CT and MRI findings among African-Americans with Alzheimer's disease, vascular dementia, and stroke without dementia.


:We compared CT and MRI findings among 78 Alzheimer's disease (AD), 66 vascular dementia (VaD), and 41 stroke without dementia (SWD) African-American patients to identify possible neuroimaging indicators of dementia. The patients with AD and VaD were generally older and less educated than those with SWD. VaD and SWD patients had a higher frequency of cardiovascular disease risk factors than those with AD. In multivariate analysis, the CT data showed that the presence of white matter lesions, nonlacunar infarcts, and left subcortical infarcts were predictors of VaD when compared with AD, whereas atrophy of the third ventricle and equal distribution of white matter lesions distinguished VaD from SWD. On MRI, atrophy of the temporal sulci, temporal horns, and the third ventricle, and right hemisphere infarcts, distinguished AD from VaD, while atrophy of the third ventricle differentiated VaD from SWD. These data suggest that atrophy, especially at the level of the third ventricle, presence of infarcts, and white matter lesions may be useful predictors of dementia subtype. Furthermore, the qualitative CT and MRI findings among our African-American patients were similar to those reported in other dementia studies.






Charletta D,Gorelick PB,Dollear TJ,Freels S,Harris Y




Has Abstract


1995-08-01 00:00:00












  • Altered polyamine excretion in Duchenne muscular dystrophy.

    abstract::Increased urinary levels of the polyamines, putrescine, spermidine, and spermine are present in Duchenne muscular dystrophy (DMD) patients. Alterations in excretion are detectable when based on nanomoles per milligram creatinine, micromoles per 24-hour urine collection, or nanomoles per kilogram body weight per 24-hou...


    pub_type: 杂志文章


    authors: Russell DH,Stern LZ

    更新日期:1981-01-01 00:00:00

  • Body mass index and the risk of Parkinson disease.

    abstract:OBJECTIVE:To examine the association between body mass index (BMI) and the risk of Parkinson disease (PD). METHODS:Study cohorts included 22,367 Finnish men and 23,439 women 25 to 59 years of age without a history of PD at baseline. Hazards ratios (HRs) of incident PD were estimated for different levels of BMI. RESUL...


    pub_type: 杂志文章


    authors: Hu G,Jousilahti P,Nissinen A,Antikainen R,Kivipelto M,Tuomilehto J

    更新日期:2006-12-12 00:00:00

  • A Roma founder BIN1 mutation causes a novel phenotype of centronuclear myopathy with rigid spine.

    abstract:OBJECTIVE:To describe a large series of BIN1 patients, in which a novel founder mutation in the Roma population of southern Spain has been identified. METHODS:Patients diagnosed with centronuclear myopathy (CNM) at 5 major reference centers for neuromuscular disease in Spain (n = 53) were screened for BIN1 mutations. ...


    pub_type: 杂志文章,多中心研究


    authors: Cabrera-Serrano M,Mavillard F,Biancalana V,Rivas E,Morar B,Hernández-Laín A,Olive M,Muelas N,Khan E,Carvajal A,Quiroga P,Diaz-Manera J,Davis M,Ávila R,Domínguez C,Romero NB,Vílchez JJ,Comas D,Laing NG,Laporte J,Ka

    更新日期:2018-07-24 00:00:00

  • Homocysteine and progression of generalized small-vessel disease: the SMART-MR Study.

    abstract:OBJECTIVES:Assuming the involvement of homocysteine in a generalized small-vessel disease, we investigated the association of homocysteine levels with progression of white matter lesions, lacunar infarcts, and kidney disease. METHODS:Within the SMART-MR (Second Manifestations of ARTerial disease-Magnetic Resonance) St...


    pub_type: 杂志文章


    authors: Kloppenborg RP,Geerlings MI,Visseren FL,Mali WP,Vermeulen M,van der Graaf Y,Nederkoorn PJ,SMART Study Group.

    更新日期:2014-03-04 00:00:00

  • Cabergoline in Parkinson's disease: long-term follow-up.

    abstract::We treated 36 patients with motor fluctuations and dyskinesias on chronic levodopa therapy with cabergoline (CBG) once a day for a mean period of 14.2 +/- 5.8 months. There was a significant increase in the "on" hours and a reduction in "off-period" dystonia. Ten patients continued to show a marked improvement after 2...


    pub_type: 杂志文章


    authors: Lera G,Vaamonde J,Rodriguez M,Obeso JA

    更新日期:1993-12-01 00:00:00

  • Reducing neurodisparity: Recommendations of the 2017 AAN Diversity Leadership Program.

    abstract::Many advances in prevention, diagnosis, and treatment of neurologic disease have emerged in the last few decades, resulting in reduced mortality and decreased disability. However, these advances have not benefitted all populations equally. A growing body of evidence indicates that barriers to care fall along racial an...


    pub_type: 杂志文章,评审


    authors: Marulanda-Londoño ET,Bell MW,Hope OA,Leacock RO,O'Carroll CB,Posas J 3rd,Stover NP,Young R,Hamilton R

    更新日期:2019-02-05 00:00:00

  • Factors influencing outcome of prednisone dose reduction in myasthenia gravis.

    abstract::We reviewed retrospectively 114 prednisone dose reduction attempts in 63 myasthenic patients. Dose reduction was considered successful if a patient remained asymptomatic for more than 1 year on no prednisone or a stable low dose of prednisone. Successful dose reduction attempts were more common in patients taking azat...


    pub_type: 杂志文章


    authors: Miano MA,Bosley TM,Heiman-Patterson TD,Reed J,Sergott RC,Savino PJ,Schatz NJ

    更新日期:1991-06-01 00:00:00

  • Congenital retardation and central motor defect with later evolution of seizure disorder, orofacial dysplasia, and amyotrophy. A clinicopathologic report.

    abstract::Retarded mental and motor development was observed during the first year of life of a full-term female who had been delivered with difficulty. Generalized psychomotor seizures and dysplastic "acromegalic" facial changes began to develop when she was 8 years old, and generalized amyotrophy developed over the next sever...


    pub_type: 杂志文章


    authors: Landau WM,Torack RM,Guggenheim MA

    更新日期:1976-09-01 00:00:00

  • Beta oscillations and urinary voiding in Parkinson disease.

    abstract:OBJECTIVES:To investigate the role of beta oscillations in urinary voiding and their association with lower urinary tract symptoms in Parkinson disease (PD). METHODS:We used surgically implanted deep brain stimulation electrodes to record local field potential signals from the subthalamic nucleus (STN) and globus pall...


    pub_type: 杂志文章


    authors: Roy HA,Aziz TZ,Fitzgerald JJ,Green AL

    更新日期:2018-04-24 00:00:00

  • MRI in patients with suspected vascular parkinsonism.

    abstract::To determine whether MRI can reveal more vascular lesions in patients clinically suspected of having vascular parkinsonism, we compared 15 such patients with 15 patients who had idiopathic Parkinson's disease and 10 hypertensive controls. Patients with suspected vascular parkinsonism had significantly more subcortical...


    pub_type: 杂志文章


    authors: Zijlmans JC,Thijssen HO,Vogels OJ,Kremer HP,Poels PJ,Schoonderwaldt HC,Merx JL,van 't Hof MA,Thien T,Horstink MW

    更新日期:1995-12-01 00:00:00

  • A human brain network derived from coma-causing brainstem lesions.

    abstract:OBJECTIVE:To characterize a brainstem location specific to coma-causing lesions, and its functional connectivity network. METHODS:We compared 12 coma-causing brainstem lesions to 24 control brainstem lesions using voxel-based lesion-symptom mapping in a case-control design to identify a site significantly associated w...


    pub_type: 杂志文章


    authors: Fischer DB,Boes AD,Demertzi A,Evrard HC,Laureys S,Edlow BL,Liu H,Saper CB,Pascual-Leone A,Fox MD,Geerling JC

    更新日期:2016-12-06 00:00:00

  • Postmenopausal hormone therapy and Alzheimer disease: A prospective cohort study.

    abstract:OBJECTIVE:To explore the association between postmenopausal hormone therapy (HT) and Alzheimer disease (AD). METHODS:Twenty-year follow-up data from the Kuopio Osteoporosis Risk Factor and Prevention study cohort were used. Self-administered questionnaires were sent to all women aged 47-56 years, residing in Kuopio Pr...


    pub_type: 杂志文章


    authors: Imtiaz B,Tuppurainen M,Rikkonen T,Kivipelto M,Soininen H,Kröger H,Tolppanen AM

    更新日期:2017-03-14 00:00:00

  • Mitochondrial DNA alterations as a source of human disorders.

    abstract::The mitochondrial genome has an underdeveloped "DNA repair repertoire" compared with the nuclear genome, making the mitochondrial DNA more susceptible to mutations by endogenous factors such as defects of the mitochondrial polymerase itself, and by exogenous factors such as radiation and UV light. Increased sensitivit...


    pub_type: 杂志文章,评审


    authors: Tritschler HJ,Medori R

    更新日期:1993-02-01 00:00:00

  • Predictors of relapse rate in MS clinical trials.

    abstract:BACKGROUND:The annual relapse rate has been commonly used as a primary efficacy endpoint in phase III multiple sclerosis (MS) clinical trials. The aim of this study was to determine the relative contribution of different possible prognostic factors available at baseline to the on-study relapse rate in MS. METHODS:A to...


    pub_type: 杂志文章


    authors: Held U,Heigenhauser L,Shang C,Kappos L,Polman C,Sylvia Lawry Centre for MS Research.

    更新日期:2005-12-13 00:00:00

  • Incidence of migraine relative to menstrual cycle phases of rising and falling estrogen.

    abstract:OBJECTIVE:To investigate the association between urinary hormone levels and migraine, with particular reference to rising and falling levels of estrogen across the menstrual cycle in women with menstrual and menstrually related migraine. METHODS:Women with regular menstrual cycles, who were not using hormonal contrace...


    pub_type: 杂志文章


    authors: MacGregor EA,Frith A,Ellis J,Aspinall L,Hackshaw A

    更新日期:2006-12-26 00:00:00

  • Evidence for a genetic predisposition for status epilepticus.

    abstract::The role of genetic factors in determining risk for status epilepticus (SE) was examined in twins identified using the population-based Virginia Twin Registry. Concordance rates for SE were 0.38 for monozygotic (MZ) and 0.00 for dizygotic (DZ) twins, with the rate in MZs being significantly increased over DZs. The pre...


    pub_type: 杂志文章


    authors: Corey LA,Pellock JM,Boggs JG,Miller LL,DeLorenzo RJ

    更新日期:1998-02-01 00:00:00

  • Interferon-beta-1b slows progression of atrophy in RRMS: Three-year follow-up in NAb- and NAb+ patients.

    abstract:OBJECTIVE:To determine the effect of interferon-beta-1b (IFNbeta-1b) treatment on total contrast-enhancing lesions (CEL), white matter lesion load (WMLL), and cerebral atrophy (CA) in patients with relapsing-remitting multiple sclerosis (RRMS) using serial monthly MRI. METHODS:An open-label baseline-vs-treatment cross...


    pub_type: 临床试验,杂志文章


    authors: Frank JA,Richert N,Bash C,Stone L,Calabresi PA,Lewis B,Stone R,Howard T,McFarland HF

    更新日期:2004-03-09 00:00:00

  • Nonseptic cardiogenic cerebral embolic stroke: clinical-CT correlations.

    abstract::We studied 35 patients with nonseptic cardiogenic cerebral emboli. In 28 cases, there was sudden onset with maximal neurologic deficit within 1 hour; in 7 cases, there was progression in 24 hours. In six cases, neurologic abnormality worsened in the first week after an initial period of stabilization. CT showed eviden...


    pub_type: 杂志文章


    authors: Weisberg LA

    更新日期:1985-06-01 00:00:00

  • Transient obstructive sleep apnea and asystole in association with presumed viral encephalopathy.

    abstract::Evidence suggests that untreated obstructive sleep apnea (OSA) can lead to hypertension, cardiovascular disease, and stroke. Conversely, the systemic effects of a wide variety of critical illnesses can lead to CNS dysfunction, which can precipitate respiratory failure. Reported is a patient in whom an acute encephalop...


    pub_type: 杂志文章


    authors: Dyken ME,Yamada T,Berger HA

    更新日期:2003-05-27 00:00:00

  • Linkage of the locus for cerebral cavernous hemangiomas to human chromosome 7q in four families of Mexican-American descent.

    abstract:OBJECTIVE:To determine with greater precision the map location of the locus associated with familial cavernous hemangiomas. BACKGROUND:Cavernous malformations of the brain are a significant cause of seizures, progressive or apoplectic neurologic deficit, and headache. Prevalence estimates from autopsy series vary from...


    pub_type: 杂志文章


    authors: Polymeropoulos MH,Hurko O,Hsu F,Rubenstein J,Basnet S,Lane K,Dietz H,Spetzler RF,Rigamonti D

    更新日期:1997-03-01 00:00:00

  • Psychiatric adverse events during levetiracetam therapy.

    abstract::The prevalence and psychopathologic features of psychiatric adverse events (PAE) in 517 patients taking levetiracetam (LEV) were investigated. Fifty-three (10.1%) patients developed PAE. A significant association was found with previous psychiatric history, history of febrile convulsions, and history of status epilept...


    pub_type: 杂志文章


    authors: Mula M,Trimble MR,Yuen A,Liu RS,Sander JW

    更新日期:2003-09-09 00:00:00

  • How transient are transient ischemic attacks?

    abstract::Information on 1,343 hospitalized patients in the Cornell Neurology Database with final diagnoses of transient ischemic attacks (TIA), reversible ischemic neurologic deficits (RIND), or ischemic stroke was examined in order to determine the duration of ischemic deficits. Episodes resolved within the first 24 hours (cl...


    pub_type: 杂志文章


    authors: Levy DE

    更新日期:1988-05-01 00:00:00

  • A case-control study of HIV-1-related dementia and co-infection with HHV-8.

    abstract::This nested case-control study assessed the putative protective effect of human herpesvirus-8 (HHV-8) against HIV-1-related dementia (dementia). The HHV-8 seropositivity of 210 male age- and HIV disease stage-matched cases and controls was compared. The overall HHV-8 seropositivity of 66% was similar among demented HI...


    pub_type: 杂志文章,多中心研究


    authors: Polk S,Muñoz A,Sacktor NC,Jenkins FJ,Cohen B,Miller EN,Jacobson LP

    更新日期:2002-09-24 00:00:00

  • Effect of yoga as add-on therapy in migraine (CONTAIN): A randomized clinical trial.

    abstract:OBJECTIVE:To evaluate the effectiveness of yoga as an adjuvant to conventional medical management on clinical outcomes in patients with migraine. METHODS:CONTAIN was a prospective, randomized, open-label superiority trial with blinded endpoint assessment carried out at a single tertiary care academic hospital in New D...


    pub_type: 杂志文章,随机对照试验


    authors: Kumar A,Bhatia R,Sharma G,Dhanlika D,Vishnubhatla S,Singh RK,Dash D,Tripathi M,Srivastava MVP

    更新日期:2020-05-26 00:00:00

  • Education Research: Physician identification and patient satisfaction on an academic neurology inpatient service.

    abstract:OBJECTIVE:To determine the relationship between neurology inpatient satisfaction and (1) number of physicians involved in the patient's care and (2) patients' ability to identify their physicians. METHODS:A 10-item questionnaire addressing patient satisfaction and identification of physicians on the care team was admi...


    pub_type: 杂志文章


    authors: Leon Guerrero CR,Anderson T,Zazulia AR

    更新日期:2018-02-13 00:00:00

  • Cerebrospinal fluid and blood assays of diagnostic usefulness in multiple sclerosis.

    abstract::Although the ultimate diagnosis of multiple sclerosis (MS) still remains clinical, confirmatory laboratory aids can be of marked assistance, especially in early and atypical cases. Whereas numerous tests have been described, the only ones to withstand scrutiny in numerous laboratories have been various immunoglobulin ...


    pub_type: 杂志文章,评审


    authors: Johnson KP

    更新日期:1980-07-01 00:00:00

  • Forced collectionism after orbitofrontal damage.

    abstract::A collector is a person who collects things on purpose, either as a hobby or business, or for personal satisfaction, e.g., stamp, coin, or art collector. In such instances, the act of collecting things represents voluntary, controlled, goal-directed, selective searching. Pathologic patterns of collecting have been obs...


    pub_type: 杂志文章


    authors: Volle E,Beato R,Levy R,Dubois B

    更新日期:2002-02-12 00:00:00

  • Familial clustering of seizure types within the idiopathic generalized epilepsies.

    abstract:OBJECTIVE:To examine the genetic relationships among epilepsies with different seizure types--myoclonic, absence, and generalized tonic-clonic--within the idiopathic generalized epilepsies (IGEs). BACKGROUND:Careful phenotype definition in the epilepsies may allow division into groups that share susceptibility genes. ...


    pub_type: 杂志文章


    authors: Winawer MR,Marini C,Grinton BE,Rabinowitz D,Berkovic SF,Scheffer IE,Ottman R

    更新日期:2005-08-23 00:00:00

  • MS, MRI, and the 2010 McDonald criteria: a Canadian expert commentary.

    abstract::Since the first development of diagnostic criteria for multiple sclerosis (MS), there have been regular revisions of disease definitions and diagnostic thresholds aimed at improving specificity while maintaining sensitivity. The central requirements for diagnosis of MS are dissemination in space (DIS) and disseminatio...


    pub_type: 杂志文章


    authors: Selchen D,Bhan V,Blevins G,Devonshire V,Duquette P,Grand'Maison F,Kremenchutzky M,Lapierre Y,Li D,von Riedemann SJ,Freedman M

    更新日期:2012-12-04 00:00:00

  • Amyotrophic lateral sclerosis: thyrotropin-releasing hormone and histidyl proline diketopiperazine in the spinal cord and cerebrospinal fluid.

    abstract::In spinal cords from seven amyotrophic lateral sclerosis (ALS) patients and four controls, we found no difference in thyrotropin-releasing hormone (TRH) concentration relative to protein content, but there was a reduction per tissue wet weight in ALS. Immunohistochemical localization of TRH in ALS cord was unaltered. ...


    pub_type: 杂志文章


    authors: Jackson IM,Adelman LS,Munsat TL,Forte S,Lechan RM

    更新日期:1986-09-01 00:00:00