Abstract:
:We evaluated the therapeutic efficacy of gamma aminobutyric acid (GABA) system stimulation in four patients with classical Huntington's disease and one with the hypokinetic-rigid form. Orally administered THIP (4,5,6,7-tetrahydroisoxazolo-[5,4,-c] pyridin-3-ol), a novel GABA receptor agonist, failed to improve motor or cognitive function during a 2-week trial. At maximum levels, THIP mimicked another putative GABA agonist, muscimol, in causing unsteadiness of gait, diminished attention to sensory stimuli, and somnolence. These effects suggest that central GABA systems participate in the regulation of some human and behavioral functions. CSF content of homovanillic acid, a major metabolite of dopamine, increased during high-dose THIP therapy, suggesting that augmentation of dopaminergic function may have contributed to the drug's lack of efficacy.
journal_name
Neurologyjournal_title
Neurologyauthors
Foster NL,Chase TN,Denaro A,Hare TA,Tamminga CAdoi
10.1212/wnl.33.5.637subject
Has Abstractpub_date
1983-05-01 00:00:00pages
637-9issue
5eissn
0028-3878issn
1526-632Xjournal_volume
33pub_type
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