Abstract:
OBJECTIVE:To determine whether there is a relationship between aortic plaques and intracranial (IC) atherosclerosis. METHODS:We reviewed 922 patients with stroke who had both transesophageal echocardiography and cerebral angiography. The plaques of these patients were classified as either complex aortic plaques (CAP), which protruded > or =4 mm or were present as mobile lesions in the proximal aorta, or simple aortic plaques (SAP), which were <4 mm or present in the descending aorta. Cerebral artery atherosclerosis was classified as either an IC or extracranial (EC) atherosclerosis. RESULTS:Among the 922 patients, we found aortic plaques in 237 patients (26%). There were 111 (47%) patients of SAP, 74 (31%) patients with CAP, and 52 (22%) patients that had both SAP and CAP. Angiography showed IC or EC atherosclerosis in 511 patients (55%). The presence of aortic plaques was significantly associated with IC or EC atherosclerosis. The significance appeared to be due to the strong association between the presence of SAP and IC atherosclerosis (51% SAP vs 35% no plaques; odds ratio = 1.94, 95% CI: 1.17 to 3.21). In the multiple logistic regression analysis, SAP were independent predictors of IC atherosclerosis CONCLUSIONS:The presence of simple aortic plaques may be a marker of advanced vascular disease. Detection of simple aortic plaques during transesophageal echocardiography may have clinical implications because patients with these plaques frequently had concomitant intracranial atherosclerosis, a risk factor for stroke.
journal_name
Neurologyjournal_title
Neurologyauthors
Nam HS,Han SW,Lee JY,Ahn SH,Ha JW,Rim SJ,Lee BI,Heo JHdoi
10.1212/01.wnl.0000238511.72927.3csubject
Has Abstractpub_date
2006-10-10 00:00:00pages
1184-8issue
7eissn
0028-3878issn
1526-632Xpii
67/7/1184journal_volume
67pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:BACKGROUND:Although phenylketonuria is a treatable disease, patients with late or nonoptimal phenylalanine-restricted diet may experience brain damage. The authors used tridimensional MRI and a voxelwise analysis method to investigate possible volume changes in the brain parenchyma of patients with phenylketonuria. ME...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000204415.39853.4a
更新日期:2006-04-11 00:00:00
abstract:BACKGROUND:The American Academy of Neurology (AAN) ALS Practice Parameter was published in April 1999. The ALS CARE Database has been collecting data on the management of patients with ALS in North America since 1996. OBJECTIVE:To compare the management of patients with ALS in North America as recorded in the ALS CARE...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.3.500
更新日期:2001-08-14 00:00:00
abstract::In 11 patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and 11 patients with chronic idiopathic axonal polyneuropathy (CIAP), absent myotatic reflexes were significantly associated more often with CIDP than with CIAP, an absent biceps-reflex having the highest sensitivity and specificity for the d...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.7.1573
更新日期:1999-10-22 00:00:00
abstract:OBJECTIVE:To determine the patterns of diffusivity associated with cognitive domain functions in older adults without dementia. METHODS:We studied older adults without dementia (n = 220) who underwent neuropsychometric testing and a diffusion tensor imaging (DTI) examination at 3 T in a cross-sectional study. Memory, ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31822313dc
更新日期:2011-07-05 00:00:00
abstract:OBJECTIVES:Many patients with traumatic brain injury (TBI) report chronic fatigue, and previous studies showed a potential relationship between sleepiness and fatigue in these patients. Our study first looked at the impact of objective and subjective sleepiness on fatigue in patients with TBI. We then investigated how ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000334753.49193.48
更新日期:2008-11-11 00:00:00
abstract::It is generally believed that a diet high in carbohydrate improves exercise tolerance in patients with carnitine palmitoyltransferase II (CPT II) deficiency, but it has never been systematically investigated. The authors investigated the effect of a high- vs low-carbohydrate diet on exercise tolerance in four patients...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/01.wnl.0000078195.05396.20
更新日期:2003-08-26 00:00:00
abstract:OBJECTIVE:To assess the safety, tolerability, and biological activity of glial cell line-derived neurotrophic factor (GDNF) administered by an implanted intracerebroventricular (ICV) catheter and access port in advanced PD. BACKGROUND:GDNF is a peptide that promotes survival of dopamine neurons. It improved 6-OHDA- or...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/wnl.60.1.69
更新日期:2003-01-14 00:00:00
abstract::The authors report two patients with suspected brain death who required confirmatory tests other than clinical examination because of prolonged barbiturate administration for intracranial hypertension. Absence of intracranial blood flow was documented on CT angiography and confirmed by CT perfusion images. Cerebral an...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.62.4.652
更新日期:2004-02-24 00:00:00
abstract:OBJECTIVE:To investigate the cognitive skills of patients with relapsing remitting multiple sclerosis (RRMS), secondary progressive MS (SPMS), and primary progressive MS (PPMS) relative to healthy control subjects and to assess whether there is heterogeneity in the type of cognitive disabilities demonstrated by patient...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000129828.03714.90
更新日期:2004-07-27 00:00:00
abstract:OBJECTIVE:To assess longitudinal follow-up of the incidence of multiple sclerosis (MS) through five decades and estimate the prevalence rate in Hordaland County, Norway, on January 1, 2003. METHODS:All patients with MS diagnosed from 1953 to 2003 were identified in the patient records of the Department of Neurology, H...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000195549.95448.b9
更新日期:2006-01-24 00:00:00
abstract::Estrogen have been reported in animal studies to both enhance and block central dopaminergic activity and in one clinical report to improve tardive dyskinesia. In the present study estrogen (Premarin, 2.5 mg per day) administration caused varying degrees of improvement in less than one-third of 21 patients with chorea...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.32.5.547
更新日期:1982-05-01 00:00:00
abstract:OBJECTIVE:To create and validate a simple, standardized version of the antisaccade (AS) task that requires no specialized equipment for use as a measure of executive function in multicenter clinical studies. METHODS:The bedside AS (BAS) task consisted of 40 pseudorandomized AS trials presented on a laptop computer. BA...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0b013e318258f785
更新日期:2012-06-05 00:00:00
abstract:OBJECTIVE:There is controversy about the clinical consequences of intermediate alleles (IAs) in Huntington disease (HD). The main objective of this study was to establish the clinical manifestations of IA carriers for a prospective, international, European HD registry. METHODS:We assessed a cohort of participants at r...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002944
更新日期:2016-08-09 00:00:00
abstract:BACKGROUND:The relationship between age-related memory decline and hippocampal anatomic changes is a matter of debate. OBJECTIVES:To investigate the relationship between age-related memory decline and MRI hippocampal anatomic changes in a cohort of healthy individuals. METHODS:In this cross-sectional study, 76 health...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181cb3e39
更新日期:2010-01-19 00:00:00
abstract:OBJECTIVE:To characterize children with new-onset seizures presenting as status epilepticus at a tertiary care children's hospital. METHODS:Prospectively collected data were reviewed from a database derived from a mandated critical care pathway. A total of 1,382 patients presented with new-onset seizures between 2001 ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181d0cca2
更新日期:2010-02-23 00:00:00
abstract::To study the anti-Schwann cell activity of serum from patients with Guillain-Barré syndrome (GBS), we used a 51Cr-release cytotoxicity assay. Specific release of 51Cr mediated by GBS serum did not differ from that with normals or disease controls. Heating sera from GBS patients or controls at 56 or 50 degrees C for 30...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.9.1240
更新日期:1984-09-01 00:00:00
abstract:OBJECTIVE:To explore sensitivity of optical coherence tomography (OCT) in detecting prior unilateral optic neuritis. METHODS:This is a retrospective, observational clinical study of all patients who presented from January 1, 2014, to January 6, 2017, with unilateral optic neuritis and OCT available at least 3 months a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006873
更新日期:2019-02-05 00:00:00
abstract::We performed a multicenter prospective study on the incidence and prognosis of Guillain-Barré syndrome (GBS) in the Emilia-Romagna region (3,909,512 inhabitants), Italy, over a 2-year period (1992-1993). The case finding method was based on a surveillance system including neurologic departments, all private and public...
journal_title:Neurology
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::A patient with clinical and radiographic findings initially suggesting a neoplasm was diagnosed as having Hodgkin disease. Computerized axial tomography demonstrated profound diffuse decreased density similar to that seen in cases of cerebral edema or leukomalacia. Cerebral angiography showed blood vessels with a bead...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.27.6.588
更新日期:1977-06-01 00:00:00
abstract:BACKGROUND:In acute cerebral ischemia, two variables characterize the extent of hypoperfusion: the volume of hypoperfused tissue and the intensity of hypoperfusion within these regions. We evaluated the determinants of the intensity of hypoperfusion within oligemic regions among patients who were eligible for recanaliz...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000335929.06390.d3
更新日期:2008-11-25 00:00:00
abstract:OBJECTIVE:To ascertain the prevalence and determinants of neuropathy in patients with Parkinson disease (PD), in particular, the roles of vitamin B12 and levodopa exposure. METHODS:We performed a cross-sectional study of 37 patients with PD and 37 age- and gender-matched controls, using a sensitive and validated neuro...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31823a0ee4
更新日期:2011-11-29 00:00:00
abstract:OBJECTIVE:To compare the effects of carbamazepine and lamotrigine monotherapy for people with partial onset seizures or generalized onset tonic-clonic seizures. METHODS:A systematic review and meta-analysis using data on individual patients from randomized trials comparing lamotrigine with carbamazepine monotherapy. T...
journal_title:Neurology
pub_type: 杂志文章,meta分析,评审
doi:10.1212/01.wnl.0000210517.03902.6e
更新日期:2006-05-09 00:00:00
abstract:OBJECTIVE:The pedunculopontine nucleus region (PPNR) is being investigated as a target for deep brain stimulation (DBS) in Parkinson disease (PD), particularly for gait and postural impairment. A greater understanding of how PPNR activities and oscillations are modulated with voluntary movements is crucial to the devel...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181f25b35
更新日期:2010-09-14 00:00:00
abstract::We report a 38-year-old nurse who developed amyotrophic lateral sclerosis (ALS) beginning in September 1990. In May 1991, her 38-year-old husband developed dysarthria, which progressed to typical ALS. This is the fourth report in the literature of conjugal ALS occurring outside of Guam. Although this event is most lik...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.43.11.2378
更新日期:1993-11-01 00:00:00
abstract::Single motor unit firing rates were measured from the first dorsal interosseous muscle (FDI) of normal subjects and patients with partial denervation of that muscle. Motor unit discharges were recorded at various levels of voluntary, stationary, isometric contraction of the FDI. The mean increase in firing rate associ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.12.1241
更新日期:1978-12-01 00:00:00
abstract:OBJECTIVE:To identify modifying factors that preserve functional independence among individuals at high dementia risk. METHODS:Health and Retirement Study participants aged 65 years or older without baseline activities of daily living (ADL) limitations (n = 4,922) were interviewed biennially for up to 12 years. Dement...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000357
更新日期:2014-04-29 00:00:00
abstract::Immunomodulating agents have beneficial effects in the treatment of multiple sclerosis (MS), decreasing the frequency of relapses, the progression of disability, and MRI measures of disease activity. Despite the efficacy of these agents, many patients continue to show progression of disability, breakthrough relapses, ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.63.12_suppl_6.s41
更新日期:2004-12-28 00:00:00
abstract::Cerebrospinal fluid (CSF) pressure was measured in four groups of patients: 116 with acute pseudotumor cerebri, 18 with chronic pseudotumor cerebri, 41 obese and 15 nonobese normal patients undergoing spinal anesthesia. Spinal fluid pressure between 200 and 250 mm H2O was found in members of each group. This suggests ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.10.1386
更新日期:1983-10-01 00:00:00
abstract::We studied the effects of long-term fish oil (FO) dietary supplementation on brain edema, polymorphonuclear neutrophil (PMN) infiltration, and infarct size in a rat stroke model. Rats were given regular rat chow with or without FO supplement (20% of total calories) for 7 weeks. Body weight did not differ between the t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.6.1227
更新日期:1993-06-01 00:00:00
abstract::A national survey, based on a probability sample of patients admitted to short-term hospitals in the United States during 1973 to 1974 with a discharge diagnosis of an intracranial neoplasm, was conducted in 157 hospitals. The annual incidence was estimated at 17,000 for primary intracranial neoplasms and 17,400 for s...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.2.219
更新日期:1985-02-01 00:00:00