Abstract:
:A model of latent infection by varicella-zoster virus (VZV) was obtained in the adult rat. Inoculation of VZV-infected cells in the skin led to infection of the peripheral nervous system. Latency was characterized by a long-lasting presence of the viral genome, of selected viral gene transcripts, and of at least one viral protein in the dorsal root ganglia. Reactivation has not been obtained in vivo, but has occurred ex vivo after repeated stresses. Many similarities with VZV latency in humans were found, making this model useful for vaccine and antiviral studies.
journal_name
Neurologyjournal_title
Neurologyauthors
Sadzot-Delvaux C,Debrus S,Nikkels A,Piette J,Rentier Bdoi
10.1212/wnl.45.12_suppl_8.s18subject
Has Abstractpub_date
1995-12-01 00:00:00pages
S18-20issue
12 Suppl 8eissn
0028-3878issn
1526-632Xjournal_volume
45pub_type
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