Modulation of the renin-angiotensin-aldosterone system for the secondary prevention of stroke.

abstract：:The pathologic substrate of essential tremor (ET) remains unknown. The authors studied 10 patients with ET and 10 volunteers using a multislice MR spectroscopy imaging sequence. Left and right cerebellar hemisphere NAA/CR and NAA/Cho ratios were significantly smaller in the ET patients than healthy subjects. The autho...

journal_title：Neurology

authors： Pagan FL,Butman JA,Dambrosia JM,Hallett M

更新日期：2003-04-22 00:00:00

abstract：:We studied the cerebral effects of oxygen-derived free radicals generated from the xanthine oxidase/hypoxanthine/ADP-Fe3+ system. Xanthine oxidase/hypoxanthine/ADP-Fe3+ solution (0.1 ml) was infused into caudate putamen, and brain was frozen rapidly in situ. Brain water and sodium content increased concomitant with de...

journal_title：Neurology

authors： Chan PH,Schmidley JW,Fishman RA,Longar SM

更新日期：1984-03-01 00:00:00

abstract：BACKGROUND:Chronic cerebrospinal venous insufficiency (CCSVI) was proposed as the causal trigger for developing multiple sclerosis (MS). However, current data are contradictory and a gold standard for venous flow assessment is missing. OBJECTIVE:To compare structural magnetic resonance venography (MRV) and dynamic ext...

journal_title：Neurology

authors： Doepp F,Würfel JT,Pfueller CF,Valdueza JM,Petersen D,Paul F,Schreiber SJ

更新日期：2011-11-08 00:00:00

abstract：:We performed a quantitative immunocytochemical study using a polyclonal antibody directed against choline acetyltransferase (ChAT) in the lower pontine reticular formation in four control subjects and three patients with progressive supranuclear palsy (PSP). In the normal brains, there was detectable ChAT-like immunor...

journal_title：Neurology

authors： Malessa S,Hirsch EC,Cervera P,Javoy-Agid F,Duyckaerts C,Hauw JJ,Agid Y

更新日期：1991-10-01 00:00:00

abstract：:Extracranial and intracranial angioplasty and stenting of the cerebral vessels are being performed more frequently. One clinical trial demonstrated equivalent outcomes between extracranial carotid angioplasty and carotid endarterectomy, but the results in both groups were suboptimal. Concerns remain about the iatrogen...

journal_title：Neurology

authors： Chaturvedi S,Fessler R

更新日期：2002-09-10 00:00:00

abstract：:Symptoms in patients with demyelinating disorders are associated with 3 important conduction abnormalities: complete conduction block, rate-dependent conduction block, and slowed impulse conduction. The recent observation that the electrogenic Na/K pump causes the nerve membrane hyperpolarization responsible for rate-...

journal_title：Neurology

authors： Kaji R,Sumner AJ

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:Idiopathic adult-onset primary dystonia usually affects the upper body and remains focal. Underlying mechanisms are unknown, and there are only limited neuropathologic studies in the literature. Recently, ubiquitinated perinuclear inclusion bodies were found in the brainstem of patients with DYT1-related dys...

journal_title：Neurology

authors： Holton JL,Schneider SA,Ganesharajah T,Gandhi S,Strand C,Shashidharan P,Barreto J,Wood NW,Lees AJ,Bhatia KP,Revesz T

更新日期：2008-02-26 00:00:00

abstract：OBJECTIVE:To investigate evidence of the potential role of early cortical vulnerability in the development of primary progressive aphasia (PPA). METHOD:A woman with a diagnosis of PPA and her 9 adult siblings, 7 with developmental language disabilities, underwent neuropsychological testing, structural MRI, and resting...

journal_title：Neurology

authors： Weintraub S,Rader B,Coventry C,Sridhar J,Wood J,Guillaume KA,Coppola G,Ramos EM,Bonakdarpour B,Rogalski EJ,Mesulam MM

更新日期：2020-08-18 00:00:00

abstract：OBJECTIVE:To study the efficacy and safety of low-dose oral tetrahydrocannabinol (THC) in the treatment of dementia-related neuropsychiatric symptoms (NPS). METHODS:This is a randomized, double-blind, placebo-controlled study. Patients with dementia and clinically relevant NPS were randomly assigned to receive THC 1.5...

journal_title：Neurology

authors： van den Elsen GA,Ahmed AI,Verkes RJ,Kramers C,Feuth T,Rosenberg PB,van der Marck MA,Olde Rikkert MG

更新日期：2015-06-09 00:00:00

abstract：:The authors compared the transcranial color-coded duplex pattern of the middle cerebral arteries (MCAs) before and after IV and combined IV-intra-arterial (IV-IA) thrombolysis in consecutive first-ever stroke patients. Patients receiving combined IV-IA thrombolysis showed greater improvement in flow signal and higher ...

journal_title：Neurology

authors： Perren F,Loulidi J,Graves R,Yilmaz H,Rüfenacht D,Landis T,Sztajzel R

更新日期：2006-07-25 00:00:00

abstract：OBJECTIVE:To examine associations of orthostatic hypotension (OH) with dementia and long-term cognitive decline and to update previously published results in the same cohort for stroke with an additional 16 years of follow-up. METHODS:We analyzed data from 11,709 participants without a history of coronary heart diseas...

journal_title：Neurology

authors： Rawlings AM,Juraschek SP,Heiss G,Hughes T,Meyer ML,Selvin E,Sharrett AR,Windham BG,Gottesman RF

更新日期：2018-08-21 00:00:00

abstract：OBJECTIVE:To determine the risk, predictors, and prognosis of independence loss and institutionalization in patients with early Parkinson disease (PD). METHODS:We conducted a prospective population-based 5-year longitudinal study following 189 patients with incident PD and 174 controls matched for age, sex, and comorb...

journal_title：Neurology

authors： Bjornestad A,Tysnes OB,Larsen JP,Alves G

更新日期：2016-10-11 00:00:00

abstract：:The triad of normal-pressure hydrocephalus, parkinsonism, and primary empty sella appeared in a 70-year-old woman. There was dramatic resolution of the extrapyramidal signs and symptoms on treatment with levodopa-carbidopa and ventriculojugular shunt. The syndrome may be the result of several mechanisms, but an altera...

journal_title：Neurology

authors： Spagna VA,Maeder MC,Johnson JC,Mazzaferri EL

更新日期：1978-11-01 00:00:00

abstract：:Postprandial hypotension occurs commonly in patients with autonomic failure and may be due to attenuation of the normal sympathetic nervous system activation in response to meal ingestion. In a randomized, double-blind, placebo-controlled study, we investigated the therapeutic effect of the norepinephrine precursor 3,...

journal_title：Neurology

authors： Freeman R,Young J,Landsberg L,Lipsitz L

更新日期：1996-12-01 00:00:00

abstract：:We investigated 185 families with ALS for evidence of anticipation and mitochondrial inheritance. Although initial analysis demonstrated significant anticipation of age at death between generations in patients with familial ALS, further analysis demonstrated features of regression to the mean, suggesting that the perc...

journal_title：Neurology

authors： Bradley M,Bradley L,de Belleroche J,Orrell RW

更新日期：2005-05-10 00:00:00

abstract：OBJECTIVE:To investigate the effect of postoperative delirium on longitudinal brain microstructural changes, as measured by diffusion tensor imaging. METHODS:We studied a subset of the larger Successful Aging after Elective Surgery (SAGES) study cohort of older adults (≥70 years) without dementia undergoing elective s...

journal_title：Neurology

authors： Cavallari M,Dai W,Guttmann CRG,Meier DS,Ngo LH,Hshieh TT,Fong TG,Schmitt E,Press DZ,Travison TG,Marcantonio ER,Jones RN,Inouye SK,Alsop DC,SAGES Study Group.

更新日期：2017-09-05 00:00:00

abstract：:In patients with cranial dystonia, we compared the effects of central anticholinergic, peripheral anticholinergic, and placebo treatments in a double-blind crossover study. One of the nine patients who completed the study improved markedly with central anticholinergic therapy. The three treatments were indistinguishab...

journal_title：Neurology

authors： Nutt JG,Hammerstad JP,deGarmo P,Carter J

更新日期：1984-02-01 00:00:00

abstract：:Relating the onset of clinical attacks as recorded on a videotape to surface and depth electrographic events improves our ability to define the local or diffuse origin of seizures. In two patients with complex partial seizures, all 14 attacks appeared 3 to 6 seconds after focal discharges began in the amygdala or hipp...

journal_title：Neurology

authors： Delgado-Escueta AV,Nashold B,Freedman M,Keplinger C,Waddell G,Miller P,Carwille S

更新日期：1979-04-01 00:00:00

abstract：:The authors pooled four population-based European studies to determine the risk for institutionalization and death after stroke. Risk for institutionalization was assessed in 13,095 subjects. Survival was calculated for prevalent stroke in 7929 individuals and incident stroke in 8550 individuals. The adjusted risk of ...

journal_title：Neurology

authors： Schmidt R,Breteler MM,Inzitari D,Fratiglioni L,Hofman A,Launer LJ

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:To compare in the Vertebral Artery Ischaemia Stenting Trial (VIST) the risks and benefits of vertebral angioplasty and stenting with best medical treatment (BMT) alone for symptomatic vertebral artery stenosis. METHODS:VIST was a prospective, randomized, open-blinded endpoint clinical trial performed in 14 h...

journal_title：Neurology

authors： Markus HS,Larsson SC,Kuker W,Schulz UG,Ford I,Rothwell PM,Clifton A,VIST Investigators.

更新日期：2017-09-19 00:00:00

abstract：:We describe the clinical, imaging, and pathologic findings in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). The patient experienced her first stroke-like episode at age forty-four. Brain MRI, obtained at symptom onset, at 3 weeks, and at 1 year, revealed migr...

journal_title：Neurology

authors： Clark JM,Marks MP,Adalsteinsson E,Spielman DM,Shuster D,Horoupian D,Albers GW

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:To analyze the frequency of neurologic events during commercial airline flights and to assess whether onboard emergency medical kits are adequate for in-flight neurologic emergencies. METHODS:Collaboration of the Mayo Clinic's Departments of Emergency Medicine and Medical Transportation Service and the Divis...

journal_title：Neurology

authors： Sirven JI,Claypool DW,Sahs KL,Wingerchuk DM,Bortz JJ,Drazkowski J,Caselli R,Zanick D

更新日期：2002-06-25 00:00:00

abstract：OBJECTIVE:To describe risk and risk factors of epilepsy after hospitalization for brain infection in adults in Sweden. METHODS:This was a matched retrospective cohort study based on the comprehensive National Patient and Cause of Death Registers. All individuals age >18 without prior epilepsy who received inpatient ca...

journal_title：Neurology

authors： Zelano J,Westman G

更新日期：2020-12-15 00:00:00

abstract：OBJECTIVE:To determine whether comorbidity is associated with clinical (relapses, disability worsening) and MRI outcomes in multiple sclerosis (MS) by conducting a secondary analysis of the CombiRx clinical trial. METHODS:CombiRx compared interferon beta-1a, glatiramer acetate, and the combination of these agents. For...

journal_title：Neurology

authors： Salter A,Kowalec K,Fitzgerald KC,Cutter G,Marrie RA

更新日期：2020-08-04 00:00:00

abstract：:We report the vasocapacitance of the cerebral circulation, as determined by cerebral blood flow reactivity to induced hypercapnia using fluoromethane positron emission tomography, in 32 patients with unilateral anterior circulation transient ischemic attacks. A hemodynamic subset of eight patients, defined based on ex...

journal_title：Neurology

authors： Levine RL,Lagreze HL,Dobkin JA,Hanson JM,Satter MR,Rowe BR,Nickles RJ

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:To perform an open-label, long-term efficacy and safety/tolerability study of vagus nerve stimulation (VNS) of 454 patients with refractory epilepsy. METHODS:Subjects were enrolled from five clinical trials of VNS between 1988 and 1995 after undergoing an implantation of a pulse generator in the chest and a ...

journal_title：Neurology

authors： Morris GL 3rd,Mueller WM

更新日期：1999-11-10 00:00:00

abstract：:We studied performance on tests of visual neglect and left lateral gaze after caloric stimulation in 18 patients with left-sided visual neglect after strokes. Except for one patient with absent vestibulo-ocular responses, all improved during caloric stimulation on the left by cold (LC) or on the right by warm water (R...

journal_title：Neurology

authors： Rubens AB

更新日期：1985-07-01 00:00:00

abstract：:Studies of automobile accident frequency among drivers with AD have yielded conflicting results about the risk of accidents. To develop a practice parameter regarding driving and AD the authors performed a systematic review of the literature. The authors identified well-designed, controlled studies of driving and AD u...

journal_title：Neurology

authors： Dubinsky RM,Stein AC,Lyons K

更新日期：2000-06-27 00:00:00

abstract：:The authors recorded the acoustic startle response in 32 patients with stroke, 6 patients with incomplete cervical cord lesions, and 26 controls. Increased startle occurred in about one quarter of both stroke and spinal cord injury patients. The response in biceps demonstrated the greatest deviation from normal, with ...

journal_title：Neurology

authors： Jankelowitz SK,Colebatch JG

更新日期：2004-01-13 00:00:00

abstract：:Three patients with postanoxic intention myoclonus, two patients with intention tremor, and one patient with cerebral palsy were administered L-5-hydroxytryptophan (L-5HTP), the precursor of serotonin, in combination with MK 486, a peripheral amino acid decarboxylase inhibitor. L-5HTP combined with MK 486 were potent ...

journal_title：Neurology

authors： Van Woert MH,Sethy VH

更新日期：1975-02-01 00:00:00