Abstract:
:We observed a highly topographically specific and consistent pattern of degeneration in the auditory system of Alzheimer's disease (AD) patients. Senile plaques (SP) and neurofibrillary tangles (NFT) were distributed throughout the ventral nucleus of the medial geniculate body (MGB) and the central nucleus of the inferior colliculus (IC) in nine of nine AD patients. Adjacent nuclei within the MGB and IC were consistently spared. NFT and SP were also present in the primary auditory and the auditory association cortices. In all control tissues, there were neither SP nor NFT in any of the above sites. The cochlear nuclei were normal in tissues from both AD and control patients. The ventral nucleus of the MGB is the major thalamic relay station for auditory function and receives fibers from neurons of the central nucleus of the IC, with projections arranged tonotopically in a laminar pattern corresponding to a gradient of high-to-low frequency ranges. The degenerative changes distributed throughout these nuclei suggest that neuronal loss may include all frequency ranges in AD. In contrast, the clinical features of presbycusis in elderly patients include only high-frequency loss due to lesions peripherally in the cochlea or auditory nerves, rather than in the central auditory nuclei. These histologic changes in the brains of AD patients may provide an additional basis for altered cognitive function due to primary sensory deafferentation.
journal_name
Neurologyjournal_title
Neurologyauthors
Sinha UK,Hollen KM,Rodriguez R,Miller CAdoi
10.1212/wnl.43.4.779subject
Has Abstractpub_date
1993-04-01 00:00:00pages
779-85issue
4eissn
0028-3878issn
1526-632Xjournal_volume
43pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::The clinical and radiologic impact of developing neutralizing antibodies (NAbs) to interferon beta (IFNbeta) while on this therapy for multiple sclerosis (MS) is assessed. On the basis of Class II and III evidence, it is concluded that treatment of patients with MS with IFNbeta (Avonex, Betaseron, or Rebif) is associa...
journal_title:Neurology
pub_type:
doi:10.1212/01.wnl.0000258545.73854.cf
更新日期:2007-03-27 00:00:00
abstract::We studied acetaminophen sulfation, plasma sulfate levels, and the activity of sulfotransferase in blood platelets in patients with Parkinson's disease, Huntington's disease, and in controls and did not find any abnormality in the patient groups, independent of the use of medication. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.7.1373
更新日期:1993-07-01 00:00:00
abstract::We developed a rating scale for tic disorders that uses only objective criteria and accommodates the variety of tic manifestations. Using short videotaped recordings with the examiner out of the taping room, we measured five tic variables: number of body areas affected, frequency of motor tics and vocalizations, and s...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.9.1542
更新日期:1987-09-01 00:00:00
abstract:OBJECTIVE:The current literature provides discrepant results regarding preoperative sociodemographic and clinical factors, and no information about preoperative cerebral metabolic patterns associated with apathy after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson disease. METHODS:To resolve this is...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000941
更新日期:2014-10-28 00:00:00
abstract::Successful screening for neuropathy in patients with diabetes is available using the 10 g Semmes-Weinstein monofilament (Mid-Delta Health Systems, Inc., Belzoni, MS) (touch/pressure sensation) and the Neurothesiometer (Horwell Scientific, London, UK; vibration perception threshold). In healthy volunteers and patients ...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.59.4.611
更新日期:2002-08-27 00:00:00
abstract::The incidence of MS was assessed in a nationwide cohort study of 31,990 employees of Danish utility companies between 1900 and 1993. Overall, 32 cases of MS were diagnosed, as compared with 23.7 expected from national incidence rates, to yield a standardized incidence ratio of 1.35 (95% confidence interval, 0.92 to 1....
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.6.1279
更新日期:1999-04-12 00:00:00
abstract:OBJECTIVE:With diagnostic criteria alterations, increased MRI availability, and awareness of therapies, temporal changes in incidence and prevalence rates may occur, with an increase in the proportion of mildly affected persons diagnosed with multiple sclerosis (MS). The authors assessed temporal trends in the delay fr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000178891.20579.64
更新日期:2005-10-11 00:00:00
abstract:OBJECTIVES:To investigate whether severity and progression of periventricular and deep white matter lesions (WML) and lacunar infarcts were associated with progression of brain atrophy. METHODS:Within the SMART-MR study, a prospective cohort on MRI changes in patients with symptomatic atherosclerotic disease, 565 pati...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182749f02
更新日期:2012-11-13 00:00:00
abstract:BACKGROUND:According to widely used criteria (Bohan and Peter criteria, 1975), dermatomyositis (DM) is differentiated from polymyositis (PM) only by skin changes. More recent criteria also include histopathologic characteristics enabling the distinction between PM and DM and the differentiation of sporadic inclusion bo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.61.3.316
更新日期:2003-08-12 00:00:00
abstract::Noninvasive positive pressure ventilation prolongs survival in ALS but its effect on quality of life is unknown. The authors prospectively studied quality of life using the SF-36 questionnaire in a cohort of 16 ventilated patients with ALS. Noninvasive positive pressure ventilation improved scores in the "Vitality" do...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.1.153
更新日期:2001-07-10 00:00:00
abstract::We developed a scheme using routinely available data to estimate the risk of human immunodeficiency virus (HIV) dementia in HIV-infected persons over time. We performed a longitudinal review of medical records from more than 100 medical facilities in 11 U.S. cities. A total of 19,462 HIV-infected persons without histo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.2.392
更新日期:1998-02-01 00:00:00
abstract:OBJECTIVE:Myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG) associated disorder (MOGAD) often manifests with recurrent CNS demyelinating attacks. The optimal treatment for reducing relapses is unknown. To help determine the efficacy of long-term immunotherapy in preventing relapse in patients with MOGAD, w...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009758
更新日期:2020-07-14 00:00:00
abstract:OBJECTIVE:Histologic studies show that the amygdala is affected by Alzheimer disease (AD) pathology, and its medial aspect is the most involved. We aimed to assess in vivo local structural differences in the amygdala of patients with AD using high-field MRI. METHODS:A total of 19 patients with AD (mean age 76, SD 6 ye...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31820d62d9
更新日期:2011-02-22 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Posterior cortical atrophy (PCA) is a progressive neurodegenerative syndrome that presents with cortical visual dysfunction and relatively preserved memory. Although higher cortical visual syndromes are well known in PCA, visual field defects detected by computerized visual field (CVF) perimetr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31823e9f2a
更新日期:2011-12-13 00:00:00
abstract::We studied 96 Chinese patients with TIAs using transcranial Doppler and duplex ultrasonography. We found intracranial stenosis or occlusion in 51% of cases and extracranial disease in 19% of cases. The most common intracranial lesion was stenosis of the terminal internal carotid artery or proximal middle cerebral arte...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.2.524
更新日期:1997-02-01 00:00:00
abstract::Recent genetic studies show that the apolipoprotein E epsilon 4 allele (ApoE-epsilon 4) is a risk factor for Alzheimer's disease (AD). If ApoE-epsilon 4 individuals develop AD as they get older, we would expect a decrease in ApoE-epsilon 4 allele frequency with increasing age. We found a marked decline in ApoE-epsilon...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.8.1513
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:Several lines of evidence suggest that inflammatory mechanisms contribute to AD. OBJECTIVE:To examine whether several markers of inflammation are associated with cognitive decline in African-American and white well-functioning elders. METHODS:The authors studied 3,031 African-American and white men and wom...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000073620.42047.d7
更新日期:2003-07-08 00:00:00
abstract::We analyzed the clinical, CT, and angiographic findings in 50 black patients with carotid transient ischemic attacks (TIAs). Thirty-two percent had TIAs lasting less than 1 hour, 26% had TIAs lasting 1 to 6 hours, and 42% had TIAs lasting 6 to 24 hours. Fifty-two percent of TIA patients had CT evidence of cerebral inf...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.9.1410
更新日期:1991-09-01 00:00:00
abstract:OBJECTIVE:To describe the clinical, genetic and MR characteristics of patients with familial mesial temporal lobe epilepsy (MTLE). DESIGN/METHODS:The familial occurrence of MTLE was identified by a systematic search of family history of seizures in patients followed in the authors' epilepsy clinic. All probands and, w...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.2.166
更新日期:2001-01-23 00:00:00
abstract::Mutations in DJ-1 are a cause of autosomal recessive parkinsonism. Polymorphism of genes implicated in hereditary forms of parkinsonism may be a predisposing factor in sporadic Parkinson's disease (PD). The authors analyzed whether a polymorphism (g.168_185del) within exon 1 of DJ-1 contributes to the risk of sporadic...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000083992.28066.7e
更新日期:2003-10-14 00:00:00
abstract::Presenilin (PSEN)1 mutations are responsible for many cases of autosomal dominant Alzheimer disease (AD), although the clinical spectrum has not been fully defined. The authors describe two members of a kindred with a novel PSEN1 mutation (R278I) presenting with language impairment and relative preservation of memory....
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000143060.98164.1a
更新日期:2004-11-09 00:00:00
abstract::Neurologic disorders are among the most frequent causes of morbidity and mortality in the United States. Moreover, the current shortfall of neurologists is expected to worsen over the coming decade. As a consequence, many patients with neurologic disorders will be treated by physicians and primary care providers witho...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006716
更新日期:2019-01-22 00:00:00
abstract::The minimum exposure to estrogen required to cause estrogen-withdrawal migraine has been studied by giving long-acting estradiol valerate to four women and short-acting estradiol benzoate to two women. It was found that several days of exposure to high estrogen levels were needed to cause migraine on estrogen withdraw...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.3.239
更新日期:1975-03-01 00:00:00
abstract:OBJECTIVE:Motor signs are functionally disabling features of Huntington disease. Characteristic motor signs define disease manifestation. Their severity and onset are assessed by the Total Motor Score of the Unified Huntington's Disease Rating Scale, a categorical scale limited by interrater variability and insensitivi...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0b013e3182020123
更新日期:2010-12-14 00:00:00
abstract::The association of APOE genotypes with cerebral microbleeds (CMBs) was examined on the basis of the location of CMBs in 414 patients who were admitted primarily because of stroke. With respect to possession of the epsilon2 or epsilon4 allele, the adjusted odds ratio was 1.94 (1.05 to 3.58) for lobar CMBs but 1.21 (0.6...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000183311.48144.7f
更新日期:2005-11-08 00:00:00
abstract::We studied two families with an unusual variant of neurofibromatosis (NF). The first family had spinal neurofibromas and café au lait spots (CLS), the second spinal neurofibromas without CLS. Other signs of NF1 or NF2, such as cutaneous tumors, Lisch nodules, or acoustic tumors, were absent. The inheritance pattern in...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.12.1923
更新日期:1991-12-01 00:00:00
abstract::Phenotypic heterogeneity of sporadic Creutzfeldt-Jakob disease (CJD) has been linked to biochemically distinct types of the protease-resistant form of the prion protein (type 1 and type 2 PrP(Sc)). We investigated 14 cases of sporadic CJD and found that both type 1 and type 2 PrP(Sc) coexisted in 5 subjects. The disti...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.9.2173
更新日期:1999-12-10 00:00:00
abstract:OBJECTIVE:To investigate long-term employment outcomes after resective epilepsy surgery in a national population-based cohort of adults. METHODS:In the Swedish National Epilepsy Surgery Register, all adults who were operated with resective epilepsy surgery from 1995 to 2010 were identified. Two-year follow-up was avai...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002069
更新日期:2015-10-27 00:00:00
abstract:OBJECTIVE:To detect and quantify lesions of the small-caliber sural nerve (SN) in symptomatic and asymptomatic transthyretin familial amyloid polyneuropathy (TTR-FAP) by high-resolution magnetic resonance neurography (MRN) in correlation with electrophysiologic and histopathologic findings. METHODS:Twenty-five patient...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004178
更新日期:2017-08-01 00:00:00
abstract::We used [18F]-2-fluoro-2-deoxy-D-glucose (FDG) and PET to study regional cerebral glucose utilization in seven patients with fatal familial insomnia (FFI), an inherited prion disease with a mutation at codon 178 of the prion protein gene. Four patients were methionine/methionine homozygotes at codon 129 (symptom durat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.1.126
更新日期:1997-07-01 00:00:00