Brain injury, edema, and vascular permeability changes induced by oxygen-derived free radicals.

abstract：:Previous reports and the Physicians' Desk Reference caution against the use of levodopa in Parkinson's disease (PD) patients with melanoma. A critical review of the literature reveals only anecdotal evidence to support a link between levodopa and melanoma. In fact, levodopa has an antitumor effect on melanoma. We repo...

journal_title：Neurology

authors： Weiner WJ,Singer C,Sanchez-Ramos JR,Goldenberg JN

更新日期：1993-04-01 00:00:00

abstract：:We report of a woman aged 52 years born to consanguineous parents and seeking treatment for progressive dementia and delusion. Neurologic examination revealed dementia and emotional instability, indifference, and confabulation. There was also mild spasticity of the bilateral lower limbs. MRI revealed diffuse white mat...

journal_title：Neurology

authors： Ohtake H,Shimohata T,Terajima K,Kimura T,Jo R,Kaseda R,Iizuka O,Takano M,Akaiwa Y,Goto H,Kobayashi H,Sugai T,Muratake T,Hosoki T,Shioiri T,Okamoto K,Onodera O,Tanaka K,Someya T,Nakada T,Tsuji S

更新日期：2004-05-11 00:00:00

abstract：:We performed a retrospective study on a series of 119 of our patients who have Friedreich's disease to assess the predictive value of age at onset, gender, and left ventricular hypertrophy in regard to disease progression. Outcome variables were survival, time to loss of independent gait, and time to confinement in a ...

journal_title：Neurology

authors： De Michele G,Perrone F,Filla A,Mirante E,Giordano M,De Placido S,Campanella G

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVE:To report long-term safety and efficacy outcomes of a large cohort of patients with medically refractory isolated dystonia treated with subthalamic nucleus (STN) deep brain stimulation (DBS). METHODS:Twenty patients (12 male, 8 female; mean age 49 ± 16.3 years) with medically refractory isolated dystonia wer...

journal_title：Neurology

authors： Ostrem JL,San Luciano M,Dodenhoff KA,Ziman N,Markun LC,Racine CA,de Hemptinne C,Volz MM,Heath SL,Starr PA

更新日期：2017-01-03 00:00:00

abstract：OBJECTIVES:To further improve the distinction between primary angiitis of the CNS (PACNS) and reversible cerebral vasoconstriction syndrome (RCVS). METHODS:We compared 2 large French cohorts of patients with PACNS (n = 110, retrospectively and prospectively enrolled) and RCVS (n = 173, prospectively enrolled). RESULT...

journal_title：Neurology

authors： de Boysson H,Parienti JJ,Mawet J,Arquizan C,Boulouis G,Burcin C,Naggara O,Zuber M,Touzé E,Aouba A,Bousser MG,Pagnoux C,Ducros A

更新日期：2018-10-16 00:00:00

abstract：:The mitochondrial genome has an underdeveloped "DNA repair repertoire" compared with the nuclear genome, making the mitochondrial DNA more susceptible to mutations by endogenous factors such as defects of the mitochondrial polymerase itself, and by exogenous factors such as radiation and UV light. Increased sensitivit...

journal_title：Neurology

authors： Tritschler HJ,Medori R

更新日期：1993-02-01 00:00:00

abstract：OBJECTIVE:To determine whether vascular and neurodegenerative factors influence cognition before clinically relevant Alzheimer disease pathology, we analyzed MRI measures and amyloid imaging in an ethnoracially diverse cohort of cognitively normal individuals older than 60 years. METHODS:Participants (n = 154; mean ag...

journal_title：Neurology

authors： Han JW,Maillard P,Harvey D,Fletcher E,Martinez O,Johnson DK,Olichney JM,Farias ST,Villeneuve S,Jagust W,Mungas D,DeCarli C

更新日期：2020-11-10 00:00:00

abstract：:Photoparoxysmal response (PPR) is sometimes incidentally encountered in EEGs performed for evaluation of nonepileptic symptoms. We conducted the first long-term study of a cohort of nonepileptic patients to determine their risk of having seizures subsequent to incidental recording of PPR. After 6 to 12 years (mean, 9 ...

journal_title：Neurology

authors： So EL,Ruggles KH,Ahmann PA,Olson KA

更新日期：1993-09-01 00:00:00

abstract：:Using an in vitro blood-nerve barrier (BNB) model, the authors tested the effect of various monoclonal antiganglioside antibodies on BNB function. Only anti-GM1 antibody significantly facilitated BNB leakage in a concentration-dependent, complement-independent manner. This study provided evidence that anti-GM1 antibod...

journal_title：Neurology

authors： Kanda T,Iwasaki T,Yamawaki M,Tai T,Mizusawa H

更新日期：2000-08-22 00:00:00

abstract：OBJECTIVE:To determine the prognostic value of selected biomarkers in clinically isolated syndromes (CIS) for conversion to multiple sclerosis (MS) and disability accrual. METHODS:Data were acquired from 2 CIS cohorts. The screening phase evaluated patients developing clinically definite MS (CIS-CDMS) and patients who...

journal_title：Neurology

authors： Arrambide G,Espejo C,Eixarch H,Villar LM,Alvarez-Cermeño JC,Picón C,Kuhle J,Disanto G,Kappos L,Sastre-Garriga J,Pareto D,Simon E,Comabella M,Río J,Nos C,Tur C,Castilló J,Vidal-Jordana A,Galán I,Arévalo MJ,Auger C

更新日期：2016-09-13 00:00:00

abstract：OBJECTIVE:We prospectively investigated the role of depressive symptoms (DS) on all-cause dementia in a population with small vessel disease (SVD), considering onset age of DS and cognitive performance. METHODS:The RUN DMC study (Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort) is a prospect...

journal_title：Neurology

authors： van Uden IW,van der Holst HM,van Leijsen EM,Tuladhar AM,van Norden AG,de Laat KF,Claassen JA,van Dijk EJ,Kessels RP,Richard E,Tendolkar I,de Leeuw FE

更新日期：2016-09-13 00:00:00

abstract：OBJECTIVE:To investigate the role of alcohol as a causal factor for intracerebral hemorrhage (ICH) and whether its effects might vary according to the pathogenic mechanisms underlying cerebral bleeding. METHODS:We performed a case-control analysis, comparing a cohort of consecutive white patients with ICH aged 55 year...

journal_title：Neurology

authors： Costa P,Grassi M,Iacoviello L,Zedde M,Marcheselli S,Silvestrelli G,DeLodovici ML,Sessa M,Zini A,Paciaroni M,Azzini C,Gamba M,Del Sette M,Toriello A,Gandolfo C,Bonifati DM,Tassi R,Cavallini A,Chiti A,Calabrò RS,Gri

更新日期：2018-07-17 00:00:00

abstract：:We reviewed retrospectively 114 prednisone dose reduction attempts in 63 myasthenic patients. Dose reduction was considered successful if a patient remained asymptomatic for more than 1 year on no prednisone or a stable low dose of prednisone. Successful dose reduction attempts were more common in patients taking azat...

journal_title：Neurology

authors： Miano MA,Bosley TM,Heiman-Patterson TD,Reed J,Sergott RC,Savino PJ,Schatz NJ

更新日期：1991-06-01 00:00:00

abstract：:Cholinergic neurons in the nucleus ambiguus (NA) were counted in autopsy tissue obtained from five patients with multiple system atrophy (MSA), four patients with PD, and five controls. The number of neurons in the dorsal NA was not significantly different among the three groups. Neurons in the ventrolateral portion o...

journal_title：Neurology

authors： Benarroch EE,Schmeichel AM,Parisi JE

更新日期：2003-01-14 00:00:00

abstract：OBJECTIVE:Activation of the type 1 interferon (IFN1) pathway is a prominent feature of dermatomyositis (DM) muscle and may play a role in the pathogenesis of this disease. However, the relevance of the IFN1 pathway in patients with other types of myositis such as the antisynthetase syndrome (AS), immune-mediated necrot...

journal_title：Neurology

authors： Pinal-Fernandez I,Casal-Dominguez M,Derfoul A,Pak K,Plotz P,Miller FW,Milisenda JC,Grau-Junyent JM,Selva-O'Callaghan A,Paik J,Albayda J,Christopher-Stine L,Lloyd TE,Corse AM,Mammen AL

更新日期：2019-09-17 00:00:00

abstract：OBJECTIVE:To evaluate the effects of sleep on partial seizures arising from various brain regions. METHODS:The authors prospectively studied 133 patients with localization-related epilepsy undergoing video-EEG monitoring over a 2-year period. Seizure type, site of onset, sleep/wake state at onset, duration, and epilep...

journal_title：Neurology

authors： Herman ST,Walczak TS,Bazil CW

更新日期：2001-06-12 00:00:00

abstract：OBJECTIVE:To compare effects of immediate-release (IR) and sustained-release (CR) carbidopa/levodopa in levodopa-naive PD patients. BACKGROUND:It was hypothesized that the long-acting preparation would be associated with fewer long-term complications. METHODS:A total of 618 patients were studied in 36 centers worldwi...

journal_title：Neurology

authors： Koller WC,Hutton JT,Tolosa E,Capilldeo R

更新日期：1999-09-22 00:00:00

abstract：OBJECTIVE:Charcot-Marie-Tooth (CMT) disease is the most common inherited neuromuscular disorder, affecting 1 in 2,500 individuals. Mitochondrial DNA (mtDNA) mutations are not generally considered within the differential diagnosis of patients with uncomplicated inherited neuropathy, despite the essential requirement of ...

journal_title：Neurology

authors： Pitceathly RD,Murphy SM,Cottenie E,Chalasani A,Sweeney MG,Woodward C,Mudanohwo EE,Hargreaves I,Heales S,Land J,Holton JL,Houlden H,Blake J,Champion M,Flinter F,Robb SA,Page R,Rose M,Palace J,Crowe C,Longman C,Lu

更新日期：2012-09-11 00:00:00

abstract：:Evidence suggests that untreated obstructive sleep apnea (OSA) can lead to hypertension, cardiovascular disease, and stroke. Conversely, the systemic effects of a wide variety of critical illnesses can lead to CNS dysfunction, which can precipitate respiratory failure. Reported is a patient in whom an acute encephalop...

journal_title：Neurology

authors： Dyken ME,Yamada T,Berger HA

更新日期：2003-05-27 00:00:00

abstract：:Recurrent episodes of oscillopsia, rotational vertigo, and postural imbalance were elicited and modulated by changing the horizontal head positions of a patient with an arachnoid cyst in the right cerebellopontine angle that distorted the vestibulocochlear nerve. Oculomotor analysis revealed two different types of att...

journal_title：Neurology

authors： Arbusow V,Strupp M,Dieterich M,Jäger L,Hischa A,Schulz P,Brandt T

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE:To investigate recovery of medical decision-making capacity (MDC) over the first year following traumatic brain injury (TBI). METHODS:A total of 177 participants (111 persons with TBI and 66 healthy controls) were recruited from an inpatient/outpatient TBI rehabilitation unit and outpatient neurology departm...

journal_title：Neurology

authors： Steward KA,Gerstenecker A,Triebel KL,Kennedy R,Novack TA,Dreer LE,Marson DC

更新日期：2016-09-06 00:00:00

abstract：OBJECTIVE:To determine whether increased risk of acute ischemic stroke (AIS) following herpes zoster (HZ) might be modified by the status of zoster vaccine live (ZVL) vaccination and antiviral treatment following HZ. METHODS:We included 87,405 Medicare fee-for-service beneficiaries aged ≥66 years diagnosed with HZ and...

journal_title：Neurology

authors： Yang Q,George MG,Chang A,Tong X,Merritt R,Hong Y

更新日期：2020-08-11 00:00:00

abstract：:Coma is rare in temporal arteritis (TA). We describe a patient with TA who suddenly developed coma with a triphasic EEG pattern that resolved after initiation of steroid treatment. Although the arterial lesions in TA are segmental in nature, TA may present with signs of diffuse neurologic deficit; early treatment can ...

journal_title：Neurology

authors： Tomer Y,Neufeld MY,Shoenfeld Y

更新日期：1992-02-01 00:00:00

abstract：OBJECTIVE:Coccidioides species are the most common etiologic agents of chronic meningitis in regions endemic for coccidioidomycosis. Occasionally, even short-term travel to endemic regions results in the acquisition of meningeal disease, so awareness of this complication of coccidioidomycosis is important even in nonen...

journal_title：Neurology

authors： Drake KW,Adam RD

更新日期：2009-11-24 00:00:00

abstract：:Noninvasive positive pressure ventilation prolongs survival in ALS but its effect on quality of life is unknown. The authors prospectively studied quality of life using the SF-36 questionnaire in a cohort of 16 ventilated patients with ALS. Noninvasive positive pressure ventilation improved scores in the "Vitality" do...

journal_title：Neurology

authors： Lyall RA,Donaldson N,Fleming T,Wood C,Newsom-Davis I,Polkey MI,Leigh PN,Moxham J

更新日期：2001-07-10 00:00:00

abstract：:Postprandial hypotension occurs commonly in patients with autonomic failure and may be due to attenuation of the normal sympathetic nervous system activation in response to meal ingestion. In a randomized, double-blind, placebo-controlled study, we investigated the therapeutic effect of the norepinephrine precursor 3,...

journal_title：Neurology

authors： Freeman R,Young J,Landsberg L,Lipsitz L

更新日期：1996-12-01 00:00:00

abstract：:We analyzed the association of HLA-DR and -DQ haplotypes and alleles with multiple sclerosis (MS) in 91 patients and 91 controls from Iceland using the relative predispositional effect method. The aim was to establish whether there is heterogeneity in HLA associations with MS, whether there are both predispositional a...

journal_title：Neurology

authors： Haegert DG,Swift FV,Benedikz J

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVE:To determine whether blood-based biomarkers can differentiate older veterans with and without traumatic brain injury (TBI) and cognitive impairment (CogI). METHODS:We enrolled 155 veterans from 2 veterans' retirement homes: 90 without TBI and 65 with TBI history. Participants were further separated into CogI...

journal_title：Neurology

authors： Peltz CB,Kenney K,Gill J,Diaz-Arrastia R,Gardner RC,Yaffe K

更新日期：2020-09-01 00:00:00

abstract：:It is generally believed that a diet high in carbohydrate improves exercise tolerance in patients with carnitine palmitoyltransferase II (CPT II) deficiency, but it has never been systematically investigated. The authors investigated the effect of a high- vs low-carbohydrate diet on exercise tolerance in four patients...

journal_title：Neurology

authors： Ørngreen MC,Ejstrup R,Vissing J

更新日期：2003-08-26 00:00:00

abstract：BACKGROUND:Serum copper not bound to ceruloplasmin ("free") appears slightly elevated in patients with Alzheimer disease (AD). We explored whether a deregulation of the free copper pool can predict AD clinical worsening. METHODS:We assessed levels of copper, iron, zinc, transferrin, ceruloplasmin, peroxides, total ant...

journal_title：Neurology

authors： Squitti R,Bressi F,Pasqualetti P,Bonomini C,Ghidoni R,Binetti G,Cassetta E,Moffa F,Ventriglia M,Vernieri F,Rossini PM

更新日期：2009-01-06 00:00:00