Abstract:
:We enrolled 116 patients in a multicenter, randomized, double-blind controlled trial of an 8-week course of 11 plasma exchange (PE) treatments in exacerbations of MS. The control group received sham PE, and both groups received identical treatment with IM ACTH and oral cyclophosphamide. Serum IgG decreased in the PE and sham treatment groups by 76% versus 22% by treatment 5, and by 64% versus 14% by treatment 11. PE also produced significant reductions in IgA, IgM, C3, and fibrinogen. PE patients had moderately enhanced improvement at 2 weeks relative to the sham group. PE patients with relapsing/remitting disease had significantly enhanced improvement at 4 weeks and there was also an increased improvement at 12 months, although this latter effect disappeared when we analyzed relapsing/remitting patients as a separate subgroup. Life table analysis showed the median time to recover preattack disability status was shorter in PE- than in sham-treated relapsing/remitting patients (4 vs. 13 weeks), a result confirmed by raw disability status scores in which there was recovery to their average preattack disability score by 3 months. PE given with ACTH plus cyclophosphamide enhances recovery from an exacerbation of disease in relapsing/remitting patients, although we observed no clear long-term benefits.
journal_name
Neurologyjournal_title
Neurologyauthors
Weiner HL,Dau PC,Khatri BO,Petajan JH,Birnbaum G,McQuillen MP,Fosburg MT,Feldstein M,Orav EJdoi
10.1212/wnl.39.9.1143subject
Has Abstractpub_date
1989-09-01 00:00:00pages
1143-9issue
9eissn
0028-3878issn
1526-632Xjournal_volume
39pub_type
临床试验,杂志文章,随机对照试验相关文献
NEUROLOGY文献大全abstract::Although people with migraine are aware of their headaches they are often not aware that they have migraine. This can lead to inappropriate or ineffective use of treatments, delays in seeking appropriate care, and miscommunication during clinical encounters. This article assesses self-recognition of migraine and ident...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.9_suppl_6.s21
更新日期:2002-05-14 00:00:00
abstract:BACKGROUND:Multiple sclerosis (MS) is a neurodegenerative disease associated with marked impairments in health-related quality of life (HRQoL). Although standard clinical end points such as the Expanded Disability Status Scale and annualized relapse rate remain useful in assessing MS activity and severity, these measur...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181dbb884
更新日期:2010-04-27 00:00:00
abstract::The authors report results of SPECT cerebral perfusion studies in two patients with familial dysautonomia (FD) during dysautonomic crises and when clinically stable. SPECT imaging studies used 99mTc ethylene cysteine dimer. During dysautonomic crises, regions in the temporoparietal and frontal lobes had increased upta...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.1.122
更新日期:2000-07-12 00:00:00
abstract:OBJECTIVE:To perform a psychometric evaluation of the inflammatory neuropathy cause and treatment (INCAT) sensory sumscore (ISS) in sensory-motor immune-mediated polyneuropathies. This new sensory scale was evaluated to strive for uniformity in assessing sensory deficit in these disorders. METHODS:The ISS comprises vi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.4.943
更新日期:2000-02-22 00:00:00
abstract::Prostaglandins B1 and B2 were topically applied to the pial vessels of mice and arteriolar constriction was observed. This constriction could be significantly increased if serotonin was added to B1, but not when norepinephrine was added. Response to B2 was not enhanced by the simultaneous addition of either serotonin ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.12.1169
更新日期:1975-12-01 00:00:00
abstract::Loading doses of 15 to 20 mg per kilogram of both phenobarbital and phenytoin, administered intravenously, are necessary in the newborn to achieve rapid therapeutic plasma anticonvulsant levels. Maintenance doses of 3 to 4 mg per kilogram of both agents will maintain therapeutic levels. Phenytoin is, however, not pred...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.9.1107
更新日期:1981-09-01 00:00:00
abstract:OBJECTIVE:To determine if migraine with aura is associated with neuroinflammation, which has been suggested by preclinical models of cortical spreading depression (CSD) as well as imaging of human pain conditions. METHODS:Thirteen migraineurs with aura and 16 healthy controls received integrated PET/MRI brain scans wi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007371
更新日期:2019-04-23 00:00:00
abstract:OBJECTIVE:To test the hypothesis that transcranial magnetic resonance-guided focused ultrasound (tcMRgFUS) thalamotomy is effective, durable, and safe for patients with medication-refractory essential tremor (ET), we assessed clinical outcomes at 3-year follow-up of a controlled multicenter prospective trial. METHODS:...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000008561
更新日期:2019-12-10 00:00:00
abstract::We studied 10 patients with transient global amnesia (TGA). Routine electroencephalograms (EEGs) were normal in six; two showed mild temporal lobe abnormalities, one had bitemporal delta activity with rare sharp waves, and one showed bioccipital rhythmic theta activity. Nasopharyngeal (NP) recordings were obtained in ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.6.869
更新日期:1979-06-01 00:00:00
abstract:BACKGROUND:We evaluated the clinicoradiologic characteristics of patients with branch occlusive disease (BOD)-type intracranial atherosclerotic stroke (ICAS) compared with those of patients with non-BOD-type ICAS or with small artery disease (SAD). METHODS:We analyzed 201 consecutive patients with acute infarcts withi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31824c4699
更新日期:2012-03-20 00:00:00
abstract::We describe a case of West Nile virus (WNV) infection in an HIV-infected patient who presented with an isolated flaccid monoparesis of the right upper extremity. To our knowledge, this is the first reported case of flaccid paralysis caused by WNV infection in an HIV-infected patient. We then review the medical literat...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000253223.07720.bb
更新日期:2007-02-13 00:00:00
abstract::We compared 42 myasthenia gravis (MG) patients with thymoma with 42 generalized MG patients without thymoma using a modified Osserman classification. The mean Osserman grades at diagnosis, 6 months, and 5 and 10 years post-thymectomy did not differ between groups. Our results indicate that thymoma is not a negative de...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.51.4.1198
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVE:To demonstrate whether the cerebral hemispheres (language dominant versus nondominant) affect immune function differentially in humans by delineating the effects of resections for epilepsy surgery on T-cell indices. BACKGROUND:Cerebral lateralization has been postulated to affect immunomodulation. Differenti...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.6.1183
更新日期:1999-04-12 00:00:00
abstract:OBJECTIVE:This study was conducted to determine the relationship of frontal lobe cortical thickness and basal ganglia volumes to measures of cognition in adults with sickle cell anemia (SCA). METHODS:Participants included 120 adults with SCA with no history of neurologic dysfunction and 33 healthy controls (HCs). Part...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000000188
更新日期:2014-03-11 00:00:00
abstract::We analyzed the clinical, CT, and angiographic findings in 50 black patients with carotid transient ischemic attacks (TIAs). Thirty-two percent had TIAs lasting less than 1 hour, 26% had TIAs lasting 1 to 6 hours, and 42% had TIAs lasting 6 to 24 hours. Fifty-two percent of TIA patients had CT evidence of cerebral inf...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.9.1410
更新日期:1991-09-01 00:00:00
abstract:OBJECTIVE:To assess the genetic contribution of TBK1, a gene implicated in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and FTD-ALS, in Belgian FTD and ALS patient cohorts containing a significant part of genetically unresolved patients. METHODS:We sequenced TBK1 in a hospital-based cohort of 48...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002220
更新日期:2015-12-15 00:00:00
abstract:OBJECTIVE:To determine whether there is a relationship between aortic plaques and intracranial (IC) atherosclerosis. METHODS:We reviewed 922 patients with stroke who had both transesophageal echocardiography and cerebral angiography. The plaques of these patients were classified as either complex aortic plaques (CAP),...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000238511.72927.3c
更新日期:2006-10-10 00:00:00
abstract:OBJECTIVE:We aimed to compare survival in the multiple sclerosis (MS) population with a matched cohort from the general population, and to evaluate the association of comorbidity with survival in both populations. METHODS:Using population-based administrative data, we identified 5,797 persons with MS and 28,807 contro...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001718
更新日期:2015-07-21 00:00:00
abstract:OBJECTIVE:To evaluate the utility of "clinic room" case presentation in the ambulatory care setting. BACKGROUND:Neurology is increasingly an outpatient specialty. The transition from ward to clinic presents challenges for student and resident education. Interaction between attending physician and trainee is limited by...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1999-01-15 00:00:00
abstract::We studied the effects of botulinum toxin A in 12 patients with spasticity and in eight patients with rigidity. The study design was a double-blind, placebo-controlled crossover trial with botulinum toxin A versus saline. Using the Ashworth Scale for spasticity and the Unified Parkinson's Disease Rating Scale for rigi...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.45.4.712
更新日期:1995-04-01 00:00:00
abstract::Despite evidence for the efficacy of thrombolytic therapy in acute ischemic stroke, only 1 to 7% of patients receive this therapy. The authors sought to determine the reasons for exclusion from tissue plasminogen activator (tPA) in an acute setting and found avoidable causes in 18% of patients. Improvements in intraho...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000152041.20486.2F
更新日期:2005-02-22 00:00:00
abstract::We studied two families with an unusual variant of neurofibromatosis (NF). The first family had spinal neurofibromas and café au lait spots (CLS), the second spinal neurofibromas without CLS. Other signs of NF1 or NF2, such as cutaneous tumors, Lisch nodules, or acoustic tumors, were absent. The inheritance pattern in...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.12.1923
更新日期:1991-12-01 00:00:00
abstract:OBJECTIVE:To investigate the clinical profile of rofecoxib, a long-acting (approximately 17-hour half-life) selective cyclo-oxygenase-2 inhibitor, for the acute treatment of migraine. METHODS:A randomized, double-blind, placebo-controlled, parallel-group study was conducted. Patients age > or =18 treated a moderate or...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/01.wnl.0000123260.61631.c4
更新日期:2004-05-11 00:00:00
abstract:OBJECTIVE:To assess whether genetic subgroups in recent amyotrophic lateral sclerosis (ALS) trials responded to treatment with lithium carbonate, but that the treatment effect was lost in a large cohort of nonresponders. METHODS:Individual participant data were obtained from 3 randomized trials investigating the effic...
journal_title:Neurology
pub_type: 杂志文章,meta分析,评审
doi:10.1212/WNL.0000000000004606
更新日期:2017-10-31 00:00:00
abstract::Fatigue is a common but poorly understood symptom in Parkinson's disease (PD). Using previously validated scales, we asked 58 nondemented PD patients and 58 controls to fill out questionnaires assessing fatigue and depression and found that PD patients were more depressed and more fatigued than age-matched controls. A...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.10.2016
更新日期:1993-10-01 00:00:00
abstract::We sought to determine whether geriatric patients with late-life-onset major depression have more subcortical hyperintensities on MRI and greater cognitive impairment than age-matched geriatric patients with early-life-onset major depression, suggesting that subcortical disease may be etiologic in late-life depression...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.6.1567
更新日期:1996-06-01 00:00:00
abstract:OBJECTIVE:To explore the incidence of depression and anxiety and to measure quality of life in women with idiopathic intracranial hypertension (IIH), a matched group cross-sectional study was conducted. Women with IIH (n = 28) were compared with control groups of weight- and age-matched women not diagnosed with IIH (n ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.2.319
更新日期:2000-01-25 00:00:00
abstract::We studied the cerebral effects of oxygen-derived free radicals generated from the xanthine oxidase/hypoxanthine/ADP-Fe3+ system. Xanthine oxidase/hypoxanthine/ADP-Fe3+ solution (0.1 ml) was infused into caudate putamen, and brain was frozen rapidly in situ. Brain water and sodium content increased concomitant with de...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.3.315
更新日期:1984-03-01 00:00:00
abstract:OBJECTIVE:To undertake an effectiveness and safety analysis of EVT in patients with LVO and NIH Stroke Scale (NIHSS) score ≤6 using datasets of multicenter and multinational nature. METHODS:We pooled patients with anterior circulation occlusion from 3 prospective international cohorts. Patients were eligible if presen...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000010955
更新日期:2020-12-15 00:00:00
abstract::We tested the effect of bovine cortex phosphatidylserine (BC-PS), a membrane phospholipid known to inhibit the release of the cytokine tumor necrosis factor (TNF), in SJL/J mice sensitized for adoptively transferred experimental autoimmune encephalomyelitis (EAE). Control, sensitized mice developed severe clinical and...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.1_part_1.153
更新日期:1993-01-01 00:00:00