Abstract:
:Using an in vitro blood-nerve barrier (BNB) model, the authors tested the effect of various monoclonal antiganglioside antibodies on BNB function. Only anti-GM1 antibody significantly facilitated BNB leakage in a concentration-dependent, complement-independent manner. This study provided evidence that anti-GM1 antibody, frequently detected in sera from patients with inflammatory neuropathies, may participate BNB dysfunction and contribute to development of neuropathy.
journal_name
Neurologyjournal_title
Neurologyauthors
Kanda T,Iwasaki T,Yamawaki M,Tai T,Mizusawa Hdoi
10.1212/wnl.55.4.585subject
Has Abstractpub_date
2000-08-22 00:00:00pages
585-7issue
4eissn
0028-3878issn
1526-632Xjournal_volume
55pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::The results of a multicenter, double-blind, placebo-controlled clinical trial of the efficacy and safety of progabide (PGB) in the treatment of partial seizures are presented. This study was performed with a number of rigorous controls not usually present in clinical trials. These included uniform co-medication in whi...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.37.6.963
更新日期:1987-06-01 00:00:00
abstract:OBJECTIVE:We aimed to create an index to stratify cryptogenic stroke (CS) patients with patent foramen ovale (PFO) by their likelihood that the stroke was related to their PFO. METHODS:Using data from 12 component studies, we used generalized linear mixed models to predict the presence of PFO among patients with CS, a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182a08d59
更新日期:2013-08-13 00:00:00
abstract:BACKGROUND:Natalizumab is an antibody directed against integrin alpha4 that reduces disease activity in patients with multiple sclerosis (MS) by blocking migration of T and B cells into the CNS. The goal of this study was to characterize the effects of natalizumab treatment on cytokine production and expression of acti...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181a8266f
更新日期:2009-06-02 00:00:00
abstract:OBJECTIVE:To report on the long-term outcomes of deep brain stimulation (DBS) of the thalamic ventral intermediate nucleus (VIM) in Parkinson disease (PD), essential tremor (ET), and dystonic tremor. METHODS:One hundred fifty-nine patients with PD, ET, and dystonia underwent VIM DBS due to refractory tremor at the Gre...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004295
更新日期:2017-09-26 00:00:00
abstract::As there is currently no standardized assessment tool for evaluating Parkinson disease (PD) patients for deep brain stimulation (DBS), the authors developed the Florida Surgical Questionnaire for Parkinson Disease (FLASQ-PD). Part I of the study was a retrospective analysis of 174 patients presenting for a surgical sc...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/01.wnl.0000133122.14824.25
更新日期:2004-07-13 00:00:00
abstract::The objective of this study was to clarify the clinical and radiologic features, risk factors, and prognosis of basilar embolism without permanent basilar artery occlusion. Forty-five patients (mean age, 59 years) with basilar artery embolism participated in the study. Patients with basilar artery occlusion were exclu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.5.1346
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVE:This study assessed the strength of military-related concussion-, psychological-, and behavioral-related measures to predict neurobehavioral symptom (NBS) reporting in order to help clarify the extent to which persistent NBS reflect lingering effects of concussion vs other psychological/behavioral factors amo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006034
更新日期:2018-08-21 00:00:00
abstract::A 5-year-old child with clinical and radiologic evidence of Leigh syndrome (LS) showed a T-->C mutation at position nt 8993 in the mitochondrial DNA (instead of the more common T-->G substitution), resulting in an amino acid change from a highly conserved leucine to proline in subunit 6 of mitochondrial ATPase. The mu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.5.972
更新日期:1994-05-01 00:00:00
abstract:OBJECTIVE:To report 2 patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who presented acutely with Miller Fisher syndrome and polyneuritis cranialis, respectively. METHODS:Patient data were obtained from medical records from the University Hospital "Príncipe de Asturias," Alcalá de He...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009619
更新日期:2020-08-04 00:00:00
abstract:OBJECTIVES:Many patients with traumatic brain injury (TBI) report chronic fatigue, and previous studies showed a potential relationship between sleepiness and fatigue in these patients. Our study first looked at the impact of objective and subjective sleepiness on fatigue in patients with TBI. We then investigated how ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000334753.49193.48
更新日期:2008-11-11 00:00:00
abstract:OBJECTIVE:To study the association of PD with preceding smoking, alcohol, and coffee consumption using a case-control design. METHODS:The authors used the medical records linkage system of the Rochester Epidemiology Project to identify 196 subjects who developed PD in Olmsted County, MN, during the years 1976 to 1995....
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.9.1350
更新日期:2000-11-14 00:00:00
abstract::Four patients with primary writing tremor had a focal, task-specific tremor that responded to anticholinergic drugs. Physiologic features included EMG activity alternating in antagonist muscles, 5- to 20-microV cerebral potentials evoked by stretch of pronator teres, and no C-reflexes. Another patient had myoclonic je...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.9.1387
更新日期:1985-09-01 00:00:00
abstract:OBJECTIVE:To investigate the pathogenesis of proximal diabetic neuropathy (PDN) with nerve and muscle biopsies. BACKGROUND:Recent evidence suggests that nerve ischemia secondary to immune-mediated vasculopathy rather than diabetic microangiopathy may be responsible for PDN. METHOD:- Fifteen patients with PDN and two ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.1.83
更新日期:2000-07-12 00:00:00
abstract:OBJECTIVE:We aimed to assess the innervation density of dermal nerves in human skin biopsies by bright-field immunohistochemistry. METHODS:The size of dermal area where nerve length was quantified was validated in 30 skin biopsy sections (5 controls and 5 patients with small-fiber neuropathy [SFN]). It was obtained di...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318225ab51
更新日期:2011-07-19 00:00:00
abstract::Subarachnoid neurolysis using ethanol to destroy selectively the posterior roots of the spinal cord is a method for providing pain relief in patients with advanced cancer. Weakness of the extremities is a complication of the procedure that has been attributed to spread of the neurolytic agent to the anterior roots. Th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.7.1522
更新日期:2000-04-11 00:00:00
abstract::We studied a patient with autopsy-proven Hallervorden-Spatz syndrome (HSS) and the previously unreported finding of high-density lesions in the basal ganglia on CT. The diagnosis of HSS should be considered in a patient with dystonia and basal ganglia mineralization on CT. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.1.154
更新日期:1988-01-01 00:00:00
abstract::The authors examined the neural function of a postmeningitic deaf-blind patient who regained his hearing with a multichannel cochlear implant. Auditory stimuli activated the temporal cortices of both sides in a manner similar to that of controls, reflecting the successful recruitment of the auditory cortex after impla...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000234141.72891.13
更新日期:2006-09-12 00:00:00
abstract::A median safinamide (SAF) dose of 70 mg/day (range 40 to 90 mg/day) increased the percentage of parkinsonian patients improving their motor scores by > or =30% from baseline (responders) after 3 months from 21.4% (placebo) to 37.5% (p < 0.05, calculated by logistic regression analysis). In a subgroup of 101 patients u...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/01.wnl.0000134672.44217.f7
更新日期:2004-08-24 00:00:00
abstract:OBJECTIVE:To explore alterations in gray matter volume in patients with functional movement disorders. METHODS:We obtained T1-weighted MRI on 48 patients with clinically definite functional movement disorders, a subset of functional neurologic symptom disorder characterized by abnormal involuntary movements, and on 55...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006514
更新日期:2018-11-13 00:00:00
abstract::The visual-motor adaptation to lateral displacement of vision by prism glasses was studied in normal individuals and patients with cerebellar dysfunction, Parkinson's disease, right or left cerebral hemisphere lesions, Alzheimer's disease, or Korsakoff's syndrome. Adaptation was analyzed in two phases, the return to n...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.6.766
更新日期:1983-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the episodic migraine (EM)-obesity association and the influence of age, race, and sex on this relationship. METHODS:We examined the EM-obesity association and the influence of age, race, and sex in 3,862 adult participants of both black and white race interviewed in the National Comorbidity Surv...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182a824f7
更新日期:2013-10-08 00:00:00
abstract:OBJECTIVE:To determine the patterns of diffusivity associated with cognitive domain functions in older adults without dementia. METHODS:We studied older adults without dementia (n = 220) who underwent neuropsychometric testing and a diffusion tensor imaging (DTI) examination at 3 T in a cross-sectional study. Memory, ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31822313dc
更新日期:2011-07-05 00:00:00
abstract::A patient presented with bilateral brachial plexus neuropathy which 2 weeks later evolved into a polyneuropathy involving all four extremities. On further investigation, the patient was found to have systemic lupus erythematosus. Treatment with steroids was accompanied by complete resolution of the neurologic findings...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.12.1633-a
更新日期:1979-12-01 00:00:00
abstract::To examine animal exposure in ALS patients, a case-control study was undertaken on 40 ALS patients and 40 closely matched controls. Exposure to pets of any kind and to small dogs in the period from birth until 10 years before onset of ALS symptoms was significantly increased. Affected men showed a trend toward increas...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.5.717
更新日期:1985-05-01 00:00:00
abstract::No uniformly accepted hypothesis explains the genesis and rupture of intracranial aneurysms. We followed 5,184 men and women prospectively for 26 years; 36 cases of aneurysmal subarachnoid hemorrhage (SAH) accounted for 62% of all intracranial hemorrhages. Blood pressure before SAH was higher in these patients than in...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.7.847
更新日期:1984-07-01 00:00:00
abstract::We studied five patients with nonhemorrhagic thalamic infarction with neuropsychological tests, CT, and somatosensory evoked responses (SERs). The three patients with left thalamic lesions had abnormalities of language, memory, visuospatial processing, intellect, and personality-changes compatible with dementia. The t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.1.14
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVE:To validate a neuropsychological algorithm for dementia diagnosis. METHODS:We developed a neuropsychological algorithm in a sample of 1,023 elderly residents of Cache County, UT. We compared algorithmic and clinical dementia diagnoses both based on DSM-III-R criteria. The algorithm diagnosed dementia when th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.6.1290
更新日期:2000-03-28 00:00:00
abstract:OBJECTIVE:The presence of cranial autonomic symptoms often leads to a misdiagnosis of "sinus headache" in adult migraineurs, leading to unnecessary treatments and delaying appropriate migraine therapy. In this study, we examined the frequency of cranial autonomic symptoms in pediatric/adolescent patients with migraine....
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0b013e31829d872a
更新日期:2013-07-30 00:00:00
abstract:OBJECTIVE:SCN8A encodes the sodium channel voltage-gated α8-subunit (Nav1.6). SCN8A mutations have recently been associated with epilepsy and neurodevelopmental disorders. We aimed to delineate the phenotype associated with SCN8A mutations. METHODS:We used high-throughput sequence analysis of the SCN8A gene in 683 pat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001211
更新日期:2015-02-03 00:00:00
abstract:OBJECTIVE:To determine the usefulness of the 14-3-3 test in patients with dementia of various causes. BACKGROUND:Recent reports have suggested that the detection of the 14-3-3 protein in the CSF of patients with Creutzfeldt--Jakob disease is a highly sensitive and specific marker of the disease that might be used as a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.11.1528
更新日期:2001-06-12 00:00:00