Abstract:
OBJECTIVE:To determine whether, and to what degree, preclinical Alzheimer disease (AD) confounds studies of healthy aging where "healthy" is based on cognitive normality alone. METHODS:We examined the effects of preclinical AD in cognitively normal older individuals using resting-state functional connectivity MRI. We investigated 2 groups of cognitively normal participants: one group with evidence of preclinical AD as assessed by CSF markers of AD and the other group with normal CSF biomarkers. RESULTS:There were significant interactions between age and biomarker status in the default-mode, dorsal attention, and salience resting-state networks. In the group with evidence of preclinical AD, there were dramatic changes in functional connectivity with age. In the group without evidence of preclinical AD, those changes were greatly attenuated. In most regions with significant interactions of age and biomarker status, the age-related change in functional connectivity in the normal biomarker group was indistinguishable from zero. CONCLUSIONS:These results suggest that preclinical AD accounts for a substantial portion of the reported effects of aging in the extant functional connectivity literature.
journal_name
Neurologyjournal_title
Neurologyauthors
Brier MR,Thomas JB,Snyder AZ,Wang L,Fagan AM,Benzinger T,Morris JC,Ances BMdoi
10.1212/WNL.0000000000000939subject
Has Abstractpub_date
2014-10-28 00:00:00pages
1613-9issue
18eissn
0028-3878issn
1526-632Xpii
WNL.0000000000000939journal_volume
83pub_type
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