Abstract:
OBJECTIVE:To evaluate the episodic migraine (EM)-obesity association and the influence of age, race, and sex on this relationship. METHODS:We examined the EM-obesity association and the influence of age, race, and sex in 3,862 adult participants of both black and white race interviewed in the National Comorbidity Survey Replication. EM diagnostic criteria were based on the International Classification of Headache Disorders. Body mass index was classified as underweight (<18.5 kg/m(2)), normal (18.5-24.9 kg/m(2)), overweight (25-29.9 kg/m(2)), or obese (≥30 kg/m(2)). Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for EM were estimated using logistic regression. Models were stratified by age (<50/≥50 years), race (white/black), and sex (male/female). RESULTS:A total of 188 participants fulfilled criteria for EM. In all participants, the adjusted odds of EM were 81% greater in individuals who were obese compared with those of normal weight (OR 1.81; 95% CI: 1.27-2.57; p = 0.001), with a significant trend of increasing odds of EM with increasing obesity status from normal weight to overweight to obese (p = 0.001). In addition, stratified analyses demonstrated that the odds of EM were greater in obese as compared with normal-weight individuals who were 1) younger than 50 years of age (OR 1.86; 95% CI: 1.20-2.89; p for trend = 0.008), 2) white (OR 2.06; 95% CI: 1.41-3.01; p for trend ≤0.001), or 3) female (OR 1.95; 95% CI: 1.38-2.76; p for trend ≤0.001). CONCLUSION:The odds of EM are increased in those with obesity, with the strongest relationships among those younger than 50 years, white individuals, and women.
journal_name
Neurologyjournal_title
Neurologyauthors
Peterlin BL,Rosso AL,Williams MA,Rosenberg JR,Haythornthwaite JA,Merikangas KR,Gottesman RF,Bond DS,He JP,Zonderman ABdoi
10.1212/WNL.0b013e3182a824f7subject
Has Abstractpub_date
2013-10-08 00:00:00pages
1314-21issue
15eissn
0028-3878issn
1526-632Xpii
WNL.0b013e3182a824f7journal_volume
81pub_type
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