THIP treatment of Huntington's disease.

Abstract:

:We evaluated the therapeutic efficacy of gamma aminobutyric acid (GABA) system stimulation in four patients with classical Huntington's disease and one with the hypokinetic-rigid form. Orally administered THIP (4,5,6,7-tetrahydroisoxazolo-[5,4,-c] pyridin-3-ol), a novel GABA receptor agonist, failed to improve motor or cognitive function during a 2-week trial. At maximum levels, THIP mimicked another putative GABA agonist, muscimol, in causing unsteadiness of gait, diminished attention to sensory stimuli, and somnolence. These effects suggest that central GABA systems participate in the regulation of some human and behavioral functions. CSF content of homovanillic acid, a major metabolite of dopamine, increased during high-dose THIP therapy, suggesting that augmentation of dopaminergic function may have contributed to the drug's lack of efficacy.

journal_name

Neurology

journal_title

Neurology

authors

Foster NL,Chase TN,Denaro A,Hare TA,Tamminga CA

doi

10.1212/wnl.33.5.637

subject

Has Abstract

pub_date

1983-05-01 00:00:00

pages

637-9

issue

5

eissn

0028-3878

issn

1526-632X

journal_volume

33

pub_type

临床试验,杂志文章
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