Development and initial validation of a screening tool for Parkinson disease surgical candidates.


:As there is currently no standardized assessment tool for evaluating Parkinson disease (PD) patients for deep brain stimulation (DBS), the authors developed the Florida Surgical Questionnaire for Parkinson Disease (FLASQ-PD). Part I of the study was a retrospective analysis of 174 patients presenting for a surgical screening. Part II was a multicenter study to assess the correlation of FLASQ-PD scores. The results of this study suggest that the FLASQ-PD may be a useful triage tool for screening PD patients for DBS surgery.






Okun MS,Fernandez HH,Pedraza O,Misra M,Lyons KE,Pahwa R,Tarsy D,Scollins L,Corapi K,Friehs GM,Grace J,Romrell J,Foote KD




Has Abstract


2004-07-13 00:00:00














  • Alzheimer disease risk associated with APOE4 is modified by STH gene polymorphism.

    abstract::The association of the STH gene polymorphism with Alzheimer disease (AD) is debated. In the analysis of two genetically and diagnostically distinct groups of Alzheimer patients from the USA and Italy, the authors did not find an association with the STH polymorphism. However, the APOE-4-associated risk of AD greatly i...


    pub_type: 杂志文章


    authors: Seripa D,Matera MG,D'Andrea RP,Gravina C,Masullo C,Daniele A,Bizzarro A,Rinaldi M,Antuono P,Wekstein DR,Dal Forno G,Fazio VM

    更新日期:2004-05-11 00:00:00

  • Spastic paraplegia, ataxia, mental retardation (SPAR): a novel genetic disorder.

    abstract:OBJECTIVE:To describe a kindred with a dominantly inherited neurologic disorder manifested either as uncomplicated spastic paraplegia or ataxia, spastic paraplegia, and mental retardation. METHODS:Neurologic examinations and molecular genetic analysis (exclusion of known SCA and HSP genes and loci; and trinucleotide r...


    pub_type: 杂志文章


    authors: Hedera P,Rainier S,Zhao XP,Schalling M,Lindblad K,Yuan QP,Ikeuchi T,Trobe J,Wald JJ,Eldevik OP,Kluin K,Fink JK

    更新日期:2002-02-12 00:00:00

  • Surgery for intracerebral hemorrhage.

    abstract::Intracerebral hemorrhage (ICH) represents 8 to 15% of all strokes in the United States and 20 to 30% of all strokes in Japan and China. Although ICH represents a relatively small fraction of total strokes, it is a formidable disease, with a 30-day mortality rate two- to sixfold higher than that for ischemic stroke. Fu...


    pub_type: 杂志文章,评审


    authors: Fayad PB,Awad IA

    更新日期:1998-09-01 00:00:00

  • Seizure identification by clinical description in temporal lobe epilepsy: how accurate are we?

    abstract:OBJECTIVE:To determine the accuracy of the clinical history performed by epileptologists in the identification of seizures in patients with suspected temporal lobe epilepsy. METHODS:The clinical and EEG telemetry (EEGT) monitoring data of 88 patients with suspected refractory temporal lobe seizures referred for evalua...


    pub_type: 临床试验,杂志文章


    authors: Deacon C,Wiebe S,Blume WT,McLachlan RS,Young GB,Matijevic S

    更新日期:2003-12-23 00:00:00

  • Disconnection as a mechanism for social cognition impairment in multiple sclerosis.

    abstract:OBJECTIVE:To assess the contribution of microstructural normal-appearing white matter (NAWM) damage to social cognition impairment, specifically in the theory of mind (ToM), in multiple sclerosis (MS). METHODS:We enrolled consecutively 60 patients with MS and 60 healthy controls (HC) matched on age, sex, and education...


    pub_type: 杂志文章


    authors: Batista S,Alves C,d'Almeida OC,Afonso A,Félix-Morais R,Pereira J,Macário C,Sousa L,Castelo-Branco M,Santana I,Cunha L

    更新日期:2017-07-04 00:00:00

  • Branched-chain amino acids and amyotrophic lateral sclerosis: a treatment failure? The Italian ALS Study Group.

    abstract::We initiated a double-blind, placebo-controlled trial to test the efficacy and safety of branched-chain amino acids (BCAA) (L-leucine 12 g, L-isoleucine 6 g, and L-valine 6 g daily) in amyotrophic lateral sclerosis (ALS) patients. There was an excess mortality in subjects randomized to active treatment (24 BCAA, 13 pl...


    pub_type: 临床试验,杂志文章,随机对照试验



    更新日期:1993-12-01 00:00:00

  • Practice parameter: risk of driving and Alzheimer's disease (an evidence-based review): report of the quality standards subcommittee of the American Academy of Neurology.

    abstract::Studies of automobile accident frequency among drivers with AD have yielded conflicting results about the risk of accidents. To develop a practice parameter regarding driving and AD the authors performed a systematic review of the literature. The authors identified well-designed, controlled studies of driving and AD u...


    pub_type: 杂志文章,评审


    authors: Dubinsky RM,Stein AC,Lyons K

    更新日期:2000-06-27 00:00:00

  • Exercise-induced membrane failure in paramyotonia congenita.

    abstract::A marked decrease in the amplitude of the evoked thenar compound muscle action potential followed brief exercise at room temperature in two patients with paramyotonia congenita. This decline was more rapid and pronounced in our patient with coexistent thyrotoxicosis. The prolonged recovery period in paramyotonia conge...


    pub_type: 杂志文章


    authors: Gutmann L,Riggs JE,Brick JF

    更新日期:1986-01-01 00:00:00

  • ATN profiles among cognitively normal individuals and longitudinal cognitive outcomes.

    abstract:OBJECTIVE:To examine the long-term cognitive trajectories of individuals with normal cognition at baseline and distinct amyloid/tau/neurodegeneration (ATN) profiles. METHODS:Pooling data across 4 cohort studies, 814 cognitively normal participants (mean baseline age = 59.6 years) were classified into 8 ATN groups usin...


    pub_type: 杂志文章


    authors: Soldan A,Pettigrew C,Fagan AM,Schindler SE,Moghekar A,Fowler C,Li QX,Collins SJ,Carlsson C,Asthana S,Masters CL,Johnson S,Morris JC,Albert M,Gross AL

    更新日期:2019-04-02 00:00:00

  • APOE genotype and survival in men and women with Alzheimer's disease.

    abstract:BACKGROUND:The epsilon 4 allele of the APOE gene (APOE) is more frequent in patients with AD than in the general population, but studies are inconclusive as to whether it affects rate of progression or survival. Because survival in AD is generally longer in women than in men, the authors investigated whether APOE affec...


    pub_type: 杂志文章


    authors: Dal Forno G,Carson KA,Brookmeyer R,Troncoso J,Kawas CH,Brandt J

    更新日期:2002-04-09 00:00:00

  • Movement disorders in alcoholism: a review.

    abstract::A wide variety of movement disorders are associated with alcohol abuse. Some idiopathic movement disorders are markedly improved by small amounts of alcohol and this response occasionally may lead to alcoholism. Alcohol abuse alone or combined with hepatic encephalopathy can cause various types of tremor, asterixis, a...


    pub_type: 杂志文章,评审


    authors: Neiman J,Lang AE,Fornazzari L,Carlen PL

    更新日期:1990-05-01 00:00:00

  • Immunologic studies of patients with chronic encephalitis induced by post-exposure Semple rabies vaccine.

    abstract::Neurologic complications of brain tissue-derived rabies vaccine may be chronic or progressive. Lymphocytes and serum from three patients with this form of encephalitis were studied. Two patients had positive lymphoproliferation to purified myelin, two had antibody to white matter, and one had antibody to myelin basic ...


    pub_type: 杂志文章


    authors: Hemachudha T,Griffin DE,Johnson RT,Giffels JJ

    更新日期:1988-01-01 00:00:00

  • Assessing autonomic dysfunction in early diabetic neuropathy: the Survey of Autonomic Symptoms.

    abstract:OBJECTIVE:Autonomic symptoms may occur frequently in diabetic and other neuropathies. There is a need to develop a simple instrument to measure autonomic symptoms in subjects with neuropathy and to test the validity of the instrument. METHODS:The Survey of Autonomic Symptoms (SAS) consists of 11 items in women and 12 ...


    pub_type: 杂志文章


    authors: Zilliox L,Peltier AC,Wren PA,Anderson A,Smith AG,Singleton JR,Feldman EL,Alexander NB,Russell JW

    更新日期:2011-03-22 00:00:00

  • Plasma exchange and immunosuppressive drug treatment in the Lambert-Eaton myasthenic syndrome.

    abstract::We undertook serial clinical and electromyographic muscle action potential (MAP) amplitude assessments in nine patients with the Lambert-Eaton myasthenic syndrome (LEMS) over 0.5 to 2.5 years who received plasma exchange (PE; 5 to 15 exchanges over 4 to 19 days) and immunosuppressive drug (IS) treatment (prednisolone ...


    pub_type: 杂志文章


    authors: Newsom-Davis J,Murray NM

    更新日期:1984-04-01 00:00:00

  • Predictive value of sensory and cognitive evoked potentials for awakening from coma.

    abstract:OBJECTIVES:To determine the prognostic role of late auditory (N100) and cognitive evoked potentials (MMN) for awakening in a cohort of comatose patients categorized by etiology. METHODS:The authors prospectively studied a series of 346 comatose patients. Coma was caused by stroke (n = 125), trauma (n = 96), anoxia (n ...


    pub_type: 杂志文章


    authors: Fischer C,Luauté J,Adeleine P,Morlet D

    更新日期:2004-08-24 00:00:00

  • Effect of L-dopa on visual evoked potential in patients with Parkinson's disease.

    abstract::In 47 patients with Parkinson's disease, we studied the visual evoked potential (VEP) using the pattern-reversal checkerboard (CBVEP) and the grating (GVEP) stimuli before and after 3 months of L-dopa therapy. The P100 latency in both CBVEP and GVEP was prolonged before L-dopa therapy, usually commensurate with the de...


    pub_type: 杂志文章


    authors: Bhaskar PA,Vanchilingam S,Bhaskar EA,Devaprabhu A,Ganesan RA

    更新日期:1986-08-01 00:00:00

  • The Wernicke area: Modern evidence and a reinterpretation.

    abstract::The term "Wernicke's area" is most often used as an anatomical label for the gyri forming the lower posterior left sylvian fissure. Although traditionally this region was held to support language comprehension, modern imaging and neuropsychological studies converge on the conclusion that this region plays a much large...


    pub_type: 杂志文章,评审


    authors: Binder JR

    更新日期:2015-12-15 00:00:00

  • Residual function in motor cortex contralateral to amputated hand.

    abstract:OBJECTIVE:To investigate residual function of the motor cortex corresponding to the hand of the amputated arm (MCamp). METHODS:Focal transcranial magnetic stimulation (TMS) of MCamp was performed in 10 patients 22 to 52 years after arm amputation to inhibit tonic muscle contraction in the intact hand ipsilateral to co...


    pub_type: 杂志文章


    authors: Röricht S,Meyer BU

    更新日期:2000-02-22 00:00:00

  • Sodium valproate: serial monitoring of EEG and serum levels.

    abstract::The clinical and electroencephalographic (EEG) effects of sodium valproate were studied in four patients by means of serial 24-hour EEG recordings and simultaneous hourly determinations of serum drug concentrations. The patients all had frequent clinical seizures and generalized spike-wave discharges. Valproate appear...


    pub_type: 杂志文章


    authors: Rowan AJ,Binnie CD,de Beer-Pawlikowski NK,Goedhart DM,Gutter T,van der Geest P,Meinardi H,Meijer JW

    更新日期:1979-11-01 00:00:00

  • Antiabsence drugs and inhibitory pathways.

    abstract::Conditioning stimuli to the coronal gyrus or periventricular gray matter inhibit the activity of spinal trigeminal neurons. Valproate decreased the corticofugal inhibition of the spinal trigeminal nucleus, as did ethosuximide, trimethadione, and imipramine. Valproate and ethosuximide also decreased the periventricular...


    pub_type: 杂志文章


    authors: Fromm GH,Glass JD,Chattha AS,Martinez AJ,Silverman M

    更新日期:1980-02-01 00:00:00

  • Treatment of restless legs syndrome with pregabalin: a double-blind, placebo-controlled study.

    abstract:OBJECTIVES:To assess the therapeutic efficacy, required dose, and tolerability of pregabalin in patients with idiopathic restless legs syndrome (RLS). METHODS:This was a double-blind, placebo-controlled trial with polysomnographic control, providing Class II evidence. Ninety-eight patients underwent a 2-week single-bl...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Garcia-Borreguero D,Larrosa O,Williams AM,Albares J,Pascual M,Palacios JC,Fernandez C

    更新日期:2010-06-08 00:00:00

  • Apolipoprotein E epsilon 4 and the pattern of regional brain atrophy in Alzheimer's disease.

    abstract:BACKGROUND:Although the APOE epsilon 4 allele increases the risk of developing AD, the effects of the epsilon 4 allele on brain atrophy in clinical AD patients are controversial. OBJECTIVE:To investigate a possible relationship between the genetic variants of APOE and brain atrophy in patients with AD. METHODS:Using ...


    pub_type: 杂志文章


    authors: Hashimoto M,Yasuda M,Tanimukai S,Matsui M,Hirono N,Kazui H,Mori E

    更新日期:2001-10-23 00:00:00

  • Assessment: Botulinum neurotoxin for the treatment of movement disorders (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.

    abstract:OBJECTIVE:To perform an evidence-based review of the safety and efficacy of botulinum neurotoxin (BoNT) in the treatment of movement disorders. METHODS:A literature search was performed including MEDLINE and Current Contents for therapeutic articles relevant to BoNT and selected movement disorders. Authors reviewed, a...


    pub_type: 杂志文章,meta分析


    authors: Simpson DM,Blitzer A,Brashear A,Comella C,Dubinsky R,Hallett M,Jankovic J,Karp B,Ludlow CL,Miyasaki JM,Naumann M,So Y,Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.

    更新日期:2008-05-06 00:00:00

  • Initiating treatment for idiopathic parkinsonism.

    abstract::The initial decision in the management of idiopathic parkinsonism is whether any pharmacotherapy is indicated. There is no conclusive evidence that treatment is helpful before symptoms start to affect the patient's life, although some neurologists believe that deprenyl, also known as selegiline, could be useful. Once ...


    pub_type: 杂志文章,评审


    authors: Calne DB

    更新日期:1994-07-01 00:00:00

  • Evidence against the existence of a temporal lobe epilepsy personality syndrome.

    abstract::The existence and specificity of a characteristic behavioral syndrome among patients with temporal lobe epilepsy (TLE) remains controversial. The behavioral pattern of many epilepsy patients differs from that of age-, sex-, and socioeconomic-matched control subjects. Patients with TLE and other forms of epilepsy can e...


    pub_type: 杂志文章,评审


    authors: Devinsky O,Najjar S

    更新日期:1999-01-01 00:00:00

  • Mild behavioral impairment is linked to worse cognition and brain atrophy in Parkinson disease.

    abstract:OBJECTIVE:To evaluate the associations of mild behavioral impairment (MBI) with cognitive deficits and patterns of gray matter changes in Parkinson disease (PD). METHODS:Sixty patients with PD without dementia and 29 healthy controls underwent a cognitive neuropsychological evaluation and structural MRI scan. MBI was ...


    pub_type: 杂志文章


    authors: Yoon EJ,Ismail Z,Hanganu A,Kibreab M,Hammer T,Cheetham J,Kathol I,Sarna JR,Martino D,Furtado S,Monchi O

    更新日期:2019-08-20 00:00:00

  • Late in-stent thrombosis following carotid angioplasty and stenting.

    abstract::Acute in-stent thrombosis is a well-known complication of carotid angioplasty and stenting (CAS) and often due to resistance to or inadequate treatment with platelet-inhibiting agents. The authors report three cases of a delayed in-stent thrombosis after more than a week but less than 3 months after CAS. In all cases,...


    pub_type: 杂志文章


    authors: Buhk JH,Wellmer A,Knauth M

    更新日期:2006-05-23 00:00:00

  • Kearns-Sayre syndrome and complex II deficiency.

    abstract::A 25-year-old woman with Kearns-Sayre syndrome (KSS) had complete external ophthalmoplegia, short stature, ataxia, cardiac conduction defects, and pigmentary retinopathy. Muscle biopsy revealed ragged-red fibers. Electron microscopy showed increased numbers of mitochondria with disordered structure and paracrystalline...


    pub_type: 杂志文章


    authors: Rivner MH,Shamsnia M,Swift TR,Trefz J,Roesel RA,Carter AL,Yanamura W,Hommes FA

    更新日期:1989-05-01 00:00:00

  • Internal carotid artery stent placement without emboli protection: results and long-term outcome.

    abstract::Patients with symptomatic > or = 60% (n = 134), asymptomatic > or = 80% (n = 143), and asymptomatic progressive > or = 60% (n = 25) internal carotid artery stenosis underwent stenting and were followed clinically and by Doppler-assisted duplex imaging for 27.1 +/- 15.6 months. Stroke and death from stroke occurred wit...


    pub_type: 临床试验,杂志文章


    authors: Bibl D,Lampl C,Biberhofer I,Kerschner K,Kypta A,Bergmann J,Kaindlstorfer A,Röper C,Yazdi K,Engleder C,Hofmann R,Deibl M,Leisch F,Ransmayr G

    更新日期:2005-07-12 00:00:00

  • Sex differences in Alzheimer risk: Brain imaging of endocrine vs chronologic aging.

    abstract:OBJECTIVE:This observational multimodality brain imaging study investigates emergence of endophenotypes of late-onset Alzheimer disease (AD) risk during endocrine transition states in a cohort of clinically and cognitively normal women and age-matched men. METHODS:Forty-two 40- to 60-year-old cognitively normal women ...


    pub_type: 杂志文章


    authors: Mosconi L,Berti V,Quinn C,McHugh P,Petrongolo G,Varsavsky I,Osorio RS,Pupi A,Vallabhajosula S,Isaacson RS,de Leon MJ,Brinton RD

    更新日期:2017-09-26 00:00:00