Abstract:
:While intracranial tuberculomas have become uncommon in industrial nations, 12 patients with signs and symptoms of an intracranial mass lesion were recently found to have tuberculomas. Clinical findings suggestive of tuberculosis were frequently subtle or absent. Five patients did not have extracranial tuberculosis. Two patients had intracranial tuberculomas that became superinfected with bacteria and appeared initially as pyogenic brain abscesses. Intracranial tuberculomas in this country almost always occur in adults and represent reactivation of dormant infection. Medical therapy alone is indicated as the initial therapy except in the presence of intolerably increased intracranial pressure. A chemotherapeutic regimen is suggested.
journal_name
Neurologyjournal_title
Neurologyauthors
Mayers MM,Kaufman DM,Miller MHdoi
10.1212/wnl.28.3.256subject
Has Abstractpub_date
1978-03-01 00:00:00pages
256-60issue
3eissn
0028-3878issn
1526-632Xjournal_volume
28pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::A 51-year-old man had a 4-month history of progressive headache and gradual onset of somnolence. MRI suggested spontaneous intracranial hypotension (SIH) with diencephalic compression, but he did not improve after three epidural blood patches. He became alert following intrathecal saline infusion that normalized his C...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.6.1854
更新日期:1998-06-01 00:00:00
abstract::Dementia occurs infrequently in patients with giant cell (temporal) arteritis (GCA). Three elderly women with biopsy-proven GCA showed abrupt cognitive decline during periods of clinically active GCA, 1 to 6 months after diagnostic temporal artery biopsy, during periods of corticosteroid taper. One patient had additio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.5.753
更新日期:1990-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of remote nonpainful electrical upper arm skin stimulation in reducing migraine attack pain. METHODS:This is a prospective, double-blinded, randomized, crossover, sham-controlled trial. Migraineurs applied skin electrodes to the upper arm soon after attack onset for 20 minutes, at va...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000003760
更新日期:2017-03-28 00:00:00
abstract::We measured beta-carbolinium cations (BC+s) endogenous analogs of the N-methyl-4-phenylpyridinium ion (MPP+), in the lumbar CSF of 22 patients with idiopathic Parkinson's disease (PD) and 11 age-matched controls without any symptoms of parkinsonism. Among the BC+s, 2,9-diemethylnorharmanium cation (2,9-Me2NH+), the mo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.12.2240
更新日期:1995-12-01 00:00:00
abstract::As the substantia nigra degenerates in Parkinson's disease (PD), the nigrostriatal pathway is disrupted, reducing striatal dopamine and producing PD symptoms. Although dopamine does not readily cross the blood-brain barrier, its precursor, levodopa, does. Levodopa is absorbed in the small bowel and is rapidly cataboli...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.50.6_suppl_6.s11
更新日期:1998-06-01 00:00:00
abstract::We followed 419 patients with a first, unprovoked, primarily or secondarily generalized tonic-clonic seizure, randomized to immediate antiepileptic treatment or to treatment only in the event of seizure recurrence. The probability of achieving a 2-year remission was 72 vs 57% at 3 months, 84 to 79% at 3 years, and 85 ...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/01.wnl.0000249309.80510.63
更新日期:2006-12-26 00:00:00
abstract::A 25-year-old woman with Kearns-Sayre syndrome (KSS) had complete external ophthalmoplegia, short stature, ataxia, cardiac conduction defects, and pigmentary retinopathy. Muscle biopsy revealed ragged-red fibers. Electron microscopy showed increased numbers of mitochondria with disordered structure and paracrystalline...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.5.693
更新日期:1989-05-01 00:00:00
abstract::4-Aminopyridine (4-AP) has a favorable effect on the disability of certain patients with MS. We investigated the effect of 4-AP on neuropsychological performance in 20 MS patients using a randomized, double-blind, placebo-controlled, crossover design. Although there was a trend for improved performance with 4-AP for t...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.44.9.1701
更新日期:1994-09-01 00:00:00
abstract::We evaluated the therapeutic efficacy of gamma aminobutyric acid (GABA) system stimulation in four patients with classical Huntington's disease and one with the hypokinetic-rigid form. Orally administered THIP (4,5,6,7-tetrahydroisoxazolo-[5,4,-c] pyridin-3-ol), a novel GABA receptor agonist, failed to improve motor o...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.33.5.637
更新日期:1983-05-01 00:00:00
abstract:OBJECTIVE:To identify presurgical and postsurgical factors that are independently predictive of the outcome of anterior temporal lobectomy (ATL) for intractable epilepsy. BACKGROUND:There have been reports of prognostic factors in epilepsy surgery, but little is known about factors that independently predict outcome o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.2.465
更新日期:1998-08-01 00:00:00
abstract::The presence of an APOE epsilon4 allele may be a risk factor for neuropathy severity in diabetes. The authors assessed the frequency of APOE epsilon4 in patients presenting with sensory predominant neuropathy. APOE epsilon4 frequency among patients with early diabetic neuropathy and impaired glucose tolerance-associat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000148587.97690.4E
更新日期:2005-01-11 00:00:00
abstract:OBJECTIVE:To develop evidence-based recommendations for complementary and alternative medicine (CAM) in multiple sclerosis (MS). METHODS:We searched the literature (1970-March 2011; March 2011-September 2013 MEDLINE search), classified articles, and linked recommendations to evidence. RESULTS AND RECOMMENDATIONS:Clin...
journal_title:Neurology
pub_type: 杂志文章,meta分析
doi:10.1212/WNL.0000000000000250
更新日期:2014-03-25 00:00:00
abstract:BACKGROUND:Hereditary neuralgic amyotrophy (HNA) is an autosomal dominant disorder that manifests as recurrent, episodic, painful brachial neuropathies. A gene for HNA maps to chromosome 17q25.3 where mutations in SEPT9, encoding the septin-9 protein, have been identified. OBJECTIVE:To determine the frequency and type...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181a609e3
更新日期:2009-05-19 00:00:00
abstract::A randomized trial was completed to assess the feasibility of a 2-year education rehabilitation program for students with sickle cell disease and memory deficits. Eleven students were assigned to tutoring with or without memory training for 2 years. Eighty-two percent completed the program. Evidence of improvement in ...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/01.wnl.0000264421.24415.16
更新日期:2007-06-05 00:00:00
abstract::We investigated the role of ceruloplasmin in the antioxidative process in the brain in a patient with hereditary ceruloplasmin deficiency (HCD). Immunohistochemistry revealed an accumulation of Nepsilon-(carboxymethyl) lysine (CML) in basal ganglia of the HCD brain. In vitro study disclosed that ceruloplasmin inhibite...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.3.619
更新日期:1999-08-11 00:00:00
abstract:OBJECTIVES:We evaluated the frequency and predictive value of ocular fundus abnormalities among patients who presented to the emergency department (ED) with focal neurologic deficits to determine the utility of these findings in the evaluation of patients with suspected TIA and stroke. METHODS:In this cross-sectional ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001759
更新日期:2015-07-21 00:00:00
abstract:BACKGROUND:Huntington's disease (HD) is a fatal and progressive neurodegenerative disease that is accompanied by involuntary movements, cognitive dysfunction, and psychiatric symptoms. Although progressive striatal degeneration is known to occur, little is known about how the disease affects the cortex, including which...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.5.695
更新日期:2002-03-12 00:00:00
abstract::The intensive study of seizures via serial 24-hour EEG-video monitoring has allowed enhanced observation of sleep patterns among epilepsy patients and has revealed that disturbed rest is common in this population. Previous work has shown that sleep deprivation of any type can exacerbate seizure activity, leading to sp...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract::We applied quantitative methods to measure extrapyramidal signs in 50 Alzheimer's disease (AD) patients and 40 age-matched control subjects. We measured tremor using accelerometers, bradykinesia using computer-detected reaction times (RTs) and movement times (MTs), and rigidity using a strain gauge linked to a movable...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.3_part_1.500
更新日期:1993-03-01 00:00:00
abstract:OBJECTIVE:Functional or psychogenic movement disorders (FMD) present a diagnostic challenge. To diagnose FMD, clinicians must have experience with signs typical of FMD and distinguishing features from other hyperkinetic disorders. The aim of this study was to clarify the decision-making process of expert clinicians whi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003479
更新日期:2017-01-10 00:00:00
abstract::We analyzed ictal features of psychogenic seizures using video-EEG recordings in 47 patients and reviewed the medical records to determine if patients received antiepileptic drug therapy and whether they were treated pharmacologically for status epilepticus. Unresponsive behavior in the absence of motor manifestations...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.1.95
更新日期:1992-01-01 00:00:00
abstract::We describe the MR images of a patient with juvenile ALS. MRI of the brain showed bilateral hyperintensities along the corticospinal tracts extending from the corona radiata to the brainstem on T2-weighted images. These findings should be differentiated from the slight hyperintensities seen in the posterior limbs of t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.6.1879
更新日期:1998-06-01 00:00:00
abstract:BACKGROUND:Previous studies link posterior border-zone cerebral infarcts between the middle cerebral artery (MCA) and the posterior cerebral artery (PCA) to hemodynamic causes, not embolism. OBJECTIVE:To study the cause of these infarcts. METHODS:We studied 21 patients (unilateral = 18, bilateral = 3) with acute, sym...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.6.1312
更新日期:1999-10-12 00:00:00
abstract::We attempted to define the role of subtle changes in the normal-appearing white matter (NAWM) in the development of disability in multiple sclerosis (MS). Twenty-seven clinically definite MS patients with either relapsing-remitting or chronic-progressive courses and 10 sex- and age-matched controls entered the study. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.3.478
更新日期:1995-03-01 00:00:00
abstract:OBJECTIVE:To examine whether prior statin use affects outcome and intracranial hemorrhage (ICH) rates in stroke patients receiving IV thrombolysis (IVT). METHODS:In a pooled observational study of 11 IVT databases, we compared outcomes between statin users and nonusers. Outcome measures were excellent 3-month outcome ...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0b013e31822c9135
更新日期:2011-08-30 00:00:00
abstract::Recurrent stroke is a major public health concern and new treatment strategies are needed. While modulation of the renin angiotensin aldosterone system (RAAS) has proven effective in reducing recurrent cardiac events, its role in preventing recurrent cerebrovascular events remains unclear. RAAS is both a circulating a...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000130360.21618.d0
更新日期:2004-07-27 00:00:00
abstract:OBJECTIVE:To study the attributes of quantitative strength testing using hand-held dynamometry (HHD) as an efficacy measure in 2 large phase 3 amyotrophic lateral sclerosis (ALS) trials. METHODS:In the phase 3 trials of ceftriaxone and dexpramipexole, 513 and 943 patients, respectively, were enrolled in double-blind, ...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0000000000002941
更新日期:2016-08-09 00:00:00
abstract:OBJECTIVE:Pigmented orthochromatic leukodystrophy (POLD) and hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS) are rare neurodegenerative disorders characterized by cerebral white matter abnormalities, myelin loss, and axonal swellings. The striking overlap of clinical and pathologic features of these...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31828726a7
更新日期:2013-03-12 00:00:00
abstract:OBJECTIVE:To investigate whether repetitive transcranial magnetic stimulation (rTMS) can modify spasticity. METHODS:We used high-frequency (5 Hz) and low-frequency (1 Hz) rTMS protocols in 19 remitting patients with relapsing-remitting multiple sclerosis and lower limb spasticity. RESULTS:A single session of 1 Hz rTM...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000257818.16952.62
更新日期:2007-03-27 00:00:00
abstract::We analyzed the association of HLA-DR and -DQ haplotypes and alleles with multiple sclerosis (MS) in 91 patients and 91 controls from Iceland using the relative predispositional effect method. The aim was to establish whether there is heterogeneity in HLA associations with MS, whether there are both predispositional a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.4.1107
更新日期:1996-04-01 00:00:00