Involvement of the human pedunculopontine nucleus region in voluntary movements.

Abstract:

OBJECTIVE:The pedunculopontine nucleus region (PPNR) is being investigated as a target for deep brain stimulation (DBS) in Parkinson disease (PD), particularly for gait and postural impairment. A greater understanding of how PPNR activities and oscillations are modulated with voluntary movements is crucial to the development of neuromodulation strategies. METHODS:We studied 7 patients with PD who underwent DBS electrode implantations in the PPNR. PPNR local field potential and EEG were recorded while patients performed self-paced wrist and ankle movements. RESULTS:Back-averaging of the PPNR recording showed movement-related potentials before electromyography onset. Frequency analysis showed 2 discrete movement-related frequency bands in the theta (6- to 10-Hz) and beta (14- to 30-Hz) ranges. The PPNR theta band showed greater event-related desynchronization with movements in the ON than in the OFF medication state and was coupled with the sensorimotor cortices in the ON state only. Beta event-related desynchronization was observed in the PPNR during the premovement and movement execution phases in the OFF state. In contrast, premovement PPNR beta event-related synchronization occurred in the ON state. Moreover, beta band coherence between the PPNR and the midline prefrontal region was observed during movement preparation in the ON but not the OFF state. CONCLUSIONS:Activities of PPNR change during movement preparation and execution in patients with PD. Dopaminergic medications modulate PPNR activities and promote the interactions between the cortex and PPNR. Beta oscillations may have different functions in the basal ganglia and PPNR, and may be prokinetic rather than antikinetic in the PPNR.

journal_name

Neurology

journal_title

Neurology

authors

Tsang EW,Hamani C,Moro E,Mazzella F,Poon YY,Lozano AM,Chen R

doi

10.1212/WNL.0b013e3181f25b35

subject

Has Abstract

pub_date

2010-09-14 00:00:00

pages

950-9

issue

11

eissn

0028-3878

issn

1526-632X

pii

WNL.0b013e3181f25b35

journal_volume

75

pub_type

杂志文章
  • Core cerebrospinal fluid biomarker profile in cerebral amyloid angiopathy: A meta-analysis.

    abstract:OBJECTIVE:To perform a meta-analysis of 4 core CSF biomarkers (β-amyloid [Aβ]42, Aβ40, total tau [t-tau], and phosphorylated tau [p-tau]) to assess which of these are most altered in sporadic cerebral amyloid angiopathy (CAA). METHODS:We systematically searched PubMed for eligible studies reporting data on CSF biomark...

    journal_title:Neurology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1212/WNL.0000000000005030

    authors: Charidimou A,Friedrich JO,Greenberg SM,Viswanathan A

    更新日期:2018-02-27 00:00:00

  • Effect of hematin in porphyric neuropathy.

    abstract::Early, intravenous administration of hematin in a patient with acute intermittent porphyria and severe quadriparesis may have produced partial but remarkable improvement of neuropathy, and resulted in simultaneous decline of porphyrin precursors in the blood. Intermittent, biweekly hematin infusions given 1 month afte...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.27.11.1053

    authors: Bosch EP,Pierach CA,Bossenmaier I,Cardinal R,Thorson M

    更新日期:1977-11-01 00:00:00

  • Avoidance of dyskinesia: preclinical evidence for continuous dopaminergic stimulation.

    abstract::Current concepts suggest that avoidance of pulsatile stimulation of dopamine receptors in Parkinson's disease (PD) can prevent the onset of dyskinesia. In MPTP-treated primates, repeated administration of levodopa or other short-acting dopamine agonist drugs leads to the onset of marked involuntary movements. In contr...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.62.1_suppl_1.s47

    authors: Jenner P

    更新日期:2004-01-13 00:00:00

  • Gender, cognitive decline, and risk of AD in older persons.

    abstract:BACKGROUND:Cross-sectional studies suggest gender differences in cognitive function and risk of AD in older persons. However, longitudinal studies comparing change in cognitive function and risk of AD in men and women have had mixed results. The authors investigated gender differences in rate of decline for different c...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000065892.67099.2a

    authors: Barnes LL,Wilson RS,Schneider JA,Bienias JL,Evans DA,Bennett DA

    更新日期:2003-06-10 00:00:00

  • West Nile virus infection presenting as acute flaccid paralysis in an HIV-infected patient: a case report and review of the literature.

    abstract::We describe a case of West Nile virus (WNV) infection in an HIV-infected patient who presented with an isolated flaccid monoparesis of the right upper extremity. To our knowledge, this is the first reported case of flaccid paralysis caused by WNV infection in an HIV-infected patient. We then review the medical literat...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/01.wnl.0000253223.07720.bb

    authors: Torno M,Vollmer M,Beck CK

    更新日期:2007-02-13 00:00:00

  • Neuropathological findings in Sneddon's syndrome.

    abstract::The authors report the neuropathologic findings in a case of Sneddon's syndrome. There were multiple small, predominantly cortical, infarcts, with focal hyperplasia and fibrotic occlusion of arterial vessels in the superficial white matter, cortex, and leptomeninges. A very occasional arterial thrombus was seen. These...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000055931.66009.d3

    authors: Hilton DA,Footitt D

    更新日期:2003-04-08 00:00:00

  • Relationship of motor symptoms to intellectual deficits in Parkinson disease.

    abstract::We studied 60 patients with idiopathic Parkinson disease with motor and neuropsychologic tests to ascertain whether the severity of motor symptoms was associated with the degree of neuropsychologic deficity. Significant correlations were found between the severity of brady kinesia and impaired performance on tests ass...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.32.2.133

    authors: Mortimer JA,Pirozzolo FJ,Hansch EC,Webster DD

    更新日期:1982-02-01 00:00:00

  • Apolipoprotein E and functional recovery from brain injury following postacute rehabilitation.

    abstract:OBJECTIVE:APOE epsilon4 has been associated with late-onset familial and sporadic AD and delayed recovery from head injury. The authors examined the relationship between functional recovery of patients with head injury and the APOE alleles. METHODS:Thirty-one patients with head injury who had completed the Acute Neuro...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.55.10.1536

    authors: Lichtman SW,Seliger G,Tycko B,Marder K

    更新日期:2000-11-28 00:00:00

  • Medial medullary infarction with central sparing.

    abstract::A 35-year-old woman had cardiac arrest requiring treatment with a left ventricular assist device. After regaining consciousness, examination revealed upbeating nystagmus, otherwise normal bulbar function, left arm dysmetria, and numbness periorally and in areas she described as "a turtleneck of numbness with a T-shirt...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000436939.70528.03

    authors: Ryman DC,Ju YE

    更新日期:2013-12-03 00:00:00

  • Lapse of consciousness and automatisms in temporal lobe epilepsy: a videotape analysis.

    abstract::Videotape analysis of 76 attacks in 14 epileptics showed two electro-clinical types of psychomotor attacks. The first and most common type had three clinical phases, consisting of an initial motionless stare, stereotyped movements, and reactive automatisms during impaired consciousness. The second and less common type...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.27.2.144

    authors: Escueta AV,Kunze U,Waddell G,Boxley J,Nadel A

    更新日期:1977-02-01 00:00:00

  • Applying the HIV-associated neurocognitive disorder diagnostic criteria to HIV-infected youth.

    abstract:OBJECTIVE:The aim of this study was to apply the HIV-associated neurocognitive disorders (HAND) criteria for diagnosing HAND in HIV-infected adults, in a cohort of HIV-infected youth to thus establish whether this system is able to detect a spectrum of neurocognitive disorders (ND) in HIV-infected youth. METHODS:We us...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000002669

    authors: Hoare J,Phillips N,Joska JA,Paul R,Donald KA,Stein DJ,Thomas KG

    更新日期:2016-07-05 00:00:00

  • Mitochondrial DNA haplogroups and mutations in children with acquired central demyelination.

    abstract:OBJECTIVE:We investigated mitochondrial DNA (mtDNA) variants in children with a first episode of acquired demyelinating syndromes (PD-ADS) of the CNS and their relationship to disease phenotype, including subsequent diagnosis of multiple sclerosis (MS). METHODS:This exploratory analysis included the initial 213 childr...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e31820ee1bb

    authors: Venkateswaran S,Zheng K,Sacchetti M,Gagne D,Arnold DL,Sadovnick AD,Scherer SW,Banwell B,Bar-Or A,Simon DK,Canadian Pediatric Demyelinating Disease Network.

    更新日期:2011-03-01 00:00:00

  • Basilar migraine, seizures, and severe epileptiform EEG abnormalities.

    abstract::Four adolescents had basilar migraine, infrequent cerebral seizures, and severe EEG abnormalities. The clinical course was benign, with normal personality, mentation, and neurologic examination. Almost continuous EEG abnormalities, consisting of rhythmic temporo-occipital sharp and slow wave discharges, or generalized...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.28.6.584

    authors: Camfield PR,Metrakos K,Andermann F

    更新日期:1978-06-01 00:00:00

  • Education Research: Online Alzheimer education for high school and college students: A randomized controlled trial.

    abstract:OBJECTIVE:Alzheimer disease (AD) risk factors are present throughout the lifespan. This randomized controlled trial evaluated the effectiveness of various online education strategies concerning AD risk reduction and brain health in younger populations. METHOD:High school and college students were recruited via social ...

    journal_title:Neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1212/WNL.0000000000009859

    authors: Saif N,Niotis K,Dominguez M,Hodes JF,Woodbury M,Amini Y,Sadek G,Scheyer O,Caesar E,Hristov H,Knowlton N,Lee P,McInnis M,Isaacson RS

    更新日期:2020-10-20 00:00:00

  • Incidence and prevalence of epilepsy among older U.S. Medicare beneficiaries.

    abstract:OBJECTIVE:To determine the prevalence and incidence of epilepsy among U.S. Medicare beneficiaries aged 65 years old and over, and to compare rates across demographic groups. METHODS:We performed a retrospective analysis of Medicare administrative claims for 2001-2005, defining prevalent cases as persons with ≥1 claim ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3182477edc

    authors: Faught E,Richman J,Martin R,Funkhouser E,Foushee R,Kratt P,Kim Y,Clements K,Cohen N,Adoboe D,Knowlton R,Pisu M

    更新日期:2012-02-14 00:00:00

  • Predictors of relapse rate in MS clinical trials.

    abstract:BACKGROUND:The annual relapse rate has been commonly used as a primary efficacy endpoint in phase III multiple sclerosis (MS) clinical trials. The aim of this study was to determine the relative contribution of different possible prognostic factors available at baseline to the on-study relapse rate in MS. METHODS:A to...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000187122.71735.1f

    authors: Held U,Heigenhauser L,Shang C,Kappos L,Polman C,Sylvia Lawry Centre for MS Research.

    更新日期:2005-12-13 00:00:00

  • Estimation of the temporal probability of human immunodeficiency virus (HIV) dementia after risk stratification for HIV-infected persons.

    abstract::We developed a scheme using routinely available data to estimate the risk of human immunodeficiency virus (HIV) dementia in HIV-infected persons over time. We performed a longitudinal review of medical records from more than 100 medical facilities in 11 U.S. cities. A total of 19,462 HIV-infected persons without histo...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.50.2.392

    authors: Qureshi AI,Hanson DL,Jones JL,Janssen RS

    更新日期:1998-02-01 00:00:00

  • Physiologic events initiating REM sleep in patients with the postpolio syndrome.

    abstract:BACKGROUND:We previously studied the occurrence of muscle tone reduction (MTR), sawtooth waves (STW), and REM in sleep, and found a stereotypical sequence of these events in normal subjects. Patients with the postpolio syndrome may have involvement of the reticular formation in the brainstem, an area known to mediate i...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.52.3.516

    authors: Siegel H,McCutchen C,Dalakas MC,Freeman A,Graham B,Alling D,Sato S

    更新日期:1999-02-01 00:00:00

  • Inflammatory markers and cognition in well-functioning African-American and white elders.

    abstract:BACKGROUND:Several lines of evidence suggest that inflammatory mechanisms contribute to AD. OBJECTIVE:To examine whether several markers of inflammation are associated with cognitive decline in African-American and white well-functioning elders. METHODS:The authors studied 3,031 African-American and white men and wom...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000073620.42047.d7

    authors: Yaffe K,Lindquist K,Penninx BW,Simonsick EM,Pahor M,Kritchevsky S,Launer L,Kuller L,Rubin S,Harris T

    更新日期:2003-07-08 00:00:00

  • The utility and generality of Mini-Mental State Examination scores in Alzheimer's disease.

    abstract::The present study sought to evaluate the validity and generality of the Mini-Mental State Examination (MMSE) and its subsection scores. We gave the MMSE and other neuropsychological tests to 51 patients with probable Alzheimer's disease. On the basis of correlational and factor analyses, overall performance on the MMS...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.40.12.1894

    authors: Giordani B,Boivin MJ,Hall AL,Foster NL,Lehtinen SJ,Bluemlein LA,Berent S

    更新日期:1990-12-01 00:00:00

  • Quantitative MRI criteria for optic pathway enlargement in neurofibromatosis type 1.

    abstract:OBJECTIVE:To determine quantitative size thresholds for enlargement of the optic nerve, chiasm, and tract in children with neurofibromatosis type 1 (NF1). METHODS:Children 0.5-18.6 years of age who underwent high-resolution T1-weighted MRI were eligible for inclusion. This consisted of children with NF1 with or withou...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000002771

    authors: Avery RA,Mansoor A,Idrees R,Biggs E,Alsharid MA,Packer RJ,Linguraru MG

    更新日期:2016-06-14 00:00:00

  • Practice parameter: evaluation of children and adolescents with recurrent headaches: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society.

    abstract:OBJECTIVE:The Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society develop practice parameters as strategies for patient management based on analysis of evidence. For this parameter, the authors reviewed available evidence on the evaluation of the...

    journal_title:Neurology

    pub_type: 指南,杂志文章,实务指引

    doi:10.1212/wnl.59.4.490

    authors: Lewis DW,Ashwal S,Dahl G,Dorbad D,Hirtz D,Prensky A,Jarjour I,Quality Standards Subcommittee of the American Academy of Neurology.,Practice Committee of the Child Neurology Society.

    更新日期:2002-08-27 00:00:00

  • A 21-aminosteroid inhibits stimulated monocyte hydrogen peroxide and chemiluminescence measurements from MS patients and controls.

    abstract::Monocytes are recruited to active sites of multiple sclerosis (MS) demyelination and may promote local tissue injury by generating an inflammatory response, mediated in part by the production of toxic oxygen metabolites. Corticosteroids are frequently and effectively used to ameliorate MS exacerbations, despite inadeq...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.41.2_part_1.297

    authors: Fisher M,Levine PH,Doyle EM,Arpano MM,Bergeron DA,Cohen RA,Hoogasian JJ

    更新日期:1991-02-01 00:00:00

  • Caregiver preference for rivastigmine patches versus capsules for the treatment of Alzheimer disease.

    abstract::Alzheimer disease (AD) has a significant impact on caregivers. Administering and managing medications is one of their many daily tasks. More effective modes of drug administration may benefit patient and caregiver, and may improve compliance. A prospective outcome of the IDEAL (Investigation of TransDermal Exelon in A...

    journal_title:Neurology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1212/01.wnl.0000281848.25142.11

    authors: Blesa R,Ballard C,Orgogozo JM,Lane R,Thomas SK

    更新日期:2007-07-24 00:00:00

  • Cranial dystonia: double-blind crossover study of anticholinergics.

    abstract::In patients with cranial dystonia, we compared the effects of central anticholinergic, peripheral anticholinergic, and placebo treatments in a double-blind crossover study. One of the nine patients who completed the study improved markedly with central anticholinergic therapy. The three treatments were indistinguishab...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1212/wnl.34.2.215

    authors: Nutt JG,Hammerstad JP,deGarmo P,Carter J

    更新日期:1984-02-01 00:00:00

  • A study of congenital nystagmus: waveforms.

    abstract::Eighteen patients with congenital nystagmus were studied with the techniques of electronystagmography and computer analysis. We found several complex wave forms of congenital nystagmus in the primary position of gaze above those of jerk and pendular nystagmus as defined clinically. An etiologic classification of motor...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.26.4.326

    authors: Yee RD,Wong EK,Baloh RW,Honrubia V

    更新日期:1976-04-01 00:00:00

  • Autosomal dominant progressive external ophthalmoplegia: distribution of multiple mitochondrial DNA deletions.

    abstract:OBJECTIVE:To relate signs and symptoms to morphologic changes and presence of multiple mitochondrial DNA (mtDNA) deletions in a patient with autosomal dominant progressive external ophthalmoplegia (adPEO) and mitochondrial myopathy. BACKGROUND:An etiologic association between the somatic multiple mtDNA deletions in ad...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.53.1.79

    authors: Moslemi AR,Melberg A,Holme E,Oldfors A

    更新日期:1999-07-13 00:00:00

  • Melioidosis and bilateral third-nerve palsies.

    abstract::Central nervous system involvement in melioidosis is unusual. We describe a 34-year-old man who developed a Pseudomonas pseudomallei meningitis, manifested as bilateral third-nerve palsies, 13 years after having been in southeast Asia. Diagnosis was established by a fourfold rise in the serum antibody titer for the ba...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.34.1.105

    authors: Beck RW,Janssen RS,Smiley ML,Schatz NJ,Savino PJ,Rubin DH

    更新日期:1984-01-01 00:00:00

  • HLA-DRB1*15 influences the development of brain tissue damage in early PPMS.

    abstract:OBJECTIVES:To investigate whether (1) there were differences between HLA-DRB1*15-positive and -negative patients at baseline, and (2) HLA-DRB1*15-positive patients showed a greater development of brain and spinal cord damage, as assessed by MRI, and greater progression of disability, during a 5-year follow-up, compared...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000000959

    authors: Tur C,Ramagopalan S,Altmann DR,Bodini B,Cercignani M,Khaleeli Z,Miller DH,Thompson AJ,Ciccarelli O

    更新日期:2014-11-04 00:00:00

  • Modulation of the renin-angiotensin-aldosterone system for the secondary prevention of stroke.

    abstract::Recurrent stroke is a major public health concern and new treatment strategies are needed. While modulation of the renin angiotensin aldosterone system (RAAS) has proven effective in reducing recurrent cardiac events, its role in preventing recurrent cerebrovascular events remains unclear. RAAS is both a circulating a...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/01.wnl.0000130360.21618.d0

    authors: Sokol SI,Portnay EL,Curtis JP,Nelson MA,Hebert PR,Setaro JF,Foody JM

    更新日期:2004-07-27 00:00:00