CT and MRI findings among African-Americans with Alzheimer's disease, vascular dementia, and stroke without dementia.


:We compared CT and MRI findings among 78 Alzheimer's disease (AD), 66 vascular dementia (VaD), and 41 stroke without dementia (SWD) African-American patients to identify possible neuroimaging indicators of dementia. The patients with AD and VaD were generally older and less educated than those with SWD. VaD and SWD patients had a higher frequency of cardiovascular disease risk factors than those with AD. In multivariate analysis, the CT data showed that the presence of white matter lesions, nonlacunar infarcts, and left subcortical infarcts were predictors of VaD when compared with AD, whereas atrophy of the third ventricle and equal distribution of white matter lesions distinguished VaD from SWD. On MRI, atrophy of the temporal sulci, temporal horns, and the third ventricle, and right hemisphere infarcts, distinguished AD from VaD, while atrophy of the third ventricle differentiated VaD from SWD. These data suggest that atrophy, especially at the level of the third ventricle, presence of infarcts, and white matter lesions may be useful predictors of dementia subtype. Furthermore, the qualitative CT and MRI findings among our African-American patients were similar to those reported in other dementia studies.






Charletta D,Gorelick PB,Dollear TJ,Freels S,Harris Y




Has Abstract


1995-08-01 00:00:00












  • Presenting features and value of diagnostic procedures in leptomeningeal metastases.

    abstract:OBJECTIVE:To study the presenting features and value of routine diagnostic procedures in patients with leptomeningeal metastases (LMM) related to the primary malignancy to improve diagnostic assessment. METHODS:The authors studied the presenting features and value of routine diagnostic procedures in relation to the hi...


    pub_type: 杂志文章


    authors: van Oostenbrugge RJ,Twijnstra A

    更新日期:1999-07-22 00:00:00

  • Cyproheptadine reduces or prevents ischemic central nervous system damage.

    abstract::Several drugs that inhibit the effects of serotonin may reduce or prevent experimental CNS ischemic damage, but these drugs are not approved for human use in the United States. Administration of cyproheptadine (which is available for clinical use) 15 minutes before or 5 minutes after the onset increased the duration o...


    pub_type: 杂志文章


    authors: Zivin JA

    更新日期:1985-04-01 00:00:00

  • Association of aortic plaque with intracranial atherosclerosis in patients with stroke.

    abstract:OBJECTIVE:To determine whether there is a relationship between aortic plaques and intracranial (IC) atherosclerosis. METHODS:We reviewed 922 patients with stroke who had both transesophageal echocardiography and cerebral angiography. The plaques of these patients were classified as either complex aortic plaques (CAP),...


    pub_type: 杂志文章


    authors: Nam HS,Han SW,Lee JY,Ahn SH,Ha JW,Rim SJ,Lee BI,Heo JH

    更新日期:2006-10-10 00:00:00

  • The frequency of CD5+ B lymphocytes in the peripheral blood of patients with myasthenia gravis.

    abstract::A subset of human B lymphocytes expresses Leu-1 (CD5), a pan-T cell marker, which is the equivalent of the murine Lyt-1 molecule. CD5+ B cells produce autoantibodies in vitro; therefore, they may play a role in the pathogenesis of autoimmune disorders. In myasthenia gravis (MG), autoantibodies are directed against the...


    pub_type: 杂志文章


    authors: Ragheb S,Lisak RP

    更新日期:1990-07-01 00:00:00

  • The incidence and significance of anti-natalizumab antibodies: results from AFFIRM and SENTINEL.

    abstract:OBJECTIVE:To determine the incidence and clinical effects of antibodies that develop during treatment with natalizumab. METHODS:In two randomized, double-blind, placebo-controlled studies (natalizumab safety and efficacy in relapsing remitting multiple sclerosis [MS, AFFIRM] and safety and efficacy of natalizumab in c...


    pub_type: 杂志文章,随机对照试验


    authors: Calabresi PA,Giovannoni G,Confavreux C,Galetta SL,Havrdova E,Hutchinson M,Kappos L,Miller DH,O'Connor PW,Phillips JT,Polman CH,Radue EW,Rudick RA,Stuart WH,Lublin FD,Wajgt A,Weinstock-Guttman B,Wynn DR,Lynn F,Panzar

    更新日期:2007-10-02 00:00:00

  • Elevated cortical zinc in Alzheimer disease.

    abstract:OBJECTIVE:To determine whether changes in brain biometals in Alzheimer disease (AD) and in normal brain tissue are tandemly associated with amyloid beta-peptide (Abeta) burden and dementia severity. METHODS:The authors measured zinc, copper, iron, manganese, and aluminum and Abeta levels in postmortem neocortical tiss...


    pub_type: 杂志文章


    authors: Religa D,Strozyk D,Cherny RA,Volitakis I,Haroutunian V,Winblad B,Naslund J,Bush AI

    更新日期:2006-07-11 00:00:00

  • Corpus callosotomy for epilepsy. I. Seizure effects.

    abstract::Twenty-two patients were analyzed 2 or more years after corpus callosum section (9 partial, 13 total). Forty-one percent had class 1 outcome (elimination of secondarily generalized and complex partial seizures), 32% had class 2 outcome (elimination of secondarily generalized seizures), and 27% had class 3 outcome (no ...


    pub_type: 杂志文章


    authors: Spencer SS,Spencer DD,Williamson PD,Sass K,Novelly RA,Mattson RH

    更新日期:1988-01-01 00:00:00

  • Influenza and myoglobinuria in brothers.

    abstract::Two adult brothers became ill within 48 hours of each other, and both had severe myoglobinuria. One brother died of oliguric renal failure. The other did not have renal failure and survived. Acute influenza A infection was documented serologically and from throat washings in the surviving brother, and by isolation of ...


    pub_type: 杂志文章


    authors: Zamkoff K,Rosen N

    更新日期:1979-03-01 00:00:00

  • Head growth and neurodevelopment of infants born to HIV-1-infected drug-using women.

    abstract:OBJECTIVE:To describe neurodevelopment and head growth in HIV-1-infected and exposed uninfected infants with and without in utero exposure to opiates and cocaine. METHODS:Using data from a multicenter cohort study of HIV-1-infected women and their children, the authors fit repeated measures regression models to estima...


    pub_type: 杂志文章,多中心研究


    authors: Macmillan C,Magder LS,Brouwers P,Chase C,Hittelman J,Lasky T,Malee K,Mellins CA,Velez-Borras J

    更新日期:2001-10-23 00:00:00

  • Higher frequency of dementia in older HIV-1 individuals: the Hawaii Aging with HIV-1 Cohort.

    abstract:BACKGROUND:Antiretroviral therapy has improved survival for HIV-1-infected individuals. The neuroepidemiologic implications of HIV-1 in an aging population are not well known, particularly the prevalence of HIV-associated dementia (HAD). METHODS:The authors report a baseline cross-sectional analysis of 202 HIV-1-serop...


    pub_type: 杂志文章


    authors: Valcour V,Shikuma C,Shiramizu B,Watters M,Poff P,Selnes O,Holck P,Grove J,Sacktor N

    更新日期:2004-09-14 00:00:00

  • Alterations in bcl-2 and caspase gene family protein expression in human temporal lobe epilepsy.

    abstract:OBJECTIVE:To address the role of cell death regulatory genes of the bcl-2 and caspase families in the neuropathology of human epilepsy using tissue extracted from patients undergoing temporal lobectomy for intractable seizures. METHODS:Using Western blotting and immunohistochemistry, the authors investigated the expre...


    pub_type: 杂志文章


    authors: Henshall DC,Clark RS,Adelson PD,Chen M,Watkins SC,Simon RP

    更新日期:2000-07-25 00:00:00

  • Psychiatric features in diffuse Lewy body disease: a clinicopathologic study using Alzheimer's disease and Parkinson's disease comparison groups.

    abstract::We conducted a retrospective study to determine the frequency of depression, hallucinations, and delusions in patients with diffuse Lewy body disease (DLBD) and to compare these findings with those in Alzheimer's disease (AD) and Parkinson's disease (PD). One hundred twelve subjects were included in the study. Of thes...


    pub_type: 杂志文章


    authors: Klatka LA,Louis ED,Schiffer RB

    更新日期:1996-11-01 00:00:00

  • Distinct brain networks underlie cognitive dysfunction in Parkinson and Alzheimer diseases.

    abstract:OBJECTIVE:To determine whether cognitive impairment in Parkinson disease (PD) and Alzheimer disease (AD) derives from the same network pathology. METHODS:We analyzed 18F-fluorodeoxyglucose PET scans from 40 patients with AD and 40 age-matched healthy controls from the Alzheimer's Disease Neuroimaging Initiative and sc...


    pub_type: 杂志文章


    authors: Mattis PJ,Niethammer M,Sako W,Tang CC,Nazem A,Gordon ML,Brandt V,Dhawan V,Eidelberg D

    更新日期:2016-11-01 00:00:00

  • Neurodevelopmental outcome after endovascular treatment of vein of Galen malformations.

    abstract:OBJECTIVE:To assess neurodevelopmental outcome after endovascular treatment of vein of Galen malformations (VOGM). METHODS:Outcome of patients who underwent endovascular treatment for VOGM between 1983 and 2002 was assessed by chart review and parental questionnaires. Development was classified as normal, minor delay ...


    pub_type: 杂志文章


    authors: Fullerton HJ,Aminoff AR,Ferriero DM,Gupta N,Dowd CF

    更新日期:2003-11-25 00:00:00

  • TENS for the treatment of writer's cramp dystonia: a randomized, placebo-controlled study.

    abstract::Manipulation of afferent inputs may temporarily modulate dystonic spasms. Ten patients with writer's cramp were enrolled in a double-blind, randomized, crossover study in which the effects of transcutaneous electrical stimulation (TENS) and placebo treatment were compared. Patients were evaluated using four measures o...


    pub_type: 杂志文章,随机对照试验


    authors: Tinazzi M,Farina S,Bhatia K,Fiaschi A,Moretto G,Bertolasi L,Zarattini S,Smania N

    更新日期:2005-06-14 00:00:00

  • Teaching the next generation of neurologists.

    abstract::Educators of the next generation of neurologists will face several challenges, including changes in academic medical centers and hospitals, changes in the scope and practice of neurology itself, and changes in trainees, related to both access to information technology and professional goals. This article, which origin...


    pub_type: 杂志文章


    authors: Elkind MS

    更新日期:2009-02-17 00:00:00

  • Myasthenia gravis activities of daily living profile.

    abstract::The authors have developed an MG activities of daily living (ADL) profile (MG-ADL)-a simple eight-question survey of MG symptoms. In 254 consecutive encounters with established MG patients, the authors compared scores from the MG-ADL to the quantitative MG score (QMG)-a standardized, reliable scale used in clinical tr...


    pub_type: 杂志文章


    authors: Wolfe GI,Herbelin L,Nations SP,Foster B,Bryan WW,Barohn RJ

    更新日期:1999-04-22 00:00:00

  • Penetrance of Parkinson disease in glucocerebrosidase gene mutation carriers.

    abstract:OBJECTIVE:Glucocerebrosidase (GBA) gene mutations represent a strong risk factor for Parkinson disease (PD). PD penetrance in GBA mutation carriers, which represents a key issue for genetic counseling, especially for relatives of patients with Gaucher disease (GD), is unknown. Our objective was to estimate PD penetranc...


    pub_type: 杂志文章


    authors: Anheim M,Elbaz A,Lesage S,Durr A,Condroyer C,Viallet F,Pollak P,Bonaïti B,Bonaïti-Pellié C,Brice A,French Parkinson Disease Genetic Group.

    更新日期:2012-02-07 00:00:00

  • Repetitive phrenic nerve stimulation in myasthenia gravis.

    abstract:OBJECTIVE:In patients with MG it may be difficult to determine whether respiratory insufficiency is due to a defect in neuromuscular transmission. We therefore studied the clinical value of repetitive electrical stimulation of the phrenic nerve. METHODS:Repetitive phrenic nerve stimulation at 3 Hz was performed in 25 ...


    pub_type: 杂志文章


    authors: Zifko UA,Nicolle MW,Grisold W,Bolton CF

    更新日期:1999-09-22 00:00:00

  • Localizing value of torsional nystagmus in small midbrain lesions.

    abstract:BACKGROUND:The topodiagnostic value and specificity of nystagmus in patients with mesencephalic lesions and its relation to tonic torsional deficits and vertical saccade deficits is controversial and anecdotal. METHODS:The authors examined 11 patients with vascular MRI-identified mesencephalic lesions and clinical evi...


    pub_type: 临床试验,杂志文章


    authors: Helmchen C,Rambold H,Kempermann U,Büttner-Ennever JA,Büttner U

    更新日期:2002-12-24 00:00:00

  • Hemiballism and metastatic brain tumor.

    abstract::We describe a 78-year-old man with right hemiballism as the presenting symptom of a metastatic occult adenocarcinoma of the lung. CT demonstrated two contrast-enhancing lesions: one in the left subthalamic region and the other in the left parietal region. Metastatic tumor was confirmed at autopsy. ...


    pub_type: 杂志文章


    authors: Glass JP,Jankovic J,Borit A

    更新日期:1984-02-01 00:00:00

  • Fatal ataxic encephalopathy and carnitine acetyltransferase deficiency: a functional defect of pyruvate oxidation?

    abstract::A 3-year 8-month-old girl died after 14 months of illness characterized by episodes of intermittent ataxia associated with oculomotor palsy, hypotonia, mental confusion, and disturbances of consciousness. In the last 4 months of life, there were signs of liver dysfunction. Pyruvate dehydrogenase and alpha-ketoglutarat...


    pub_type: 杂志文章


    authors: DiDonato S,Rimoldi M,Moise A,Bertagnoglio B,Uziel G

    更新日期:1979-12-01 00:00:00

  • Establishment of epilepsy surgery in Peru.

    abstract::Epilepsy surgery is a well-established treatment for certain types of intractable epilepsy. While there is a relatively high number of epilepsy surgery centers in Canada and the United States, the same cannot be said about many other parts of the world, such as South America. Although there are notable exceptions, suc...


    pub_type: 杂志文章


    authors: Steven DA,Vasquez CM,Delgado JC,Zapata-Luyo W,Becerra A,Barreto E,Arango MF,Burneo JG

    更新日期:2018-08-21 00:00:00

  • Molecular genetic investigations in the CCM1 gene in sporadic cerebral cavernomas.

    abstract:OBJECTIVE:Cerebral cavernous malformations (CCM) occur in familial and sporadic forms that cannot be distinguished by phenotype. Mutations in Krit1, a gene located at the CCM1 locus on chromosome 7q21, account for the majority of familial CCM cases. The authors investigated the role that mutations at the CCM1 locus pla...


    pub_type: 杂志文章


    authors: Reich P,Winkler J,Straube A,Steiger HJ,Peraud A

    更新日期:2003-04-08 00:00:00

  • The thymus gland in elderly patients with myasthenia gravis.

    abstract::This study was undertaken to determine the amount and histologic appearance of the persistent thymic tissue removed post mortem from 20 patients over 60 years of age with myasthenia gravis. One patient died several days after thymectomy. No recognizable thymic tissue on gross examination was seen in any patient. On mi...


    pub_type: 杂志文章


    authors: Perlo VP,Arnason B,Castleman B

    更新日期:1975-03-01 00:00:00

  • Teaching Video NeuroImages: myokymia and nerve hyperexcitability as components of Morvan syndrome due to malignant thymoma.

    abstract::A 50-year-old woman with a history of metastatic malignant thymoma presented with diffuse neuropathic pain involving the extremities and torso prior to chemotherapy and radiation. She also developed episodic diarrhea, diaphoresis, fevers, insomnia, and encephalopathy. Examination revealed rippling muscles (video on th...


    pub_type: 杂志文章


    authors: Lukas RV,Rezania K,Malec M,Salgia R

    更新日期:2013-01-29 00:00:00

  • Relationship between Meige syndrome and alpha-methyldopa-induced parkinsonism.

    abstract::We studied two patients with Meige syndrome who developed alpha-methyldopa-induced parkinsonism. Opposite responses of parkinsonian and dystonic symptoms to antiparkinson drugs in some cases suggest a functionally reciprocal relationship between these disorders. ...


    pub_type: 杂志文章


    authors: Sechi GP,Demontis G,Rosati G

    更新日期:1985-11-01 00:00:00

  • Establishment of primary stroke centers: a survey of physician attitudes and hospital resources.

    abstract:OBJECTIVES:To survey US physicians involved in acute stroke care to determine the proportion of hospitals that currently meet the recommended Brain Attack Coalition (BAC) criteria for Primary Stroke Centers (PSC) and obtain opinions regarding the value of stroke centers. METHODS:A survey regarding the BAC guidelines f...


    pub_type: 杂志文章


    authors: Kidwell CS,Shephard T,Tonn S,Lawyer B,Murdock M,Koroshetz W,Alberts M,Hademenos GJ,Saver JL

    更新日期:2003-05-13 00:00:00

  • Effect of age at onset on progression and mortality in Parkinson's disease.

    abstract::We examined longitudinal disability scores in 54 patients with Parkinson's disease followed for 6 years at UCLA. We sorted data into 3 groups based on age at onset of symptoms: group A, onset under 50 years; group B, 50 to 59 years; group C, 60 years or older. There were no significant differences between groups initi...


    pub_type: 杂志文章


    authors: Diamond SG,Markham CH,Hoehn MM,McDowell FH,Muenter MD

    更新日期:1989-09-01 00:00:00

  • Quantitative evaluation of the effects of L-dopa in torsion dystonia: a case report.

    abstract::We used electrophysiologic methods in the diagnosis of torsion dystonia and the evaluation of therapy in a 7-year-old child. Electromyographic (EMG) activity patterns in five leg muscles were recorded during specific voluntary and passive movements as well as during gait. We found patterns of coactivation in leg muscl...


    pub_type: 杂志文章


    authors: Richards CL,Bédard PJ,Fortin G,Malouin F

    更新日期:1983-08-01 00:00:00