Abstract:
:We initiated a double-blind, placebo-controlled trial to test the efficacy and safety of branched-chain amino acids (BCAA) (L-leucine 12 g, L-isoleucine 6 g, and L-valine 6 g daily) in amyotrophic lateral sclerosis (ALS) patients. There was an excess mortality in subjects randomized to active treatment (24 BCAA, 13 placebo) when a total of 126 ALS patients had been recruited. This finding, associated with the lack of efficacy of BCAA (measured by comparing the disability scales in the two treatment groups), led the Data Monitoring Committee to require cessation of the trial.
journal_name
Neurologyjournal_title
Neurologyauthors
doi
10.1212/wnl.43.12.2466subject
Has Abstractpub_date
1993-12-01 00:00:00pages
2466-70issue
12eissn
0028-3878issn
1526-632Xjournal_volume
43pub_type
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