Abstract:
:We evaluated the ability of nurse clinicians to assess parkinsonian signs in older persons with a modified version of the motor section of the Unified Parkinson's Disease Rating Scale (UPDRS). After completing a structured training protocol, three nurse clinicians and a neurologist with expertise in movement disorders administered a modified UPDRS to 75 older persons. The nurses repeated the assessment about 3 weeks later. Inter-rater agreement and short-term temporal stability were estimated for each item, the total modified UPDRS score, and for summary measures of bradykinesia, postural reflex impairment, rigidity, and tremor, and a global parkinsonian sign score. We performed our assessment in Catholic religious communities in the Chicago area, using consecutive subjects at four communities participating in the Religious Orders Study, a longitudinal, clinical-pathologic study of older persons. Our results showed that nurses were not a significant source of variability, with intraclass correlations exceeding 0.97 for all items, and they showed good to excellent agreement with the neurologist for most modified UPDRS items. Correlations between nurses and neurologist exceeded 0.90 for the total modified UPDRS, ranged from 0.76 to 0.95 for the four parkinsonian domain scores, and exceeded 0.90 for the global parkinsonian sign score. Nurses showed fair to good agreement with themselves over the 3-week interval for most modified UPDRS items. Correlations over the 3-week interval exceeded 0.90 for the total modified UPDRS score, ranged from 0.70 to 0.95 for the four domain scores, and exceeded 0.90 for the global parkinsonian sign score. Ratings of parkinsonian signs by nurse clinicians corresponded closely to those of a neurologist with expertise in movement disorders and showed good inter-rater agreement and temporal stability. With appropriate training, nurse clinicians can reliably administer the modified UPDRS.
journal_name
Neurologyjournal_title
Neurologyauthors
Bennett DA,Shannon KM,Beckett LA,Goetz CG,Wilson RSdoi
10.1212/wnl.49.6.1580subject
Has Abstractpub_date
1997-12-01 00:00:00pages
1580-7issue
6eissn
0028-3878issn
1526-632Xjournal_volume
49pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:BACKGROUND:To date, there is no accepted clinical diagnostic test for Parkinson disease (PD) that is based on biochemical analysis of blood or CSF. The discovery of mutations in the SNCA gene encoding α-synuclein in familial parkinsonism and the accumulation of α-synuclein in the PD brain suggested a critical role for ...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0b013e3181fd613b
更新日期:2010-11-16 00:00:00
abstract:OBJECTIVE:The natural history of succinic semialdehyde dehydrogenase (SSADH) deficiency in adulthood is unknown; we elucidate the clinical manifestations of the disease later in life. METHODS:A 63-year-old man with long-standing intellectual disability was diagnosed with SSADH deficiency following hospitalization for ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001906
更新日期:2015-09-08 00:00:00
abstract::The association of the human leukocyte antigen (HLA)-DR2 allele with brain MRI signal abnormalities and with the development of MS was assessed in 178 patients enrolled in the Optic Neuritis Treatment Trial. HLA haplotype DR2 was present in 85 (48%) of the 178 patients. Its presence was associated with increased odds ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.9.1859
更新日期:2000-05-09 00:00:00
abstract:OBJECTIVE:To determine whether changes in cerebral structure are present after preeclampsia that may explain increased cerebrovascular risk in these women. METHODS:We conducted a case control study in women between 5 and 15 years after either a preeclamptic or normotensive pregnancy. Brain MRI was performed. Analysis ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003765
更新日期:2017-03-28 00:00:00
abstract::Dialysis encephalopathy is a progressive, fatal condition that occurs in patients receiving hemodialysis. It is characterized by abnormalities in speech, myoclonic jerks, and striking changes on the electroencephalogram. We observed dramatic reversal of the clinical symptoms and electroencephalographic abnormalities i...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.12.1130
更新日期:1976-12-01 00:00:00
abstract::The progressive myoclonus epilepsies (PMEs) are a devastating group of rare disorders(1) that manifest with increasing action myoclonus, which is also present at rest but activates with stimuli such as noise, light, or touch. Ultimately, patients become wheelchair-bound and experience early death. Neurologic signs tha...
journal_title:Neurology
pub_type: 评论,杂志文章
doi:10.1212/WNL.0000000000000091
更新日期:2014-02-04 00:00:00
abstract:OBJECTIVE:To test the hypothesis that, in the context of robotic therapy designed to enhance proprioceptive feedback via a Hebbian model, integrity of both somatosensory and motor systems would be important in understanding interparticipant differences in treatment-related motor gains. METHODS:In 30 patients with chro...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/WNL.0000000000007041
更新日期:2019-03-05 00:00:00
abstract:OBJECTIVE:To determine whether pergolide, a mixed D1/D2/D3 dopamine agonist, is efficacious and safe in the treatment of children with chronic tic disorders and Tourette syndrome. BACKGROUND:Neuroleptics, which block dopamine transmission, are currently used to treat children with severe tics, but major side effects a...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/01.wnl.0000044058.64647.7e
更新日期:2003-02-25 00:00:00
abstract::We have discovered a new Italian pedigree with autosomal-dominant ALS. The pedigree, at present, comprises 75 members distributed in five generations. ALS was diagnosed in eight patients. The mean +/- SD age of onset of the disease was 46.8 +/- 13.5 years, with a range of 29 to 63 years. The mean +/- SD duration of th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.2.347
更新日期:1994-02-01 00:00:00
abstract::We studied a patient in a minimally conscious state using PET and cognitive evoked potentials. Cerebral metabolism was below half of normal values. Auditory stimuli with emotional valence (infant cries and the patient's own name) induced a much more widespread activation than did meaningless noise; the activation patt...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000137421.30792.9b
更新日期:2004-09-14 00:00:00
abstract:BACKGROUND:The APOE epsilon4 allele has emerged as a major genetic factor for Alzheimer disease (AD), and its presence has been associated with an increase in beta-amyloid senile plaques (SPs) and neuritic plaques (NPs). Whether it affects neurofibrillary tangle (NFT) accumulation or cholinergic losses in AD remains co...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000128091.92139.0f
更新日期:2004-06-08 00:00:00
abstract:BACKGROUND:Differentiating idiopathic late-onset cerebellar ataxia (ILOCA) from ataxia due to the cerebellar subtype of multiple-system atrophy (MSA-C) can be difficult in the early stages of the disease METHODS:The authors analyzed the levels of various CSF biomarkers in 27 patients with MSA-C and 18 patients with IL...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000227891.25592.8c
更新日期:2006-08-08 00:00:00
abstract:OBJECTIVE:To evaluate interictal, circulating sphingolipids in women migraineurs. METHODS:In the fasting state, serum samples were obtained pain-free from 88 women with episodic migraine (EM; n=52) and from controls (n=36). Sphingolipids were detected and quantified by high-performance liquid chromatography coupled wi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002004
更新日期:2015-10-06 00:00:00
abstract::The relationship between multiple sclerosis (MS) and primary Sjögren's syndrome (PSS) is ambiguous; it was suggested that some patients diagnosed with MS may instead have PSS. In a recent epidemiologic study, the prevalence of PSS was 2.7% in southern Sweden. We randomly selected 30 patients with definite MS from our ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.4.845
更新日期:1992-04-01 00:00:00
abstract::We observed a highly topographically specific and consistent pattern of degeneration in the auditory system of Alzheimer's disease (AD) patients. Senile plaques (SP) and neurofibrillary tangles (NFT) were distributed throughout the ventral nucleus of the medial geniculate body (MGB) and the central nucleus of the infe...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.4.779
更新日期:1993-04-01 00:00:00
abstract::Two cohorts of 20 patients diagnosed with neoplastic meningitis (NM) with or without encephalopathy were matched with respect to age, sex, primary tumor, and performance status. Median survival was 10 weeks (range 6 to 20 weeks) in the cohort with NM-related encephalopathy compared to 24 weeks (range 8 to 40 weeks) in...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000145599.06491.71
更新日期:2004-12-14 00:00:00
abstract:OBJECTIVE:To understand the experience and identify drivers and mitigating factors of burnout and well-being among US neurologists. METHODS:Inductive data analysis was applied to free text comments (n = 676) from the 2016 American Academy of Neurology survey of burnout, career satisfaction, and well-being. RESULTS:Re...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004526
更新日期:2017-10-17 00:00:00
abstract::Idiopathic cervical dystonia (CD) is the most common of the adult-onset focal dystonias. It manifests as involuntary muscle contractions that cause twisting or turning of the neck. The resulting abnormal head and neck postures are heterogeneous in their presentation. Because of the variable presentation of the disease...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract::In four patients who received periocular injections of botulinum toxin for blepharospasm, abnormal neuromuscular transmission was demonstrated by single-fiber EMG in arm muscles. The time course with which the abnormalities developed and cleared, as well as the inverse relationship between the neuromuscular jitter and...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.4.545
更新日期:1986-04-01 00:00:00
abstract:OBJECTIVE:To determine the influence of all possible imaging strategies on the appropriateness ratings for carotid endarterectomy, because less accurate noninvasive techniques are replacing contrast angiography, which was used in the major efficacy trials. METHODS:An expert panel, using appropriateness methodology, ra...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000115097.61748.bf
更新日期:2004-03-23 00:00:00
abstract::Gamma hydroxybutyrate was administered to adult cats by intravenous infusion at varying dosages while an electroencephalogram (EEG) was recorded from electrodes placed stereotactically in the right and left hippocampus and thalamic intralaminar nucleus and from cortical electrodes. Blood cerebrospinal fluid samples we...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.1.51
更新日期:1976-01-01 00:00:00
abstract::Until 1995, treatment of strokes consisted exclusively of efforts to prevent recurrence. Proof that tissue plasminogen activator is useful for acute management is changing the approach to stroke patients. The development process has been difficult and the current treatment recommendations have been controversial. Rece...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.53.1.14
更新日期:1999-07-13 00:00:00
abstract:OBJECTIVE:Spinal cord (SC) lesions are frequently found in multiple sclerosis (MS), but are rare in healthy aging and cerebrovascular patients. Our aim was to analyze the contribution of SC involvement in clinically isolated syndrome (CIS) in diagnosing MS according the McDonald 2010 criteria and in predicting conversi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31827b1a67
更新日期:2013-01-01 00:00:00
abstract::HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is endemic in the Caribbean basin and Japan. Because of the close proximity of the United States to the Caribbean and the presence of HTLV-I-seropositive persons in the United States, we sought reports of patients who were HTLV-I seropositive and had ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.9.1355
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:Virtually all adult studies of APOE genotypes and cognition have included individuals over 60. In older adults, epsilon 4 carriers may manifest greater cognitive asymmetries than non-epsilon 4 carriers even in the absence of overall mean differences. General cognitive ability may also be affected by aging an...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000286941.74372.cc
更新日期:2008-05-06 00:00:00
abstract::Functional brain imaging has been a standard tool in the basic and clinical neurosciences for at least 2 decades, and structural brain imaging can claim an even longer track record of successful use for diagnosis of neurodegenerative disease. It is instructive to recall the ways in which brain imaging has been used to...
journal_title:Neurology
pub_type: 评论,社论
doi:10.1212/WNL.0b013e31827b9305
更新日期:2013-01-08 00:00:00
abstract::Cognitive impairment is a frequent manifestation of advanced human immunodeficiency virus (HIV) infection. The response to antiretroviral medication is often partial and poorly sustained. Recent studies suggest that free radical production within the CNS and neuronal apoptosis may play important roles in the pathogene...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.50.3.645
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to assess the relation of retinal microvascular signs and incident stroke and stroke mortality in an older population. METHODS:The authors took retinal photographs on baseline participants (3,654 patients aged 49+ years) of the Blue Mountains Eye Study (1992 to 1994). They asses...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000179177.15900.ca
更新日期:2005-10-11 00:00:00
abstract::Alzheimer's disease is characterized by relative sparing of primary sensory and motor cortex and a lack of sensory or motor symptomatology. We report a case of presenile onset dementia accompanied by a slowly progressive hemiparesis. Autopsy examination showed severe pathologic involvement of somatosensory cortex with...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.1.14
更新日期:1990-01-01 00:00:00
abstract::Many new treatments under development for Alzheimer disease (AD) will be disease-modifying rather than symptomatic. Clinical evaluation of these treatments will require primary and secondary prevention trials. We describe some of the methodologic challenges in designing primary prevention trials for AD and illustrate ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.67.9_suppl_3.s2
更新日期:2006-11-14 00:00:00