Experimental brush-evoked allodynia activates posterior parietal cortex.

Abstract:

OBJECTIVE:To study the brain activation pattern of coexisting experimental ongoing pain and brush-evoked allodynia (pain evoked by innocuous brush) with the use of PET. BACKGROUND:Neuropathic pain usually has two essential phenomena: ongoing pain and brush-evoked allodynia, which coexist and may influence each other. Capsaicin induces both ongoing pain and brush-evoked allodynia. METHODS:Eight healthy right-handed volunteers participated in eight H2(15)O PET scans with two blocks of four randomized conditions: 1) rest, 2) brush, 3) capsaicin pain, and 4) capsaicin pain + brush (brush-evoked allodynia). Capsaicin was injected intradermally on the nondominant forearm and the subjects rated pain intensity and unpleasantness on 100-mm visual analogue scales. RESULTS:Pain intensity and unpleasantness were significantly higher during brush-evoked allodynia (74 +/- 4 and 67 +/- 4 mm) compared with capsaicin pain alone (60 +/- 4 and 51 +/- 5 mm). Brush-evoked allodynia, but not capsaicin pain alone, increased blood flow significantly in the contralateral right sensory association cortex Brodmann area (BA) 5/7, and in bilateral prefrontal cortex BA 9/10/47 and insula. No significant activity was seen in thalamus or primary somatosensory cortex (SI). Direct comparison between capsaicin pain and brush-evoked allodynia revealed significant increase in contralateral BA 5/7 only. CONCLUSIONS:The specific activation of contralateral BA 5/7 indicates that this brain region is important to the processing of brush-evoked allodynia. The involvement of BA 5/7 in brush-evoked allodynia is claimed to reflect multisensory input to this region, its role in conscious pain perception, and its neuroplastic properties.

journal_name

Neurology

journal_title

Neurology

authors

Witting N,Kupers RC,Svensson P,Arendt-Nielsen L,Gjedde A,Jensen TS

doi

10.1212/wnl.57.10.1817

subject

Has Abstract

pub_date

2001-11-27 00:00:00

pages

1817-24

issue

10

eissn

0028-3878

issn

1526-632X

journal_volume

57

pub_type

临床试验,杂志文章,随机对照试验
  • Changes in referral pattern and its effect on outcome in patients with Guillain-Barré syndrome.

    abstract::The authors assessed the referral pattern and outcome in patients with Guillain-Barré syndrome (n = 266) after the introduction of intravenous immunoglobulin (IVIg). Fewer patients were transferred from small to large hospitals after the introduction of IVIg (p = 0.05). This did not result in a worse outcome in patien...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.56.4.564

    authors: Van Koningsveld R,Van Doorn PA,Schmitz PI,Van der Meché FG

    更新日期:2001-02-27 00:00:00

  • Recent cases of intracranial tuberculomas.

    abstract::While intracranial tuberculomas have become uncommon in industrial nations, 12 patients with signs and symptoms of an intracranial mass lesion were recently found to have tuberculomas. Clinical findings suggestive of tuberculosis were frequently subtle or absent. Five patients did not have extracranial tuberculosis. T...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.28.3.256

    authors: Mayers MM,Kaufman DM,Miller MH

    更新日期:1978-03-01 00:00:00

  • Effect of insurance status on postacute care among working age stroke survivors.

    abstract:OBJECTIVE:Utilization of postacute care is associated with improved poststroke outcomes. However, more than 20% of American adults under age 65 are uninsured. We sought to determine whether insurance status is associated with utilization and intensity of institutional postacute care among working age stroke survivors. ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3182563bf5

    authors: Skolarus LE,Meurer WJ,Burke JF,Prvu Bettger J,Lisabeth LD

    更新日期:2012-05-15 00:00:00

  • CNS vasculitis in a patient with MS on daclizumab monotherapy.

    abstract:OBJECTIVE:To report the development of CNS vasculitis in a patient with multiple sclerosis (MS) treated with daclizumab. METHODS:This report includes clinical, MRI, immunologic, and pathology data and CSF analysis. RESULTS:After completing a phase II daclizumab monotherapy study with an optimal response as evidenced ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e31827f0f42

    authors: Ohayon J,Oh U,Richert N,Martin J,Vortmeyer A,McFarland H,Bielekova B

    更新日期:2013-01-29 00:00:00

  • Automated CT perfusion imaging for acute ischemic stroke: Pearls and pitfalls for real-world use.

    abstract::Recent positive trials have thrust acute cerebral perfusion imaging into the routine evaluation of acute ischemic stroke. Updated guidelines state that in patients with anterior circulation large vessel occlusions presenting beyond 6 hours from time last known well, advanced imaging selection including perfusion-based...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/WNL.0000000000008481

    authors: Vagal A,Wintermark M,Nael K,Bivard A,Parsons M,Grossman AW,Khatri P

    更新日期:2019-11-12 00:00:00

  • Implementing standardized provider documentation in a tertiary epilepsy clinic.

    abstract:OBJECTIVE:To incorporate standardized documentation into an epilepsy clinic and to use these standardized data to compare patients' perception of epilepsy diagnosis to provider documentation. METHODS:Using quality improvement methodology, we implemented interventions to increase documentation of epilepsy diagnosis, se...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000009778

    authors: Jones FJS,Smith JR,Ayub N,Herman ST,Buchhalter JR,Fureman BE,Cash SS,Hoch DB,Moura LMVR

    更新日期:2020-07-14 00:00:00

  • Severe neurologic complications after hematopoietic stem cell transplantation in children.

    abstract:OBJECTIVE:To describe and evaluate the incidence and risk factors of severe neurologic events (SNE) in pediatric recipients of allogeneic or autologous hematopoietic stem cell transplantation (HSCT) for hematologic or nonhematologic diseases. METHODS:Retrospective analysis of 272 consecutive children admitted to the G...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000036608.42104.b9

    authors: Faraci M,Lanino E,Dini G,Fondelli MP,Morreale G,Dallorso S,Manzitti C,Calevo MG,Gaggero R,Castagnola E,Haupt R

    更新日期:2002-12-24 00:00:00

  • Clinical manifestations of intermediate allele carriers in Huntington disease.

    abstract:OBJECTIVE:There is controversy about the clinical consequences of intermediate alleles (IAs) in Huntington disease (HD). The main objective of this study was to establish the clinical manifestations of IA carriers for a prospective, international, European HD registry. METHODS:We assessed a cohort of participants at r...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000002944

    authors: Cubo E,Ramos-Arroyo MA,Martinez-Horta S,Martínez-Descalls A,Calvo S,Gil-Polo C,European HD Network.

    更新日期:2016-08-09 00:00:00

  • Methionine-enkephalin, substance P, and homovanillic acid in the CSF of parkinsonian patients.

    abstract::Methionine-enkephalin, substance P, and homovanillic acid concentrations were measured in the CSF of subjects not affected by neurologic disorders (group 1), and in parkinsonian patients who had a slight or moderate (group 2) or severe (group 3) disability. Homovanillic acid and substance P concentrations in the CSF o...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.34.4.516

    authors: Pezzoli G,Panerai AE,Di Giulio A,Longo A,Passerini D,Carenzi A

    更新日期:1984-04-01 00:00:00

  • Pilot age and expertise predict flight simulator performance: a 3-year longitudinal study.

    abstract:BACKGROUND:Expert knowledge may compensate for age-related declines in basic cognitive and sensory-motor abilities in some skill domains. We investigated the influence of age and aviation expertise (indexed by Federal Aviation Administration pilot ratings) on longitudinal flight simulator performance. METHODS:Over a 3...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000255943.10045.c0

    authors: Taylor JL,Kennedy Q,Noda A,Yesavage JA

    更新日期:2007-02-27 00:00:00

  • Phenotypic heterogeneity of spinal muscular atrophy mapping to chromosome 5q11.2-13.3 (SMA 5q).

    abstract::We made phenotypic analysis of 14 families with spinal muscular atrophy (SMA) linking to chromosome 5q11.2-13.3 (SMA 5q), and 2 that may not map to this locus, to assess clinical symptoms among SMA families known to result from mutation at the identical gene/locus. Although the current number of families is still smal...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.40.12.1831

    authors: Munsat TL,Skerry L,Korf B,Pober B,Schapira Y,Gascon GG,al-Rajeh SM,Dubowitz V,Davies K,Brzustowicz LM

    更新日期:1990-12-01 00:00:00

  • Change in body mass index and risk of incident Alzheimer disease.

    abstract:OBJECTIVE:To examine the association of change in body mass index (BMI) with risk of Alzheimer disease (AD). METHODS:Nine hundred eighteen older Catholic clergy participating in the Religious Orders Study without dementia at baseline were studied. Outcome measures were the clinical diagnosis of AD and change in cognit...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000176061.33817.90

    authors: Buchman AS,Wilson RS,Bienias JL,Shah RC,Evans DA,Bennett DA

    更新日期:2005-09-27 00:00:00

  • Mild cognitive impairment in the oldest old.

    abstract:BACKGROUND:No data exist on whether the syndrome of amnestic mild cognitive impairment occurs in the oldest old, or if the relationships for functional status and neuropsychometric performance based on clinical diagnosis hold true in this age group. DESIGN/METHODS:The authors performed comprehensive neurologic evaluat...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.60.3.477

    authors: Boeve B,McCormick J,Smith G,Ferman T,Rummans T,Carpenter T,Ivnik R,Kokmen E,Tangalos E,Edland S,Knopman D,Petersen R

    更新日期:2003-02-11 00:00:00

  • Practical approaches to incidental findings in brain imaging research.

    abstract::A decade of empirical work in brain imaging, genomics, and other areas of research has yielded new knowledge about the frequency of incidental findings, investigator responsibility, and risks and benefits of disclosure. Straightforward guidance for handling such findings of possible clinical significance, however, has...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/01.wnl.0000280469.17461.94

    authors: Illes J,Kirschen MP,Edwards E,Bandettini P,Cho MK,Ford PJ,Glover GH,Kulynych J,Macklin R,Michael DB,Wolf SM,Grabowski T,Seto B

    更新日期:2008-01-29 00:00:00

  • Prion disease incidence in the United States: 2003-2015.

    abstract:OBJECTIVE:To report the incidence of prion disease in the United States. METHODS:Prion disease decedents were retrospectively identified from the US national multiple cause-of-death data for 2003-2015 and matched with decedents in the National Prion Disease Pathology Surveillance Center (NPDPSC) database through compa...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000008680

    authors: Maddox RA,Person MK,Blevins JE,Abrams JY,Appleby BS,Schonberger LB,Belay ED

    更新日期:2020-01-14 00:00:00

  • A prospective study of quality of life in ALS patients treated with noninvasive ventilation.

    abstract::Noninvasive positive pressure ventilation prolongs survival in ALS but its effect on quality of life is unknown. The authors prospectively studied quality of life using the SF-36 questionnaire in a cohort of 16 ventilated patients with ALS. Noninvasive positive pressure ventilation improved scores in the "Vitality" do...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.57.1.153

    authors: Lyall RA,Donaldson N,Fleming T,Wood C,Newsom-Davis I,Polkey MI,Leigh PN,Moxham J

    更新日期:2001-07-10 00:00:00

  • Medial medullary infarction with central sparing.

    abstract::A 35-year-old woman had cardiac arrest requiring treatment with a left ventricular assist device. After regaining consciousness, examination revealed upbeating nystagmus, otherwise normal bulbar function, left arm dysmetria, and numbness periorally and in areas she described as "a turtleneck of numbness with a T-shirt...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000436939.70528.03

    authors: Ryman DC,Ju YE

    更新日期:2013-12-03 00:00:00

  • Positron emission tomography demonstrates frontal cortex and basal ganglia hypometabolism in dystonia.

    abstract::We studied 15 dystonic patients with positron emission tomography (PET) and (18F)-2-fluoro-2-deoxy-D-glucose (FDG). The group comprised patients with focal (n = 5), multifocal (n = 1), and generalized (n = 4) dystonia as well as patients with hemidystonia (n = 5). The age at onset was during childhood in four, during ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.42.8.1540

    authors: Karbe H,Holthoff VA,Rudolf J,Herholz K,Heiss WD

    更新日期:1992-08-01 00:00:00

  • Three-Tesla MRI does not improve the diagnosis of multiple sclerosis: A multicenter study.

    abstract:OBJECTIVE:In the work-up of patients presenting with a clinically isolated syndrome (CIS), 3T MRI might offer a higher lesion detection than 1.5T, but it remains unclear whether this affects the fulfilment of the diagnostic criteria for multiple sclerosis (MS). METHODS:We recruited 66 patients with CIS within 6 months...

    journal_title:Neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1212/WNL.0000000000005825

    authors: Hagens MHJ,Burggraaff J,Kilsdonk ID,de Vos ML,Cawley N,Sbardella E,Andelova M,Amann M,Lieb JM,Pantano P,Lissenberg-Witte BI,Killestein J,Oreja-Guevara C,Ciccarelli O,Gasperini C,Lukas C,Wattjes MP,Barkhof F,MAGNIMS St

    更新日期:2018-07-17 00:00:00

  • Linking MRI to daily life experience: the example of poststroke depression.

    abstract:OBJECTIVE:The state-of-the-art tools of neurology, in particular modern neuroimaging techniques, have yet to benefit from the revolution in mobile technologies that provide new insights into the mechanisms underlying clinical syndromes. This study demonstrates the manner in which mobile technologies may provide informa...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e31824528b2

    authors: Lassalle-Lagadec S,Allard M,Dilharreguy B,Schweitzer P,Swendsen J,Sibon I

    更新日期:2012-01-31 00:00:00

  • Depression and symptoms affect quality of life in psychogenic nonepileptic seizures.

    abstract:BACKGROUND:In patients with active epilepsy, adverse medication effects and severity of depression are correlated with health-related quality of life, but seizure frequency is not. We sought to examine if the same pattern exists in patients with psychogenic nonepileptic seizures (PNES). METHODS:We administered seizure...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3181b04c83

    authors: LaFrance WC Jr,Syc S

    更新日期:2009-08-04 00:00:00

  • Mild behavioral impairment is linked to worse cognition and brain atrophy in Parkinson disease.

    abstract:OBJECTIVE:To evaluate the associations of mild behavioral impairment (MBI) with cognitive deficits and patterns of gray matter changes in Parkinson disease (PD). METHODS:Sixty patients with PD without dementia and 29 healthy controls underwent a cognitive neuropsychological evaluation and structural MRI scan. MBI was ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000007968

    authors: Yoon EJ,Ismail Z,Hanganu A,Kibreab M,Hammer T,Cheetham J,Kathol I,Sarna JR,Martino D,Furtado S,Monchi O

    更新日期:2019-08-20 00:00:00

  • Electrographic seizures in pediatric ICU patients: cohort study of risk factors and mortality.

    abstract:OBJECTIVES:We aimed to determine the incidence of electrographic seizures in children in the pediatric intensive care unit who underwent EEG monitoring, risk factors for electrographic seizures, and whether electrographic seizures were associated with increased odds of mortality. METHODS:Eleven sites in North America ...

    journal_title:Neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1212/WNL.0b013e31829c5cfe

    authors: Abend NS,Arndt DH,Carpenter JL,Chapman KE,Cornett KM,Gallentine WB,Giza CC,Goldstein JL,Hahn CD,Lerner JT,Loddenkemper T,Matsumoto JH,McBain K,Nash KB,Payne E,Sánchez SM,Fernández IS,Shults J,Williams K,Yang A,Dlu

    更新日期:2013-07-23 00:00:00

  • Vimentin and desmin in maturing skeletal muscle and developmental myopathies.

    abstract::I studied vimentin and desmin immunoreactivities in the skeletal muscle of 30 human fetuses and children ranging from 8 weeks' gestation to 2 years of age, and in 45 infants and children and five adults with developmental neuromuscular diseases. Acridine orange-RNA fluorescence also identified regenerating myofibers i...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.42.8.1616

    authors: Sarnat HB

    更新日期:1992-08-01 00:00:00

  • A case-control study of Alzheimer's disease in China.

    abstract::We conducted a case-control study to assess possible factors associated with Alzheimer's disease (AD) with 70 clinically diagnosed AD patients and 140 age- and sex-matched nondemented neighborhood controls in China. Factors significantly associated with AD cases were family history of dementia in first-degree relative...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.42.8.1481

    authors: Li G,Shen YC,Li YT,Chen CH,Zhau YW,Silverman JM

    更新日期:1992-08-01 00:00:00

  • Neurology and neurologic practice in China.

    abstract::In the wake of dramatic economic success during the past 2 decades, the specialized field of neurology has undergone a significant transformation in China. With an increase in life expectancy, the problems of aging and cognition have grown. Lifestyle alterations have been associated with an epidemiologic transition bo...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e31823a0ed3

    authors: Shi FD,Jia JP

    更新日期:2011-11-29 00:00:00

  • Glucose levels and outcome after subarachnoid hemorrhage.

    abstract::In a cohort of 337 patients with subarachnoid hemorrhage (SAH), we investigated the relationship between blood glucose levels, baseline characteristics, and outcome by means of Student's t-test and multivariate logistic regression. The mean glucose levels on admission and from day 1 to 10 were significantly higher in ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000090466.68866.02

    authors: Dorhout Mees SM,van Dijk GW,Algra A,Kempink DR,Rinkel GJ

    更新日期:2003-10-28 00:00:00

  • Practice parameter update: management issues for women with epilepsy--focus on pregnancy (an evidence-based review): vitamin K, folic acid, blood levels, and breastfeeding: report of the Quality Standards Subcommittee and Therapeutics and Technology Asses

    abstract:OBJECTIVE:To reassess the evidence for management issues related to the care of women with epilepsy (WWE) during pregnancy, including preconceptional folic acid use, prenatal vitamin K use, risk of hemorrhagic disease of the newborn, clinical implications of placental and breast milk transfer of antiepileptic drugs (AE...

    journal_title:Neurology

    pub_type: 杂志文章,实务指引,评审

    doi:10.1212/WNL.0b013e3181a6b325

    authors: Harden CL,Pennell PB,Koppel BS,Hovinga CA,Gidal B,Meador KJ,Hopp J,Ting TY,Hauser WA,Thurman D,Kaplan PW,Robinson JN,French JA,Wiebe S,Wilner AN,Vazquez B,Holmes L,Krumholz A,Finnell R,Shafer PO,Le Guen C,Americ

    更新日期:2009-07-14 00:00:00

  • Uniparental disomy of chromosome 16 unmasks recessive mutations of FA2H/SPG35 in 4 families.

    abstract:OBJECTIVE:Identifying an intriguing mechanism for unmasking recessive hereditary spastic paraplegias. METHOD:Herein, we describe 4 novel homozygous FA2H mutations in 4 nonconsanguineous families detected by whole-exome sequencing or a targeted gene panel analysis providing high coverage of all known hereditary spastic...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000002843

    authors: Soehn AS,Rattay TW,Beck-Wödl S,Schäferhoff K,Monk D,Döbler-Neumann M,Hörtnagel K,Schlüter A,Ruiz M,Pujol A,Züchner S,Riess O,Schüle R,Bauer P,Schöls L

    更新日期:2016-07-12 00:00:00

  • Evidence in focus: Nusinersen use in spinal muscular atrophy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology.

    abstract:OBJECTIVE:To identify the level of evidence for use of nusinersen to treat spinal muscular atrophy (SMA) and review clinical considerations regarding use. METHODS:The author panel systematically reviewed nusinersen clinical trials for patients with SMA and assigned level of evidence statements based on the American Ac...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000006502

    authors: Michelson D,Ciafaloni E,Ashwal S,Lewis E,Narayanaswami P,Oskoui M,Armstrong MJ

    更新日期:2018-11-13 00:00:00