Abstract:
:We report of a woman aged 52 years born to consanguineous parents and seeking treatment for progressive dementia and delusion. Neurologic examination revealed dementia and emotional instability, indifference, and confabulation. There was also mild spasticity of the bilateral lower limbs. MRI revealed diffuse white matter hyperintensity on T2-weighted images accompanied by hypointense areas on fluid-attenuated inversion recovery images. A homozygous missense mutation was identified in EIF2B5.
journal_name
Neurologyjournal_title
Neurologyauthors
Ohtake H,Shimohata T,Terajima K,Kimura T,Jo R,Kaseda R,Iizuka O,Takano M,Akaiwa Y,Goto H,Kobayashi H,Sugai T,Muratake T,Hosoki T,Shioiri T,Okamoto K,Onodera O,Tanaka K,Someya T,Nakada T,Tsuji Sdoi
10.1212/01.wnl.0000123117.11264.0esubject
Has Abstractpub_date
2004-05-11 00:00:00pages
1601-3issue
9eissn
0028-3878issn
1526-632Xjournal_volume
62pub_type
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