Abstract:
:Rats were intoxicated with acrylamide monomer at 50 mg per kilogram per day; lumbar dorsal root ganglia and distal sural and tibial nerves were studied morphologically. At the sixth day of intoxication, large and small neuronal cell bodies showed a spectrum of remodeling changes that included nuclear eccentricity, cytoplasmic reorganization with an outer mantle of Nissl and an inner perinuclear zone of pigmented bodies, and increased perineuronal cells. Distal axons showed little degeneration at this time. These findings suggest that the cell body plays an important role in the pathogenesis of dying-back neurotoxic disease, and that there may be direct toxic affect on the perikaryon itself.
journal_name
Neurologyjournal_title
Neurologyauthors
Sterman ABdoi
10.1212/wnl.32.9.1023subject
Has Abstractpub_date
1982-09-01 00:00:00pages
1023-6issue
9eissn
0028-3878issn
1526-632Xjournal_volume
32pub_type
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