Abstract:
:In this study, we examined the topographic involvement of the putaminal projection neurons and their axons in the globus pallidus and substantia nigra, which we visualized by calcineurin immunostaining, in the basal ganglia of patients with striatonigral degeneration (SND). In all cases examined, there was a marked decrease in number of calcineurin-immunopositive neurons in the caudal and lateral portion of the putamen. Also, marked depletion of calcineurin-immunoreactive putaminal efferents was consistently present in the posteroventrolateral portions of the globus pallidus interna (GPi) and externa, and in the ventrolateral portion of the substantia nigra pars reticulata (SNr) topographically corresponding to the putaminal lesion. In view of the functional model of the basal ganglia "motor" circuit, these findings suggest that subregional deafferentation of the GPi/SNr (i.e., basal ganglia output nuclei) from putaminal inputs may be responsible for parkinsonism in patients with SND.
journal_name
Neurologyjournal_title
Neurologyauthors
Goto S,Matsumoto S,Ushio Y,Hirano Adoi
10.1212/wnl.47.4.1032subject
Has Abstractpub_date
1996-10-01 00:00:00pages
1032-6issue
4eissn
0028-3878issn
1526-632Xjournal_volume
47pub_type
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