Abstract:
BACKGROUND:An inverse association between cigarette smoking and the risk of idiopathic PD has been found in many epidemiologic studies. The therapeutic and possible neuroprotective effects of nicotine formulations on parkinsonian symptoms are controversial. METHODS:In a 12-week, randomized, double-blind, placebo-controlled trial, the efficacy and tolerability of transdermal nicotine patches as an add-on treatment for cardinal symptoms were evaluated in 32 nonsmoking patients with PD. After a 1-week run-in phase, patients were randomized to receive nicotine patches (containing 17.5 mg nicotine in the first and 35.0 mg nicotine in the second and third weeks) or identically appearing placebo patches. After this treatment, 3 weeks without patch application followed. The same blinded examiner assessed the patients with the Columbia University Rating Scale, the Webster scale, the Schwab-England scale, a timed walking test, with an instrumental test for fine motor skills and hand tremor, and with the Hamilton Depression Scale. RESULTS:No significant drug effects between both groups were observed in any of the scores and quantitative tests. Side effects were mild and comparable in frequency between both groups. CONCLUSIONS:With the dosage and the period of treatment chosen, transdermal nicotine patches are not effective as an add-on treatment for symptoms of PD.
journal_name
Neurologyjournal_title
Neurologyauthors
Vieregge A,Sieberer M,Jacobs H,Hagenah JM,Vieregge Pdoi
10.1212/wnl.57.6.1032subject
Has Abstractpub_date
2001-09-25 00:00:00pages
1032-5issue
6eissn
0028-3878issn
1526-632Xjournal_volume
57pub_type
临床试验,杂志文章,随机对照试验相关文献
NEUROLOGY文献大全abstract::Outcome after carpal tunnel surgery was studied retrospectively in 32 patients with peripheral neuropathy and carpal tunnel syndrome. Nocturnal paresthesias were almost universally relieved, followed in order of responsiveness by pain, numbness, and weakness. Twenty-five of 28 patients said they would have the surgery...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.4.1159
更新日期:1997-10-01 00:00:00
abstract::A clinical procedure for determining contrast sensitivity was performed on patients with suspected sella area masses. The test consisted of a series of six plates, each containing a bar pattern of fixed sinusoidal spatial frequency in which contrast varies along the length of the bar. Patients with compressive lesions...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.5.550
更新日期:1981-05-01 00:00:00
abstract::We describe a 43-year-old neurologically intact patient who reported episodes of diplopia and oscillopsia associated with a right-beating nystagmus and a skew deviation. These symptoms and signs were related to a left posterior epileptic EEG discharge. We suggest that these ocular motor signs derived from an ictal act...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.5.1469
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:Treatment of aneurysmal subarachnoid hemorrhage (SAH) has changed substantially over the last 25 years but there is a lack of reliable population-based data on whether case-fatality or functional outcomes have improved. METHODS:We determined changes in the standardized incidence and outcome of SAH in the sa...
journal_title:Neurology
pub_type: 杂志文章,meta分析,评审
doi:10.1212/WNL.0b013e3181dd42b3
更新日期:2010-05-11 00:00:00
abstract:OBJECTIVE:To define the natural history of the C9orf72 amyotrophic lateral sclerosis (C9ALS) patient population, develop disease biomarkers, and characterize patient pathologies. METHODS:We prospectively collected clinical and demographic data from 116 symptomatic C9ALS and 12 non-amyotrophic lateral sclerosis (ALS) f...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008359
更新日期:2019-10-22 00:00:00
abstract:OBJECTIVE:To determine, in a cross-sectional evaluation of nondemented individuals, if age-related memory decline is influenced by apolipoprotein E (apoE) genotype. BACKGROUND:The apoE-4 allele is an important risk factor for AD. PET in cognitively normal apoE-4 carriers (mean age, 56 years) shows reduced cerebral met...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.1.201
更新日期:1999-07-13 00:00:00
abstract::In this study, we examined the topographic involvement of the putaminal projection neurons and their axons in the globus pallidus and substantia nigra, which we visualized by calcineurin immunostaining, in the basal ganglia of patients with striatonigral degeneration (SND). In all cases examined, there was a marked de...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.4.1032
更新日期:1996-10-01 00:00:00
abstract::We describe a 28-year-old woman presenting with hypokalemic myopathy caused by 17alpha-hydroxylase/17,20-lyase deficiency caused by a homozygous mutation consisting of a G-to-C transition in the initiation codon in exon 1 of the CYP17 gene resulting in expression of an enzymatically inactive truncated P450c17 protein....
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.6.1748
更新日期:1998-12-01 00:00:00
abstract::We detected crossed cerebellar as well as uncrossed basal ganglia and thalamic diaschisis in Alzheimer's disease by positron emission tomography (PET) using 18F-fluorodeoxyglucose. We studied a series of 26 consecutive, clinically diagnosed Alzheimer cases, including 6 proven by later autopsy, and compared them with 9...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.4.541
更新日期:1989-04-01 00:00:00
abstract:OBJECTIVE:To assess cerebrovascular reactivity in response to a visual task in participants with cerebral amyloid angiopathy (CAA), Alzheimer disease (AD), and mild cognitive impairment (MCI) using fMRI. METHODS:This prospective cohort study included 40 patients with CAA, 22 with AD, 27 with MCI, and 25 healthy contro...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000010201
更新日期:2020-09-08 00:00:00
abstract:OBJECTIVE:To investigate the relationships between structural damage in the whole brain, the temporal lobes, and the frontal lobes and cognitive decline at old age. The authors hypothesized that widespread brain damage as quantified using magnetization transfer imaging (MTI) is related to global cognitive decline, wher...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.59.6.874
更新日期:2002-09-24 00:00:00
abstract::We describe the clinical, imaging, and pathologic findings in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). The patient experienced her first stroke-like episode at age forty-four. Brain MRI, obtained at symptom onset, at 3 weeks, and at 1 year, revealed migr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.1.223
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVE:To determine whether increased risk of acute ischemic stroke (AIS) following herpes zoster (HZ) might be modified by the status of zoster vaccine live (ZVL) vaccination and antiviral treatment following HZ. METHODS:We included 87,405 Medicare fee-for-service beneficiaries aged ≥66 years diagnosed with HZ and...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000010028
更新日期:2020-08-11 00:00:00
abstract::Motor axons supplying lumbrical muscles are less severely affected than axons supplying thenar muscles in the carpal tunnel syndrome; sometimes lumbrical motor fibers are less affected than digit 2 sensory fibers. This pattern is consistent with compression of both the anterior and posterior aspects of the median nerv...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.9.1499
更新日期:1987-09-01 00:00:00
abstract:OBJECTIVE:To determine the clinical value of JC virus (JCV) detection in various anatomic compartments for the diagnosis of progressive multifocal leukoencephalopathy (PML). METHODS:CSF, peripheral blood mononuclear cells (PBMC), plasma, and urine samples were evaluated from HIV-infected and uninfected individuals. JC...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.2.253
更新日期:1999-01-15 00:00:00
abstract::The predictive value of CSF oligoclonal banding for the development of clinically definite MS (CDMS) within 5 years after optic neuritis was assessed in 76 patients enrolled in the Optic Neuritis Treatment Trial. The presence of oligoclonal bands was associated with the development of CDMS (p = 0.02). However, the res...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.3.885
更新日期:1998-09-01 00:00:00
abstract::Two successive, 6-month, randomized, double-blind, controlled trials of prednisone showed that 0.75 mg/kg/d was the optimal dose to improve strength in boys with Duchenne muscular dystrophy (DMD). We attempted to maintain 93 boys on that dose for an additional 2 years. During the 3 years of observation, the decline in...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.41.12.1874
更新日期:1991-12-01 00:00:00
abstract::The authors investigated the PRNP Met129Val polymorphism in 1,393 subjects including 482 patients with Alzheimer disease (AD) and two independent control groups. In patients, PRNP Met homozygosity conferred increasing risk with decreasing age at onset (onset: 61 to 70 years, n = 151, p = 0.02, odds ratio [OR] = 1.72, ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000130198.72589.69
更新日期:2004-07-27 00:00:00
abstract:OBJECTIVE:To study the efficacy and safety of low-dose oral tetrahydrocannabinol (THC) in the treatment of dementia-related neuropsychiatric symptoms (NPS). METHODS:This is a randomized, double-blind, placebo-controlled study. Patients with dementia and clinically relevant NPS were randomly assigned to receive THC 1.5...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0000000000001675
更新日期:2015-06-09 00:00:00
abstract::Rosenthal fibers are present in several neurologic disorders. Their occurrence in widespread subependymal, subpial, and perivascular locations is thought to be diagnostic of Alexander's disease, but they have also been reported in rare adult cases. Some of these patients were neurologically intact with severe systemic...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.9.1733
更新日期:1992-09-01 00:00:00
abstract::We attempted to determine whether separable components underlie normal subjects' upward bias in bisecting vertical and radial lines under visual guidance. Twelve normal subjects indicated the midpoint of visually presented lines oriented vertically, radially, and horizontally. We placed directional labels ("TOP" and "...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.4.703
更新日期:1994-04-01 00:00:00
abstract::Automatisms are commonly seen in epilepsy, either ictally or postictally. However, most automatisms are simple, with hand movements, mouth smacking, nose-rubbing, repetition of a single word, or coughing, grunting, or screeching. Complex automatisms are less common and striking. The authors report two cases of seizure...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000031430.40085.93
更新日期:2002-11-12 00:00:00
abstract::The relevance of neutralizing antibodies (NAb) to interferon-beta (IFNbeta) for patients with MS treated with IFNbeta injections has been controversial. Published data from several double-blind, randomized clinical trials demonstrate that disease activity in IFNbeta-treated patients with MS is similar to placebo-treat...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000092363.40248.0e
更新日期:2003-11-11 00:00:00
abstract::Acquired aphasia with convulsive disorder is an unusual condition in childhood, characterized by loss of language function associated with a paroxysmal electroencephalogram. To determine the course and outcome of this disorder, we evaluated nine patients 10 to 28 years after the onset of aphasia. Four patients had rec...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.5.524
更新日期:1980-05-01 00:00:00
abstract:OBJECTIVE:To investigate botulinum toxin (BTX) effects on central and peripheral motor excitability in writer's cramp. METHODS:Using transcranial magnetic stimulation over the motor cortex and brainstem and peripheral electrical stimulation, the authors investigated measures of motor cortical and peripheral motor exci...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000095965.36574.0f
更新日期:2003-12-09 00:00:00
abstract::Eighteen patients with congenital nystagmus were studied with the techniques of electronystagmography and computer analysis. We found several complex wave forms of congenital nystagmus in the primary position of gaze above those of jerk and pendular nystagmus as defined clinically. An etiologic classification of motor...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.4.326
更新日期:1976-04-01 00:00:00
abstract::We examined measures of lead dose that reflect intensity of exposure and cumulative exposure for differential association with neuropsychological functional domains and with neuropsychological performance by age. Eighty active lead smelter workers assessed for verbal memory and visuomotoric skills had a mean (range) a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.3.639
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVE:To investigate the cognitive decline in dementia with Lewy bodies (DLBs) and characterize the contribution of Lewy bodies (LBs) to cognitive impairment in the presence of concurrent Alzheimer disease (AD). METHODS:Cognitive deficits and rates of progression attributable to DLB and AD neuropathology were inve...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000180964.60708.c2
更新日期:2005-10-25 00:00:00
abstract::In 64 patients with Parkinson's disease (PD), the basal level of prolactin (PRL) was normal. Bromocriptine (BCT) caused a significant suppression of PRL in all parkinsonian patients and controls. When given after BCT treatment, thyrotropin-releasing hormone (TRH) induced a significantly lower PRL rise in recent-onset ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.3.393
更新日期:1986-03-01 00:00:00
abstract::The frequency, patterns of inheritance and clinical phenotypes of inherited myopathies with histologic features of rimmed vacuoles, tubulofilamentous inclusions and absence of inflammation (familial and hereditary inclusion body myopathy [f-IBM]) are poorly defined. Quadriceps sparing is a characteristic of f-IBM seen...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.4.977
更新日期:1996-10-01 00:00:00