Abstract:
:In the aftermath of an acute cardiovascular event such as stroke, patients and families frequently ask whether preceding circumstances such as viral illnesses, stress, and other medical or surgical events brought on the disease. Although it seems intuitive to patients and families that acute precipitants or disease triggers play a substantial role, the evidence to support this concept has accumulated slowly.(1,2) Support for acute systemic infection as a trigger of stroke, a particularly interesting hypothesis, continues to grow.(3) The potential mechanisms underlying such a relationship include systemic inflammation, endothelial dysfunction, and activation of the clotting system by infectious organisms or the systemic response to them.(4,5).
journal_name
Neurologyjournal_title
Neurologyauthors
Jeerakathil T,Lo Wdoi
10.1212/WNL.0000000000000224subject
Has Abstractpub_date
2014-03-18 00:00:00pages
908-9issue
11eissn
0028-3878issn
1526-632Xpii
WNL.0000000000000224journal_volume
82pub_type
评论,社论相关文献
NEUROLOGY文献大全abstract:OBJECTIVES:SCN1A mutations were recently reported in several patients with severe myoclonic epilepsy in infancy (SMEI). The authors analyzed SCN1A mutations in 93 patients with SMEI and made genotype-phenotype correlation to clarify the role of this gene in the etiology of SMEI. METHODS:All patients fulfilled the crit...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000069463.41870.2f
更新日期:2003-06-24 00:00:00
abstract:OBJECTIVE:To evaluate the validity of data derived from magnetic source imaging (MSI) regarding cerebral dominance for language in patients with intractable seizure disorder. METHOD:The authors performed functional imaging of the receptive language cortex using a whole-head neuromagnetometer in 26 consecutive epilepsy...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.5.938
更新日期:1999-09-22 00:00:00
abstract:OBJECTIVE:Causes of benign positional vertigo (BPV) are mostly unknown. The aim of this study was to elucidate an association of osteoporosis with idiopathic BPV. METHODS:Two hundred nine consecutive patients with a confirmed diagnosis of idiopathic BPV underwent bone mineral densitometry of anterior-posterior lumbar ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000345016.33983.e0
更新日期:2009-03-24 00:00:00
abstract:OBJECTIVE:To determine whether objective and quantitative assessment of dysarthria and dysphagia in spinocerebellar ataxia type 2 (SCA2), specifically at pre-ataxic and early disease phases, can act as sensitive disease markers. METHODS:Forty-six individuals (16 with pre-ataxic SCA2, 14 with early-stage ataxic SCA2, a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009776
更新日期:2020-07-14 00:00:00
abstract::We conducted a randomized double-blind comparison of three doses of the novel antiepileptic drug (AED) topiramate (200, 400, and 600 mg/day) and placebo as adjunctive therapy in patients with refractory partial onset epilepsy receiving one or two other AEDs at therapeutic concentrations. A total of 181 patients comple...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/wnl.46.6.1684
更新日期:1996-06-01 00:00:00
abstract::MRI and CSF investigations revealed meningeal involvement in a 29-year-old patient with biopsy-confirmed Wegener's granulomatosis. The intracranial manifestation of Wegener's granulomatosis was supported by the detection of pathologic circulating antineutrophil cytoplasm (c-ANCA) in the CSF. We monitored disease activ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.1.263
更新日期:1997-01-01 00:00:00
abstract::Thirteen consecutive patients with thalamic deep brain stimulation (DBS) were examined serially for 3 to 5 years. Initially, all demonstrated at least 50% improvement in contralateral tremor. At last follow-up, three of eight patients with Parkinson disease no longer used DBS because tremor had markedly improved, and ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000096012.07360.1c
更新日期:2003-12-09 00:00:00
abstract::Twenty-two patients were analyzed 2 or more years after corpus callosum section (9 partial, 13 total). Forty-one percent had class 1 outcome (elimination of secondarily generalized and complex partial seizures), 32% had class 2 outcome (elimination of secondarily generalized seizures), and 27% had class 3 outcome (no ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.1.19
更新日期:1988-01-01 00:00:00
abstract::To determine the extent that different dopamine (DA) neuronal markers provide similar estimates of striatal (caudate and putamen) DA nerve terminal loss in idiopathic Parkinson's disease (PD), we compared, in postmortem striatum of 12 patients with PD and 10 matched controls, levels of five different DA neuronal marke...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.3.718
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:In patients with active epilepsy, adverse medication effects and severity of depression are correlated with health-related quality of life, but seizure frequency is not. We sought to examine if the same pattern exists in patients with psychogenic nonepileptic seizures (PNES). METHODS:We administered seizure...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181b04c83
更新日期:2009-08-04 00:00:00
abstract::Single motor unit firing rates were measured from the first dorsal interosseous muscle (FDI) of normal subjects and patients with partial denervation of that muscle. Motor unit discharges were recorded at various levels of voluntary, stationary, isometric contraction of the FDI. The mean increase in firing rate associ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.12.1241
更新日期:1978-12-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that transcranial magnetic resonance-guided focused ultrasound (tcMRgFUS) thalamotomy is effective, durable, and safe for patients with medication-refractory essential tremor (ET), we assessed clinical outcomes at 3-year follow-up of a controlled multicenter prospective trial. METHODS:...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000008561
更新日期:2019-12-10 00:00:00
abstract::This study investigates a canine model of experimental brain tumor. Particularly addressed was the usefulness of gadolinium contrast-enhanced MRI for differentiating brain tumor tissue from cerebral edema. Cultured canine glioma cells were injected into the left hemispheres of six adult mongrel dogs. All dogs develope...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.7.1235
更新日期:1987-07-01 00:00:00
abstract::We studied five patients with nonhemorrhagic thalamic infarction with neuropsychological tests, CT, and somatosensory evoked responses (SERs). The three patients with left thalamic lesions had abnormalities of language, memory, visuospatial processing, intellect, and personality-changes compatible with dementia. The t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.1.14
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVE:To assess the expression of heat shock proteins (HSP) in glioma cells in vitro and in vivo and to examine their role in resistance to apoptosis. BACKGROUND:HSP are expressed in response to various forms of stress. Constitutive HSP expression may confer resistance to cytotoxic stimuli in human cancers. METHO...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.6.1357
更新日期:2000-03-28 00:00:00
abstract::The authors describe a novel pathogenic G5540A transition in the mitochondrial transfer RNA (tRNA)Trp gene of a sporadic encephalomyopathy characterized by spinocerebellar ataxia. Clinical features also included neurosensorial deafness, peripheral neuropathy, and dementia. Biochemistry revealed a severe reduction of c...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.8.1693
更新日期:2000-04-25 00:00:00
abstract::A median safinamide (SAF) dose of 70 mg/day (range 40 to 90 mg/day) increased the percentage of parkinsonian patients improving their motor scores by > or =30% from baseline (responders) after 3 months from 21.4% (placebo) to 37.5% (p < 0.05, calculated by logistic regression analysis). In a subgroup of 101 patients u...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/01.wnl.0000134672.44217.f7
更新日期:2004-08-24 00:00:00
abstract::There are multiple difficulties in evaluating new treatments for multiple sclerosis (MS). The clinical diagnosis is imprecise, and the correlation between lesion and clinical dysfunction is incomplete. The neurologic evaluation is complex and lacks full precision. The course of MS is complex and has limited predictabi...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.30.7_part_2.8
更新日期:1980-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the utility of "clinic room" case presentation in the ambulatory care setting. BACKGROUND:Neurology is increasingly an outpatient specialty. The transition from ward to clinic presents challenges for student and resident education. Interaction between attending physician and trainee is limited by...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1999-01-15 00:00:00
abstract:OBJECTIVE:Identifying an intriguing mechanism for unmasking recessive hereditary spastic paraplegias. METHOD:Herein, we describe 4 novel homozygous FA2H mutations in 4 nonconsanguineous families detected by whole-exome sequencing or a targeted gene panel analysis providing high coverage of all known hereditary spastic...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002843
更新日期:2016-07-12 00:00:00
abstract:OBJECTIVES:Determine the frequency of and the predictive factors for abnormal ocular fundus findings among emergency department (ED) headache patients. METHODS:Cross-sectional study of prospectively enrolled adult patients presenting to our ED with a chief complaint of headache. Ocular fundus photographs were obtained...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31827f0f20
更新日期:2013-01-29 00:00:00
abstract::Sphingosine 1-phosphate receptors (S1PRs) are G protein-coupled receptors expressed by many cell types, including immune and neural cells. These receptors are promising targets for immunomodulatory and possibly neuromodulatory therapies. Fingolimod (FTY720) is a sphingosine analog that, when phosphorylated, becomes a ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31820d9507
更新日期:2011-02-22 00:00:00
abstract:OBJECTIVE:To model the temporal trajectory of β-amyloid accumulation using serial amyloid PET imaging. METHODS:Participants, aged 70-92 years, were enrolled in either the Mayo Clinic Study of Aging (n = 246) or the Mayo Alzheimer's Disease Research Center (n = 14). All underwent 2 or more serial amyloid PET examinatio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182840bbe
更新日期:2013-03-05 00:00:00
abstract:BACKGROUND:Muscle channelopathies such as paramyotonia, hyperkalemic periodic paralysis, and potassium-aggravated myotonia are caused by gain-of-function Na+ channel mutations. METHODS:Methods: Implementation of a three-dimensional radial 23Na magnetic resonance (MR) sequence with ultra-short echo times allowed the au...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000233841.75824.0f
更新日期:2006-10-10 00:00:00
abstract::Migraine does not increase the risk for complications of pregnancy for the mother or for the fetus: the incidences of toxemia, miscarriages, abnormal labour, congenital anomalies, and stillbirths are comparable to those of the general population. Several retrospective studies have shown a tendency for migraine to impr...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00
abstract::Capecitabine is used to treat advanced breast and gastrointestinal malignancies. A single case of encephalopathy and three cases of peripheral neuropathy are the only neurotoxicities reported. The authors report five additional cases of capecitabine-induced multifocal leukoencephalopathy. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000187313.83515.7e
更新日期:2005-12-13 00:00:00
abstract::In the past, stereotactic surgery was a regular treatment for prominent unilateral tremor in Parkinson's disease (PD), but follow-up studies were usually short-term and always unblinded. We examined 17 PD patients in long-term follow-up (mean, 10.9 years after surgery) and used videotapes and the Unified Parkinson's D...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.7.1311
更新日期:1992-07-01 00:00:00
abstract::A 32-year-old patient with seizures experienced decreased right-ear hearing during electrocortical stimulation mapping of the left lateral superior temporal gyrus. Audiometric testing under headphones confirmed a reversible, moderate unilateral hearing loss. Under binaural listening conditions, auditory comprehension ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000149524.11371.B1
更新日期:2005-01-25 00:00:00
abstract::Successful screening for neuropathy in patients with diabetes is available using the 10 g Semmes-Weinstein monofilament (Mid-Delta Health Systems, Inc., Belzoni, MS) (touch/pressure sensation) and the Neurothesiometer (Horwell Scientific, London, UK; vibration perception threshold). In healthy volunteers and patients ...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.59.4.611
更新日期:2002-08-27 00:00:00
abstract:OBJECTIVE:To determine the influence of all possible imaging strategies on the appropriateness ratings for carotid endarterectomy, because less accurate noninvasive techniques are replacing contrast angiography, which was used in the major efficacy trials. METHODS:An expert panel, using appropriateness methodology, ra...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000115097.61748.bf
更新日期:2004-03-23 00:00:00