Paraneoplastic opsoclonus-myoclonus associated with anti-Hu antibody.

Abstract:

:We report a 74-year-old woman with opsoclonus, myoclonus, ataxia, and encephalopathy who had small-cell lung cancer and high titers of anti-Hu antibody in her serum. At autopsy, there were perivascular inflammatory infiltrates in the brainstem, putamen, and meninges overlying the orbital frontal cortex. Immunohistochemical studies showed the expression of the Hu antigens by the tumor and the presence of deposits of anti-Hu IgG in the patient's cortex, brainstem, and cerebellum, suggesting that anti-Hu immune response was related to the patient's clinical syndrome. This case of paraneoplastic opsoclonus, myoclonus, ataxia, and encephalopathy expands the spectrum of neurologic dysfunction associated with the anti-Hu antibody.

journal_name

Neurology

journal_title

Neurology

authors

Hersh B,Dalmau J,Dangond F,Gultekin S,Geller E,Wen PY

doi

10.1212/wnl.44.9.1754

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

1754-5

issue

9

eissn

0028-3878

issn

1526-632X

journal_volume

44

pub_type

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