvan I,Grafman J

更新日期：1998-11-01 00:00:00

abstract：:Coma is rare in temporal arteritis (TA). We describe a patient with TA who suddenly developed coma with a triphasic EEG pattern that resolved after initiation of steroid treatment. Although the arterial lesions in TA are segmental in nature, TA may present with signs of diffuse neurologic deficit; early treatment can ...

journal_title：Neurology

authors： Tomer Y,Neufeld MY,Shoenfeld Y

更新日期：1992-02-01 00:00:00

abstract：OBJECTIVE:To report five stroke patients with sensory deficits including prominent chest discomfort mimicking angina. BACKGROUND:Chest wall sensory discomfort, as a part of unilateral sensory dysfunction, has seldom been recognized as a potential imitator of cardiac ischemia. METHODS:A retrospective review of stroke ...

journal_title：Neurology

authors： Gorson KC,Pessin MS,DeWitt LD,Caplan LR

更新日期：1996-02-01 00:00:00

abstract：:Human cytomegalovirus and herpes simplex virus DNA probes were labeled in vitro and hybridized to the DNA extracted from brains of patients with multiple sclerosis (MS) to detect the presence of genetic information related to these viruses. We were unable to detect any virus-related genetic information complementary t...

journal_title：Neurology

authors： Aulakh GS,Albrecht P,Tourtellotte WW

更新日期：1980-05-01 00:00:00

abstract：:The "modified host protein" model of scrapie proposes that the transmissible agent is composed of the degradation-resistant protein, Sp33-37, and that clinical and pathologic signs result from neurotoxic accumulations of this protein. Sp33-37 is an abnormal, amyloidogenic isoform of the normally occurring cellular pro...

journal_title：Neurology

authors： Bendheim PE,Brown HR,Rudelli RD,Scala LJ,Goller NL,Wen GY,Kascsak RJ,Cashman NR,Bolton DC

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:To evaluate whether subthalamic nucleus (STN) stimulation has an effect on the orthostatic regulation of patients with Parkinson disease (PD), we studied cardiovascular regulation during on and off phases of STN stimulation. METHODS:We examined 14 patients with PD (mean age 58.1 +/- 5.8 years, 4 women, 10 me...

journal_title：Neurology

authors： Stemper B,Beric A,Welsch G,Haendl T,Sterio D,Hilz MJ

更新日期：2006-11-28 00:00:00

abstract：OBJECTIVE:To assess whether hippocampal sclerosis (HS) severity is mirrored at the level of large-scale networks. METHODS:We studied preoperative high-resolution anatomical and diffusion-weighted MRI of 44 temporal lobe epilepsy (TLE) patients with histopathologic diagnosis of HS (n = 25; TLE-HS) and isolated gliosis ...

journal_title：Neurology

authors： Bernhardt BC,Fadaie F,Liu M,Caldairou B,Gu S,Jefferies E,Smallwood J,Bassett DS,Bernasconi A,Bernasconi N

更新日期：2019-05-07 00:00:00

abstract：OBJECTIVE:To describe the diagnosis and management of a 49-year-old woman with multiple sclerosis (MS) developing a progressive hemiparesis and expanding MRI lesion suspicious of progressive multifocal leukoencephalopathy (PML) 19 months after starting natalizumab. RESULTS:Polyomavirus JC (JCV)-specific qPCR in CSF wa...

journal_title：Neurology

authors： Kuhle J,Gosert R,Bühler R,Derfuss T,Sutter R,Yaldizli O,Radue EW,Ryschkewitsch C,Major EO,Kappos L,Frank S,Hirsch HH

更新日期：2011-12-06 00:00:00

abstract：OBJECTIVE:To identify the genetic and physiologic basis for recessive myasthenic congenital myopathy in 2 families, suggestive of a channelopathy involving the sodium channel gene, SCN4A. METHODS:A combination of whole exome sequencing and targeted mutation analysis, followed by voltage-clamp studies of mutant sodium ...

journal_title：Neurology

authors： Elia N,Palmio J,Castañeda MS,Shieh PB,Quinonez M,Suominen T,Hanna MG,Männikkö R,Udd B,Cannon SC

更新日期：2019-03-26 00:00:00

abstract：OBJECTIVES:To learn caregivers' preferences for the treatment of AD with a disease-slowing therapy, and to identify relationships between these preferences and the characteristics of caregivers and patients. METHODS:A structured interview with 40 caregivers of patients with AD. Preferences were measured for an AD-slow...

journal_title：Neurology

authors： Karlawish JH,Klocinski JL,Merz J,Clark CM,Asch DA

更新日期：2000-10-10 00:00:00

abstract：OBJECTIVE:To test the diagnostic accuracy of the horizontal head impulse test (h-HIT) of vestibulo-ocular reflex (VOR) function in distinguishing acute peripheral vestibulopathy (APV) from stroke. Most patients with acute vertigo, nausea/vomiting, and unsteady gait have benign APV (vestibular neuritis or labyrinthitis)...

journal_title：Neurology

authors： Newman-Toker DE,Kattah JC,Alvernia JE,Wang DZ

更新日期：2008-06-10 00:00:00