Abstract:
:We present six patients with acute fulminant episodes of CNS inflammatory demyelination who responded to therapeutic plasmapheresis after failing a course of high-dose methylprednisolone administered IV. Neurologic improvement occurred in three of the patients following the second plasmapheresis. Dramatic improvement in motor function (four patients) and language (two patients) began within 2 to 14 days and persisted during the 6 to 35 months (mean, 15 months) of follow-up. Results of this uncontrolled study suggest that plasmapheresis in the absence of other immunosuppressive drugs may have a role in the treatment of severe episodes of inflammatory demyelination in a select subset of MS patients.
journal_name
Neurologyjournal_title
Neurologyauthors
Rodriguez M,Karnes WE,Bartleson JD,Pineda AAdoi
10.1212/wnl.43.6.1100subject
Has Abstractpub_date
1993-06-01 00:00:00pages
1100-4issue
6eissn
0028-3878issn
1526-632Xjournal_volume
43pub_type
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