Spontaneous intracranial hypotension resulting in stupor caused by diencephalic compression.


:A 51-year-old man had a 4-month history of progressive headache and gradual onset of somnolence. MRI suggested spontaneous intracranial hypotension (SIH) with diencephalic compression, but he did not improve after three epidural blood patches. He became alert following intrathecal saline infusion that normalized his CSF pressure. A CSF leak was noted on spinal MRI and confirmed with CT contrast myelography. Surgical ligation of a torn dural root sleeve isolating a ruptured Tarlov's cyst resulted in permanent cure.






Pleasure SJ,Abosch A,Friedman J,Ko NU,Barbaro N,Dillon W,Fishman RA,Poncelet AN




Has Abstract


1998-06-01 00:00:00












  • Longitudinal ocular motor study in corticobasal degeneration and progressive supranuclear palsy.

    abstract:OBJECTIVE:To evaluate the usefulness of ocular motor information in the early diagnosis of corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP). METHODS:Seven PSP patients, six CBD patients, and three atypical CBD patients were followed longitudinally with repeated electrooculographic (EOG) recordi...


    pub_type: 杂志文章


    authors: Rivaud-Péchoux S,Vidailhet M,Gallouedec G,Litvan I,Gaymard B,Pierrot-Deseilligny C

    更新日期:2000-03-14 00:00:00

  • Natural history of succinic semialdehyde dehydrogenase deficiency through adulthood.

    abstract:OBJECTIVE:The natural history of succinic semialdehyde dehydrogenase (SSADH) deficiency in adulthood is unknown; we elucidate the clinical manifestations of the disease later in life. METHODS:A 63-year-old man with long-standing intellectual disability was diagnosed with SSADH deficiency following hospitalization for ...


    pub_type: 杂志文章


    authors: Lapalme-Remis S,Lewis EC,De Meulemeester C,Chakraborty P,Gibson KM,Torres C,Guberman A,Salomons GS,Jakobs C,Ali-Ridha A,Parviz M,Pearl PL

    更新日期:2015-09-08 00:00:00

  • Microstructural white matter changes in cognitively normal individuals at risk of amnestic MCI.

    abstract:OBJECTIVE:Since Alzheimer disease (AD) is a slowly progressive disorder and its pathologic features are likely to be present for many years before symptoms become manifest, we investigated whether microstructural white matter changes similar to those identified in patients with AD can be detected in cognitively normal ...


    pub_type: 杂志文章


    authors: Zhuang L,Sachdev PS,Trollor JN,Kochan NA,Reppermund S,Brodaty H,Wen W

    更新日期:2012-08-21 00:00:00

  • Cognition in multiple sclerosis: State of the field and priorities for the future.

    abstract::Cognitive decline is recognized as a prevalent and debilitating symptom of multiple sclerosis (MS), especially deficits in episodic memory and processing speed. The field aims to (1) incorporate cognitive assessment into standard clinical care and clinical trials, (2) utilize state-of-the-art neuroimaging to more thor...


    pub_type: 杂志文章,评审


    authors: Sumowski JF,Benedict R,Enzinger C,Filippi M,Geurts JJ,Hamalainen P,Hulst H,Inglese M,Leavitt VM,Rocca MA,Rosti-Otajarvi EM,Rao S

    更新日期:2018-02-06 00:00:00

  • The effects of acute and chronic ethanol administration on twitch and tetanic force production by rat gastrocnemius muscle in situ.

    abstract::The effects of acute ethanol injection on force production were measured in normal and chronic alcoholic rats. Acutely injected normal rats, acutely injected chronic alcoholic rats, and noninjected chronic alcoholic rats were compared with control groups: normal nonalcoholic rats and a dietetically deprived control gr...


    pub_type: 杂志文章


    authors: Martyn DA,Munsat TL

    更新日期:1980-02-01 00:00:00

  • Cyproheptadine reduces or prevents ischemic central nervous system damage.

    abstract::Several drugs that inhibit the effects of serotonin may reduce or prevent experimental CNS ischemic damage, but these drugs are not approved for human use in the United States. Administration of cyproheptadine (which is available for clinical use) 15 minutes before or 5 minutes after the onset increased the duration o...


    pub_type: 杂志文章


    authors: Zivin JA

    更新日期:1985-04-01 00:00:00

  • Prospective memory in patients with juvenile myoclonic epilepsy and their healthy siblings.

    abstract:OBJECTIVE:Prospective memory (PM) describes the ability to fulfill previously planned intentions and is highly dependent on executive functions. Previous studies have shown deficits in executive functions in patients with juvenile myoclonic epilepsy (JME) and in their unaffected siblings. JME has a strong genetic predi...


    pub_type: 杂志文章


    authors: Wandschneider B,Kopp UA,Kliegel M,Stephani U,Kurlemann G,Janz D,Schmitz B

    更新日期:2010-12-14 00:00:00

  • Corpus callosotomy for epilepsy. I. Seizure effects.

    abstract::Twenty-two patients were analyzed 2 or more years after corpus callosum section (9 partial, 13 total). Forty-one percent had class 1 outcome (elimination of secondarily generalized and complex partial seizures), 32% had class 2 outcome (elimination of secondarily generalized seizures), and 27% had class 3 outcome (no ...


    pub_type: 杂志文章


    authors: Spencer SS,Spencer DD,Williamson PD,Sass K,Novelly RA,Mattson RH

    更新日期:1988-01-01 00:00:00

  • Biopsy-proven cerebral vasculitis associated with cocaine abuse.

    abstract::We report cerebral vasculitis in 2 cocaine users who developed symptoms (transient blindness and persistent headache) while smoking "crack," followed by progressive widespread cerebral dysfunction with focal signs over the next few weeks. One patient had smoked crack exclusively, and the other also used cocaine intrav...


    pub_type: 杂志文章


    authors: Krendel DA,Ditter SM,Frankel MR,Ross WK

    更新日期:1990-07-01 00:00:00

  • Methionine-enkephalin, substance P, and homovanillic acid in the CSF of parkinsonian patients.

    abstract::Methionine-enkephalin, substance P, and homovanillic acid concentrations were measured in the CSF of subjects not affected by neurologic disorders (group 1), and in parkinsonian patients who had a slight or moderate (group 2) or severe (group 3) disability. Homovanillic acid and substance P concentrations in the CSF o...


    pub_type: 杂志文章


    authors: Pezzoli G,Panerai AE,Di Giulio A,Longo A,Passerini D,Carenzi A

    更新日期:1984-04-01 00:00:00

  • Dystrophin expression and somatic reversion in prednisone-treated and untreated Duchenne dystrophy. CIDD Study Group.

    abstract::The mechanism by which prednisone improves muscle strength and function in Duchenne muscular dystrophy (DMD) is unknown. We addressed the possibility that clinical improvement was related to prednisone-induced alterations in skeletal muscle dystrophin. We performed muscle biopsies on patients at the conclusion of a ra...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Burrow KL,Coovert DD,Klein CJ,Bulman DE,Kissel JT,Rammohan KW,Burghes AH,Mendell JR

    更新日期:1991-05-01 00:00:00

  • Hemifacial spasm due to contralateral acoustic neuroma: case report.

    abstract::A patient with a large acoustic neuroma had contralateral hemifacial spasm. On CT, the brainstem was markedly displaced and distorted by the tumor. After total removal of the tumor the hemifacial spasm was temporarily worse, but disappeared 14 days after the operation. ...


    pub_type: 杂志文章


    authors: Nishi T,Matsukado Y,Nagahiro S,Fukushima M,Koga K

    更新日期:1987-02-01 00:00:00

  • Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis.

    abstract::Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels > or = 1.53 microg/mL predicted progression to need for ambulatory assistance during follow-up (s...


    pub_type: 临床试验,杂志文章


    authors: Rinker JR 2nd,Trinkaus K,Cross AH

    更新日期:2006-10-10 00:00:00

  • Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants.

    abstract:OBJECTIVE:To determine the role of oxidative stress in mediating HIV dementia and to identify novel therapeutic compounds that may block this oxidative stress. METHODS:Brain tissue from patients with HIV encephalitis and macaques with simian immune deficiency virus encephalitis was immunostained for lipid peroxidation...


    pub_type: 杂志文章


    authors: Turchan J,Pocernich CB,Gairola C,Chauhan A,Schifitto G,Butterfield DA,Buch S,Narayan O,Sinai A,Geiger J,Berger JR,Elford H,Nath A

    更新日期:2003-01-28 00:00:00

  • Standard operating procedures improve acute neurologic care in a sub-Saharan African setting.

    abstract:OBJECTIVE:Quality of neurologic emergency management in an under-resourced country may be improved by standard operating procedures (SOPs). METHODS:Neurologic SOPs were implemented in a large urban (Banjul) and a small rural (Brikama) hospital in the Gambia. As quality indicators of neurologic emergency management, pe...


    pub_type: 杂志文章


    authors: Jaiteh LES,Helwig SA,Jagne A,Ragoschke-Schumm A,Sarr C,Walter S,Lesmeister M,Manitz M,Blaß S,Weis S,Schlund V,Bah N,Kauffmann J,Fousse M,Kangankan S,Ramos Cabrera A,Kronfeld K,Ruckes C,Liu Y,Nyan O,Fassbender K

    更新日期:2017-07-11 00:00:00

  • Amygdala and hippocampal volumes in children with Down syndrome: a high-resolution MRI study.

    abstract::The objective of this study was to use high-resolution MRI techniques to determine whether children with Down syndrome exhibit decreases in hippocampal and amygdala volumes similar to those demonstrated in recent studies of adults with this condition. When corrected for overall brain volumes, amygdala volumes did not ...


    pub_type: 杂志文章


    authors: Pinter JD,Brown WE,Eliez S,Schmitt JE,Capone GT,Reiss AL

    更新日期:2001-04-10 00:00:00

  • Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 200-, 400-, and 600-mg daily dosages. Topiramate YD Study Group.

    abstract::We conducted a randomized double-blind comparison of three doses of the novel antiepileptic drug (AED) topiramate (200, 400, and 600 mg/day) and placebo as adjunctive therapy in patients with refractory partial onset epilepsy receiving one or two other AEDs at therapeutic concentrations. A total of 181 patients comple...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Faught E,Wilder BJ,Ramsay RE,Reife RA,Kramer LD,Pledger GW,Karim RM

    更新日期:1996-06-01 00:00:00

  • The clinical profile of MS in Australia: a comparison between medium- and high-frequency prevalence zones.

    abstract::Recent epidemiologic studies of multiple sclerosis (MS) in Australia defined the State of Queensland as a medium-frequency zone and the more southerly placed cities of Perth, Newcastle, and Hobart as high-frequency zones. Clinical profiles in the patient populations of both frequency zones were remarkably similar in m...


    pub_type: 杂志文章


    authors: Hammond SR,English D,de Wytt C,Maxwell IC,Millingen KS,Stewart-Wynne EG,McLeod JG,McCall MG

    更新日期:1988-06-01 00:00:00

  • Fatigue in Parkinson's disease.

    abstract::Fatigue is a common but poorly understood symptom in Parkinson's disease (PD). Using previously validated scales, we asked 58 nondemented PD patients and 58 controls to fill out questionnaires assessing fatigue and depression and found that PD patients were more depressed and more fatigued than age-matched controls. A...


    pub_type: 杂志文章


    authors: Friedman J,Friedman H

    更新日期:1993-10-01 00:00:00

  • The spectrum of acute encephalitis: causes, management, and predictors of outcome.

    abstract:OBJECTIVE:To describe and analyze etiologies, clinical presentations, therapeutic management, and outcomes of patients with acute encephalitis and identify outcome predictors. METHODS:We conducted a retrospective review of patients diagnosed with acute encephalitis at Mayo Clinic Rochester between January 2000 and Dec...


    pub_type: 杂志文章


    authors: Singh TD,Fugate JE,Rabinstein AA

    更新日期:2015-01-27 00:00:00

  • Infection as cause of stroke: a contagious idea that may explain racial disparity.

    abstract::In the aftermath of an acute cardiovascular event such as stroke, patients and families frequently ask whether preceding circumstances such as viral illnesses, stress, and other medical or surgical events brought on the disease. Although it seems intuitive to patients and families that acute precipitants or disease tr...


    pub_type: 评论,社论


    authors: Jeerakathil T,Lo W

    更新日期:2014-03-18 00:00:00

  • Long-term antithrombotic treatment in intracranial hemorrhage survivors with atrial fibrillation.

    abstract:OBJECTIVE:To perform a systematic review and meta-analysis of studies reporting recurrent intracranial hemorrhage (ICH) and ischemic stroke (IS) in ICH survivors with atrial fibrillation (AF) during long-term follow-up. METHODS:A comprehensive literature search including MEDLINE, EMBASE, Cochrane library, clinical tri...


    pub_type: 杂志文章,meta分析,评审


    authors: Korompoki E,Filippidis FT,Nielsen PB,Del Giudice A,Lip GYH,Kuramatsu JB,Huttner HB,Fang J,Schulman S,Martí-Fàbregas J,Gathier CS,Viswanathan A,Biffi A,Poli D,Weimar C,Malzahn U,Heuschmann P,Veltkamp R

    更新日期:2017-08-15 00:00:00

  • Delivery of active hexosaminidase across the blood-brain barrier in rats.

    abstract::The ability to deliver enzymatically active human hexosaminidase A across the blood-brain barrier and into brain cells of the normal rat was examined. Following osmotic blood-brain barrier modification in the rat, intraarterially administered human hexosaminidase A and B were shown to cross the barrier and enter brain...


    pub_type: 杂志文章


    authors: Neuwelt EA,Barranger JA,Pagel MA,Quirk JM,Brady RO,Frenkel EP

    更新日期:1984-08-01 00:00:00

  • Magnetic resonance imaging of the head in the diagnosis of multiple sclerosis: a prospective 2-year follow-up with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT.

    abstract::We previously compared the diagnostic capabilities of MRI of the head with CT, evoked potentials, and CSF oligoclonal banding (OB) analysis in a prospective evaluation of 200 patients with suspected multiple sclerosis (MS). To examine the ability of MRI and other paraclinical tests to predict the diagnosis of clinical...


    pub_type: 杂志文章


    authors: Lee KH,Hashimoto SA,Hooge JP,Kastrukoff LF,Oger JJ,Li DK,Paty DW

    更新日期:1991-05-01 00:00:00

  • Traumatic brain injury preceding clinically diagnosed α-synucleinopathies: A case-control study.

    abstract:OBJECTIVE:To determine the association between traumatic brain injury (TBI) and any clinically diagnosed α-synucleinopathy including Parkinson disease (PD), dementia with Lewy bodies (DLB), PD dementia (PDD), and multiple system atrophy (MSA). METHODS:Using the medical records-linkage system of the Rochester Epidemiol...


    pub_type: 杂志文章


    authors: Hasan S,Mielke MM,Turcano P,Ahlskog JE,Bower JH,Savica R

    更新日期:2020-02-25 00:00:00

  • Active MS is associated with accelerated retinal ganglion cell/inner plexiform layer thinning.

    abstract:OBJECTIVE:To determine the effect of clinical and radiologic disease activity on the rate of thinning of the ganglion cell/inner plexiform (GCIP) layer and the retinal nerve fiber layer in patients with multiple sclerosis (MS) using optical coherence tomography (OCT). METHODS:One hundred sixty-four patients with MS an...


    pub_type: 杂志文章


    authors: Ratchford JN,Saidha S,Sotirchos ES,Oh JA,Seigo MA,Eckstein C,Durbin MK,Oakley JD,Meyer SA,Conger A,Frohman TC,Newsome SD,Balcer LJ,Frohman EM,Calabresi PA

    更新日期:2013-01-01 00:00:00

  • Cranial autonomic symptoms in pediatric migraine are the rule, not the exception.

    abstract:OBJECTIVE:The presence of cranial autonomic symptoms often leads to a misdiagnosis of "sinus headache" in adult migraineurs, leading to unnecessary treatments and delaying appropriate migraine therapy. In this study, we examined the frequency of cranial autonomic symptoms in pediatric/adolescent patients with migraine....


    pub_type: 杂志文章,多中心研究


    authors: Gelfand AA,Reider AC,Goadsby PJ

    更新日期:2013-07-30 00:00:00

  • Risk of premature stroke in recent immigrants (PRESARIO): population-based matched cohort study.

    abstract:BACKGROUND:New immigrants to North America, most of whom are under age 50 years, exhibit fewer risk factors for cardiovascular disease than their native-born counterparts, yet the stress of resettlement may conceivably place them at higher risk of stroke. We determined the risk of acute stroke associated with recency o...


    pub_type: 杂志文章


    authors: Saposnik G,Redelmeier DA,Lu H,Lonn E,Fuller-Thomson E,Ray JG

    更新日期:2010-02-09 00:00:00

  • Myelomalacia and hypoglycorrhachia in malignant atrophic papulosis.

    abstract::A 25-year-old man with the skin lesions of malignant atrophic papulosis had clinical and electrodiagnostic evidence of a multifocal asymmetric myelomalacia or polyradiculopathy in association with elevated CSF protein and hypoglycorrhachia. Autopsy findings included widespread infarctions and necrosis of brain, brains...


    pub_type: 杂志文章


    authors: Label LS,Tandan R,Albers JW

    更新日期:1983-07-01 00:00:00

  • Impairment of hand movements under visual guidance.

    abstract::Impairment of object-bound movements of the hand performed under visual guidance ("optic ataxia") was a prominent sign in a patient with bilateral circumscribed infarctions in the posterior watershed territory. The sign was interpreted as resulting from defective integration of panoramic visual information with propri...


    pub_type: 杂志文章


    authors: Damasio AR,Benton AL

    更新日期:1979-02-01 00:00:00