Abstract:
:A patient with thymoma-associated neuromyotonia and voltage-gated potassium channel (Kv1.2 and Kv1.6) antibodies by immunoprecipitation and rat brain immunolabeling was treated successfully with immunoadsorption and cyclophosphamide. Curiously, glutamic acid decarboxylase antibodies, absent at onset, appeared later. Stiff-person syndrome was absent, but fast blink reflex recovery suggested enhanced brainstem excitability. The range of antibodies produced in thymoma-associated neuromyotonia is richer, and the timing of antibody appearance more complex, than previously suspected.
journal_name
Neurologyjournal_title
Neurologyauthors
Antozzi C,Frassoni C,Vincent A,Regondi MC,Andreetta F,Bernasconi P,Ciano C,Chang T,Cornelio F,Spreafico R,Mantegazza Rdoi
10.1212/01.WNL.0000156945.39471.2Csubject
Has Abstractpub_date
2005-04-12 00:00:00pages
1290-3issue
7eissn
0028-3878issn
1526-632Xpii
64/7/1290journal_volume
64pub_type
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