The juvenile and chronic forms of GM2 gangliosidosis: clinical and enzymatic heterogeneity.

abstract：OBJECTIVE:To determine the association between hypertensive disorders of pregnancy (HDP) and cognitive impairment 15 years after pregnancy, we measured cognitive performance in 115 women with a history of HDP and in 481 women with a previous normotensive pregnancy. METHODS:This was a nested cohort study embedded in a ...

journal_title：Neurology

authors： Adank MC,Hussainali RF,Oosterveer LC,Ikram MA,Steegers EAP,Miller EC,Schalekamp-Timmermans S

更新日期：2021-02-02 00:00:00

abstract：:This multicenter, double-blind, crossover study compared Tegretol-XR and Tegretol tablets with respect to trough plasma carbamazepine (CBZ) concentrations, seizure control, tolerability, and safety. We randomized 96 patients with epilepsy to 56-day monotherapy with their usual daily CBZ dose administered as (1) Tegret...

journal_title：Neurology

authors：

更新日期：1995-09-01 00:00:00

abstract：OBJECTIVE:Glucocerebrosidase (GBA) gene mutations represent a strong risk factor for Parkinson disease (PD). PD penetrance in GBA mutation carriers, which represents a key issue for genetic counseling, especially for relatives of patients with Gaucher disease (GD), is unknown. Our objective was to estimate PD penetranc...

journal_title：Neurology

authors： Anheim M,Elbaz A,Lesage S,Durr A,Condroyer C,Viallet F,Pollak P,Bonaïti B,Bonaïti-Pellié C,Brice A,French Parkinson Disease Genetic Group.

更新日期：2012-02-07 00:00:00

abstract：OBJECTIVE:We performed propensity score (PS) models to compare the outcome of patients with myasthenia gravis (MG) submitted to 2 different surgical approaches: extended transsternal (T-3b) or thoracoscopic extended thymectomy (VATET). METHODS:Patients' clinical data were retrieved from the MG database of the C. Besta...

journal_title：Neurology

authors： Brenna G,Antozzi C,Montomoli C,Baggi F,Mantegazza R,INCB-MG Group.

更新日期：2017-07-11 00:00:00

abstract：:Research and development of the adenosine A2A receptor selective antagonist KW6002 have focused on developing a novel nondopaminergic therapy for Parkinson's disease (PD). Salient pharmacologic features of KW6002 were investigated in several animal models of PD. In rodent and primate models, KW6002 provides symptomati...

journal_title：Neurology

authors： Kase H,Aoyama S,Ichimura M,Ikeda K,Ishii A,Kanda T,Koga K,Koike N,Kurokawa M,Kuwana Y,Mori A,Nakamura J,Nonaka H,Ochi M,Saki M,Shimada J,Shindou T,Shiozaki S,Suzuki F,Takeda M,Yanagawa K,Richardson PJ,Jenner P

更新日期：2003-12-09 00:00:00

abstract：:Oligoclonal bands ( OCBs ) were examined in CSF from 23 normal controls, 8 cases of inflammatory neurologic diseases, 24 cases of noninflammatory neurologic diseases, 27 sporadic cases of MS, and the 29 MS twin pairs, by isoelectric focusing followed by silver staining or western transblotting and immunoperoxidase sta...

journal_title：Neurology

authors： Xu XH,McFarlin DE

更新日期：1984-06-01 00:00:00

abstract：:Regional levels of brain monoamines and their metabolites were examined in a rat model of reversible and diffuse forebrain ischemia with and without reperfusion. During ischemia, blood flow decreased by 87 to 95%, but recovered to control values during recirculation. Norepinephrine and serotonin decreased in the cereb...

journal_title：Neurology

authors： Harik SI,Yoshida S,Busto R,Ginsberg MD

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:Pregnancy registries for women taking anticonvulsant drugs have been developed to determine more efficiently the fetal risks of each drug. A total of 722 drug-exposed pregnancies are needed to identify a sevenfold increase in the rate of occurrence of a specific abnormality, such as spina bifida, with a freq...

journal_title：Neurology

authors： Holmes LB,Baldwin EJ,Smith CR,Habecker E,Glassman L,Wong SL,Wyszynski DF

更新日期：2008-05-27 00:00:00

abstract：:In patients with spatial neglect, contralesional reflexive saccades toward suddenly appearing targets show direction-specific deficits. We examined whether these deficits also occur during free exploration of space. Neglect patients' voluntary eye movements showed reduced amplitudes for saccades in all directions but ...

journal_title：Neurology

authors： Niemeier M,Karnath HO

更新日期：2000-01-25 00:00:00

abstract：OBJECTIVE:To analyze the impact of neutralizing antibodies (NAbs) on the clinical efficacy of IFNbeta. METHODS:This was an open-label study involving 78 patients with multiple sclerosis treated with Betaferon 8 million IU (MIU) subcutaneously (SC) every other day (n = 20), Rebif 22 micro g SC 3 times weekly (n = 25), ...

journal_title：Neurology

authors： Malucchi S,Sala A,Gilli F,Bottero R,Di Sapio A,Capobianco M,Bertolotto A

更新日期：2004-06-08 00:00:00

abstract：:Two hypertensive men presented clinically with small, largely unilateral hematomas of the pons and midbrain demonstrated by computerized tomography. Clinical manifestations included "ocular bobbing," complex forms of ophthalmoplegia, Cheyne-Stokes respiration, and pyramidal tract signs. The "typical" sings of massive ...

journal_title：Neurology

authors： Kase CS,Maulsby GO,Mohr JP

更新日期：1980-06-01 00:00:00

abstract：OBJECTIVE:To describe the clinical features of cardiac injury associated with neurogenic pulmonary edema (NPE) in patients with acute subarachnoid hemorrhage (SAH). BACKGROUND:NPE is generally viewed as a form of noncardiogenic pulmonary edema related to massive sympathetic discharge. METHODS:Case series. RESULTS:We...

journal_title：Neurology

authors： Mayer SA,Fink ME,Homma S,Sherman D,LiMandri G,Lennihan L,Solomon RA,Klebanoff LM,Beckford A,Raps EC

更新日期：1994-05-01 00:00:00

abstract：:We systematically reviewed and analyzed published and unpublished cases of lamotrigine-associated adverse drug reactions consistent with the features of the anticonvulsant hypersensitivity syndrome (AHS) to identify characteristics of the syndrome. We identified 26 cases (mean age, 28+/-18 years; range, 3.5 to 74 year...

journal_title：Neurology

authors： Schlienger RG,Knowles SR,Shear NH

更新日期：1998-10-01 00:00:00

abstract：:We studied two patients with Meige syndrome who developed alpha-methyldopa-induced parkinsonism. Opposite responses of parkinsonian and dystonic symptoms to antiparkinson drugs in some cases suggest a functionally reciprocal relationship between these disorders. ...

journal_title：Neurology

authors： Sechi GP,Demontis G,Rosati G

更新日期：1985-11-01 00:00:00

abstract：:Rats were intoxicated with acrylamide monomer at 50 mg per kilogram per day; lumbar dorsal root ganglia and distal sural and tibial nerves were studied morphologically. At the sixth day of intoxication, large and small neuronal cell bodies showed a spectrum of remodeling changes that included nuclear eccentricity, cyt...

journal_title：Neurology

authors： Sterman AB

更新日期：1982-09-01 00:00:00

abstract：OBJECTIVE:To clarify the relationship between depressive symptoms and the clinical and neuropathologic manifestations of dementia. METHODS:In a clinical-pathologic cohort study, 1,764 older persons without cognitive impairment at enrollment completed annual clinical evaluations for a mean of 7.8 years. The evaluations...

journal_title：Neurology

authors： Wilson RS,Capuano AW,Boyle PA,Hoganson GM,Hizel LP,Shah RC,Nag S,Schneider JA,Arnold SE,Bennett DA

更新日期：2014-08-19 00:00:00

abstract：:A 17-month-old boy developed herpes zoster ophthalmicus (HZO) and delayed contralateral hemiparesis following intrauterine varicella exposure. CT demonstrated multiple areas of hypodensity in the left basal ganglia, and angiography showed occlusion of left lenticulostriate arteries. As in most adults with HZO and dela...

journal_title：Neurology

authors： Leis AA,Butler IJ

更新日期：1987-09-01 00:00:00

abstract：OBJECTIVE:To evaluate patients with early HIV-cognitive motor complex (HIV-CMC) for possible regional cerebral blood flow (rCBF) abnormalities on perfusion MRI (pMRI). BACKGROUND:Nuclear medicine techniques have demonstrated global and focal cerebral perfusion abnormalities in patients with HIV dementia. Ultrafast pMR...

journal_title：Neurology

authors： Chang L,Ernst T,Leonido-Yee M,Speck O

更新日期：2000-01-25 00:00:00

abstract：OBJECTIVES:To evaluate basal ganglia changes along the amyotrophic lateral sclerosis (ALS)-ALS-frontotemporal dementia (FTD) continuum using multiple, complementary imaging techniques. METHODS:Sixty-seven C9orf72-negative patients with ALS and 39 healthy controls were included in a cross-sectional quantitative MRI stu...

journal_title：Neurology

authors： Machts J,Loewe K,Kaufmann J,Jakubiczka S,Abdulla S,Petri S,Dengler R,Heinze HJ,Vielhaber S,Schoenfeld MA,Bede P

更新日期：2015-10-13 00:00:00

abstract：:We reviewed the clinical and laboratory features of 81 patients who had trigeminal sensory neuropathy (TSN) and a connective tissue disease (CTD). The neuropathy developed before the symptoms of CTD in 6/81 patients (7%), and in 38/81 patients (47%) TSN and CTD were diagnosed concurrently. The most frequently associat...

journal_title：Neurology

authors： Hagen NA,Stevens JC,Michet CJ Jr

更新日期：1990-06-01 00:00:00

abstract：OBJECTIVE:To compare neurofilament light (NfL) and tau as blood-based biomarkers for acute sports-related concussion (SRC) and determine whether their concentrations at different time points after the injury are associated with prolonged time to return to play (RTP). METHODS:A total of 288 professional hockey players ...

journal_title：Neurology

authors： Shahim P,Tegner Y,Marklund N,Blennow K,Zetterberg H

更新日期：2018-05-15 00:00:00

abstract：OBJECTIVE:To demonstrate that progress has been made in unifying brain death determination guidelines in the last decade by directly comparing the policies of the US News and World Report's top 50 ranked neurologic institutions from 2006 and 2015. METHODS:We solicited official hospital guidelines in 2015 from these to...

journal_title：Neurology

authors： Wang HH,Varelas PN,Henderson GV,Wijdicks EF,Greer DM

更新日期：2017-02-07 00:00:00

abstract：:This community-based study analyzed 54 patients with definite or probable tuberculous meningitis (TBM) in New Mexico from 1970 through 1990. Patients ranged in age from 4 months to 86 years. The highest age-specific incidence occurred in the elderly, but 22% of patients were less than 10 years old. Native American pat...

journal_title：Neurology

authors： Davis LE,Rastogi KR,Lambert LC,Skipper BJ

更新日期：1993-09-01 00:00:00

abstract：:Prompted by the observation that a fellow medical student sneezed at about the same time in class every morning, we recorded the time of each of the 118 sneezes she made on 69 days over a 6.5-month period. Analysis of the sneeze times with the goodness-of-fit test revealed a highly nonuniform distribution (p < 0.0001)...

journal_title：Neurology

authors： Grant AC,Roter EP

更新日期：1994-03-01 00:00:00

abstract：OBJECTIVE:To describe clinical characteristics, imaging findings, morbidity, and mortality in a single-center cohort of 12 pediatric cavernous sinus thrombosis cases and to review all cases available in recent English literature. METHODS:Clinical data and radiographic studies on 12 cases from our institution were anal...

journal_title：Neurology

authors： Smith DM,Vossough A,Vorona GA,Beslow LA,Ichord RN,Licht DJ

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:Nonmotor symptoms (sleep dysfunction, sensory symptoms, autonomic dysfunction, mood disorders, and cognitive abnormalities) in Parkinson disease (PD) are a major cause of morbidity, yet are often underrecognized. This evidence-based practice parameter evaluates treatment options for the nonmotor symptoms of P...

journal_title：Neurology

authors： Zesiewicz TA,Sullivan KL,Arnulf I,Chaudhuri KR,Morgan JC,Gronseth GS,Miyasaki J,Iverson DJ,Weiner WJ,Quality Standards Subcommittee of the American Academy of Neurology.

更新日期：2010-03-16 00:00:00

abstract：:Pathology and imaging studies have shown that patients with Parkinson disease (PD) have a prolonged period of uncertain duration when vulnerable neuronal populations are degenerating, but typical motor symptoms have not yet developed. This provides both an opportunity-it may be best to test new medications and, ultima...

journal_title：Neurology

authors： Marek K,Jennings D

更新日期：2009-02-17 00:00:00

abstract：:Human subjects normally have miniature eye movements during tasks that require steady visual fixation. These eye movements were compared in 12 control subjects and 4 patients with degenerative cerebellar disorders. Slow drifts, small fixation saccades, square waves, saccadic oscillations, flutter, and vertical nystagm...

journal_title：Neurology

authors： Hotson JR

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:The clinical characteristics of Tourette syndrome (TS) present challenges for the systematic determination of whether individuals are affected and severity. Vocal and motor tics wax and wane, decrease over time, and may be voluntarily suppressible, and therefore may be absent at interview. Current instrument...

journal_title：Neurology

authors： Robertson MM,Banerjee S,Kurlan R,Cohen DJ,Leckman JF,McMahon W,Pauls DL,Sandor P,van de Wetering BJ

更新日期：1999-12-10 00:00:00

abstract：OBJECTIVE:To evaluate differences in cerebrovascular reactivity (CVR) to mild hypercapnia in obese/overweight individuals with and without insulin resistance (IR) compared to comparable lean controls. METHODS:A total of 60 cognitively normal participants (20 lean controls and 24 obese/overweight individuals with and 1...

journal_title：Neurology

authors： Frosch OH,Yau PL,Osorio RS,Rusinek H,Storey P,Convit A

更新日期：2017-07-18 00:00:00