Assessment of motor function after stereotactic pallidotomy.

Abstract:

:Despite a paucity of controlled data, stereotactic pallidotomy is increasingly used for the treatment of advanced Parkinson's disease (PD). To study the efficacy of the procedure on the cardinal PD features of rigidity, tremor, bradykinesia, and postural instability, we blindly rated randomized videos of 34 patients recorded in the "off' state immediately before and 3 months after unilateral stereotactic lesioning of the globus pallidus internus. Total "off' time Unified Parkinson's Disease Rating Scale motor scores improved 13.6% from 28.9 +/- 7.5 to 25.0 +/- 7.0 (p < 0.001). Particularly robust improvement was seen in contralateral tremor, gait, and arising from a chair (p < 0.001). Significant improvement was also seen in ipsilateral tremor, contralateral and some ipsilateral dexterity measures, and body bradykinesia. Most other features tended toward improvement but did not reach statistical significance. We conclude that pallidotomy is a safe and effective treatment of parkinsonian symptoms, many of which improve bilaterally.

journal_name

Neurology

journal_title

Neurology

authors

Ondo WG,Jankovic J,Lai EC,Sankhla C,Khan M,Ben-Arie L,Schwartz K,Grossman RG,Krauss JK

doi

10.1212/wnl.50.1.266

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

266-70

issue

1

eissn

0028-3878

issn

1526-632X

journal_volume

50

pub_type

杂志文章
  • Elevated risk of Alzheimer's disease among workers with likely electromagnetic field exposure.

    abstract::We conducted a case-control study of the possible association of occupations with likely exposure to electromagnetic fields and Alzheimer's disease (AD) with patients from the Alzheimer Disease Treatment and Diagnostic Center, Rancho Los Amigos Medical Center, Downey, CA. Patients with definite or probable AD were the...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.47.6.1477

    authors: Sobel E,Dunn M,Davanipour Z,Qian Z,Chui HC

    更新日期:1996-12-01 00:00:00

  • Beta oscillations and urinary voiding in Parkinson disease.

    abstract:OBJECTIVES:To investigate the role of beta oscillations in urinary voiding and their association with lower urinary tract symptoms in Parkinson disease (PD). METHODS:We used surgically implanted deep brain stimulation electrodes to record local field potential signals from the subthalamic nucleus (STN) and globus pall...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000005355

    authors: Roy HA,Aziz TZ,Fitzgerald JJ,Green AL

    更新日期:2018-04-24 00:00:00

  • Brain-behavior correlations in hemispatial neglect using CT and SPECT: the Sunnybrook Stroke Study.

    abstract:OBJECTIVE:Structural and functional lesion localization in patients with hemispatial neglect. DESIGN:Location and severity of brain damage on CT and SPECT correlated with neglect performance as assessed with a battery of drawings, line bisection, and line and shape cancellation subtests. PATIENTS:Participants include...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.50.4.901

    authors: Leibovitch FS,Black SE,Caldwell CB,Ebert PL,Ehrlich LE,Szalai JP

    更新日期:1998-04-01 00:00:00

  • Cervical puncture to deliver nusinersen in patients with spinal muscular atrophy.

    abstract:OBJECTIVE:To report our experience delivering intrathecal nusinersen through cervical puncture in patients with spinal muscular atrophy (SMA) with no lumbar access. BACKGROUND:SMA is a neuromuscular disorder characterized by profound muscle weakness, atrophy, and paralysis due to degeneration of the anterior horn cell...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000006006

    authors: Veerapandiyan A,Pal R,D'Ambrosio S,Young I,Eichinger K,Collins E,Westesson PL,Kwon J,Ciafaloni E

    更新日期:2018-08-14 00:00:00

  • A variant of the anti-Purkinje cell antibody in a patient with paraneoplastic cerebellar degeneration.

    abstract::An anti-Purkinje cell antibody was found in the serum and CSF of a man with adenocarcinoma of the lung and paraneoplastic cerebellar degeneration (PCD). This antibody differed from the autoantibodies found in patients with gynecologic cancer and PCD in that it produced a different pattern of Purkinje cell cytoplasmic ...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.38.7.1018

    authors: Anderson NE,Budde-Steffen C,Wiley RG,Thurman L,Rosenblum MK,Nadeau SE,Posner JB

    更新日期:1988-07-01 00:00:00

  • The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators.

    abstract::Sphingosine 1-phosphate receptors (S1PRs) are G protein-coupled receptors expressed by many cell types, including immune and neural cells. These receptors are promising targets for immunomodulatory and possibly neuromodulatory therapies. Fingolimod (FTY720) is a sphingosine analog that, when phosphorylated, becomes a ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e31820d9507

    authors: Soliven B,Miron V,Chun J

    更新日期:2011-02-22 00:00:00

  • Seizures and their outcome in progressive multifocal leukoencephalopathy.

    abstract::Seizures are not expected in progressive multifocal leukoencephalopathy (PML), a condition considered to be restricted to the white matter. Review of medical records of 89 patients with possible or proven PML showed an 18% prevalence of seizures. Seizures usually responded well to treatment and did not affect survival...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000194227.16696.11

    authors: Lima MA,Drislane FW,Koralnik IJ

    更新日期:2006-01-24 00:00:00

  • Familial spastic paraplegia, peroneal neuropathy, and crural hypopigmentation: a new neurocutaneous syndrome.

    abstract::A neurocutaneous syndrome is described in which spastic paraplegia, peroneal neuropathy, and crural hypopigmentation are inherited in a dominant pattern. Spastic paraplegia becomes clinically apparent during adolescence or in childhood and progresses slowly throughout the adult years with a variability in severity of ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.31.6.754

    authors: Stewart RM,Tunell G,Ehle A

    更新日期:1981-06-01 00:00:00

  • The humoral response in the pathogenesis of gluten ataxia.

    abstract:OBJECTIVE:To characterize humoral response to cerebellum in patients with gluten ataxia. BACKGROUND:Gluten ataxia is a common neurologic manifestation of gluten sensitivity. METHODS:The authors assessed the reactivity of sera from patients with gluten ataxia (13), newly diagnosed patients with celiac disease without ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.58.8.1221

    authors: Hadjivassiliou M,Boscolo S,Davies-Jones GA,Grünewald RA,Not T,Sanders DS,Simpson JE,Tongiorgi E,Williamson CA,Woodroofe NM

    更新日期:2002-04-23 00:00:00

  • Abeta1-42 promotes cholinergic sprouting in patients with AD and Lewy body variant of AD.

    abstract:BACKGROUND:The neurodegenerative process in Alzheimer's disease (AD) and in the Lewy body variant of AD (LBV) patients is characterized by cholinergic dysfunction and deposition of amyloid beta-peptide (Abeta) 1-40 and 1-42; however, the differential effects of Abeta species on the cholinergic system are not completely...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000073987.79060.4b

    authors: Masliah E,Alford M,Adame A,Rockenstein E,Galasko D,Salmon D,Hansen LA,Thal LJ

    更新日期:2003-07-22 00:00:00

  • Decreased striatal monoaminergic terminals in Huntington disease.

    abstract:OBJECTIVE:To evaluate the integrity of the dorsal striatal dopaminergic innervation in rigid and choreic Huntington disease (HD). BACKGROUND:Some patients with HD have an akinetic-rigid phenotype. It has been suggested that nigrostriatal in addition to striatal pathology is present in this subgroup. The authors sought...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.54.9.1753

    authors: Bohnen NI,Koeppe RA,Meyer P,Ficaro E,Wernette K,Kilbourn MR,Kuhl DE,Frey KA,Albin RL

    更新日期:2000-05-09 00:00:00

  • Incidence and prevalence of epilepsy among older U.S. Medicare beneficiaries.

    abstract:OBJECTIVE:To determine the prevalence and incidence of epilepsy among U.S. Medicare beneficiaries aged 65 years old and over, and to compare rates across demographic groups. METHODS:We performed a retrospective analysis of Medicare administrative claims for 2001-2005, defining prevalent cases as persons with ≥1 claim ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3182477edc

    authors: Faught E,Richman J,Martin R,Funkhouser E,Foushee R,Kratt P,Kim Y,Clements K,Cohen N,Adoboe D,Knowlton R,Pisu M

    更新日期:2012-02-14 00:00:00

  • Effect of diet on exercise tolerance in carnitine palmitoyltransferase II deficiency.

    abstract::It is generally believed that a diet high in carbohydrate improves exercise tolerance in patients with carnitine palmitoyltransferase II (CPT II) deficiency, but it has never been systematically investigated. The authors investigated the effect of a high- vs low-carbohydrate diet on exercise tolerance in four patients...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1212/01.wnl.0000078195.05396.20

    authors: Ørngreen MC,Ejstrup R,Vissing J

    更新日期:2003-08-26 00:00:00

  • A compulsive collecting behavior following an A-com aneurysmal rupture.

    abstract::Hoarding behavior associated with focal brain injury is rarely reported. The authors report a 46-year-old man with pathologic collecting behavior after a left orbitofrontal and caudate injury from an aneurysmal rupture of anterior communicating artery. His hoarding, an impulse control disorder or an ego-syntonic compu...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.56.3.398

    authors: Hahm DS,Kang Y,Cheong SS,Na DL

    更新日期:2001-02-13 00:00:00

  • Endothelial and leukocyte-derived microvesicles and cardiovascular risk after stroke-PROSCIS-B.

    abstract:OBJECTIVE:To determine the role of circulating microvesicles (MV) on long-term cardiovascular outcomes after stroke, we measured them in patients with first-ever stroke with a 3-year follow-up. METHODS:In the Prospective Cohort With Incident Stroke Berlin (PROSCIS-B), patients with first-ever ischemic stroke were foll...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000011223

    authors: Huo S,Kränkel N,Nave AH,Sperber PS,Rohmann JL,Piper SK,Heuschmann P,Landmesser U,Endres M,Siegerink B,Liman TGG

    更新日期:2020-11-12 00:00:00

  • Surgical treatment of intractable neonatal-onset seizures: the role of positron emission tomography.

    abstract::We have performed positron emission tomography (PET) with 2-deoxy-2[18F]fluoro-D-glucose (FDG) in eight infants and children (aged 18 days to 5 years) with medically refractory epilepsy of neonatal onset. It was hypothesized that in at least some of these infants a surgical approach (focal resection, cerebral hemisphe...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.38.8.1178

    authors: Chugani HT,Shewmon DA,Peacock WJ,Shields WD,Mazziotta JC,Phelps ME

    更新日期:1988-08-01 00:00:00

  • The Workforce Task Force report: clinical implications for neurology.

    abstract::The American Academy of Neurology Workforce Task Force (WFTF) report predicts a future shortfall of neurologists in the United States. The WFTF data also suggest that for most states, the current demand for neurologist services already exceeds the supply, and by 2025 the demand for neurologists will be even higher. Th...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/WNL.0b013e31829d8783

    authors: Freeman WD,Vatz KA,Griggs RC,Pedley T

    更新日期:2013-07-30 00:00:00

  • History of head trauma and risk of intracranial meningioma: population-based case-control study.

    abstract::A population-based case-control study in western Washington state was performed to assess the relation between head trauma and meningioma. Based on 200 case and 400 control subjects, head trauma was associated with an increased risk of meningioma (odds ratio = 1.83; 95% CI = 1.28, 2.62), especially head traumas occurr...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.58.12.1849

    authors: Phillips LE,Koepsell TD,van Belle G,Kukull WA,Gehrels JA,Longstreth WT Jr

    更新日期:2002-06-25 00:00:00

  • The utility of the electroencephalogram in the evaluation of patients presenting with headache: a review of the literature.

    abstract::Electroencephalography has traditionally been considered a useful adjunct to the clinical evaluation of headache. We performed a literature review to determine whether evidence supports the routine use of the electroencephalogram (EEG) for patients with headache. After excluding case reports, case series in which subj...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.45.7.1263

    authors: Gronseth GS,Greenberg MK

    更新日期:1995-07-01 00:00:00

  • Extending neurologic services to rural children.

    abstract::The University of Kentucky provides neurologic services to rural children by a traveling clinic. In 1978, 438 children (including 231 new patients) made 646 clinic visits. The primary diagnoses were appropriate for a neurology clinic; epilepsy was the most common (74 of 231) among new patients. A community survey of s...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.29.9_part_1.1298

    authors: Baumann RJ,Leonidakis MG

    更新日期:1979-09-01 00:00:00

  • Interferon beta-1b in secondary progressive MS: a combined analysis of the two trials.

    abstract:BACKGROUND:A European (EU) and a North American (NA) placebo-controlled study with interferon beta-1b (IFNB-1b) in secondary progressive multiple sclerosis (SPMS) showed divergent results with regard to their primary outcome of sustained Expanded Disability Status Scale (EDSS) progression, while effects were similar on...

    journal_title:Neurology

    pub_type: 杂志文章,meta分析

    doi:10.1212/01.wnl.0000145561.08973.4f

    authors: Kappos L,Weinshenker B,Pozzilli C,Thompson AJ,Dahlke F,Beckmann K,Polman C,McFarland H,European (EU-SPMS) Interferon beta-1b in Secondary Progressive Multiple Sclerosis Trial Steering Committee and Independent Advisory Board.,North Ame

    更新日期:2004-11-23 00:00:00

  • Tolcapone in stable Parkinson's disease: efficacy and safety of long-term treatment. The Tolcapone Stable Study Group.

    abstract::In this double-blind, placebo-controlled trial, we investigated the effect of the catechol-O-methyltransferase inhibitor tolcapone 100 or 200 mg three times daily on activities of daily living and motor function in 298 patients with parkinsonism receiving levodopa but without motor fluctuations. At 6 months, both dosa...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1212/wnl.49.3.665

    authors: Waters CH,Kurth M,Bailey P,Shulman LM,LeWitt P,Dorflinger E,Deptula D,Pedder S

    更新日期:1997-09-01 00:00:00

  • Psychiatric features in diffuse Lewy body disease: a clinicopathologic study using Alzheimer's disease and Parkinson's disease comparison groups.

    abstract::We conducted a retrospective study to determine the frequency of depression, hallucinations, and delusions in patients with diffuse Lewy body disease (DLBD) and to compare these findings with those in Alzheimer's disease (AD) and Parkinson's disease (PD). One hundred twelve subjects were included in the study. Of thes...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.47.5.1148

    authors: Klatka LA,Louis ED,Schiffer RB

    更新日期:1996-11-01 00:00:00

  • Temporal reorganization to overcome monocular demyelination.

    abstract:OBJECTIVE:To identify the source of delayed visual evoked potential (VEP) latencies in the fellow eyes of patients with optic neuritis (ON) and determine whether these latencies stem from clinically silent demyelination or reflect an adaptive process for synchronization with the affected eyes. METHODS:The study sample...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3182a1aa3e

    authors: Raz N,Chokron S,Ben-Hur T,Levin N

    更新日期:2013-08-20 00:00:00

  • Miller Fisher syndrome and Haemophilus influenzae infection.

    abstract:OBJECTIVE:To examine the association between Miller Fisher syndrome (MFS) and antecedent Haemophilus influenzae infection. BACKGROUND:Little is known about agents in prior respiratory tract infection of MFS, whereas antecedent upper respiratory symptoms are frequent. H. influenzae is a major pathogen that can cause hu...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.57.4.686

    authors: Koga M,Yuki N,Tai T,Hirata K

    更新日期:2001-08-28 00:00:00

  • POLG mutations causing ophthalmoplegia, sensorimotor polyneuropathy, ataxia, and deafness.

    abstract::The authors identified two novel heterozygous missense transitions in the gene for the mitochondrial polymerase gammaA subunit (POLG) in a family with an autosomal recessive syndrome comprising progressive external ophthalmoplegia (PEO), polyneuropathy, ataxia, sensorineural hearing loss, and affective disorders. Thes...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.62.2.316

    authors: Mancuso M,Filosto M,Bellan M,Liguori R,Montagna P,Baruzzi A,DiMauro S,Carelli V

    更新日期:2004-01-27 00:00:00

  • Neurovascular decoupling is associated with severity of cerebral amyloid angiopathy.

    abstract:OBJECTIVES:We used functional MRI (fMRI), transcranial Doppler ultrasound, and visual evoked potentials (VEPs) to determine the nature of blood flow responses to functional brain activity and carbon dioxide (CO2) inhalation in patients with cerebral amyloid angiopathy (CAA), and their association with markers of CAA se...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000435291.49598.54

    authors: Peca S,McCreary CR,Donaldson E,Kumarpillai G,Shobha N,Sanchez K,Charlton A,Steinback CD,Beaudin AE,Flück D,Pillay N,Fick GH,Poulin MJ,Frayne R,Goodyear BG,Smith EE

    更新日期:2013-11-05 00:00:00

  • Adaptation to lateral displacement of vision in patients with lesions of the central nervous system.

    abstract::The visual-motor adaptation to lateral displacement of vision by prism glasses was studied in normal individuals and patients with cerebellar dysfunction, Parkinson's disease, right or left cerebral hemisphere lesions, Alzheimer's disease, or Korsakoff's syndrome. Adaptation was analyzed in two phases, the return to n...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.33.6.766

    authors: Weiner MJ,Hallett M,Funkenstein HH

    更新日期:1983-06-01 00:00:00

  • Intermittent negative pressure ventilation in the treatment of respiratory failure in progressive neuromuscular disease.

    abstract::Five men with degenerative neuromuscular diseases (three with amyotrophic lateral sclerosis [ALS] and two with Duchenne's muscular dystrophy [DMD]) who had respiratory failure were treated with intermittent negative pressure ventilation (NPV). One patient with ALS in severe acute respiratory failure was successfully t...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.37.12.1874

    authors: Braun SR,Sufit RL,Giovannoni R,O'Connor M,Peters H

    更新日期:1987-12-01 00:00:00

  • "Undiagnosing" multiple sclerosis: the challenge of misdiagnosis in MS.

    abstract:OBJECTIVE:To describe the clinical characteristics of encounters with patients misdiagnosed with multiple sclerosis (MS). METHODS:A cross-sectional Internet-based physician survey of MS specialists was performed. RESULTS:The response rate for the survey was 50.4%. Of those who responded, the majority (95%) reported h...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e318259e1b2

    authors: Solomon AJ,Klein EP,Bourdette D

    更新日期:2012-06-12 00:00:00