Abstract:
:We studied 15 dystonic patients with positron emission tomography (PET) and (18F)-2-fluoro-2-deoxy-D-glucose (FDG). The group comprised patients with focal (n = 5), multifocal (n = 1), and generalized (n = 4) dystonia as well as patients with hemidystonia (n = 5). The age at onset was during childhood in four, during adolescence in two, and during adulthood in nine of the subjects. In dystonic patients, global cerebral glucose metabolism was unaltered when compared with normal controls, whereas the pattern of regional cerebral metabolic rate for glucose (rCMR[Glu]) was significantly different (p = 0.0001). rCMR(Glu) was significantly decreased in the caudate and lentiform nucleus and in the frontal projection field of the mediodorsal thalamic nucleus. The study confirms the concept that dystonia is caused by impaired connections between the basal ganglia, the thalamus, and frontal association areas.
journal_name
Neurologyjournal_title
Neurologyauthors
Karbe H,Holthoff VA,Rudolf J,Herholz K,Heiss WDdoi
10.1212/wnl.42.8.1540subject
Has Abstractpub_date
1992-08-01 00:00:00pages
1540-4issue
8eissn
0028-3878issn
1526-632Xjournal_volume
42pub_type
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