Abstract:
:Many new treatments under development for Alzheimer disease (AD) will be disease-modifying rather than symptomatic. Clinical evaluation of these treatments will require primary and secondary prevention trials. We describe some of the methodologic challenges in designing primary prevention trials for AD and illustrate these with examples from the ADAPT (Alzheimer Disease Anti-Inflammatory Prevention Trial) Study and GEM (Ginkgo in Evaluation of Memory) Study. Primary prevention trials for AD present many design challenges. In most situations, secondary prevention trials provide the most feasible first step toward primary prevention.
journal_name
Neurologyjournal_title
Neurologyauthors
Green RC,DeKosky STdoi
10.1212/wnl.67.9_suppl_3.s2subject
Has Abstractpub_date
2006-11-14 00:00:00pages
S2-5issue
9 Suppl 3eissn
0028-3878issn
1526-632Xpii
67/9_suppl_3/S2journal_volume
67pub_type
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