Idiopathic cervical dystonia: an overview.

abstract：OBJECTIVE:To examine the effects of natalizumab on low-contrast letter acuity as a prespecified tertiary endpoint in two randomized clinical trials and to evaluate the usefulness of low-contrast letter acuity testing as a candidate test of visual function in multiple sclerosis (MS). METHODS:AFFIRM and SENTINEL were ra...

journal_title：Neurology

authors： Balcer LJ,Galetta SL,Calabresi PA,Confavreux C,Giovannoni G,Havrdova E,Hutchinson M,Kappos L,Lublin FD,Miller DH,O'Connor PW,Phillips JT,Polman CH,Radue EW,Rudick RA,Stuart WH,Wajgt A,Weinstock-Guttman B,Wynn DR,Lyn

更新日期：2007-04-17 00:00:00

abstract：BACKGROUND:Previous studies have suggested a variety of factors that may be associated with the presence of hippocampal formation (HF) atrophy in patients with complex partial seizures (CPS), including a history of complex or prolonged febrile seizures (FS), age at seizure onset, and epilepsy duration. OBJECTIVE:To de...

journal_title：Neurology

authors： Theodore WH,Bhatia S,Hatta J,Fazilat S,DeCarli C,Bookheimer SY,Gaillard WD

更新日期：1999-01-01 00:00:00

abstract：:Restless legs syndrome (RLS) is characterized by an urge to move the legs. The symptoms are more intense in the evening and during periods of inactivity. RLS symptoms are relieved by movement. It is classified as a sleep disorder, but in many ways it is actually a disorder of wakefulness that seems to intrude upon the...

journal_title：Neurology

authors： Auerbach S,Walters AS

更新日期：2014-04-08 00:00:00

abstract：:We report a family with Machado-Joseph disease (MJD) that was previously diagnosed with dentatorubral-pallidoluysian atrophy (DRPLA), on the basis of the neuropathologic findings. Because the clinical and pathologic reevaluation strongly suggested a diagnosis of MJD, we conducted a genetic study in the family. Two pat...

journal_title：Neurology

authors： Sakai T,Antoku Y,Kawakami H,Maruyama H,Nakamura S,Tanaka K

更新日期：1996-04-01 00:00:00

abstract：:We investigated the modulatory effects of human interferon beta (IFN-beta) and gamma (IFN-gamma) on expression of class I and II major histocompatibility complex (MHC) antigens and intercellular adhesion molecule-1 (ICAM-1) in fetal human astrocytes in culture using flow cytometry and immunocytochemistry. Under the ba...

journal_title：Neurology

authors： Satoh J,Paty DW,Kim SU

更新日期：1995-02-01 00:00:00

abstract：:We report a Japanese boy with muscular dystrophy whose clinical symptoms were intermediate between those usually considered typical of Duchenne and Becker muscular dystrophies. The patient had a large inframe deletion extending from exons 3 to 41 of the dystrophin gene, which would be expected to cause the production ...

journal_title：Neurology

authors： Takeshima Y,Nishio H,Narita N,Wada H,Ishikawa Y,Ishikawa Y,Minami R,Nakamura H,Matsuo M

更新日期：1994-09-01 00:00:00

abstract：:We initiated a double-blind, placebo-controlled trial to test the efficacy and safety of branched-chain amino acids (BCAA) (L-leucine 12 g, L-isoleucine 6 g, and L-valine 6 g daily) in amyotrophic lateral sclerosis (ALS) patients. There was an excess mortality in subjects randomized to active treatment (24 BCAA, 13 pl...

journal_title：Neurology

authors：

更新日期：1993-12-01 00:00:00

abstract：:We tested serum specimens from patients with HAM/TSP and asymptomatic HTLV-I carriers from endemic areas of Japan, Jamaica, Colombia, and Chile for neutralizing antibodies against HTLV-I. The data suggest a trend for neutralizing activity to be found more frequently in the sera from HAM/TSP patients than in sera from ...

journal_title：Neurology

authors： Minagawa H,Yoshida T,Itoyama Y,Mora CA,Albert P,Mori R

更新日期：1992-11-01 00:00:00

abstract：:Gulf War illness (GWI), which afflicts at least 25% of veterans who served in the 1990-1991 war in the Persian Gulf, is thought to be caused by deployment exposures to various neurotoxicants, including pesticides, anti-nerve gas pills, and low-level nerve agents including sarin/cyclosarin. GWI is a multisymptom disord...

journal_title：Neurology

authors： Qiang L,Rao AN,Mostoslavsky G,James MF,Comfort N,Sullivan K,Baas PW

更新日期：2017-05-16 00:00:00

abstract：OBJECTIVE:To compare characteristics between Black and White patients with amyotrophic lateral sclerosis (ALS) in order to identify disparities and phenotypic variability. METHODS:We performed database review for patients seen between 1997 and 2020 at the Emory ALS Center in Atlanta, Georgia. Patients with ALS were in...

journal_title：Neurology

authors： Brand D,Polak M,Glass JD,Fournier CN

更新日期：2020-12-28 00:00:00

abstract：OBJECTIVE:To discuss the indications and timing for resective surgery in patients with Sturge-Weber syndrome (SWS) and medication-resistant epilepsy. BACKGROUND:SWS that causes epilepsy severe enough to merit surgery is rare. Because of the variable natural history of the disease, it is difficult to establish clear-cu...

journal_title：Neurology

authors： Arzimanoglou AA,Andermann F,Aicardi J,Sainte-Rose C,Beaulieu MA,Villemure JG,Olivier A,Rasmussen T

更新日期：2000-11-28 00:00:00

abstract：:The authors demonstrate the potential for poststroke return of activation in regions normally involved in touch discrimination in a serial, whole-brain fMRI study of a patient with marked sensory loss followed by good recovery. A return of activation in ipsilesional primary and bilateral secondary somatosensory cortic...

journal_title：Neurology

authors： Carey LM,Abbott DF,Puce A,Jackson GD,Syngeniotis A,Donnan GA

更新日期：2002-09-10 00:00:00

abstract：:Cross-sectional studies have not adequately resolved the question of whether subjects infected with HIV-1 may suffer cognitive decline during the early, asymptomatic stages of the infection. We studied longitudinally 238 asymptomatic healthy HIV-1-infected homosexual/bisexual men (CDC groups 2 and 3) and 170 uninfecte...

journal_title：Neurology

authors： Selnes OA,Miller E,McArthur J,Gordon B,Muñoz A,Sheridan K,Fox R,Saah AJ

更新日期：1990-02-01 00:00:00

abstract：OBJECTIVES:To investigate whether the human sciatic nerve might have a consistent somatotopic organization according to proximal fascicle input by spinal nerves. METHODS:Twelve patients (55.3 ± 15.5 years) with confirmed lesions of either the L5 or S1 spinal nerve root underwent magnetic resonance neurography of sciat...

journal_title：Neurology

authors： Bäumer P,Weiler M,Bendszus M,Pham M

更新日期：2015-04-28 00:00:00

abstract：OBJECTIVE:To study the usefulness of corticospinally mediated excitatory responses and transcallosal inhibition (TI) elicited by transcranial magnetic stimulation (TMS) as a surrogate marker of disability in patients with different courses of MS. METHODS:Focal TMS of the motor cortex was performed in 118 patients with...

journal_title：Neurology

authors： Schmierer K,Irlbacher K,Grosse P,Röricht S,Meyer BU

更新日期：2002-10-22 00:00:00

abstract：:Rare reflex epilepsies are a clinical curiosity but may also give insight into neurocognitive processes. The authors present a patient whose seizures were precipitated by drawing but not by writing. This dissociation complements previous reports on selective impairment of writing. EEG revealed a focus in the right fro...

journal_title：Neurology

authors： Kho KH,van den Bergh WM,Spetgens WP,Leijten FS

更新日期：2006-03-14 00:00:00

abstract：OBJECTIVE:To determine the prognostic value of selected biomarkers in clinically isolated syndromes (CIS) for conversion to multiple sclerosis (MS) and disability accrual. METHODS:Data were acquired from 2 CIS cohorts. The screening phase evaluated patients developing clinically definite MS (CIS-CDMS) and patients who...

journal_title：Neurology

authors： Arrambide G,Espejo C,Eixarch H,Villar LM,Alvarez-Cermeño JC,Picón C,Kuhle J,Disanto G,Kappos L,Sastre-Garriga J,Pareto D,Simon E,Comabella M,Río J,Nos C,Tur C,Castilló J,Vidal-Jordana A,Galán I,Arévalo MJ,Auger C

更新日期：2016-09-13 00:00:00

abstract：OBJECTIVE:To explore sensitivity of optical coherence tomography (OCT) in detecting prior unilateral optic neuritis. METHODS:This is a retrospective, observational clinical study of all patients who presented from January 1, 2014, to January 6, 2017, with unilateral optic neuritis and OCT available at least 3 months a...

journal_title：Neurology

authors： Xu SC,Kardon RH,Leavitt JA,Flanagan EP,Pittock SJ,Chen JJ

更新日期：2019-02-05 00:00:00

abstract：OBJECTIVE:To investigate the sensitivity of MRI of the spine compared with CT myelography (CTM) in detecting CSF leaks. METHODS:Between July 1998 and October 2010, 12 patients with orthostatic headache and a CTM-confirmed spinal CSF leak underwent an MRI of the spine with and without contrast. Using CTM as the gold st...

journal_title：Neurology

authors： Starling A,Hernandez F,Hoxworth JM,Trentman T,Halker R,Vargas BB,Hastriter E,Dodick D

更新日期：2013-11-12 00:00:00

abstract：:Recent epidemiologic studies of multiple sclerosis (MS) in Australia defined the State of Queensland as a medium-frequency zone and the more southerly placed cities of Perth, Newcastle, and Hobart as high-frequency zones. Clinical profiles in the patient populations of both frequency zones were remarkably similar in m...

journal_title：Neurology

authors： Hammond SR,English D,de Wytt C,Maxwell IC,Millingen KS,Stewart-Wynne EG,McLeod JG,McCall MG

更新日期：1988-06-01 00:00:00

abstract：:Rosenthal fibers are present in several neurologic disorders. Their occurrence in widespread subependymal, subpial, and perivascular locations is thought to be diagnostic of Alexander's disease, but they have also been reported in rare adult cases. Some of these patients were neurologically intact with severe systemic...

journal_title：Neurology

authors： Friedman JH,Ambler M

更新日期：1992-09-01 00:00:00

abstract：:The Finnish Twin Cohort includes all Finnish same-sexed twins born before 1958 and alive in 1967; the number of individuals alive in 1975 was 33,247. We performed a search for cases with Parkinson's disease among this cohort by linking the Twin Cohort Register with the Finnish Hospital Discharge Register and the Finni...

journal_title：Neurology

authors： Marttila RJ,Kaprio J,Koskenvuo M,Rinne UK

更新日期：1988-08-01 00:00:00

abstract：OBJECTIVE:To develop a scientifically sound and clinically relevant evidence-based guideline for the treatment of painful diabetic neuropathy (PDN). METHODS:We performed a systematic review of the literature from 1960 to August 2008 and classified the studies according to the American Academy of Neurology classificati...

journal_title：Neurology

authors： Bril V,England J,Franklin GM,Backonja M,Cohen J,Del Toro D,Feldman E,Iverson DJ,Perkins B,Russell JW,Zochodne D,American Academy of Neurology.,American Association of Neuromuscular and Electrodiagnostic Medicine.,American Acade

更新日期：2011-05-17 00:00:00

abstract：:The biochemical hallmark of adult Refsum disease (ARD) is an isolated deficiency in the breakdown of phytanic acid. This usually results from a PHYH gene defect, although some cases have been found to carry a PEX7 defect. We describe the phenotype of such a patient, indistinguishable from that of classic ARD. Hence, w...

journal_title：Neurology

authors： Horn MA,van den Brink DM,Wanders RJ,Duran M,Poll-The BT,Tallaksen CM,Stokke OH,Moser H,Skjeldal OH

更新日期：2007-02-27 00:00:00

abstract：OBJECTIVE:To examine the relationships between age at onset and duration of seizure disorder with severity of hippocampal sclerosis (HS) and cognitive functioning in patients with HS and unilateral temporal lobe epilepsy. METHODS:Twenty-six subjects had left temporal lobe seizure onset; 20 had right temporal onset. Me...

journal_title：Neurology

authors： Fuerst D,Shah J,Kupsky WJ,Johnson R,Shah A,Hayman-Abello B,Ergh T,Poore Q,Canady A,Watson C

更新日期：2001-07-24 00:00:00

abstract：:Serum ratios of monoclonal immunoglobulin (Ig) to total protein, monoclonal immunoglobulin to albumin, CSF/serum Ig-albumin index, and CSF to serum monoclonal immunoglobulin were obtained in 21 patients with multiple myeloma and 2 with Waldenström's macroglobulinemia. Twelve patients (3 with CNS complications) showed ...

journal_title：Neurology

authors： Hansotia P,Gani K,Friedenberg W

更新日期：1983-11-01 00:00:00

abstract：OBJECTIVE:To investigate the prevalence, predictors, and clinical relevance of cortical superficial siderosis (cSS) progression in cerebral amyloid angiopathy (CAA). METHODS:Consecutive patients with symptomatic CAA meeting Boston criteria in a prospective cohort underwent baseline and follow-up MRI within 1 year. cSS...

journal_title：Neurology

authors： Pongpitakmetha T,Fotiadis P,Pasi M,Boulouis G,Xiong L,Warren AD,Schwab KM,Rosand J,Gurol ME,Greenberg SM,Viswanathan A,Charidimou A

更新日期：2020-04-28 00:00:00

abstract：:Ninety-seven chronic alcoholics, both impaired and unimpaired, without clinically evident liver disease, showed significantly more cerebral atrophy on computed tomography than age-matched neurologic controls. Age was the variable most highly correlated with cerebral atrophy measurements, and it accounted for most of t...

journal_title：Neurology

authors： Carlen PL,Wilkinson DA,Wortzman G,Holgate R,Cordingley J,Lee MA,Huszar L,Moddel G,Singh R,Kiraly L,Rankin JG

更新日期：1981-04-01 00:00:00

abstract：:Stenosis or occlusion of the major arteries of the head and neck may cause hemodynamic impairment of the distal cerebral circulation. Hemodynamic factors may play an important role in the pathogenesis of ischemic stroke for patients with cerebrovascular disease. Several neuroimaging methods are currently available for...

journal_title：Neurology

authors： Derdeyn CP,Grubb RL Jr,Powers WJ

更新日期：1999-07-22 00:00:00

abstract：OBJECTIVE:To assess the determinants of amyotrophic lateral sclerosis (ALS) phenotypes in a population-based cohort. METHODS:The study population included 2,839 patients with ALS diagnosed in Piemonte, Italy (1995-2015). Patients were classified according to motor (classic, bulbar, flail arm, flail leg, predominantly ...

journal_title：Neurology

authors： Chiò A,Moglia C,Canosa A,Manera U,D'Ovidio F,Vasta R,Grassano M,Brunetti M,Barberis M,Corrado L,D'Alfonso S,Iazzolino B,Peotta L,Sarnelli MF,Solara V,Zucchetti JP,De Marchi F,Mazzini L,Mora G,Calvo A

更新日期：2020-02-25 00:00:00