Abstract:
:The incidence of MS in the Orkney Islands has been updated from 1941 to September 21, 1983. Since 1965, MS incidence rates have fallen significantly when compared with those for 1941 to 1964. Alterations in age-specific prevalence, mean duration of illness, and mean age of the MS population are consistent with the decline in incidence of MS in recent years. Although the reason for the decreasing incidence is uncertain, it is consistent with the hypothesis that MS may be caused by canine distemper virus.
journal_name
Neurologyjournal_title
Neurologyauthors
Cook SD,Cromarty JI,Tapp W,Poskanzer D,Walker JD,Dowling PCdoi
10.1212/wnl.35.4.545subject
Has Abstractpub_date
1985-04-01 00:00:00pages
545-51issue
4eissn
0028-3878issn
1526-632Xjournal_volume
35pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::Using a perceptual technique it is shown that patients with chronic external ophthalmoplegia have shortened vestibular responses. It is postulated that this is secondary to the retinal image slip experienced by these patients during head movements and a useful compensatory mechanism to suppress motion-induced sickness...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000067992.17185.60
更新日期:2003-06-24 00:00:00
abstract::We describe the clinical, pathologic, and ultrastructural findings in a case of juvenile onset neuronal ceroid-lipofuscinosis without visual symptoms or retinal abnormalities. The histochemical and ultrastructural characteristics of the neuronal lipopigment were similar to those in typical cases of neuronal ceroid-lip...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.7.710
更新日期:1978-07-01 00:00:00
abstract::Generic substitution is practiced widely in both hospital and community settings. There have been several reports of reduced serum concentrations and seizure exacerbation following generic substitution of Tegretol. We describe the first 2 cases of carbamazepine toxicity resulting from the substitution of Tegretol with...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.12.2696
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVE:To determine age- and sex-specific AD prevalence rates for whites using each of four severity-based definitions of a case: a person diagnosed as having at least questionable AD, one diagnosed as having at least mild AD, one diagnosed as having moderate or severe AD, and one diagnosed as having severe AD. MET...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.2.198
更新日期:2000-07-25 00:00:00
abstract:BACKGROUND:Most cavernous sinus dural arteriovenous malformations (CSdAVM) have a benign clinical course. Those CSdAVM that drain into cortical veins have an increased risk for neurologic complications. OBJECTIVE:To find whether a specific clinical sign predicts cortical venous drainage (CVD) in CSdAVM. METHODS:The r...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.58.10.1521
更新日期:2002-05-28 00:00:00
abstract::An infant with transient neonatal myasthenia gravis had a double-blood-volume exchange transfusion because of maternal-fetal blood group incompatibility. This seemed to accelerate both decline in antiacetylcholine antibody titer and clinical improvement. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.7.911
更新日期:1981-07-01 00:00:00
abstract::We studied lymphocyte subsets and major histocompatibility complex (MHC) class II antigens in frozen brain tissues from three patients with subacute sclerosing panencephalitis (SSPE) using immunocytochemical techniques. Perivascular cuffs consisted predominantly of T cells and MHC class II-positive cells. In the paren...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.10.1639
更新日期:1991-10-01 00:00:00
abstract:OBJECTIVE:To identify the metabolic signature of the various levels of cognitive deficits in amyotrophic lateral sclerosis (ALS) using 18F-2-fluoro-2-deoxy-d-glucose-PET (18F-FDG-PET). METHODS:A total of 170 ALS cases consecutively enrolled at the ALS Center of Turin underwent brain 18F-FDG-PET and were classified as ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002242
更新日期:2016-01-05 00:00:00
abstract:OBJECTIVE:To determine whether brain function is altered in cognitively normal individuals at high risk for AD several years before the typical age at onset for this illness. BACKGROUND:Neuropathologic alterations in AD precede cognitive impairment by several years. It is unknown whether functional alterations in neur...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.7.1391
更新日期:1999-10-22 00:00:00
abstract::We evaluated the ability of nurse clinicians to assess parkinsonian signs in older persons with a modified version of the motor section of the Unified Parkinson's Disease Rating Scale (UPDRS). After completing a structured training protocol, three nurse clinicians and a neurologist with expertise in movement disorders...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.6.1580
更新日期:1997-12-01 00:00:00
abstract::Two successive, 6-month, randomized, double-blind, controlled trials of prednisone showed that 0.75 mg/kg/d was the optimal dose to improve strength in boys with Duchenne muscular dystrophy (DMD). We attempted to maintain 93 boys on that dose for an additional 2 years. During the 3 years of observation, the decline in...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.41.12.1874
更新日期:1991-12-01 00:00:00
abstract:OBJECTIVE:To determine the role of weight loss in the treatment of idiopathic intracranial hypertension (IIH) in obese women. METHODS:Chart review of 250 patients with suspected IIH revealed 58 women who met our criteria, did not undergo early surgical intervention, and had adequate documentation of visual status, pap...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.4.1094
更新日期:1998-04-01 00:00:00
abstract::We tested the hypothesis that asymptomatic carriers of dopa-responsive dystonia (DRD) have increased dopamine D2 receptors in the striatum that protect them from the clinical manifestations of dopaminergic deficiency. We examined striatal D2-receptor binding in (1) symptomatic subjects (treated and untreated) and (2) ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.4.1028
更新日期:1998-04-01 00:00:00
abstract::The role of gender in the pathogenesis of Alzheimer's disease (AD) is an important issue that remains controversial. We compared men and women in late-onset familial AD kindreds for the risk of developing AD by studying 26 well-characterized familial AD kindreds from the Oregon Alzheimer Disease Center and, for confir...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.1.126
更新日期:1996-01-01 00:00:00
abstract::A 51-year-old man had a 4-month history of progressive headache and gradual onset of somnolence. MRI suggested spontaneous intracranial hypotension (SIH) with diencephalic compression, but he did not improve after three epidural blood patches. He became alert following intrathecal saline infusion that normalized his C...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.6.1854
更新日期:1998-06-01 00:00:00
abstract::We report longitudinal data on a group of 29 male patients 50 years of age or older who were initially diagnosed as having idiopathic REM sleep behavior disorder (RBD) after extensive polysomnographic and neurologic evaluations. Thirty-eight percent (11/29) were eventually diagnosed as having a parkinsonian disorder (...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.2.388
更新日期:1996-02-01 00:00:00
abstract::The childhood type fo dermatomyositis, which occurs in children and young adults, shows a specific constellation of pathologic changes in muscle. Capillary necrosis leads to capillary loss, generally starting on the periphery of muscle fascicles. Electron microscopy discloses undulating tubules in endothelial cells, l...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.10.952
更新日期:1976-10-01 00:00:00
abstract::Since the emergence of the specialty, neurologists have worked with a rather restricted list of relatively inexpensive pharmacologic agents. This is rapidly changing with the development of new agents for the treatment of migraine, multiple sclerosis, Parkinson's disease, Alzheimer's disease, and epilepsy, accelerated...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.3.569
更新日期:1995-03-01 00:00:00
abstract::We used the Mayo Clinic medical records linkage system to detect all cases of intracranial vascular malformation (IVM) among residents of Olmsted County, Minnesota from 1965 to 1992 and found 48 IVMs over the 27-year period, including four patients with IVM detected at autopsy, without prior symptoms. Twenty-nine of 4...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.4.949
更新日期:1996-04-01 00:00:00
abstract:OBJECTIVE:To study the attributes of quantitative strength testing using hand-held dynamometry (HHD) as an efficacy measure in 2 large phase 3 amyotrophic lateral sclerosis (ALS) trials. METHODS:In the phase 3 trials of ceftriaxone and dexpramipexole, 513 and 943 patients, respectively, were enrolled in double-blind, ...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0000000000002941
更新日期:2016-08-09 00:00:00
abstract::Three patients presented with unilateral progressive optic neuropathy. None of these patients had signs of symptoms referable to the chiasm or eye, thus confining their decline in vision to the optic nerve. Clinical and neuroradiographic evidence suggested a meningioma involving the optic nerve at the orbital-canalicu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.6.597
更新日期:1982-06-01 00:00:00
abstract::A 35-year-old woman had cardiac arrest requiring treatment with a left ventricular assist device. After regaining consciousness, examination revealed upbeating nystagmus, otherwise normal bulbar function, left arm dysmetria, and numbness periorally and in areas she described as "a turtleneck of numbness with a T-shirt...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000436939.70528.03
更新日期:2013-12-03 00:00:00
abstract::Recent positive trials have thrust acute cerebral perfusion imaging into the routine evaluation of acute ischemic stroke. Updated guidelines state that in patients with anterior circulation large vessel occlusions presenting beyond 6 hours from time last known well, advanced imaging selection including perfusion-based...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0000000000008481
更新日期:2019-11-12 00:00:00
abstract::We reviewed the outcome (developmental, neurologic, and seizure) and prognostic factors of 57 cases of infantile spasms (17 cryptogenic, 40 symptomatic). The mean developmental score of the cryptogenic group (71.2 +/- 24.2) was significantly higher than that of the symptomatic group (48.4 +/- 24.5), as assessed by the...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.11.2322
更新日期:1993-11-01 00:00:00
abstract::Dr. Masur and colleagues(1) from the Childhood Absence Epilepsy Study Group tried to answer a few important questions regarding childhood absence epilepsy (CAE) in their article "Pretreatment cognitive deficits and treatment effects on attention in childhood absence epilepsy." First, they wanted to know whether childr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000436060.67147.25
更新日期:2013-10-29 00:00:00
abstract::Proton nuclear magnetic resonance spectroscopy is a noninvasive technique allowing the localized, in vivo detection of proton-containing brain metabolites. We used this technique to study eight patients with cerebral infarction or ischemia. A stimulated echo-pulse sequence with chemical shift imaging was used to acqui...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.7.1408
更新日期:1992-07-01 00:00:00
abstract::We investigated blood-brain barrier (BBB) function in relation to Alzheimer's disease (AD) and vascular dementia (VAD) in the very elderly. Sixty-five 85-year-old persons from a population-based sample were followed for 3 years; 29 were demented at age 85 (13 with AD, 14 with VAD, and 2 with other dementias), 7 develo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.4.966
更新日期:1998-04-01 00:00:00
abstract:OBJECTIVE:We sought to assess the prevalence, correlates, and consequences of periodic limb movements of sleep (PLMS) in persons with obstructive sleep apnea (OSA) and the effect (worsening or improvement) of continuous positive airway pressure (CPAP) therapy on PLMS in a large prospective multicenter randomized contro...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008844
更新日期:2020-04-28 00:00:00
abstract:OBJECTIVE:To present the current terminology and natural history of neurofibromatosis 1 (NF1) cutaneous neurofibromas (cNF). METHODS:NF1 experts from various research and clinical backgrounds reviewed the terms currently in use for cNF as well as the clinical, histologic, and radiographic features of these tumors usin...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000005792
更新日期:2018-07-10 00:00:00
abstract:BACKGROUND:Demyelination alone may not explain the progressive disability that frequently develops in MS. An alternative explanation for irreversible disability assumes a contribution from axonal injury or loss. In theory, axonal injury may occur in the focal areas characterized by early inflammation, or can be more di...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.5.1155
更新日期:2000-03-14 00:00:00