HTLV-I-associated myelopathy/tropical spastic paraparesis in the United States.

abstract：OBJECTIVE:To clarify the relationship between depressive symptoms and the clinical and neuropathologic manifestations of dementia. METHODS:In a clinical-pathologic cohort study, 1,764 older persons without cognitive impairment at enrollment completed annual clinical evaluations for a mean of 7.8 years. The evaluations...

journal_title：Neurology

authors： Wilson RS,Capuano AW,Boyle PA,Hoganson GM,Hizel LP,Shah RC,Nag S,Schneider JA,Arnold SE,Bennett DA

更新日期：2014-08-19 00:00:00

abstract：:Four patients with primary writing tremor had a focal, task-specific tremor that responded to anticholinergic drugs. Physiologic features included EMG activity alternating in antagonist muscles, 5- to 20-microV cerebral potentials evoked by stretch of pronator teres, and no C-reflexes. Another patient had myoclonic je...

journal_title：Neurology

authors： Ravits J,Hallett M,Baker M,Wilkins D

更新日期：1985-09-01 00:00:00

abstract：OBJECTIVES:More than a decade has passed since the last major workforce survey of child neurologists in the United States; thus, a reassessment of the child neurology workforce is needed, along with an inaugural assessment of a new related field, neurodevelopmental disabilities. METHODS:The American Academy of Pediatr...

journal_title：Neurology

authors： Kang PB,Bale JF Jr,Mintz M,Joshi SM,Gilbert DL,Radabaugh C,Ruch-Ross H,Section on Neurology Executive Committee of the American Academy of Pediatrics, and the Board of Directors of the Child Neurology Society.

更新日期：2016-09-27 00:00:00

abstract：:To assess the possible role of amine neurotransmitters in human epilepsy, we measured metabolites of serotonin (5-hydroxyindoleacetic acid [5-HIAA]), dopamine (homovanillic acid [HVA]), and norepinephrine (3-methoxy-4-hydroxyphenylethylene glycol [MHPG]) in the lumbar cerebrospinal fluid (CSF) of patients with partial...

journal_title：Neurology

authors： Laxer KD,Sourkes TL,Fang TY,Young SN,Gauthier SG,Missala K

更新日期：1979-08-01 00:00:00

abstract：:A neurocutaneous syndrome is described in which spastic paraplegia, peroneal neuropathy, and crural hypopigmentation are inherited in a dominant pattern. Spastic paraplegia becomes clinically apparent during adolescence or in childhood and progresses slowly throughout the adult years with a variability in severity of ...

journal_title：Neurology

authors： Stewart RM,Tunell G,Ehle A

更新日期：1981-06-01 00:00:00

abstract：OBJECTIVE:To assess cerebrovascular reactivity in response to a visual task in participants with cerebral amyloid angiopathy (CAA), Alzheimer disease (AD), and mild cognitive impairment (MCI) using fMRI. METHODS:This prospective cohort study included 40 patients with CAA, 22 with AD, 27 with MCI, and 25 healthy contro...

journal_title：Neurology

authors： Switzer AR,Cheema I,McCreary CR,Zwiers A,Charlton A,Alvarez-Veronesi A,Sekhon R,Zerna C,Stafford RB,Frayne R,Goodyear BG,Smith EE

更新日期：2020-09-08 00:00:00

abstract：:We studied brain sections from 10 patients with the acquired immunodeficiency syndrome (AIDS) and progressive multifocal leukoencephalopathy (PML) by in situ hybridization with a biotin-labeled JC virus (JCV) DNA probe and by immunohistochemistry using antibody against the JCV capsid antigen. We compared the results w...

journal_title：Neurology

authors： Aksamit AJ,Gendelman HE,Orenstein JM,Pezeshkpour GH

更新日期：1990-07-01 00:00:00

abstract：OBJECTIVE:APOE epsilon4 has been associated with late-onset familial and sporadic AD and delayed recovery from head injury. The authors examined the relationship between functional recovery of patients with head injury and the APOE alleles. METHODS:Thirty-one patients with head injury who had completed the Acute Neuro...

journal_title：Neurology

authors： Lichtman SW,Seliger G,Tycko B,Marder K

更新日期：2000-11-28 00:00:00

abstract：OBJECTIVE:To identify the cause of hypokalemic periodic paralysis (HOKPP) in a family whose disease is not caused by a mutation in the dihydropyridine-sensitive (DHP) receptor alpha1-subunit gene (CACNA1S). BACKGROUND:Hypokalemic periodic paralysis is primarily caused by mutations within CACNA1S. Genetic heterogeneity...

journal_title：Neurology

authors： Bulman DE,Scoggan KA,van Oene MD,Nicolle MW,Hahn AF,Tollar LL,Ebers GC

更新日期：1999-12-10 00:00:00

abstract：OBJECTIVE:We sought to assess the prevalence, correlates, and consequences of periodic limb movements of sleep (PLMS) in persons with obstructive sleep apnea (OSA) and the effect (worsening or improvement) of continuous positive airway pressure (CPAP) therapy on PLMS in a large prospective multicenter randomized contro...

journal_title：Neurology

authors： Budhiraja R,Javaheri S,Pavlova MK,Epstein LJ,Omobomi O,Quan SF

更新日期：2020-04-28 00:00:00

abstract：:We present six patients with acute fulminant episodes of CNS inflammatory demyelination who responded to therapeutic plasmapheresis after failing a course of high-dose methylprednisolone administered IV. Neurologic improvement occurred in three of the patients following the second plasmapheresis. Dramatic improvement ...

journal_title：Neurology

authors： Rodriguez M,Karnes WE,Bartleson JD,Pineda AA

更新日期：1993-06-01 00:00:00

abstract：OBJECTIVE:To investigate whether quantitative MR techniques can be used to distinguish between mesial temporal sclerosis in patients with a history of prolonged febrile convulsion and in patients without such a history. METHODS:Quantitative hippocampal T2 relaxometry, hippocampal volumetry, and single voxel (1)H-MRS d...

journal_title：Neurology

authors： Scott RC,Gadian DG,Cross JH,Wood SJ,Neville BG,Connelly A

更新日期：2001-06-26 00:00:00

abstract：:The malformation of inverse cerebellum and occipital encephalocele is situated morphologically between the Arnold-Chiari and Dandy-Walker malformations. In the three reported cases, hydrocephalus was not present, concomitant malformations of the lamina terminalis were present in two, and polymicrogyria was found in al...

journal_title：Neurology

authors： Smith MT,Huntington HW

更新日期：1977-03-01 00:00:00

abstract：:We present a patient with levodopa-resistant parkinsonism due to basal ganglia calcification related to surgically-induced hypoparathyroidism. The calcification was seen on computerized axial tomography but not on skull x-rays. Such calcification should be looked for in all cases of levodopa-resistant parkinsonism, si...

journal_title：Neurology

authors： Klawans HL,Lupton M,Simon L

更新日期：1976-03-01 00:00:00

abstract：OBJECTIVE:To assess the frequency of this finding in patients with minor stroke and TIAs compared to those with stroke mimics and to evaluate the level of agreement between examiners to detect an upgoing thumb sign. METHODS:We previously reported an upgoing thumb sign as a subtle clinical finding in patients with tran...

journal_title：Neurology

authors： Hachinski V,Alsubaie R,Azarpazhooh MR

更新日期：2017-07-25 00:00:00

abstract：OBJECTIVE:To assess the feasibility of using MRI measurements as a surrogate endpoint for disease progression in a therapeutic trial for AD. METHODS:A total of 362 patients with probable AD from 38 different centers participated in the MRI portion of a 52-week randomized placebo-controlled trial of milameline, a musca...

journal_title：Neurology

authors： Jack CR Jr,Slomkowski M,Gracon S,Hoover TM,Felmlee JP,Stewart K,Xu Y,Shiung M,O'Brien PC,Cha R,Knopman D,Petersen RC

更新日期：2003-01-28 00:00:00

abstract：:The ability of two noninvasive diagnostic methods--oculoplethysmography-carotid phonoangiography (OPG/CPA) and directional Doppler ultrasonography--to detect extracranial cerebrovascular disease was examined in 400 consecutive studies. Cerebral arteriography was performed in 74 patients. Transient ischemic attack was ...

journal_title：Neurology

authors： Ginsberg MD,Greenwood SA,Goldberg HI

更新日期：1979-05-01 00:00:00

abstract：:The authors report a case of hereditary multiple exostoses (HME) with neurologic complications, and review the literature. A 23-year-old man exhibited a worsening spastic paraparesis with sphincter dysfunction. The cranial nerves and the exteroceptive and deep sensations were apparently undamaged. The family history, ...

journal_title：Neurology

authors： Ferrari G,Taddei L,Vivenza C,Rossi G

更新日期：1979-07-01 00:00:00

abstract：:Acetylcholinesterase (AChE) inhibitors were first administered in Europe to human subjects in the 1860s, and synthetic derivatives of the natural alkaloid inhibitors were developed in the 1930s to modulate peripheral cholinergic function. However, only within the last decade have these agents been systematically studi...

journal_title：Neurology

authors： Taylor P

更新日期：1998-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the associations of mild behavioral impairment (MBI) with cognitive deficits and patterns of gray matter changes in Parkinson disease (PD). METHODS:Sixty patients with PD without dementia and 29 healthy controls underwent a cognitive neuropsychological evaluation and structural MRI scan. MBI was ...

journal_title：Neurology

authors： Yoon EJ,Ismail Z,Hanganu A,Kibreab M,Hammer T,Cheetham J,Kathol I,Sarna JR,Martino D,Furtado S,Monchi O

更新日期：2019-08-20 00:00:00

abstract：:A young girl who initially presented with jaw hypomobility at age 4 years subsequently developed signs of a slowly progressive myopathy. Rods were found in all sampled muscles, and were associated with fibrous contractures in the temporomandibular joint muscles. Rods in fibers undergoing necrosis displayed a pattern o...

journal_title：Neurology

authors： Powers JM,Young GF,Bass EB Jr,Reed FE Jr

更新日期：1980-09-01 00:00:00

abstract：:Immitation synkinesia is usually associated with thalamic or parietal lesions. Analysis of three cases shows that the lesions may affect the posterior columns of the spinal cord or even the peripheral nervous system. In our cases, two facts stand out, a large measure of integrity of motor activity and predominant dist...

journal_title：Neurology

authors： Cambier J,Dehen H

更新日期：1977-07-01 00:00:00

abstract：:We treated 36 patients with motor fluctuations and dyskinesias on chronic levodopa therapy with cabergoline (CBG) once a day for a mean period of 14.2 +/- 5.8 months. There was a significant increase in the "on" hours and a reduction in "off-period" dystonia. Ten patients continued to show a marked improvement after 2...

journal_title：Neurology

authors： Lera G,Vaamonde J,Rodriguez M,Obeso JA

更新日期：1993-12-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that, in the context of robotic therapy designed to enhance proprioceptive feedback via a Hebbian model, integrity of both somatosensory and motor systems would be important in understanding interparticipant differences in treatment-related motor gains. METHODS:In 30 patients with chro...

journal_title：Neurology

authors： Ingemanson ML,Rowe JR,Chan V,Wolbrecht ET,Reinkensmeyer DJ,Cramer SC

更新日期：2019-03-05 00:00:00

abstract：OBJECTIVE:To investigate the safety and efficacy of escalating doses of the semi-synthetic triterpenoid omaveloxolone in patients with mitochondrial myopathy. METHODS:In cohorts of 8-13, 53 participants were randomized double-blind to 12 weeks of treatment with omaveloxolone 5, 10, 20, 40, 80, or 160 mg, or placebo. O...

journal_title：Neurology

authors： Madsen KL,Buch AE,Cohen BH,Falk MJ,Goldsberry A,Goldstein A,Karaa A,Koenig MK,Muraresku CC,Meyer C,O'Grady M,Scaglia F,Shieh PB,Vockley J,Zolkipli-Cunningham Z,Haller RG,Vissing J

更新日期：2020-02-18 00:00:00

abstract：OBJECTIVE:To assess the genetic contribution of TBK1, a gene implicated in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and FTD-ALS, in Belgian FTD and ALS patient cohorts containing a significant part of genetically unresolved patients. METHODS:We sequenced TBK1 in a hospital-based cohort of 48...

journal_title：Neurology

authors： Gijselinck I,Van Mossevelde S,van der Zee J,Sieben A,Philtjens S,Heeman B,Engelborghs S,Vandenbulcke M,De Baets G,Bäumer V,Cuijt I,Van den Broeck M,Peeters K,Mattheijssens M,Rousseau F,Vandenberghe R,De Jonghe P,Cras P

更新日期：2015-12-15 00:00:00

abstract：OBJECTIVES:Based on the hippocampus disconnection hypothesis in Alzheimer disease (AD), which postulates that uncoupling from cortical inputs contributes to disinhibition-like changes in hippocampus activity, we suggested that in patients with AD, the more the intrinsic functional connectivity between hippocampus and p...

journal_title：Neurology

authors： Tahmasian M,Pasquini L,Scherr M,Meng C,Förster S,Mulej Bratec S,Shi K,Yakushev I,Schwaiger M,Grimmer T,Diehl-Schmid J,Riedl V,Sorg C,Drzezga A

更新日期：2015-05-12 00:00:00

abstract：OBJECTIVE:To assess the onset of ocrelizumab efficacy on brain MRI measures of disease activity in the phase II study in relapsing-remitting multiple sclerosis (RRMS), and relapse rate in the pooled phase III studies in relapsing multiple sclerosis (RMS). METHODS:Brain MRI activity was determined in the phase II trial...

journal_title：Neurology

authors： Barkhof F,Kappos L,Wolinsky JS,Li DKB,Bar-Or A,Hartung HP,Belachew S,Han J,Julian L,Sauter A,Napieralski J,Koendgen H,Hauser SL

更新日期：2019-11-05 00:00:00

abstract：OBJECTIVE:We hypothesized that cardiac electrical instability and abnormal autonomic tone result from cumulative cardiac injury sustained in recurrent seizures. We tested this hypothesis by comparing T-wave alternans (TWA) and heart rate variability (HRV), both established markers of sudden cardiac death (SCD) risk, in...

journal_title：Neurology

authors： Pang TD,Nearing BD,Krishnamurthy KB,Olin B,Schachter SC,Verrier RL

更新日期：2019-09-03 00:00:00

abstract：OBJECTIVE:To survey brain death criteria throughout the world. BACKGROUND:The clinical diagnosis of brain death allows organ donation or withdrawal of support. Declaration of brain death follows a certain set of examinations. The code of practice throughout the world has not been systematically investigated. METHODS:...

journal_title：Neurology

authors： Wijdicks EF

更新日期：2002-01-08 00:00:00