Abstract:
OBJECTIVE:To investigate possible leptomeningeal contrast enhancement using postcontrast fluid-attenuated inversion recovery (FLAIR) MRI as an additional marker of inflammation in patients with multiple sclerosis (MS). METHODS:A cohort of 112 patients (73 women) with clinically definitive MS or a clinically isolated syndrome suggestive of CNS demyelination were included. A pathologic control group of 5 stroke patients was also examined. MRI was performed on a 3T system including FLAIR, T2-weighted, T1-weighted-contrast injection, followed by T1-weighted and FLAIR. RESULTS:Of the 112 patients, 39 had an acute relapse at the time of MRI. In total, 96 contrast-enhancing lesions were identified on postcontrast T1-weighted images. The pathologic control group demonstrated the sensitivity of postcontrast FLAIR images demonstrating leptomeningeal enhancement in all cases. In contrast, only 1 out of 112 examined patients with MS showed a single area of abnormal leptomeningeal contrast enhancement. CONCLUSIONS:In contrast to intraparenchymal blood-brain barrier (BBB) dysfunction that is frequently seen in patients with MS, BBB dysfunction of leptomeningeal vessels is usually not detectable in patients with early MS.
journal_name
Neurologyjournal_title
Neurologyauthors
Eisele P,Griebe M,Szabo K,Wolf ME,Alonso A,Engelhardt B,Hennerici MG,Gass Adoi
10.1212/WNL.0000000000001286subject
Has Abstractpub_date
2015-02-24 00:00:00pages
770-5issue
8eissn
0028-3878issn
1526-632Xpii
WNL.0000000000001286journal_volume
84pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:Kennedy disease (KD), or spinobulbomuscular atrophy, is a slowly progressive inherited neurodegenerative disorder, marked by prominent fasciculations that typically precede the development of other symptoms. Although the genetic basis of KD relates to triplet (CAG) repeat expansion in the androgen receptor (A...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000279521.81846.59
更新日期:2007-11-06 00:00:00
abstract:OBJECTIVE:To explore the causal relationships between sleep, major depressive disorder (MDD), and Alzheimer disease (AD). METHODS:We conducted bidirectional 2-sample Mendelian randomization analyses. Genetic associations were obtained from the largest genome-wide association studies currently available in UK Biobank (...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000010463
更新日期:2020-10-06 00:00:00
abstract:OBJECTIVE:To determine the patterns of diffusivity associated with cognitive domain functions in older adults without dementia. METHODS:We studied older adults without dementia (n = 220) who underwent neuropsychometric testing and a diffusion tensor imaging (DTI) examination at 3 T in a cross-sectional study. Memory, ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31822313dc
更新日期:2011-07-05 00:00:00
abstract:OBJECTIVE:The study aims to examine α-synuclein in the CSF of patients with severe traumatic brain injury (TBI) and its relationship with clinical characteristics and long-term outcomes. METHODS:This prospective case-control study enrolled patients with severe TBI (Glasgow Coma Score ≤ 8) who underwent ventriculostomy...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182904d43
更新日期:2013-04-30 00:00:00
abstract:OBJECTIVE:To investigate whether the fornix and mamillary bodies, being part of the limbic system, are abnormal in patients with mesial temporal lobe epilepsy (MTLE). BACKGROUND:The limbic system comprises the hippocampal formation, fornix, mamillary bodies, thalamus, and other integrated structures. This system is im...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.3.496
更新日期:1999-08-11 00:00:00
abstract::Evaluating rehabilitation requires rating scales that detect change. The authors examined Barthel Index (BI) data from 1,495 patients at a neurorehabilitation unit to determine whether total scale responsiveness accurately reflects item responsiveness. Total score effect sizes were moderate to large (0.47 to 1.09). It...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000116136.22922.d6
更新日期:2004-05-25 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Human herpesvirus 8 (HHV-8) has been found in association with Kaposi's sarcomas in human immunodeficiency virus (HIV)-positive and -negative patients, primary effusion lymphomas (PELs), multicentric Castleman's disease, and multiple myeloma. The PELs share several features with acquired immuno...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.2.335
更新日期:1998-02-01 00:00:00
abstract:OBJECTIVE:To determine if progressive brain atrophy could be detected over 1- and 2-year intervals in relapsing MS, based on annual MR studies from the Multiple Sclerosis Collaborative Research Group (MSCRG) trial of interferon beta-1a (Avonex). METHODS:All subjects had mild to moderate disability, with baseline expan...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/wnl.53.1.139
更新日期:1999-07-13 00:00:00
abstract::Spinal cord compression by extramedullary hemopoietic tissue is a rare complication of hemolytic anemias. This is the first report of this complication in hemolytic anemia caused by pyruvate-kinase deficiency. Indium scan, computed tomography (CT) scan, and myelography were helpful in diagnosis. Surgery and radiothera...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.4.510
更新日期:1979-04-01 00:00:00
abstract:OBJECTIVE:To determine the influence of all possible imaging strategies on the appropriateness ratings for carotid endarterectomy, because less accurate noninvasive techniques are replacing contrast angiography, which was used in the major efficacy trials. METHODS:An expert panel, using appropriateness methodology, ra...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000115097.61748.bf
更新日期:2004-03-23 00:00:00
abstract::INeuro@neurolist.mcg. edu: An e-mail discussion list for neurologists Neuro@neurolist.mcg.edu (Neurolist) is a discussion list for neurologists. This Internet tool, established in 1994, allows the worldwide community of neurologists to communicate quickly and efficiently using e-mail, web browsers, and newsreaders. Ne...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.9.1891
更新日期:1999-06-10 00:00:00
abstract::We performed a quantitative immunocytochemical study using a polyclonal antibody directed against choline acetyltransferase (ChAT) in the lower pontine reticular formation in four control subjects and three patients with progressive supranuclear palsy (PSP). In the normal brains, there was detectable ChAT-like immunor...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.10.1593
更新日期:1991-10-01 00:00:00
abstract:BACKGROUND:Deep brain stimulation of the internal global pallidus (GPi) and the subthalamic nucleus (STN) has become a treatment alternative in advanced PD. Although the effects of GPi stimulation have been examined recently, little is known about STN stimulation effects on motor cortex excitability. METHODS:The effec...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.59.5.700
更新日期:2002-09-10 00:00:00
abstract::Placebo, or sham surgery, as a control condition in surgical clinical trials in Parkinson disease (PD) remains controversial. The authors reviewed the adverse effects reported in double blind, placebo surgery controlled trials for PD. Placebo surgeries were generally safe and well tolerated but the number of subjects ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000171957.90640.b5
更新日期:2005-10-11 00:00:00
abstract:OBJECTIVE:To compare the clinical features of patients with chronic daily headache (CDH) with idiopathic intracranial hypertension without papilledema (IIHWOP) to those with normal CSF pressure. METHODS:A case-control study was conducted at a tertiary headache center. Cases consisted of 25 consecutive patients (24 wom...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.1.245
更新日期:1998-07-01 00:00:00
abstract::We made phenotypic analysis of 14 families with spinal muscular atrophy (SMA) linking to chromosome 5q11.2-13.3 (SMA 5q), and 2 that may not map to this locus, to assess clinical symptoms among SMA families known to result from mutation at the identical gene/locus. Although the current number of families is still smal...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.12.1831
更新日期:1990-12-01 00:00:00
abstract::Delusions and other manifestations of psychotic behavior are common side effects in Parkinson's disease (PD) patients chronically treated with dopaminergic drugs. Clozapine, a dibenzodiazepine derivative, is an antipsychotic drug largely devoid of extrapyramidal side effects. We evaluated the effects of low doses of c...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.45.3.432
更新日期:1995-03-01 00:00:00
abstract:OBJECTIVE:The state-of-the-art tools of neurology, in particular modern neuroimaging techniques, have yet to benefit from the revolution in mobile technologies that provide new insights into the mechanisms underlying clinical syndromes. This study demonstrates the manner in which mobile technologies may provide informa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31824528b2
更新日期:2012-01-31 00:00:00
abstract::Noninvasive positive pressure ventilation prolongs survival in ALS but its effect on quality of life is unknown. The authors prospectively studied quality of life using the SF-36 questionnaire in a cohort of 16 ventilated patients with ALS. Noninvasive positive pressure ventilation improved scores in the "Vitality" do...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.1.153
更新日期:2001-07-10 00:00:00
abstract::Childhood absence epilepsy (CAE) is defined by absence seizures in a normally developing child, with onset between 4 and 10 years of age.(1) Typical absence seizures consist of behavioral arrest with or without automatisms, usually last 30-60 seconds, and demonstrate a characteristic 3-Hz generalized spike-wave (GSW) ...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000000380
更新日期:2014-05-06 00:00:00
abstract:OBJECTIVE:To characterize the molecular basis of a novel fast-channel congenital myasthenic syndrome. METHODS:We used the candidate gene approach to identify the pathogenic mutation in the acetylcholine receptor (AChR) ε subunit, genetically engineered the mutant AChR into HEK cells, and evaluated the level of express...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31825b5bda
更新日期:2012-07-31 00:00:00
abstract::We performed a retrospective study on a series of 119 of our patients who have Friedreich's disease to assess the predictive value of age at onset, gender, and left ventricular hypertrophy in regard to disease progression. Outcome variables were survival, time to loss of independent gait, and time to confinement in a ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.5.1260
更新日期:1996-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the prospective association of long-term intake of vegetables and fruits with late-life subjective cognitive function (SCF). METHODS:Among 27,842 men with a mean age of 51 years in 1986, we used multinomial logistic regression to examine the relation of vegetable and fruit consumption to future S...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006684
更新日期:2019-01-01 00:00:00
abstract::We gave three adult rhesus monkeys seven IV injections of manganese chloride at approximately 1-week intervals. We evaluated neurologic status by serial clinical examinations and performed a levodopa test if the animal developed features of basal ganglia dysfunction. After the animals were killed, we performed neuropa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.2.492
更新日期:1996-02-01 00:00:00
abstract:OBJECTIVE:To measure changes in psychometric state, neural activation, brain volume (BV), and cerebral metabolite concentrations during treatment of minimal hepatic encephalopathy. METHODS:As proof of principle, 22 patients with well-compensated, biopsy-proven cirrhosis of differing etiology and previous minimal hepat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31828726e1
更新日期:2013-03-12 00:00:00
abstract:OBJECTIVE:To study activin signaling and its blockade in sporadic inclusion body myositis (sIBM) through translational studies and a randomized controlled trial. METHODS:We measured transforming growth factor β signaling by SMAD2/3 phosphorylation in muscle biopsies of 50 patients with neuromuscular disease (17 with s...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000001070
更新日期:2014-12-09 00:00:00
abstract::We studied electrically elicited blink reflex responses in patients with hemifacial spasm (HFS) by applying single isolated, as well as paired (conditioning and test), stimuli at both sides of the face. Responses after single stimuli were of larger size on the side of the spasm compared with the uninvolved side and co...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.8.1061
更新日期:1989-08-01 00:00:00
abstract::Pathology and imaging studies have shown that patients with Parkinson disease (PD) have a prolonged period of uncertain duration when vulnerable neuronal populations are degenerating, but typical motor symptoms have not yet developed. This provides both an opportunity-it may be best to test new medications and, ultima...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0b013e318198df97
更新日期:2009-02-17 00:00:00
abstract:OBJECTIVE:To systematically review the evidence concerning the diagnostic yield of genetic and metabolic evaluation of children with global developmental delay or intellectual disability (GDD/ID). METHODS:Relevant literature was reviewed, abstracted, and classified according to the 4-tiered American Academy of Neurolo...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0b013e3182345896
更新日期:2011-10-25 00:00:00
abstract::A woman had a progressive neurologic syndrome beginning at age 3 and lasting for three decades. Clinical manifestations included severe mental deterioration, spastic paralysis, myoclonus, and tremors. A postmortem examination showed ubiquitous infiltration of neurons by lipofuscin and deposits of pigment in the globus...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.5.500
更新日期:1978-05-01 00:00:00