Can we image premotor Parkinson disease?

abstract：OBJECTIVE:To validate the Narcolepsy Severity Scale (NSS), a brief clinical instrument to evaluate the severity and consequences of symptoms in patients with narcolepsy type 1 (NT1). METHODS:A 15-item scale to assess the frequency and severity of excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, slee...

journal_title：Neurology

authors： Dauvilliers Y,Beziat S,Pesenti C,Lopez R,Barateau L,Carlander B,Luca G,Tafti M,Morin CM,Billiard M,Jaussent I

更新日期：2017-04-04 00:00:00

abstract：BACKGROUND:Galantamine is a reversible, competitive cholinesterase inhibitor that also allosterically modulates nicotinic acetylcholine receptors. These mechanisms of action provided the rationale for a therapeutic trial of galantamine in AD. METHODS:A 6-month, multicenter, double-blind trial was undertaken in 636 pat...

journal_title：Neurology

authors： Raskind MA,Peskind ER,Wessel T,Yuan W

更新日期：2000-06-27 00:00:00

abstract：OBJECTIVE:To identify neural sites associated with gaze-evoked tinnitus (GET), an unusual condition that may follow cerebellar-pontine angle surgery. METHODS:The authors examined eight patients with GET and used PET to map the neural sites activated by lateral gaze in them and seven age- and sex-matched control subjec...

journal_title：Neurology

authors： Lockwood AH,Wack DS,Burkard RF,Coad ML,Reyes SA,Arnold SA,Salvi RJ

更新日期：2001-02-27 00:00:00

abstract：OBJECTIVE:We pooled the results of studies on natural history of cavernous malformations (CM) to calculate point estimates and investigate main sources of heterogeneity. METHODS:We searched MEDLINE, EMBASE, and ISI Web of Science for relevant studies published before May 2015. We used fixed or random effects models an...

journal_title：Neurology

authors： Taslimi S,Modabbernia A,Amin-Hanjani S,Barker FG 2nd,Macdonald RL

更新日期：2016-05-24 00:00:00

abstract：OBJECTIVE:To study the usefulness of corticospinally mediated excitatory responses and transcallosal inhibition (TI) elicited by transcranial magnetic stimulation (TMS) as a surrogate marker of disability in patients with different courses of MS. METHODS:Focal TMS of the motor cortex was performed in 118 patients with...

journal_title：Neurology

authors： Schmierer K,Irlbacher K,Grosse P,Röricht S,Meyer BU

更新日期：2002-10-22 00:00:00

abstract：OBJECTIVE:To examine the severity of impairments in the decision-making abilities (understanding, appreciation, reasoning, and choice) and competency to make a decision to use an Alzheimer disease (AD)-slowing medication in patients with AD and the relationships between these impairments, insight, and overall cognition...

journal_title：Neurology

authors： Karlawish JH,Casarett DJ,James BD,Xie SX,Kim SY

更新日期：2005-05-10 00:00:00

abstract：:The authors report an autosomal dominant episodic ataxia that is clinically distinct from the other episodic ataxias. Vestibular ataxia, vertigo, tinnitus, and interictal myokymia are prominent; attacks are diminished by acetazolamide. Linkage analyses of markers flanking the EA1 and EA2 loci demonstrate genetic exclu...

journal_title：Neurology

authors： Steckley JL,Ebers GC,Cader MZ,McLachlan RS

更新日期：2001-10-23 00:00:00

abstract：:Epilepsia partialis continua (EPC) may occur during nonketotic hyperglycemia but has not been described with diabetic ketoacidosis. The authors report a patient with EPC associated with ketotic hyperglycemia. Brain MRI showed two areas of abnormal signal intensity in the left precentral gyrus and in the right cerebell...

journal_title：Neurology

authors： Placidi F,Floris R,Bozzao A,Romigi A,Baviera ME,Tombini M,Izzi F,Sperli F,Marciani MG

更新日期：2001-08-14 00:00:00

abstract：:In a series of 44 consecutive patients with Charcot-Marie-Tooth disease (CMT), we found restless legs syndrome (RLS) in 10 of 27 CMT type 2 (CMT2) patients (37%) and in none of 17 CMT type 1 patients (p = 0.004). In the CMT2 patients, RLS was associated with positive sensory symptoms (10/10 versus 10/17; p = 0.026). T...

journal_title：Neurology

authors： Gemignani F,Marbini A,Di Giovanni G,Salih S,Terzano MG

更新日期：1999-03-23 00:00:00

abstract：:Sensory disturbance in the unilateral hand and ipsilateral mouth region, the cheiro-oral syndrome, may be due to cortical, thalamic, or brainstem lesions. We report five patients with this syndrome due to infarction at the border of the posterior limb of the internal capsule and the corona radiata. The sensory fibers ...

journal_title：Neurology

authors： Isono O,Kawamura M,Shiota J,Araki S,Hirayama K

更新日期：1993-01-01 00:00:00

abstract：:We compared 42 myasthenia gravis (MG) patients with thymoma with 42 generalized MG patients without thymoma using a modified Osserman classification. The mean Osserman grades at diagnosis, 6 months, and 5 and 10 years post-thymectomy did not differ between groups. Our results indicate that thymoma is not a negative de...

journal_title：Neurology

authors： Bril V,Kojic J,Dhanani A

更新日期：1998-10-01 00:00:00

abstract：:A 53-year-old man presented with multiple right cranial nerve palsies that included the tongue. When the tongue was protruded, it deviated to the right. However, when the tongue was not protruded, he could readily turn the tip of the tongue to the left, but not to the right. Protrusion of the tongue requires the actio...

journal_title：Neurology

authors： Riggs JE

更新日期：1984-10-01 00:00:00

abstract：OBJECTIVE:To assess the prevalence of brain MRI abnormalities in people with epilepsy in rural China and to compare it with that of individuals in the United Kingdom. METHODS:Brain MRI scans were obtained in people with epilepsy who participated in a rural community-based program in China between July 2010 and Decembe...

journal_title：Neurology

authors： Davagnanam I,Chen Z,Hoskote C,Ding D,Yang B,Wang Y,Wang T,Li W,Duncan JS,Wang W,Sander JW,Kwan P

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:To identify regional metabolic brain networks related specifically to the presence of tremor in PD. BACKGROUND:The pathophysiology of parkinsonian tremor is unknown. Because tremor in PD occurs mainly in repose, we used resting state PET with 18F-fluorodeoxyglucose (FDG) to identify specific metabolic brain ...

journal_title：Neurology

authors： Antonini A,Moeller JR,Nakamura T,Spetsieris P,Dhawan V,Eidelberg D

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:The present retrospective cohort study compares the long-term functional outcome, improvement or deterioration, of patients considered in a vegetative state (VS) or a minimally conscious state (MCS) 1 year after coma onset, then yearly for up to 5 years. METHODS:We reviewed the clinical courses of 12 patient...

journal_title：Neurology

authors： Luauté J,Maucort-Boulch D,Tell L,Quelard F,Sarraf T,Iwaz J,Boisson D,Fischer C

更新日期：2010-07-20 00:00:00

abstract：OBJECTIVES:We evaluated the frequency and predictive value of ocular fundus abnormalities among patients who presented to the emergency department (ED) with focal neurologic deficits to determine the utility of these findings in the evaluation of patients with suspected TIA and stroke. METHODS:In this cross-sectional ...

journal_title：Neurology

authors： Vuong LN,Thulasi P,Biousse V,Garza P,Wright DW,Newman NJ,Bruce BB

更新日期：2015-07-21 00:00:00

abstract：BACKGROUND:Although the APOE epsilon 4 allele increases the risk of developing AD, the effects of the epsilon 4 allele on brain atrophy in clinical AD patients are controversial. OBJECTIVE:To investigate a possible relationship between the genetic variants of APOE and brain atrophy in patients with AD. METHODS:Using ...

journal_title：Neurology

authors： Hashimoto M,Yasuda M,Tanimukai S,Matsui M,Hirono N,Kazui H,Mori E

更新日期：2001-10-23 00:00:00

abstract：:The authors investigated the PRNP Met129Val polymorphism in 1,393 subjects including 482 patients with Alzheimer disease (AD) and two independent control groups. In patients, PRNP Met homozygosity conferred increasing risk with decreasing age at onset (onset: 61 to 70 years, n = 151, p = 0.02, odds ratio [OR] = 1.72, ...

journal_title：Neurology

authors： Riemenschneider M,Klopp N,Xiang W,Wagenpfeil S,Vollmert C,Müller U,Förstl H,Illig T,Kretzschmar H,Kurz A

更新日期：2004-07-27 00:00:00

abstract：OBJECTIVE:To validate a neuropsychological algorithm for dementia diagnosis. METHODS:We developed a neuropsychological algorithm in a sample of 1,023 elderly residents of Cache County, UT. We compared algorithmic and clinical dementia diagnoses both based on DSM-III-R criteria. The algorithm diagnosed dementia when th...

journal_title：Neurology

authors： Tschanz JT,Welsh-Bohmer KA,Skoog I,West N,Norton MC,Wyse BW,Nickles R,Breitner JC

更新日期：2000-03-28 00:00:00

abstract：:Idiopathic trigeminal sensory neuropathy is a benign disorder. We report two patients with transient MRI abnormalities, suggesting transient inflammation of the trigeminal nerve caused temporary facial sensory symptoms. ...

journal_title：Neurology

authors： Rorick MB,Chandar K,Colombi BJ

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVE:To report long-term safety and efficacy outcomes of a large cohort of patients with medically refractory isolated dystonia treated with subthalamic nucleus (STN) deep brain stimulation (DBS). METHODS:Twenty patients (12 male, 8 female; mean age 49 ± 16.3 years) with medically refractory isolated dystonia wer...

journal_title：Neurology

authors： Ostrem JL,San Luciano M,Dodenhoff KA,Ziman N,Markun LC,Racine CA,de Hemptinne C,Volz MM,Heath SL,Starr PA

更新日期：2017-01-03 00:00:00

abstract：OBJECTIVE:To evaluate possible abnormal increase in thalamic glutamate/glutamine levels for restless legs syndrome (RLS) indicating increased glutamatergic activity producing arousal that at night disrupts and shortens sleep. METHODS:(1)H MRS of the right thalamus was performed using a 1.5 T GE MRI scanner and the PRO...

journal_title：Neurology

authors： Allen RP,Barker PB,Horská A,Earley CJ

更新日期：2013-05-28 00:00:00

abstract：OBJECTIVE:To investigate the sensitivity of MRI of the spine compared with CT myelography (CTM) in detecting CSF leaks. METHODS:Between July 1998 and October 2010, 12 patients with orthostatic headache and a CTM-confirmed spinal CSF leak underwent an MRI of the spine with and without contrast. Using CTM as the gold st...

journal_title：Neurology

authors： Starling A,Hernandez F,Hoxworth JM,Trentman T,Halker R,Vargas BB,Hastriter E,Dodick D

更新日期：2013-11-12 00:00:00

abstract：OBJECTIVE:Autonomic symptoms may occur frequently in diabetic and other neuropathies. There is a need to develop a simple instrument to measure autonomic symptoms in subjects with neuropathy and to test the validity of the instrument. METHODS:The Survey of Autonomic Symptoms (SAS) consists of 11 items in women and 12 ...

journal_title：Neurology

authors： Zilliox L,Peltier AC,Wren PA,Anderson A,Smith AG,Singleton JR,Feldman EL,Alexander NB,Russell JW

更新日期：2011-03-22 00:00:00

abstract：OBJECTIVE:With diagnostic criteria alterations, increased MRI availability, and awareness of therapies, temporal changes in incidence and prevalence rates may occur, with an increase in the proportion of mildly affected persons diagnosed with multiple sclerosis (MS). The authors assessed temporal trends in the delay fr...

journal_title：Neurology

authors： Marrie RA,Cutter G,Tyry T,Hadjimichael O,Campagnolo D,Vollmer T

更新日期：2005-10-11 00:00:00

abstract：:We studied the nature and causes of delusions after infarction of the right cerebral hemisphere. Delusions involved orientation in time and place, events in the recent past, and the identities of familiar individuals. Some were transient and disorganized, and others were more fixed. No particular site in the right hem...

journal_title：Neurology

authors： Levine DN,Grek A

更新日期：1984-05-01 00:00:00

abstract：BACKGROUND:Using a stereologic approach, the density of nerve fibers innervating sweat gland (SG) fragments in patients with diabetes mellitus (DM) and healthy controls using protein gene product (PGP), tyrosine hydroxylase (TH), and vasoactive intestinal peptide (VIP) was measured to determine which marker best detect...

journal_title：Neurology

authors： Liu Y,Billiet J,Ebenezer GJ,Pan B,Hauer P,Wei J,Polydefkis M

更新日期：2015-04-21 00:00:00

abstract：OBJECTIVE:The aim of this prospective study was to survey our patients about their experience with our clinic's telemedicine program to better understand telemedicine's utility for families, and to improve patient satisfaction and ultimately patient care. METHODS:This was a prospective survey study of patients and the...

journal_title：Neurology

authors： Qubty W,Patniyot I,Gelfand A

更新日期：2018-05-08 00:00:00

abstract：:We used single-photon emission computed tomography (SPECT) to study postictal cerebral blood flow (CBF) in 51 patients with temporal lobe epilepsy. There were 78 seizures studied, 77 by early postictal injection of Tc-99m HMPAO (delay from seizure onset = 4.3 +/- 4.5 min) and one by ictal injection. Increased focal te...

journal_title：Neurology

authors： Rowe CC,Berkovic SF,Austin MC,McKay WJ,Bladin PF

更新日期：1991-07-01 00:00:00

abstract：:We gave three adult rhesus monkeys seven IV injections of manganese chloride at approximately 1-week intervals. We evaluated neurologic status by serial clinical examinations and performed a levodopa test if the animal developed features of basal ganglia dysfunction. After the animals were killed, we performed neuropa...

journal_title：Neurology

authors： Olanow CW,Good PF,Shinotoh H,Hewitt KA,Vingerhoets F,Snow BJ,Beal MF,Calne DB,Perl DP

更新日期：1996-02-01 00:00:00