Determinants of the distribution and severity of hypoperfusion in patients with ischemic stroke.

abstract：:Measurements of cerebral metabolism in patients with Alzheimer's disease (AD) using PET are artifactually depressed due to partial volume averaging of brain tissue activity with enlarged CSF spaces. To investigate the effects of correction for the expansion of CSF spaces on regional metabolic measures, as well as the ...

journal_title：Neurology

authors： Meltzer CC,Zubieta JK,Brandt J,Tune LE,Mayberg HS,Frost JJ

更新日期：1996-08-01 00:00:00

abstract：:To assess the possible role of amine neurotransmitters in human epilepsy, we measured metabolites of serotonin (5-hydroxyindoleacetic acid [5-HIAA]), dopamine (homovanillic acid [HVA]), and norepinephrine (3-methoxy-4-hydroxyphenylethylene glycol [MHPG]) in the lumbar cerebrospinal fluid (CSF) of patients with partial...

journal_title：Neurology

authors： Laxer KD,Sourkes TL,Fang TY,Young SN,Gauthier SG,Missala K

更新日期：1979-08-01 00:00:00

abstract：OBJECTIVE:We used transcranial magnetic stimulation to investigate the effect of diurnal variability on cortical excitability in patients with epilepsy. METHODS:Thirty drug-naive patients with epilepsy (20 idiopathic generalized epilepsy [IGE], including 10 juvenile myoclonic epilepsy [JME], and 10 focal epilepsy) and...

journal_title：Neurology

authors： Badawy RA,Macdonell RA,Jackson GD,Berkovic SF

更新日期：2009-07-21 00:00:00

abstract：OBJECTIVES:To describe clinical-radiologic characteristics in a prospective series of patients having both confirmed reversible cerebral vasoconstriction syndrome (RCVS) and cervical artery dissection (CeAD). METHODS:From January 2004 to December 2011, from our prospective cohorts of RCVS and CeAD, we studied patients...

journal_title：Neurology

authors： Mawet J,Boukobza M,Franc J,Sarov M,Arnold M,Bousser MG,Ducros A

更新日期：2013-08-27 00:00:00

abstract：:In patients with cranial dystonia, we compared the effects of central anticholinergic, peripheral anticholinergic, and placebo treatments in a double-blind crossover study. One of the nine patients who completed the study improved markedly with central anticholinergic therapy. The three treatments were indistinguishab...

journal_title：Neurology

authors： Nutt JG,Hammerstad JP,deGarmo P,Carter J

更新日期：1984-02-01 00:00:00

abstract：:Apraxia is the loss of the ability to perform learned skilled movements correctly. In right-handers, apraxia and aphasia are most frequently associated with left-hemisphere lesions. When they are dissociated, however, aphasia is more common in the absence of apraxia than vice versa. There are two hypotheses that can a...

journal_title：Neurology

authors： Foundas AL,Henchey R,Gilmore RL,Fennell EB,Heilman KM

更新日期：1995-07-01 00:00:00

abstract：OBJECTIVE:To determine the effect of clinical and radiologic disease activity on the rate of thinning of the ganglion cell/inner plexiform (GCIP) layer and the retinal nerve fiber layer in patients with multiple sclerosis (MS) using optical coherence tomography (OCT). METHODS:One hundred sixty-four patients with MS an...

journal_title：Neurology

authors： Ratchford JN,Saidha S,Sotirchos ES,Oh JA,Seigo MA,Eckstein C,Durbin MK,Oakley JD,Meyer SA,Conger A,Frohman TC,Newsome SD,Balcer LJ,Frohman EM,Calabresi PA

更新日期：2013-01-01 00:00:00

abstract：:Salla disease is a lysosomal storage disorder associated with increased urinary excretion of free sialic acid. The main clinical features in 34 patients were severe psychomotor retardation of early onset, ataxia, athetosis, rigidity, spasticity, and impaired speech. Growth retardation, thick calvarium, and exotropia w...

journal_title：Neurology

authors： Renlund M,Aula P,Raivio KO,Autio S,Sainio K,Rapola J,Koskela SL

更新日期：1983-01-01 00:00:00

abstract：:Serial determinations of spinal fluid homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were made in four patients with the Lesch-Nyhan syndrome over a 5-year period. Control spinal fluids for age-matched comparison were obtained from 194 neurologic and nonneurologic pediatric patients. A rapid decline i...

journal_title：Neurology

authors： Silverstein FS,Johnston MV,Hutchinson RJ,Edwards NL

更新日期：1985-06-01 00:00:00

abstract：OBJECTIVE:Current prehospital scales used to detect large vessel occlusion reveal very low endovascular thrombectomy (EVT) rates among selected patients. We developed a novel prehospital scale, the Madrid-Direct Referral to Endovascular Center (M-DIRECT), to identify EVT candidates for direct transfer to EVT-capable ce...

journal_title：Neurology

authors： Rodríguez-Pardo J,Riera-López N,Fuentes B,Alonso de Leciñana M,Secades-García S,Álvarez-Fraga J,Busca-Ostolaza P,Carneado-Ruiz J,Díaz-Guzmán J,Egido-Herrero J,Gil-Núñez A,Masjuan-Vallejo J,Real-Martínez V,Vivancos-Mora J,Díez

更新日期：2020-02-25 00:00:00

abstract：OBJECTIVE:To report the clinical and pelvic CT findings in six patients with obturator mononeuropathy caused by cancer. DESIGN:A clinical case series of six patients followed for 2 months to 10 years (one patient lost to follow-up). SETTING:Three referral centers. PATIENTS:Three men and three women, ages 52 to 81 ye...

journal_title：Neurology

authors： Rogers LR,Borkowski GP,Albers JW,Levin KH,Barohn RJ,Mitsumoto H

更新日期：1993-08-01 00:00:00

abstract：:We studied the effects of bromocriptine on periodic limb movements in sleep (PLMS) of narcoleptic patients. Bromocriptine significantly reduced the number and index of PLMS without improving the nocturnal sleep disruption in that disorder. These results support the hypothesis that dopaminergic mechanisms are involved ...

journal_title：Neurology

authors： Boivin DB,Lorrain D,Montplaisir J

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVE:To describe neurodevelopment and head growth in HIV-1-infected and exposed uninfected infants with and without in utero exposure to opiates and cocaine. METHODS:Using data from a multicenter cohort study of HIV-1-infected women and their children, the authors fit repeated measures regression models to estima...

journal_title：Neurology

authors： Macmillan C,Magder LS,Brouwers P,Chase C,Hittelman J,Lasky T,Malee K,Mellins CA,Velez-Borras J

更新日期：2001-10-23 00:00:00

abstract：BACKGROUND:Two recent studies suggest that the risk of ALS is increased among Gulf War veterans. It is not known whether military service outside of the Gulf War is associated with increased risk of ALS. METHODS:The authors prospectively assessed the relation between service in the military and ALS mortality among par...

journal_title：Neurology

authors： Weisskopf MG,O'Reilly EJ,McCullough ML,Calle EE,Thun MJ,Cudkowicz M,Ascherio A

更新日期：2005-01-11 00:00:00

abstract：OBJECTIVE:To quantify the isoprostane 8,12-iso-iPF2alpha-VI in brain tissues obtained from patients with AD, patients with frontotemporal dementia (FTD), and controls. BACKGROUND:Enhanced brain oxidative stress with secondary damage to cellular macromolecules may play a role in the pathogenesis of AD and FTD. The isop...

journal_title：Neurology

authors： Yao Y,Zhukareva V,Sung S,Clark CM,Rokach J,Lee VM,Trojanowski JQ,Praticò D

更新日期：2003-08-26 00:00:00

abstract：:We enrolled 116 patients in a multicenter, randomized, double-blind controlled trial of an 8-week course of 11 plasma exchange (PE) treatments in exacerbations of MS. The control group received sham PE, and both groups received identical treatment with IM ACTH and oral cyclophosphamide. Serum IgG decreased in the PE a...

journal_title：Neurology

authors： Weiner HL,Dau PC,Khatri BO,Petajan JH,Birnbaum G,McQuillen MP,Fosburg MT,Feldstein M,Orav EJ

更新日期：1989-09-01 00:00:00

abstract：:A 30-year-old woman was thought to have Friedreich's disease because of progressive ataxia, dysarthria, and titubation from age 3 years. Her diet was normal, and there were neither symptoms nor laboratory evidence of liver disease or fat malabsorption. Serum vitamin E content and the ratio of serum vitamin E to total ...

journal_title：Neurology

authors： Stumpf DA,Sokol R,Bettis D,Neville H,Ringel S,Angelini C,Bell R

更新日期：1987-01-01 00:00:00

abstract：:Serum ratios of monoclonal immunoglobulin (Ig) to total protein, monoclonal immunoglobulin to albumin, CSF/serum Ig-albumin index, and CSF to serum monoclonal immunoglobulin were obtained in 21 patients with multiple myeloma and 2 with Waldenström's macroglobulinemia. Twelve patients (3 with CNS complications) showed ...

journal_title：Neurology

authors： Hansotia P,Gani K,Friedenberg W

更新日期：1983-11-01 00:00:00

abstract：:We studied 35 patients with nonseptic cardiogenic cerebral emboli. In 28 cases, there was sudden onset with maximal neurologic deficit within 1 hour; in 7 cases, there was progression in 24 hours. In six cases, neurologic abnormality worsened in the first week after an initial period of stabilization. CT showed eviden...

journal_title：Neurology

authors： Weisberg LA

更新日期：1985-06-01 00:00:00

abstract：:The progressive myoclonus epilepsies (PMEs) are a devastating group of rare disorders(1) that manifest with increasing action myoclonus, which is also present at rest but activates with stimuli such as noise, light, or touch. Ultimately, patients become wheelchair-bound and experience early death. Neurologic signs tha...

journal_title：Neurology

authors： Knupp K,Wirrell E

更新日期：2014-02-04 00:00:00

abstract：:The authors reviewed the incidence of cancer, repetitive nerve stimulation findings, and response to treatment in 73 patients with Lambert-Eaton myasthenic syndrome. Thirty-one patients (42%) had lung cancer, 29 small cell. Doubling of the compound motor action potential amplitude in three tested distal muscles was se...

journal_title：Neurology

authors： Tim RW,Massey JM,Sanders DB

更新日期：2000-06-13 00:00:00

abstract：OBJECTIVE:The authors investigated chronic cerebellar reorganization following unilateral cortical lesions in children and adults using PET to measure benzodiazepine receptor (BZR) binding with [11C]flumazenil (FMZ) and glucose metabolism with 2-deoxy-2[18F]fluoro-D-glucose (FDG). BACKGROUND:Crossed cerebellar diaschi...

journal_title：Neurology

authors： Niimura K,Chugani DC,Muzik O,Chugani HT

更新日期：1999-03-10 00:00:00

abstract：:A 46-year-old man had metastasis to the central tegmental tract of the pons with ipsilateral olivary hypertrophy. Although the phenomenon of palatal myochlonus has been repeatedly correlated with the finding of olivary hypertrophy, no palatal myoclonus was noted on repeated examinations. The clinical pathologic correl...

journal_title：Neurology

authors： Robin JJ,Alcala H

更新日期：1975-08-01 00:00:00

abstract：:This manuscript provides a practical summary of guidelines for institution of apomorphine subcutaneous injectable therapy, including patient education, pre-treatment issues, dosage titration and side-effect care. The timing of each injection is crucial if an impending "off" period is to be averted. Patients need to be...

journal_title：Neurology

authors： Bowron A

更新日期：2004-03-23 00:00:00

abstract：:A term neonate was being treated with intravenous phenytoin. To maintain a serum level above 10 micrograms per milliliter and abolish seizure activity, it was necessary to carry out repeated serum concentration measurements, administer several loading doses, and administer an unusually large maintenance dose (25 mg pe...

journal_title：Neurology

authors： Whelan HT,Hendeles L,Haberkern CM,Neims AH

更新日期：1983-01-01 00:00:00

abstract：:We report 9 patients with an isolated infarct of the anterior part of the rostral cerebellum, ie, the territory of the lateral branch of the superior cerebellar artery. Clinicoanatomic correlations are based on CT, MRI, or both in 8 patients and on pathologic data in the ninth. The main clinical features were ipsilate...

journal_title：Neurology

authors： Amarenco P,Roullet E,Goujon C,Chéron F,Hauw JJ,Bousser MG

更新日期：1991-02-01 00:00:00

abstract：OBJECTIVE:Pigmented orthochromatic leukodystrophy (POLD) and hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS) are rare neurodegenerative disorders characterized by cerebral white matter abnormalities, myelin loss, and axonal swellings. The striking overlap of clinical and pathologic features of these...

journal_title：Neurology

authors： Nicholson AM,Baker MC,Finch NA,Rutherford NJ,Wider C,Graff-Radford NR,Nelson PT,Clark HB,Wszolek ZK,Dickson DW,Knopman DS,Rademakers R

更新日期：2013-03-12 00:00:00

abstract：BACKGROUND:An inverse association between cigarette smoking and the risk of idiopathic PD has been found in many epidemiologic studies. The therapeutic and possible neuroprotective effects of nicotine formulations on parkinsonian symptoms are controversial. METHODS:In a 12-week, randomized, double-blind, placebo-contr...

journal_title：Neurology

authors： Vieregge A,Sieberer M,Jacobs H,Hagenah JM,Vieregge P

更新日期：2001-09-25 00:00:00

abstract：OBJECTIVE:To describe the phenotypic spectrum and genetics of periventricular nodular heterotopia (PNH) caused by FLN1 mutations in four men. BACKGROUND:X-linked PNH caused by FLN1 mutations (MIM #300049) implies prenatal or early postnatal lethality in boys and 50% recurrence risk in daughters of affected women. MET...

journal_title：Neurology

authors： Guerrini R,Mei D,Sisodiya S,Sicca F,Harding B,Takahashi Y,Dorn T,Yoshida A,Campistol J,Krämer G,Moro F,Dobyns WB,Parrini E

更新日期：2004-07-13 00:00:00

abstract：:We recorded interictal spikes with closely spaced scalp electrodes and sphenoidal electrodes in four patients with temporal lobe epilepsy. We used multiple dipole modeling to study the number, three-dimensional intracerebral location, time activity, and functional relationship of the neuronal sources underlying the ep...

journal_title：Neurology

authors： Baumgartner C,Lindinger G,Ebner A,Aull S,Serles W,Olbrich A,Lurger S,Czech T,Burgess R,Lüders H

更新日期：1995-01-01 00:00:00