Analysis of MRI patterns aids prediction of progression in X-linked adrenoleukodystrophy.

abstract：OBJECTIVE:To define the clinical and radiologic features of brainstem gliomas (BSGs) in children with neurofibromatosis type 1 (NF1). METHODS:We performed a retrospective cross-sectional study of 133 children with NF1 and concurrent BSGs cared for at 4 NF1 referral centers. BSG was determined using radiographic criter...

journal_title：Neurology

authors： Mahdi J,Shah AC,Sato A,Morris SM,McKinstry RC,Listernick R,Packer RJ,Fisher MJ,Gutmann DH

更新日期：2017-04-18 00:00:00

abstract：OBJECTIVE:To assess the effects of gabapentin on sensory and motor symptoms in patients with restless legs syndrome (RLS). METHODS:Patients with RLS (22 idiopathic, 2 secondary to iron deficiency) were randomized and treated for 6 weeks with either gabapentin or placebo. After a 1-week washout they crossed over to the...

journal_title：Neurology

authors： Garcia-Borreguero D,Larrosa O,de la Llave Y,Verger K,Masramon X,Hernandez G

更新日期：2002-11-26 00:00:00

abstract：OBJECTIVE:To examine the severity of impairments in the decision-making abilities (understanding, appreciation, reasoning, and choice) and competency to make a decision to use an Alzheimer disease (AD)-slowing medication in patients with AD and the relationships between these impairments, insight, and overall cognition...

journal_title：Neurology

authors： Karlawish JH,Casarett DJ,James BD,Xie SX,Kim SY

更新日期：2005-05-10 00:00:00

abstract：:The forearm segment of the ulnar nerve is difficult to assess if the nerve has been injured severely at the wrist. A new, simple nerve conduction technique of recording from the sensory dorsal branch of the nerve localizes the lesion and enables easier evaluation of that segment than do other techniques. ...

journal_title：Neurology

authors： Jabre JF

更新日期：1980-08-01 00:00:00

abstract：:There is a widely held belief that most patients presenting with senile chorea have late-onset Huntington's disease (HD) with an unknown family history. We measured CAG trinucleotide repeat expansion in the HD gene in four patients with a clinical presentation of senile chorea and found that CAG repetition lengths wer...

journal_title：Neurology

authors： Shinotoh H,Calne DB,Snow B,Hayward M,Kremer B,Theilmann J,Hayden MR

更新日期：1994-11-01 00:00:00

abstract：OBJECTIVE:Physician prediction of outcome in critically ill neurologic patients impacts treatment decisions and goals of care. In this observational study, we prospectively compared predictions by neurointensivists to patient outcomes at 6 months. METHODS:Consecutive neurologic patients requiring mechanical ventilatio...

journal_title：Neurology

authors： Finley Caulfield A,Gabler L,Lansberg MG,Eyngorn I,Mlynash M,Buckwalter MS,Venkatasubramanian C,Wijman CA

更新日期：2010-04-06 00:00:00

abstract：:MRI and CSF investigations revealed meningeal involvement in a 29-year-old patient with biopsy-confirmed Wegener's granulomatosis. The intracranial manifestation of Wegener's granulomatosis was supported by the detection of pathologic circulating antineutrophil cytoplasm (c-ANCA) in the CSF. We monitored disease activ...

journal_title：Neurology

authors： Spranger M,Schwab S,Meinck HM,Tischendorf M,Sis J,Breitbart A,Andrassy K

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:Using interictal alpha-[11C]methyl-l-tryptophan ([11C]AMT) PET scan, the authors have undertaken a quantitative analysis of all tubers visible on MRI or 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) PET, to determine the relationship between [11C]AMT uptake and epileptic activity on EEG. BACKGROUND:Tuberous scl...

journal_title：Neurology

authors： Asano E,Chugani DC,Muzik O,Shen C,Juhász C,Janisse J,Ager J,Canady A,Shah JR,Shah AK,Watson C,Chugani HT

更新日期：2000-05-23 00:00:00

abstract：:We studied 13 patients with severe drug-induced parkinsonism (DIP) using L-6-[18F]fluorodopa positron emission tomography (18F-dopa PET) to investigate the integrity of their dopaminergic nigrostriatal projections. Twelve of these patients were subsequently followed clinically for a median of 23.5 months (range, 6 to ...

journal_title：Neurology

authors： Burn DJ,Brooks DJ

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between the presence of a circadian body temperature rhythm and behaviorally assessed consciousness levels in patients with disorders of consciousness (DOC; i.e., vegetative state/unresponsive wakefulness syndrome or minimally conscious state). METHODS:In a cross-sectional stu...

journal_title：Neurology

authors： Blume C,Lechinger J,Santhi N,del Giudice R,Gnjezda MT,Pichler G,Scarpatetti M,Donis J,Michitsch G,Schabus M

更新日期：2017-05-16 00:00:00

abstract：OBJECTIVE:To localize a gene predisposing to benign epilepsy of childhood with centrotemporal spikes (BECTS). BACKGROUND:BECTS, or rolandic epilepsy, is the most prevalent idiopathic epilepsy syndrome in childhood. Functional relevant defects in the alpha 4 subunit of the neuronal nicotinic acetylcholine receptor (ACh...

journal_title：Neurology

authors： Neubauer BA,Fiedler B,Himmelein B,Kämpfer F,Lässker U,Schwabe G,Spanier I,Tams D,Bretscher C,Moldenhauer K,Kurlemann G,Weise S,Tedroff K,Eeg-Olofsson O,Wadelius C,Stephani U

更新日期：1998-12-01 00:00:00

abstract：:Comprehensive management of patients with multiple sclerosis (MS) includes treatment to modify the disease course and interventions to address the persistent symptoms and consequences of this chronic illness, which can affect patients for decades. Although much excitement and attention accompanies new therapeutic init...

journal_title：Neurology

authors： Cohen BA

更新日期：2008-12-09 00:00:00

abstract：OBJECTIVE:We aimed to compare survival in the multiple sclerosis (MS) population with a matched cohort from the general population, and to evaluate the association of comorbidity with survival in both populations. METHODS:Using population-based administrative data, we identified 5,797 persons with MS and 28,807 contro...

journal_title：Neurology

authors： Marrie RA,Elliott L,Marriott J,Cossoy M,Blanchard J,Leung S,Yu N

更新日期：2015-07-21 00:00:00

abstract：:The majority of patients with traumatic brain injury (TBI) are classified as having a mild TBI. Despite being categorized as mild, these individuals report ongoing and complex symptoms, which negatively affect their ability to complete activities of daily living and overall quality of life. Some of the major symptoms ...

journal_title：Neurology

authors： Elenberger J,Kim B,de Castro-Abeger A,Rex TS

更新日期：2020-11-03 00:00:00

abstract：:A 61-year-old woman presented with two paraneoplastic neurologic disorders--Lambert-Eaton myasthenic syndrome (LEMS) and subacute cerebellar degeneration (SCD)--that antedated the diagnosis of small-cell carcinoma of the lung by 15 months. Plasmapheresis initiated before the identification of the tumor had a beneficia...

journal_title：Neurology

authors： Blumenfeld AM,Recht LD,Chad DA,DeGirolami U,Griffin T,Jaeckle KA

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:Frontotemporal dementia associated with motor neuron disease (FTD-MND) is a rare neurodegenerative disorder that may be inherited by autosomal dominant trait. No major gene has been identified but a locus was mapped on chromosome 9 (9p21.3-p13.3). METHODS:Ten French families with FTD-MND were tested for lin...

journal_title：Neurology

authors： Le Ber I,Camuzat A,Berger E,Hannequin D,Laquerrière A,Golfier V,Seilhean D,Viennet G,Couratier P,Verpillat P,Heath S,Camu W,Martinaud O,Lacomblez L,Vercelletto M,Salachas F,Sellal F,Didic M,Thomas-Anterion C,Puel M

更新日期：2009-05-12 00:00:00

abstract：:The motor effects of direct agonists which act selectively on certain dopamine receptors were studied in monkeys rendered hemiparkinsonian by unilateral intracarotid injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The D-2 dopamine agonist, LY 171555, but not the D-1 agonist, SKF 38393, reduced parkin...

journal_title：Neurology

authors： Barone P,Bankiewicz KS,Corsini GU,Kopin IJ,Chase TN

更新日期：1987-10-01 00:00:00

abstract：OBJECTIVE:To assess the determinants of amyotrophic lateral sclerosis (ALS) phenotypes in a population-based cohort. METHODS:The study population included 2,839 patients with ALS diagnosed in Piemonte, Italy (1995-2015). Patients were classified according to motor (classic, bulbar, flail arm, flail leg, predominantly ...

journal_title：Neurology

authors： Chiò A,Moglia C,Canosa A,Manera U,D'Ovidio F,Vasta R,Grassano M,Brunetti M,Barberis M,Corrado L,D'Alfonso S,Iazzolino B,Peotta L,Sarnelli MF,Solara V,Zucchetti JP,De Marchi F,Mazzini L,Mora G,Calvo A

更新日期：2020-02-25 00:00:00

abstract：:Carbamazepine was compared with phenytoin in a double-blind study. Of 87 patients, data on 70 patients were complete and used for analysis. Thirty-five patients were treated with each drug. The incidence of major side effects, minor side effects, and complete control (85%) was the same in both groups. A mild but signi...

journal_title：Neurology

authors： Ramsay RE,Wilder BJ,Berger JR,Bruni J

更新日期：1983-07-01 00:00:00

abstract：:A 60-year-old patient suffered a lethal hemispheric infarction 3 days after angiographically documented occlusion of the ipsilateral cervical internal carotid artery and while receiving anticoagulant therapy. Pathologic evidence is consistent with embolism from the distal "tail" of a propagated carotid thrombus as the...

journal_title：Neurology

authors： Finklestein S,Kleinman GM,Cuneo R,Baringer JR

更新日期：1980-01-01 00:00:00

abstract：:We describe the MR images of a patient with juvenile ALS. MRI of the brain showed bilateral hyperintensities along the corticospinal tracts extending from the corona radiata to the brainstem on T2-weighted images. These findings should be differentiated from the slight hyperintensities seen in the posterior limbs of t...

journal_title：Neurology

authors： Midani H,Truwit CL,Parry GJ

更新日期：1998-06-01 00:00:00

abstract：:The authors report a double-blind, placebo-controlled, crossover study of talampanel in 49 patients with refractory partial seizures. Three doses of talampanel were investigated based on differences in patients' concomitant antiepileptic drug usage. Talampanel showed efficacy in reducing seizure frequency (p = 0.001) ...

journal_title：Neurology

authors： Chappell AS,Sander JW,Brodie MJ,Chadwick D,Lledo A,Zhang D,Bjerke J,Kiesler GM,Arroyo S

更新日期：2002-06-11 00:00:00

abstract：OBJECTIVE:The diagnosis of psychogenic nonepileptic seizures (PNES) can be challenging. In the absence of a gold standard to verify the reliability of the diagnosis by EEG-video, we sought to assess the interrater reliability of the diagnosis using EEG-video recordings. METHODS:Patient samples consisted of 22 unselect...

journal_title：Neurology

authors： Benbadis SR,LaFrance WC Jr,Papandonatos GD,Korabathina K,Lin K,Kraemer HC,NES Treatment Workshop.

更新日期：2009-09-15 00:00:00

abstract：:A kindred is described with a dominantly inherited "pure" cerebellar ataxia in which the currently known spinocerebellar ataxias have been excluded. In the eight subjects studied, a notable clinical feature is slow progression, with the three least affected having only a mild degree of gait ataxia after three or more ...

journal_title：Neurology

authors： Storey E,Gardner RJ,Knight MA,Kennerson ML,Tuck RR,Forrest SM,Nicholson GA

更新日期：2001-11-27 00:00:00

abstract：:We measured the concentrations of the monoamines, their precursors, and their metabolites, and the activity of choline acetyltransferase (ChAT) in basal ganglia and cortical regions of postmortem brains from cases with histologically verified pure Alzheimer's disease (AD), AD with diffusely distributed Lewy bodies (Le...

journal_title：Neurology

authors： Langlais PJ,Thal L,Hansen L,Galasko D,Alford M,Masliah E

更新日期：1993-10-01 00:00:00

abstract：:The authors report the neuropathologic findings in a case of Sneddon's syndrome. There were multiple small, predominantly cortical, infarcts, with focal hyperplasia and fibrotic occlusion of arterial vessels in the superficial white matter, cortex, and leptomeninges. A very occasional arterial thrombus was seen. These...

journal_title：Neurology

authors： Hilton DA,Footitt D

更新日期：2003-04-08 00:00:00

abstract：:After superficial temporal artery-middle cerebral artery bypass, cerebral blood flow (CBF) in the operated hemisphere increased in 6 of 17 patients. Preoperatively, the symptomatic hemisphere showed lower CBF in all six, lower oxygen metabolism in five, higher blood volume in four, and higher oxygen extraction in two....

journal_title：Neurology

authors： Powers WJ,Martin WR,Herscovitch P,Raichle ME,Grubb RL Jr

更新日期：1984-09-01 00:00:00

abstract：OBJECTIVE:To determine if migraine with aura is associated with neuroinflammation, which has been suggested by preclinical models of cortical spreading depression (CSD) as well as imaging of human pain conditions. METHODS:Thirteen migraineurs with aura and 16 healthy controls received integrated PET/MRI brain scans wi...

journal_title：Neurology

authors： Albrecht DS,Mainero C,Ichijo E,Ward N,Granziera C,Zürcher NR,Akeju O,Bonnier G,Price J,Hooker JM,Napadow V,Loggia ML,Hadjikhani N

更新日期：2019-04-23 00:00:00

abstract：:Fifty patients underwent superficial temporal lobectomy for intractable temporal lobe epilepsy. Total cure rate was 52%, and significant improvement was achieved in 88%. Cytoarchitectural changes in gray and white tissue were analyzed under light microscopy. Neuronal dysgenesis was correlated with the duration of seiz...

journal_title：Neurology

authors： Hardiman O,Burke T,Phillips J,Murphy S,O'Moore B,Staunton H,Farrell MA

更新日期：1988-07-01 00:00:00

abstract：:Four men with evidence of hemiatrophy resulting from early-life hemispheral injury developed unilateral hemiparkinsonism on the side of the hemiatrophy. The parkinsonism began in the fourth decade and has remained unilateral for 5 to 35 years. In all four patients, the parkinsonism was slowly progressive, but the clin...

journal_title：Neurology

authors： Klawans HL

更新日期：1981-05-01 00:00:00