Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease.

abstract：OBJECTIVE:To assess cortical inhibitory and excitatory mechanisms in obsessive-compulsive disorder (OCD). BACKGROUND:Transcranial magnetic stimulation (TMS) studies have found decreased neuronal inhibition and a reduced cortical silent period in the primary motor area in Tourette's syndrome, focal dystonia, and other ...

journal_title：Neurology

authors： Greenberg BD,Ziemann U,Corá-Locatelli G,Harmon A,Murphy DL,Keel JC,Wassermann EM

更新日期：2000-01-11 00:00:00

abstract：:We report the cases of three siblings homozygous for a mutated transthyretin (TTR) gene that causes type I familial amyloidotic polyneuropathy (FAP), in whom we made the diagnosis by identifying both the mutated TTR gene and a variant TTR in their sera. Their serum levels for the variant TTR are twice those of patient...

journal_title：Neurology

authors： Yoshinaga T,Nakazato M,Ikeda S,Ohnishi A

更新日期：1992-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the retinal nerve fiber layer (RNFL) thickness and macular volume in neuromyelitis optica (NMO) spectrum patients using optical coherence tomography (OCT). BACKGROUND:OCT can quantify damage to retinal ganglion cell axons and can identify abnormalities in multiple sclerosis and optic neuritis (ON...

journal_title：Neurology

authors： Ratchford JN,Quigg ME,Conger A,Frohman T,Frohman E,Balcer LJ,Calabresi PA,Kerr DA

更新日期：2009-07-28 00:00:00

abstract：:IgM anti-GM1 antibodies occur with increased frequency in the serum of patients with multifocal motor neuropathy (MMN). We tested the ability of serum IgM from patients with MMN to bind to GM1 ganglioside covalently bound to secondary amino groups on ELISA plates (Co-GM1). The Co-GM1 technique detected high titer (> 1...

journal_title：Neurology

authors： Pestronk A,Choksi R

更新日期：1997-11-01 00:00:00

abstract：OBJECTIVE:To investigate the risk factors of neutralizing antibody (NAB)-induced complete secondary treatment failure (cSTF) during long-term botulinum neurotoxin (BoNT) treatment in various neurologic indications. METHODS:This monocenter retrospective cohort study analyzed the data of 471 patients started on BoNT the...

journal_title：Neurology

authors： Walter U,Mühlenhoff C,Benecke R,Dressler D,Mix E,Alt J,Wittstock M,Dudesek A,Storch A,Kamm C

更新日期：2020-05-19 00:00:00

abstract：:We carried out an open study of the effects of large doses (12 to 16 gm per day) of oral choline on medically intractable human complex partial seizures (CPS). Marked increases of plasma choline concentration (75 to 300%) in three subjects were associated with (1) shorter duration of CPS, (2) less postseizure fatigue,...

journal_title：Neurology

authors： McNamara JO,Carwile S,Hope V,Luther J,Miller P

更新日期：1980-12-01 00:00:00

abstract：OBJECTIVE:To devise a neurophysiologic strategy to select X-linked Charcot-Marie-Tooth neuropathy syndrome (CMTX) families for connexin 32 mutation screening. BACKGROUND:Once the common chromosome 17 DNA duplication (CMT1A syndrome) has been excluded, clinical features are not sufficiently distinctive to select which ...

journal_title：Neurology

authors： Nicholson GA,Yeung L,Corbett A

更新日期：1998-11-01 00:00:00

abstract：:Creatine monohydrate has been shown to increase strength in studies of young healthy subjects and in a few studies with patients. Creatine monohydrate (10 g daily for 5 days to 5 g daily for 5 days) was administered to patients with neuromuscular disease in a pilot study (Study 1; n = 81), followed by a single-blinded...

journal_title：Neurology

authors： Tarnopolsky M,Martin J

更新日期：1999-03-10 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of onabotulinumtoxinA 100 U in noncatheterizing patients with multiple sclerosis (MS) with urinary incontinence (UI) due to neurogenic detrusor overactivity (NDO). METHODS:In this randomized, double-blind phase III study, patients received onabotulinumtoxinA 100 U (n = 66)...

journal_title：Neurology

authors： Tullman M,Chartier-Kastler E,Kohan A,Keppenne V,Brucker BM,Egerdie B,Mandle M,Nicandro JP,Jenkins B,Denys P

更新日期：2018-08-14 00:00:00

abstract：OBJECTIVE:To investigate the safety and efficacy of escalating doses of the semi-synthetic triterpenoid omaveloxolone in patients with mitochondrial myopathy. METHODS:In cohorts of 8-13, 53 participants were randomized double-blind to 12 weeks of treatment with omaveloxolone 5, 10, 20, 40, 80, or 160 mg, or placebo. O...

journal_title：Neurology

authors： Madsen KL,Buch AE,Cohen BH,Falk MJ,Goldsberry A,Goldstein A,Karaa A,Koenig MK,Muraresku CC,Meyer C,O'Grady M,Scaglia F,Shieh PB,Vockley J,Zolkipli-Cunningham Z,Haller RG,Vissing J

更新日期：2020-02-18 00:00:00

abstract：OBJECTIVE:In the work-up of patients presenting with a clinically isolated syndrome (CIS), 3T MRI might offer a higher lesion detection than 1.5T, but it remains unclear whether this affects the fulfilment of the diagnostic criteria for multiple sclerosis (MS). METHODS:We recruited 66 patients with CIS within 6 months...

journal_title：Neurology

authors： Hagens MHJ,Burggraaff J,Kilsdonk ID,de Vos ML,Cawley N,Sbardella E,Andelova M,Amann M,Lieb JM,Pantano P,Lissenberg-Witte BI,Killestein J,Oreja-Guevara C,Ciccarelli O,Gasperini C,Lukas C,Wattjes MP,Barkhof F,MAGNIMS St

更新日期：2018-07-17 00:00:00

abstract：:The visual-motor adaptation to lateral displacement of vision by prism glasses was studied in normal individuals and patients with cerebellar dysfunction, Parkinson's disease, right or left cerebral hemisphere lesions, Alzheimer's disease, or Korsakoff's syndrome. Adaptation was analyzed in two phases, the return to n...

journal_title：Neurology

authors： Weiner MJ,Hallett M,Funkenstein HH

更新日期：1983-06-01 00:00:00

abstract：:Some epilepsy patients quickly develop resistance to antiepileptic drugs (AEDs). We report a case of a patient with refractory epilepsy with daily seizures who initially responded to levetiracetam daily therapy, but then returned to baseline seizure frequency. However, when levetiracetam was given once weekly, the pat...

journal_title：Neurology

authors： Friedman D,French JA

更新日期：2006-02-28 00:00:00

abstract：OBJECTIVE:To improve our understanding of early β-amyloid (Aβ) accumulation processes using florbetapir-PET scan in 20- to 60-year-old individuals. METHODS:Seventy-six cognitively normal individuals aged 20 to 60 years, 57 cognitively normal older individuals (61-84 years old), and 70 patients with mild cognitive impa...

journal_title：Neurology

authors： Gonneaud J,Arenaza-Urquijo EM,Mézenge F,Landeau B,Gaubert M,Bejanin A,de Flores R,Wirth M,Tomadesso C,Poisnel G,Abbas A,Desgranges B,Chételat G

更新日期：2017-12-12 00:00:00

abstract：:A 41-year-old man presented with bilateral posterior cerebral artery infarcts. He had visual object agnosia and prosopagnosia with preservation of reading abilities. There was also defective visual memory, topographic orientation, and color perception, as well as simultanagnosia. From the clinical facts and CT finding...

journal_title：Neurology

authors： Gomori AJ,Hawryluk GA

更新日期：1984-07-01 00:00:00

abstract：BACKGROUND:Bapineuzumab, a humanized anti-amyloid-beta (Abeta) monoclonal antibody for the potential treatment of Alzheimer disease (AD), was evaluated in a multiple ascending dose, safety, and efficacy study in mild to moderate AD. METHODS:The study enrolled 234 patients, randomly assigned to IV bapineuzumab or place...

journal_title：Neurology

authors： Salloway S,Sperling R,Gilman S,Fox NC,Blennow K,Raskind M,Sabbagh M,Honig LS,Doody R,van Dyck CH,Mulnard R,Barakos J,Gregg KM,Liu E,Lieberburg I,Schenk D,Black R,Grundman M,Bapineuzumab 201 Clinical Trial Investigator

更新日期：2009-12-15 00:00:00

abstract：OBJECTIVE:To determine whether metformin is associated with a lower incidence of dementia than sulfonylureas. METHODS:This was a retrospective cohort study of US veterans ≥65 years of age with type 2 diabetes who were new users of metformin or a sulfonylurea and had no dementia. Follow-up began after 2 years of therap...

journal_title：Neurology

authors： Orkaby AR,Cho K,Cormack J,Gagnon DR,Driver JA

更新日期：2017-10-31 00:00:00

abstract：BACKGROUND:Hereditary spastic paraplegia (HSP) are classified clinically as pure when progressive spasticity occurs in isolation or complicated when other neurologic abnormalities are present. At least 22 genetic loci have been linked to HSP, 8 of which are autosomal recessive (ARHSP). HSP complicated with the presence...

journal_title：Neurology

authors： Al-Yahyaee S,Al-Gazali LI,De Jonghe P,Al-Barwany H,Al-Kindi M,De Vriendt E,Chand P,Koul R,Jacob PC,Gururaj A,Sztriha L,Parrado A,Van Broeckhoven C,Bayoumi RA

更新日期：2006-04-25 00:00:00

abstract：OBJECTIVE:To assess the evidence demonstrating efficacy, tolerability, and safety of seven new antiepileptic drugs (AEDs) (gabapentin, lamotrigine, topiramate, tiagabine, oxcarbazepine, levetiracetam, and zonisamide) in the treatment of children and adults with refractory partial and generalized epilepsies. METHODS:A ...

journal_title：Neurology

authors： French JA,Kanner AM,Bautista J,Abou-Khalil B,Browne T,Harden CL,Theodore WH,Bazil C,Stern J,Schachter SC,Bergen D,Hirtz D,Montouris GD,Nespeca M,Gidal B,Marks WJ Jr,Turk WR,Fischer JH,Bourgeois B,Wilner A,Faught R

更新日期：2004-04-27 00:00:00

abstract：:Automatisms are commonly seen in epilepsy, either ictally or postictally. However, most automatisms are simple, with hand movements, mouth smacking, nose-rubbing, repetition of a single word, or coughing, grunting, or screeching. Complex automatisms are less common and striking. The authors report two cases of seizure...

journal_title：Neurology

authors： Doherty MJ,Wilensky AJ,Holmes MD,Lewis DH,Rae J,Cohn GH

更新日期：2002-11-12 00:00:00

abstract：OBJECTIVE:To evaluate changes from baseline in patient-reported outcomes for measures of functioning and disability among patients with migraine treated with galcanezumab or placebo. METHODS:Patients with episodic migraine (4-14 monthly migraine headache days) were treated with either galcanezumab (Evaluation of LY295...

journal_title：Neurology

authors： Ford JH,Ayer DW,Zhang Q,Carter JN,Leroux E,Skljarevski V,Aurora SK,Tockhorn-Heidenreich A,Lipton RB

更新日期：2019-07-30 00:00:00

abstract：:Concentrations of cyclic adenosine 3',5' monophosphate (cAMP) were significantly lower in parkinsonian patients than in controls, but concentrations of guanosine 3',5' monophosphate (cGMP) were not altered. Both cAMP and cGMP levels were lower in patients with more severe symptoms on the left side of the body. Somatos...

journal_title：Neurology

authors： Volicer L,Beal MF,Direnfeld LK,Marquis JK,Albert ML

更新日期：1986-01-01 00:00:00

abstract：:A moderately retarded Japanese boy, with a normal male karyotype (46,XY), was diagnosed to have a subcortical band heterotopia or double cortex syndrome. The band heterotopia was relatively thick compared with that of other patients reported. On T2-weighted coronal MR sections, there were numerous radial linear struct...

journal_title：Neurology

authors： Ono J,Mano T,Andermann E,Harada K,Sakurai K,Ikeda T,Yoshihara N,Shimizu K,Okada S,Andermann F

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:Studies have suggested that mood status is associated with an increased risk of stroke, though mostly based on measures of depression defined by symptoms alone rather than diagnostic criteria representative of clinically important distress and impairment. We investigated this association based upon a large p...

journal_title：Neurology

authors： Surtees PG,Wainwright NW,Luben RN,Wareham NJ,Bingham SA,Khaw KT

更新日期：2008-03-04 00:00:00

abstract：OBJECTIVES:To determine the prognostic role of late auditory (N100) and cognitive evoked potentials (MMN) for awakening in a cohort of comatose patients categorized by etiology. METHODS:The authors prospectively studied a series of 346 comatose patients. Coma was caused by stroke (n = 125), trauma (n = 96), anoxia (n ...

journal_title：Neurology

authors： Fischer C,Luauté J,Adeleine P,Morlet D

更新日期：2004-08-24 00:00:00

abstract：:A clinical procedure for determining contrast sensitivity was performed on patients with suspected sella area masses. The test consisted of a series of six plates, each containing a bar pattern of fixed sinusoidal spatial frequency in which contrast varies along the length of the bar. Patients with compressive lesions...

journal_title：Neurology

authors： Kupersmith MJ,Siegel IM,Carr RE

更新日期：1981-05-01 00:00:00

abstract：OBJECTIVE:To determine the risk, predictors, and prognosis of independence loss and institutionalization in patients with early Parkinson disease (PD). METHODS:We conducted a prospective population-based 5-year longitudinal study following 189 patients with incident PD and 174 controls matched for age, sex, and comorb...

journal_title：Neurology

authors： Bjornestad A,Tysnes OB,Larsen JP,Alves G

更新日期：2016-10-11 00:00:00

abstract：:The authors studied the safety and tolerability of subcutaneous interferon beta-1a at different doses in 24 children with clinically definite multiple sclerosis. After a mean treatment period of 44 months, interferon beta-1a was well tolerated in 22 patients, although two experienced possible serious adverse events. A...

journal_title：Neurology

authors： Tenembaum SN,Segura MJ

更新日期：2006-08-08 00:00:00

abstract：BACKGROUND:The annual relapse rate has been commonly used as a primary efficacy endpoint in phase III multiple sclerosis (MS) clinical trials. The aim of this study was to determine the relative contribution of different possible prognostic factors available at baseline to the on-study relapse rate in MS. METHODS:A to...

journal_title：Neurology

authors： Held U,Heigenhauser L,Shang C,Kappos L,Polman C,Sylvia Lawry Centre for MS Research.

更新日期：2005-12-13 00:00:00

abstract：:The shortening reaction of tibialis anterior was observed in 6 of 25 normal subjects, in 6 of 40 patients with upper motor neuron syndromes, and in 11 of 17 patients with Parkinson's disease. The latency of the shortening reaction was comparable with that of the latter part of the long-latency stretch reflexes. The ma...

journal_title：Neurology

authors： Berardelli A,Hallett M

更新日期：1984-02-01 00:00:00