Abstract:
OBJECTIVE:To identify neural sites associated with gaze-evoked tinnitus (GET), an unusual condition that may follow cerebellar-pontine angle surgery. METHODS:The authors examined eight patients with GET and used PET to map the neural sites activated by lateral gaze in them and seven age- and sex-matched control subjects. RESULTS:In patients with GET, tinnitus loudness and pitch increased with lateral gaze and, to a lesser extent, up and down gaze. Evidence for neural activity related to GET was seen in the auditory lateral pontine tegmentum or auditory cortex. GET-associated nystagmus appears to activate the cuneus and cerebellar vermis. These sites were found in addition to an extensive network that included frontal eye fields and other sites in frontal, parietal, and temporal cortex that were activated by lateral gaze in seven control subjects and the patients. The unilateral deafness in patients with GET was associated with expansion of auditory cortical areas responsive to tones delivered to the good ear. In addition to GET, unilateral deafness, end-gaze nystagmus, and facial nerve dysfunction were common. CONCLUSIONS:Patients with GET have plastic changes in multiple neural systems that allow neural activity associated with eye movement, including those associated with the neural integrator, to stimulate the auditory system. Anomalous auditory activation is enhanced by the failure of cross-modal inhibition to suppress auditory cortical activity. The time course for the development of GET suggests that it may be due to multiple mechanisms.
journal_name
Neurologyjournal_title
Neurologyauthors
Lockwood AH,Wack DS,Burkard RF,Coad ML,Reyes SA,Arnold SA,Salvi RJdoi
10.1212/wnl.56.4.472subject
Has Abstractpub_date
2001-02-27 00:00:00pages
472-80issue
4eissn
0028-3878issn
1526-632Xjournal_volume
56pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::As there is currently no standardized assessment tool for evaluating Parkinson disease (PD) patients for deep brain stimulation (DBS), the authors developed the Florida Surgical Questionnaire for Parkinson Disease (FLASQ-PD). Part I of the study was a retrospective analysis of 174 patients presenting for a surgical sc...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/01.wnl.0000133122.14824.25
更新日期:2004-07-13 00:00:00
abstract::We performed a prospective clinical and electrophysiologic study of common peroneal (CP) neuropathy to evaluate the extent of involvement of the muscles and cutaneous areas supplied by this nerve. In 22 patients, seven had more weakness clinically in muscles innervated by the deep peroneal nerve than in those innervat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.7.1029
更新日期:1991-07-01 00:00:00
abstract::We observed a highly topographically specific and consistent pattern of degeneration in the auditory system of Alzheimer's disease (AD) patients. Senile plaques (SP) and neurofibrillary tangles (NFT) were distributed throughout the ventral nucleus of the medial geniculate body (MGB) and the central nucleus of the infe...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.4.779
更新日期:1993-04-01 00:00:00
abstract::There is evidence that treatment with an antibody to tumor necrosis factor alpha (TNF alpha) improves an animal model of multiple sclerosis (MS) and is beneficial in two systemic inflammatory disease in humans, but there are no reports about anti-TNF treatment of MS. Therefore, we treated two rapidly progressive MS pa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.6.1531
更新日期:1996-12-01 00:00:00
abstract::The authors interviewed 53 cluster headache patients who had used psilocybin or lysergic acid diethylamide (LSD) to treat their condition. Twenty-two of 26 psilocybin users reported that psilocybin aborted attacks; 25 of 48 psilocybin users and 7 of 8 LSD users reported cluster period termination; 18 of 19 psilocybin ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000219761.05466.43
更新日期:2006-06-27 00:00:00
abstract:OBJECTIVE:To investigate the association between urinary hormone levels and migraine, with particular reference to rising and falling levels of estrogen across the menstrual cycle in women with menstrual and menstrually related migraine. METHODS:Women with regular menstrual cycles, who were not using hormonal contrace...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000233888.18228.19
更新日期:2006-12-26 00:00:00
abstract:BACKGROUND:Pregnancy registries for women taking anticonvulsant drugs have been developed to determine more efficiently the fetal risks of each drug. A total of 722 drug-exposed pregnancies are needed to identify a sevenfold increase in the rate of occurrence of a specific abnormality, such as spina bifida, with a freq...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000304343.45104.d6
更新日期:2008-05-27 00:00:00
abstract::The effects of acute ethanol injection on force production were measured in normal and chronic alcoholic rats. Acutely injected normal rats, acutely injected chronic alcoholic rats, and noninjected chronic alcoholic rats were compared with control groups: normal nonalcoholic rats and a dietetically deprived control gr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.2.139
更新日期:1980-02-01 00:00:00
abstract::We describe a 78-year-old man with right hemiballism as the presenting symptom of a metastatic occult adenocarcinoma of the lung. CT demonstrated two contrast-enhancing lesions: one in the left subthalamic region and the other in the left parietal region. Metastatic tumor was confirmed at autopsy. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.2.204
更新日期:1984-02-01 00:00:00
abstract::The American Academy of Neurology has published a comprehensive review and guidelines for the use of disease-modifying therapies (DMTs) in multiple sclerosis (MS) for the first time since 2002. These guidelines represent the work of MS experts, patients, and guideline experts and are based on their review of randomize...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0000000000005574
更新日期:2018-06-12 00:00:00
abstract:OBJECTIVE:To describe a new familial association of late-onset dementia, patchy leukoencephalopathy, intracerebral hemorrhages, bilateral occipital calcifications (BOC), and external carotid artery dysplasia (ECAD). METHODS:At age 62, the proband, who was of Spanish descent, had left temporal hemorrhage in a backgroun...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.11.1661
更新日期:2000-12-12 00:00:00
abstract::We report a Japanese boy with muscular dystrophy whose clinical symptoms were intermediate between those usually considered typical of Duchenne and Becker muscular dystrophies. The patient had a large inframe deletion extending from exons 3 to 41 of the dystrophin gene, which would be expected to cause the production ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.9.1648
更新日期:1994-09-01 00:00:00
abstract:OBJECTIVE:To compare the effectiveness of upper extremity virtual reality rehabilitation training (VR) to time-matched conventional training (CT) in the subacute phase after stroke. METHODS:In this randomized, controlled, single-blind phase III multicenter trial, 120 participants with upper extremity motor impairment ...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0000000000004744
更新日期:2017-12-12 00:00:00
abstract:OBJECTIVE:To evaluate urinary neurotrophin receptor p75 extracellular domain (p75ECD) levels as disease progression and prognostic biomarkers in amyotrophic lateral sclerosis (ALS). METHODS:The population in this study comprised 45 healthy controls and 54 people with ALS, 31 of whom were sampled longitudinally. Urinar...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003741
更新日期:2017-03-21 00:00:00
abstract::A 27-year-old man, recent visitor to the Middle East, presented with 6-week history of fever (up to 102°F) followed by altered behavior and left hemiparesis. CSF was acellular with raised protein (138 mg/dL). CSF bacterial culture was sterile; adenosine deaminase normal (3 U/L); cryptococcal antigen, Venereal Disease ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31827deb63
更新日期:2013-01-15 00:00:00
abstract:OBJECTIVE:To investigate whether dietary patterns (Mediterranean diet [MedDiet], Dietary Approaches to Stop Hypertension [DASH], and A Priori Diet Quality Score [APDQS]) during adulthood are associated with midlife cognitive performance. METHODS:We studied 2,621 Coronary Artery Risk Development in Young Adults (CARDIA...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007243
更新日期:2019-04-02 00:00:00
abstract::Using a perceptual technique it is shown that patients with chronic external ophthalmoplegia have shortened vestibular responses. It is postulated that this is secondary to the retinal image slip experienced by these patients during head movements and a useful compensatory mechanism to suppress motion-induced sickness...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000067992.17185.60
更新日期:2003-06-24 00:00:00
abstract::The authors report two patients with suspected brain death who required confirmatory tests other than clinical examination because of prolonged barbiturate administration for intracranial hypertension. Absence of intracranial blood flow was documented on CT angiography and confirmed by CT perfusion images. Cerebral an...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.62.4.652
更新日期:2004-02-24 00:00:00
abstract:OBJECTIVE:Recent studies have suggested modifications of serotonin cerebral metabolism and of 5-HT(1A) receptors density in Alzheimer disease (AD). This study aims at exploring hippocampus 5-HT(1A) receptor density in patients at the amnesic mild cognitive impairment (aMCI) and mild AD dementia stages. METHODS:With us...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000271377.52421.4a
更新日期:2007-09-04 00:00:00
abstract::We retrospectively evaluated the neurologic complications in 425 patients who underwent bone marrow transplant (BMT) (310 allogeneic, 115 autologous) for leukemia. Forty-six patients (11%) developed 47 central and three peripheral neurologic complications. The most common complications were cerebral hemorrhage (3.8%),...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.4.1004
更新日期:1996-04-01 00:00:00
abstract::Epilepsy is associated with a high rate of premature mortality from direct and indirect effects of seizures, epilepsy, and antiseizure therapies. Sudden unexpected death in epilepsy (SUDEP) is the second leading neurologic cause of total lost potential life-years after stroke, yet SUDEP may account for less than half ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0000000000002253
更新日期:2016-02-23 00:00:00
abstract::INeuro@neurolist.mcg. edu: An e-mail discussion list for neurologists Neuro@neurolist.mcg.edu (Neurolist) is a discussion list for neurologists. This Internet tool, established in 1994, allows the worldwide community of neurologists to communicate quickly and efficiently using e-mail, web browsers, and newsreaders. Ne...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.9.1891
更新日期:1999-06-10 00:00:00
abstract::In 10 patients with chronic autonomic failure, the sympathetic perivascular nerve plexuses from quadriceps muscle biopsies were studied by catecholamine fluorescence and electronmicroscopy. There was almost complete absence of catecholamine fluorescence and fewer than normal numbers of small granular (noradrenergic) v...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.12.1501
更新日期:1981-12-01 00:00:00
abstract:BACKGROUND:X-linked adrenoleukodystrophy (X-ALD) has variants with widely different outcomes, hampering clinical counseling and evaluation of therapies. OBJECTIVE:To evaluate the degree to which MRI patterns can predict lesion progression. METHODS:Two hundred six boys and men with cerebral X-ALD (median age 12.2 year...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000079050.91337.83
更新日期:2003-08-12 00:00:00
abstract:OBJECTIVE:To evaluate the utility of MRI hippocampal and entorhinal cortex atrophy in predicting conversion from mild cognitive impairment (MCI) to Alzheimer disease (AD). METHODS:Baseline brain MRI was performed in 139 patients with MCI, broadly defined, and 63 healthy controls followed for an average of 5 years (ran...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000256697.20968.d7
更新日期:2007-03-13 00:00:00
abstract::Eighty-five healthy elderly subjects were prospectively evaluated for 3 years to determine motor differences between those who remain cognitively intact and those who developed cognitive impairment during prospective follow-up. The 18 subjects who developed cognitive impairment had slower finger tapping and took longe...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.50.5.1496
更新日期:1998-05-01 00:00:00
abstract:OBJECTIVE:We sought to assess the prevalence, correlates, and consequences of periodic limb movements of sleep (PLMS) in persons with obstructive sleep apnea (OSA) and the effect (worsening or improvement) of continuous positive airway pressure (CPAP) therapy on PLMS in a large prospective multicenter randomized contro...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008844
更新日期:2020-04-28 00:00:00
abstract::Two siblings and a third child exhibited a syndrome of progressive muscular weakness and wasting, closely resembling Werdnig-Hoffmann's disease. Autopsy of one of the siblings and the third child showed nearly total absence of myelin sheaths in the cranial and spinal nerve roots, relative preservation of axons, and no...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.6.565
更新日期:1976-06-01 00:00:00
abstract:BACKGROUND:Clinical trials involving patients with glioblastoma (GBM) distinguish cohorts who are treated with enzyme-inducing anticonvulsants (EIAC). Such anticonvulsants induce hepatic P450 microsomal enzymes, which accelerate the metabolism of certain chemotherapy and molecular targeted agents. However, the resultan...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181bbfeca
更新日期:2009-10-13 00:00:00
abstract::There have been few descriptions of spontaneous epidural hematoma of the spinal cord in children. Duration of symptoms in previous cases has varied from hours to days. We recently evaluated a 6-year-old girl with cord compression from an extradural clot, who complained of thoracic back pain for 3 months before becomin...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.1.120
更新日期:1979-01-01 00:00:00