Abstract:
:We studied 60 patients with idiopathic Parkinson disease with motor and neuropsychologic tests to ascertain whether the severity of motor symptoms was associated with the degree of neuropsychologic deficity. Significant correlations were found between the severity of brady kinesia and impaired performance on tests assessing visual-spatial reasoning and psychomotor speed. More severe tremor was associated with better performance on a spatial orientation memory test. There relationships remained when age, age at onset, and self-rated depression were controlled. The findings suggested that cognitive impairment may result from the same subcortical lesions that cause motor symptoms.
journal_name
Neurologyjournal_title
Neurologyauthors
Mortimer JA,Pirozzolo FJ,Hansch EC,Webster DDdoi
10.1212/wnl.32.2.133subject
Has Abstractpub_date
1982-02-01 00:00:00pages
133-7issue
2eissn
0028-3878issn
1526-632Xjournal_volume
32pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::We observed acute onset of delayed psychosis in 8 patients 1 month to 11 years after right temporoparietooccipital (TPO) stroke or trauma. The psychotic disorder included hallucinations and, in some patients delusions and agitation. All patients had spatioconstructional difficulties. None had an earlier psychiatric di...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.3.267
更新日期:1982-03-01 00:00:00
abstract::The prevalence and psychopathologic features of psychiatric adverse events (PAE) in 517 patients taking levetiracetam (LEV) were investigated. Fifty-three (10.1%) patients developed PAE. A significant association was found with previous psychiatric history, history of febrile convulsions, and history of status epilept...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000078031.32904.0d
更新日期:2003-09-09 00:00:00
abstract:OBJECTIVE:Coccidioides species are the most common etiologic agents of chronic meningitis in regions endemic for coccidioidomycosis. Occasionally, even short-term travel to endemic regions results in the acquisition of meningeal disease, so awareness of this complication of coccidioidomycosis is important even in nonen...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181c34b69
更新日期:2009-11-24 00:00:00
abstract:OBJECTIVE:To clarify the relationship between depressive symptoms and the clinical and neuropathologic manifestations of dementia. METHODS:In a clinical-pathologic cohort study, 1,764 older persons without cognitive impairment at enrollment completed annual clinical evaluations for a mean of 7.8 years. The evaluations...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000715
更新日期:2014-08-19 00:00:00
abstract:BACKGROUND:PD was associated with increased mortality before levodopa therapy became available. There have been conflicting reports of PD mortality in the modern era. OBJECTIVE:To assess current mortality rates in a large unselected population receiving treatment for parkinsonism (PKM) followed for up to 6 years. MET...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.12.2278
更新日期:2001-12-26 00:00:00
abstract:OBJECTIVE:To assess pathologic changes in prospectively characterized subjects with essential tremor (ET). METHODS:Subjects enrolled in the Sun Health Research Institute Brain and Body Donation Program were examined annually by a movement disorders neurologist, and semiannually by a behavioral neurologist and neuropsy...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000310425.76205.02
更新日期:2008-04-15 00:00:00
abstract:BACKGROUND:Previously, hyperoxia and blood volume increase were reported in the red nucleus and substantia nigra during spontaneous migraine with aura. OBJECTIVE:To further understand the pathophysiologic role of these centers, activation of brainstem structures was investigated in patients with visually triggered mig...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.59.1.72
更新日期:2002-07-09 00:00:00
abstract::A 25-year-old man with the skin lesions of malignant atrophic papulosis had clinical and electrodiagnostic evidence of a multifocal asymmetric myelomalacia or polyradiculopathy in association with elevated CSF protein and hypoglycorrhachia. Autopsy findings included widespread infarctions and necrosis of brain, brains...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.7.936
更新日期:1983-07-01 00:00:00
abstract:BACKGROUND:On proton magnetic resonance spectroscopic imaging ((1)H MRSI), there is a decrease in cerebellar N-acetylaspartate/total creatine (NAA/tCr) in essential tremor (ET), signifying cerebellar neuronal dysfunction or degeneration. Harmane, which is present in the human diet, is a potent tremor-producing neurotox...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000266663.27398.9f
更新日期:2007-08-07 00:00:00
abstract:OBJECTIVE:To perform a meta-analysis of 4 core CSF biomarkers (β-amyloid [Aβ]42, Aβ40, total tau [t-tau], and phosphorylated tau [p-tau]) to assess which of these are most altered in sporadic cerebral amyloid angiopathy (CAA). METHODS:We systematically searched PubMed for eligible studies reporting data on CSF biomark...
journal_title:Neurology
pub_type: 杂志文章,meta分析,评审
doi:10.1212/WNL.0000000000005030
更新日期:2018-02-27 00:00:00
abstract::A 14-year-old girl developed severe bilateral optic neuritis 1 week after the onset of chickenpox. Though previous case reports state that complete recovery is the rule, this child had a persistent decrease in visual acuity in the right eye and loss of color vision and defects in visual fields in both eyes. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.3.501
更新日期:1988-03-01 00:00:00
abstract:OBJECTIVE:To examine the association between cognitive function and dementia with vitamin D concentration in adults. METHODS:Five databases were searched for English-language studies up to August 2010, and included all study designs with a comparative group. Cognitive function or impairment was defined by tests of glo...
journal_title:Neurology
pub_type: 杂志文章,meta分析,评审
doi:10.1212/WNL.0b013e31826c197f
更新日期:2012-09-25 00:00:00
abstract::Spinal cord compression by extramedullary hemopoietic tissue is a rare complication of hemolytic anemias. This is the first report of this complication in hemolytic anemia caused by pyruvate-kinase deficiency. Indium scan, computed tomography (CT) scan, and myelography were helpful in diagnosis. Surgery and radiothera...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.4.510
更新日期:1979-04-01 00:00:00
abstract::Twenty-two patients were analyzed 2 or more years after corpus callosum section (9 partial, 13 total). Forty-one percent had class 1 outcome (elimination of secondarily generalized and complex partial seizures), 32% had class 2 outcome (elimination of secondarily generalized seizures), and 27% had class 3 outcome (no ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.1.19
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the predictive utility of self-reported and informant-reported functional deficits in patients with mild cognitive impairment (MCI) for the follow-up diagnosis of probable AD. METHODS:The Pfeffer Functional Activities Questionnaire (FAQ) and Lawton Instrumental Activities of Daily Living (IADL) S...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.5.758
更新日期:2002-03-12 00:00:00
abstract::MRI in five term children with congenital hemiplegia without clinically apparent prenatal or perinatal difficulties showed a focal or porencephalic enlargement of the lateral ventricle and periventricular T2 prolongation, which were identical to findings of periventricular venous infarction seen in preterm children. S...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000079370.28310.ea
更新日期:2003-08-26 00:00:00
abstract::The authors report a case of hereditary multiple exostoses (HME) with neurologic complications, and review the literature. A 23-year-old man exhibited a worsening spastic paraparesis with sphincter dysfunction. The cranial nerves and the exteroceptive and deep sensations were apparently undamaged. The family history, ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.29.7.973
更新日期:1979-07-01 00:00:00
abstract::Research and development of the adenosine A2A receptor selective antagonist KW6002 have focused on developing a novel nondopaminergic therapy for Parkinson's disease (PD). Salient pharmacologic features of KW6002 were investigated in several animal models of PD. In rodent and primate models, KW6002 provides symptomati...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000095219.22086.31
更新日期:2003-12-09 00:00:00
abstract::Alzheimer disease (AD) has a significant impact on caregivers. Administering and managing medications is one of their many daily tasks. More effective modes of drug administration may benefit patient and caregiver, and may improve compliance. A prospective outcome of the IDEAL (Investigation of TransDermal Exelon in A...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/01.wnl.0000281848.25142.11
更新日期:2007-07-24 00:00:00
abstract:OBJECTIVE:To assess the possible abnormalities in the baroreflex modulation of both the heart and the arterial vasculature, in order to better evaluate the role of baroreflex abnormalities in the generation of the cardiovascular symptoms and complications affecting the familial dysautonomia (FD) patient. METHODS:Twent...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000142034.92124.6a
更新日期:2004-10-26 00:00:00
abstract:OBJECTIVE:To perform a systematic review and meta-analysis of studies reporting recurrent intracranial hemorrhage (ICH) and ischemic stroke (IS) in ICH survivors with atrial fibrillation (AF) during long-term follow-up. METHODS:A comprehensive literature search including MEDLINE, EMBASE, Cochrane library, clinical tri...
journal_title:Neurology
pub_type: 杂志文章,meta分析,评审
doi:10.1212/WNL.0000000000004235
更新日期:2017-08-15 00:00:00
abstract::Seven patients had pendular, vertical, isolated movements of the eyes soon after severe pontine strokes. The movements had a frequency of about 2 Hz and amplitudes of 3 to 40 degrees. Other rhythmic body movements at similar frequencies occurred in four patients after a delay of 6 weeks to 9 months. The character and ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.1.86
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:This study correlated the extent of abnormalities detected by different magnetic resonance imaging (MRI) techniques [proton density (PD)-weighted, T1-weighted, and magnetization transfer imaging (MTI)] with the overall cognitive, frontal lobe, and memory impairments in patients with MS. PATIENTS:There were 3...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.6.1601
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVE:To compare characteristics between Black and White patients with amyotrophic lateral sclerosis (ALS) in order to identify disparities and phenotypic variability. METHODS:We performed database review for patients seen between 1997 and 2020 at the Emory ALS Center in Atlanta, Georgia. Patients with ALS were in...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000011396
更新日期:2020-12-28 00:00:00
abstract::Sensory disturbance in the unilateral hand and ipsilateral mouth region, the cheiro-oral syndrome, may be due to cortical, thalamic, or brainstem lesions. We report five patients with this syndrome due to infarction at the border of the posterior limb of the internal capsule and the corona radiata. The sensory fibers ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.1_part_1.51
更新日期:1993-01-01 00:00:00
abstract::Among 22 patients with human T-lymphotropic virus type I (HTLV-I)-associated chronic progressive myelopathy, agarose isoelectric focusing (AIF) revealed oligoclonal IgG bands in 21: in 3 in CSF only; in 11 in CSF and to some extent in serum; and in 7, identical patterns in CSF and serum. By immunoblot after AIF of CSF...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.12.1566
更新日期:1989-12-01 00:00:00
abstract::We studied clinical characteristics and coexisting causes of stroke in 305 patients admitted to a population-based primary care center with an initial ischemic stroke and a potential cardiac source of embolism (PCSE). Using systematic standardized cardiac, arterial, and cerebral investigations and the logistics of the...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.6.855
更新日期:1991-06-01 00:00:00
abstract:OBJECTIVES:To determine whether TMEM106B single nucleotide polymorphisms (SNPs) are associated with frontotemporal lobar degeneration (FTLD) in patients with and without mutations in progranulin (GRN) and to determine whether TMEM106B modulates GRN expression. METHODS:We performed a case-control study of 3 SNPs in TME...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31820a0e3b
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:To compare the prognostic accuracy of various acute stroke prognostic scales using a large, independent, clinical trials dataset. METHODS:We directly compared 8 stroke prognostic scales, chosen based on focused literature review (Acute Stroke Registry and Analysis of Lausanne [ASTRAL]; iSCORE; iSCORE-revised...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004332
更新日期:2017-09-05 00:00:00
abstract:OBJECTIVE:To assess frontal lobe functions of subjects with age-associated memory impairment (AAMI) and to examine whether performance on neuropsychological tests is correlated with the volume of the frontal lobes in magnetic resonance imaging. DESIGN:Cross-sectional two-group comparison. SETTING:The Memory Research ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.48.1.148
更新日期:1997-01-01 00:00:00