Abstract:
:We report a 74-year-old woman with opsoclonus, myoclonus, ataxia, and encephalopathy who had small-cell lung cancer and high titers of anti-Hu antibody in her serum. At autopsy, there were perivascular inflammatory infiltrates in the brainstem, putamen, and meninges overlying the orbital frontal cortex. Immunohistochemical studies showed the expression of the Hu antigens by the tumor and the presence of deposits of anti-Hu IgG in the patient's cortex, brainstem, and cerebellum, suggesting that anti-Hu immune response was related to the patient's clinical syndrome. This case of paraneoplastic opsoclonus, myoclonus, ataxia, and encephalopathy expands the spectrum of neurologic dysfunction associated with the anti-Hu antibody.
journal_name
Neurologyjournal_title
Neurologyauthors
Hersh B,Dalmau J,Dangond F,Gultekin S,Geller E,Wen PYdoi
10.1212/wnl.44.9.1754subject
Has Abstractpub_date
1994-09-01 00:00:00pages
1754-5issue
9eissn
0028-3878issn
1526-632Xjournal_volume
44pub_type
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