Abstract:
:Status epilepticus occurs in more than 50,000 people in the United States each year and should be considered a neurologic emergency. A variety of drugs are used to treat status epilepticus, including i.v. benzodiazepines, phenytoin, and barbiturates. They are all short of being ideal, primarily because of difficulties with administration or associated toxicity. Fosphenytoin, a prodrug and phosphate ester of phenytoin, was developed to overcome the drawbacks associated with i.v. phenytoin. With its efficacy, safety, and ease of administration, fosphenytoin is a valuable option for the treatment of status epilepticus.
journal_name
Neurologyjournal_title
Neurologyauthors
Runge JW,Allen FHdoi
10.1212/wnl.46.6_suppl_1.20ssubject
Has Abstractpub_date
1996-06-01 00:00:00pages
S20-3issue
6 Suppl 1eissn
0028-3878issn
1526-632Xjournal_volume
46pub_type
杂志文章,评审相关文献
NEUROLOGY文献大全abstract::We carried out a door-to-door-survey to screen a community of 14,010 people (Parsis living in colonies in Bombay, India) for possible neurologic diseases, and used defined diagnostic criteria to evaluate people who tested positive on the screening survey. There were three clinically definite cases of multiple sclerosi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.5.727
更新日期:1988-05-01 00:00:00
abstract::In the present study we compared the efficacy and safety of the new dopamine agonist cabergoline (CBG) with bromocriptine (BCR) in Parkinson's disease (PD). CBG has a very long half-life and can be administered as a single daily dose. Forty-four PD patients with uncontrolled motor fluctuations participated in the stud...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.47.3.785
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:Given that vagal afferents project to brainstem regions that promote alertness, the authors tested the hypothesis that vagus nerve stimulation (VNS) would improve daytime sleepiness in patients with epilepsy. METHODS:Sixteen subjects with medically refractory seizures underwent polysomnography and multiple ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.5.879
更新日期:2001-09-11 00:00:00
abstract::The intensive study of seizures via serial 24-hour EEG-video monitoring has allowed enhanced observation of sleep patterns among epilepsy patients and has revealed that disturbed rest is common in this population. Previous work has shown that sleep deprivation of any type can exacerbate seizure activity, leading to sp...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:This study explored the association between long-term epilepsy surgery outcome and changes in depressive symptoms. METHODS:Adults were enrolled between 1996 and 2001 in a multicenter prospective study to evaluate outcomes of resective epilepsy surgery. The extent of depressive symptoms and depression case st...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0b013e31823a0c90
更新日期:2011-11-29 00:00:00
abstract:OBJECTIVE:To investigate the clinical profile of rofecoxib, a long-acting (approximately 17-hour half-life) selective cyclo-oxygenase-2 inhibitor, for the acute treatment of migraine. METHODS:A randomized, double-blind, placebo-controlled, parallel-group study was conducted. Patients age > or =18 treated a moderate or...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/01.wnl.0000123260.61631.c4
更新日期:2004-05-11 00:00:00
abstract::Using an antibody against choline acetyltransferase (ChAT), mesencephalic cholinergic cell nuclei were studied in autopsy material from 3 cases of progressive supranuclear palsy (PSP) and 4 controls. ChAT-immunoreactive neurons were quantified in sections that spanned the rostrocaudal extent of each nucleus. In PSP, t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.1.25
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:To assess cortical inhibitory and excitatory mechanisms in obsessive-compulsive disorder (OCD). BACKGROUND:Transcranial magnetic stimulation (TMS) studies have found decreased neuronal inhibition and a reduced cortical silent period in the primary motor area in Tourette's syndrome, focal dystonia, and other ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.1.142
更新日期:2000-01-11 00:00:00
abstract::In the coterminous United States, MS mortality rates demonstrate a north-south gradient, which is confirmed by more sophisticated--and more expensive--prevalence studies. Mortality rates from idiopathic Parkinson's disease show a similar north-south gradient, and they correlate significantly with the MS mortality and ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.3.467
更新日期:1987-03-01 00:00:00
abstract::The authors report a double-blind, placebo-controlled, crossover study of talampanel in 49 patients with refractory partial seizures. Three doses of talampanel were investigated based on differences in patients' concomitant antiepileptic drug usage. Talampanel showed efficacy in reducing seizure frequency (p = 0.001) ...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/wnl.58.11.1680
更新日期:2002-06-11 00:00:00
abstract::We studied electrically elicited blink reflex responses in patients with hemifacial spasm (HFS) by applying single isolated, as well as paired (conditioning and test), stimuli at both sides of the face. Responses after single stimuli were of larger size on the side of the spasm compared with the uninvolved side and co...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.8.1061
更新日期:1989-08-01 00:00:00
abstract::We studied clinical characteristics and coexisting causes of stroke in 305 patients admitted to a population-based primary care center with an initial ischemic stroke and a potential cardiac source of embolism (PCSE). Using systematic standardized cardiac, arterial, and cerebral investigations and the logistics of the...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.6.855
更新日期:1991-06-01 00:00:00
abstract:OBJECTIVE:To investigate the feasibility and clinical utility of using passive electrocorticography (ECoG) for online spatial-temporal functional mapping (STFM) of language cortex in patients being monitored for epilepsy surgery. METHODS:We developed and tested an online system that exploits ECoG's temporal resolution...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002525
更新日期:2016-03-29 00:00:00
abstract:OBJECTIVES:To investigate the relationship between markers of vitamin B(12) status and brain volume loss per year over a 5-year period in an elderly population. METHODS:A prospective study of 107 community-dwelling volunteers aged 61 to 87 years without cognitive impairment at enrollment. Volunteers were assessed year...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000325581.26991.f2
更新日期:2008-09-09 00:00:00
abstract::We investigated the association of PD with a recently reported I93M mutation of the ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene, and with a new and common polymorphic variant S18Y of the same gene. We did not identify the I93M mutation in any of 139 unrelated PD cases or 113 controls. However, S18Y polymorph...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.8.1858
更新日期:1999-11-10 00:00:00
abstract:OBJECTIVE:To evaluate the effectiveness of opicapone as add-on to levodopa and the effects of switching from entacapone over 1 year of treatment in patients with fluctuating Parkinson disease. METHODS:After completion of a placebo- and entacapone-controlled double-blind study of opicapone (5, 25, or 50 mg), 495 patien...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000005557
更新日期:2018-05-22 00:00:00
abstract:OBJECTIVE:We aimed to investigate whether cognitive deficits and structural and functional connectivity changes can be detected before symptom onset in a large cohort of carriers of microtubule-associated protein tau and progranulin mutations. METHODS:In this case-control study, 75 healthy individuals (aged 20-70 year...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31828407bc
更新日期:2013-02-26 00:00:00
abstract::The efficacy and safety of donepezil as a treatment for patients with mild to moderate Alzheimer's disease (AD) was investigated in a multicenter, double-blind study. Patients were randomly assigned to treatment with placebo (n = 162), 5 mg/d donepezil (n = 154), or 10 mg/d donepezil (n = 157) for 24 weeks followed by...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/wnl.50.1.136
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVES:To survey US physicians involved in acute stroke care to determine the proportion of hospitals that currently meet the recommended Brain Attack Coalition (BAC) criteria for Primary Stroke Centers (PSC) and obtain opinions regarding the value of stroke centers. METHODS:A survey regarding the BAC guidelines f...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000063314.67393.58
更新日期:2003-05-13 00:00:00
abstract:OBJECTIVE:To determine the incidence of first seizures, epilepsy, and seizure mimics in a geographically defined area using the updated 2014 International League Against Epilepsy (ILAE) definition, which allows an epilepsy diagnosis after a single seizure when the risk of further seizures over the next 10 years is ≈60%...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009980
更新日期:2020-08-04 00:00:00
abstract::Use of neuroleptic medications is common among elderly patients. Using multivariate models, the authors found that use of antipsychotic medications, age, and disability were strong predictors of developing self-reported Parkinson disease (PD) in the subsequent year among 1992 to 2000 Medicare Current Beneficiary Surve...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000203348.13337.89
更新日期:2006-03-28 00:00:00
abstract:OBJECTIVE:Current prehospital scales used to detect large vessel occlusion reveal very low endovascular thrombectomy (EVT) rates among selected patients. We developed a novel prehospital scale, the Madrid-Direct Referral to Endovascular Center (M-DIRECT), to identify EVT candidates for direct transfer to EVT-capable ce...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008998
更新日期:2020-02-25 00:00:00
abstract::Nerve root stimulation may be employed in patients with motor neuron disease (MND) to rule out motor neuropathy with conduction block. The diagnostic utility of these studies is unknown, in part because the range of amplitude changes across nerve root segments in patients with active neuronal degeneration has not been...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.6.1907
更新日期:1998-06-01 00:00:00
abstract::A case-control study was conducted on 64 cases of "probable Alzheimer's disease" with late onset of illness (after age 70 years) and 64 controls matched by age (+/- 3 years), race, and sex. Information was obtained on birth order, lifetime medical and surgical history, personal characteristics, exposure to toxins and ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.8.1295
更新日期:1987-08-01 00:00:00
abstract::The present study quantitatively assessed volumes of the amygdala and its subnuclei in autopsied cases of advanced Alzheimer's disease (AD) for comparison with age-matched controls. Amygdalar nuclei showed significant atrophy in AD with the exception of the paralaminar portion of the basal nucleus. The magnocellular r...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.3.351
更新日期:1991-03-01 00:00:00
abstract::We studied 13 patients with severe drug-induced parkinsonism (DIP) using L-6-[18F]fluorodopa positron emission tomography (18F-dopa PET) to investigate the integrity of their dopaminergic nigrostriatal projections. Twelve of these patients were subsequently followed clinically for a median of 23.5 months (range, 6 to ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.3_part_1.552
更新日期:1993-03-01 00:00:00
abstract::In 17 patients with cough syncope, electroencephalograms showed normal interictal recordings in 12 patients, minimally abnormal recordings in 4, and a moderately abnormal recording in 1. Fourteen episodes of cough syncope (six patients) were recorded, with the EEGs showing diffuse theta and delta slowing during the ep...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.3.371
更新日期:1984-03-01 00:00:00
abstract:BACKGROUND:The major histocompatibility complex (MHC) has been consistently associated with susceptibility to MS and the course of several other human autoimmune diseases. A putative association between the course and severity of MS and the MHC remains controversial. METHODS:DR and DQ genotyping by either restriction ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.3.742
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:To verify the previously reported association between long-term use of β2-adrenoreceptor (β2AR) agonist and antagonist with reduced and increased risk of Parkinson disease (PD), respectively. METHODS:We obtained odds ratios (ORs) associating time of β2AR agonist and antagonist use with PD risk in nationwide ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007694
更新日期:2019-07-09 00:00:00
abstract:BACKGROUND:Attempts at cell-based dopamine replacement therapy in Parkinson disease (PD) have included surgical implantation of adrenal medullary, fetal mesencephalic, and cultured human mesencephalic tissue grafts. Trials involving putamenal implantation of human retinal pigment epithelial (RPE) cells in PD have also ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181bbff1c
更新日期:2009-10-06 00:00:00