Is Parkinson's disease acquired? Evidence from a geographic comparison with multiple sclerosis.

abstract：OBJECTIVE:We sought to identify rare variants influencing brain imaging phenotypes in the Framingham Heart Study by performing whole genome sequence association analyses within the Trans-Omics for Precision Medicine Program. METHODS:We performed association analyses of cerebral and hippocampal volumes and white matter...

journal_title：Neurology

authors： Sarnowski C,Satizabal CL,DeCarli C,Pitsillides AN,Cupples LA,Vasan RS,Wilson JG,Bis JC,Fornage M,Beiser AS,DeStefano AL,Dupuis J,Seshadri S,NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium.,TOPMed Neurocognitive W

更新日期：2018-01-16 00:00:00

abstract：OBJECTIVE:To determine whether changes in cerebral structure are present after preeclampsia that may explain increased cerebrovascular risk in these women. METHODS:We conducted a case control study in women between 5 and 15 years after either a preeclamptic or normotensive pregnancy. Brain MRI was performed. Analysis ...

journal_title：Neurology

authors： Siepmann T,Boardman H,Bilderbeck A,Griffanti L,Kenworthy Y,Zwager C,McKean D,Francis J,Neubauer S,Yu GZ,Lewandowski AJ,Sverrisdottir YB,Leeson P

更新日期：2017-03-28 00:00:00

abstract：:This paper reviews the issue of hepatotoxicity with the use of the catechol-O-methly transferase (COMT) inhibitors tolcapone and entacapone. Neither drug caused hepatotoxicity in preclinical toxicity testing. However, in clinical trials of tolcapone, liver chemistry tests were elevated more than 3 times above the uppe...

journal_title：Neurology

authors： Watkins P

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:To describe the clinical features and outcome of anti-NMDA receptor (NMDAR) encephalitis in patients ≥45 years old. METHOD:Observational cohort study. RESULTS:In a cohort of 661 patients with anti-NMDAR encephalitis, we identified 31 patients ≥45 years old. Compared with younger adults (18-44 years), older ...

journal_title：Neurology

authors： Titulaer MJ,McCracken L,Gabilondo I,Iizuka T,Kawachi I,Bataller L,Torrents A,Rosenfeld MR,Balice-Gordon R,Graus F,Dalmau J

更新日期：2013-09-17 00:00:00

abstract：:We studied a 55-year-old woman with macrosquare wave jerks and macrosaccadic oscillations with a vertical component. The oscillations almost completely disappeared after administration of diazepam, clonazepam, thiamylal, or phenobarbital. A disorder of GABAergic tonic inhibitory system from the substantia nigra to sup...

journal_title：Neurology

authors： Fukazawa T,Tashiro K,Hamada T,Kase M

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND:Two recent studies suggest that the risk of ALS is increased among Gulf War veterans. It is not known whether military service outside of the Gulf War is associated with increased risk of ALS. METHODS:The authors prospectively assessed the relation between service in the military and ALS mortality among par...

journal_title：Neurology

authors： Weisskopf MG,O'Reilly EJ,McCullough ML,Calle EE,Thun MJ,Cudkowicz M,Ascherio A

更新日期：2005-01-11 00:00:00

abstract：:The results of a multicenter, double-blind, placebo-controlled clinical trial of the efficacy and safety of progabide (PGB) in the treatment of partial seizures are presented. This study was performed with a number of rigorous controls not usually present in clinical trials. These included uniform co-medication in whi...

journal_title：Neurology

authors： Leppik IE,Dreifuss FE,Porter R,Bowman T,Santilli N,Jacobs M,Crosby C,Cloyd J,Stackman J,Graves N

更新日期：1987-06-01 00:00:00

abstract：:After superficial temporal artery-middle cerebral artery bypass, cerebral blood flow (CBF) in the operated hemisphere increased in 6 of 17 patients. Preoperatively, the symptomatic hemisphere showed lower CBF in all six, lower oxygen metabolism in five, higher blood volume in four, and higher oxygen extraction in two....

journal_title：Neurology

authors： Powers WJ,Martin WR,Herscovitch P,Raichle ME,Grubb RL Jr

更新日期：1984-09-01 00:00:00

abstract：OBJECTIVE:Twenty-eight percent of patients with the Guillain-Barré syndrome remain able to walk unaided. Studying patients with the mild form of Guillain-Barré syndrome can further contribute to knowledge of the spectrum of the syndrome and explore whether this subgroup may need treatment with IV immunoglobulin. METHO...

journal_title：Neurology

authors： Van Koningsveld R,Schmitz PI,Ang CW,Groen J,Osterhaus AD,Van der Meché FG,Van Doorn PA

更新日期：2002-02-26 00:00:00

abstract：:To evaluate the potential for clinical application, the reputed protective action of barbiturates in cerebral ischemia was tested in a controlled study after segmental middle cerebral artery occlusion in primates. Surviving treated animals promptly recovered consciousness, locomotion, and feeding behavior despite pers...

journal_title：Neurology

authors： Moseley JI,Laurent JP,Molinari GF

更新日期：1975-09-01 00:00:00

abstract：:Women were enrolled in our prospective cohort study of epilepsy and pregnancy to determine the developmental outcome of offspring and the immediate outcome of pregnancy. Women with epilepsy (case group) were enrolled before conception or during the first trimester, and women without epilepsy or chronic illness (contro...

journal_title：Neurology

authors： Leavitt AM,Yerby MS,Robinson N,Sells CJ,Erickson DM

更新日期：1992-04-01 00:00:00

abstract：:The authors used 1H-MRS to investigate hypothalamic metabolism in 26 patients with cluster headache (CH) and 12 healthy subjects. Hypothalamic N-acetylaspartate/creatine was reduced in patients with CH vs controls (p < 0.01). Dividing the patients into episodic CH outside- and in-cluster periods and chronic CH, the hy...

journal_title：Neurology

authors： Lodi R,Pierangeli G,Tonon C,Cevoli S,Testa C,Bivona G,Magnifico F,Cortelli P,Montagna P,Barbiroli B

更新日期：2006-04-25 00:00:00

abstract：OBJECTIVE:To track cognitive and language changes over time in patients with logopenic (lv-PPA) and semantic (sv-PPA) variants of primary progressive aphasia (PPA). METHODS:Thirteen consecutive patients with lv-PPA and 11 patients with sv-PPA underwent yearly evaluation for a mean of 3 years. Nineteen patients (11 lv-...

journal_title：Neurology

authors： Leyton CE,Hsieh S,Mioshi E,Hodges JR

更新日期：2013-03-05 00:00:00

abstract：:Genetic factors are important in Alzheimer disease (AD) and Parkinson disease but have not been well characterized in Lewy body dementia (LBD). The authors obtained family history in patients from an autopsy series of AD and LBD and in living healthy controls. A family history of dementia was more common in both LBD a...

journal_title：Neurology

authors： Woodruff BK,Graff-Radford NR,Ferman TJ,Dickson DW,DeLucia MW,Crook JE,Arvanitakis Z,Brassler S,Waters C,Barker W,Duara R

更新日期：2006-06-27 00:00:00

abstract：:We studied recovery of function in 41 patients with right hemisphere stroke. Recovery was rapid for left neglect, prosopagnosia, anosognosia, and unilateral spatial neglect on drawing (USN). Recovery was slower for h mianopia, hemiparesis, motor impersistence, and extinction. Rates of recovery were intermediate for co...

journal_title：Neurology

authors： Hier DB,Mondlock J,Caplan LR

更新日期：1983-03-01 00:00:00

abstract：OBJECTIVE:To identify the cause of hypokalemic periodic paralysis (HOKPP) in a family whose disease is not caused by a mutation in the dihydropyridine-sensitive (DHP) receptor alpha1-subunit gene (CACNA1S). BACKGROUND:Hypokalemic periodic paralysis is primarily caused by mutations within CACNA1S. Genetic heterogeneity...

journal_title：Neurology

authors： Bulman DE,Scoggan KA,van Oene MD,Nicolle MW,Hahn AF,Tollar LL,Ebers GC

更新日期：1999-12-10 00:00:00

abstract：BACKGROUND:There is controversy over whether seizures, the most common manifestation of neonatal brain injury, may themselves damage the developing brain. OBJECTIVE:To determine if neonatal seizures are independently associated with brain injury in newborns with perinatal asphyxia. METHODS:Ninety term neonates were s...

journal_title：Neurology

authors： Miller SP,Weiss J,Barnwell A,Ferriero DM,Latal-Hajnal B,Ferrer-Rogers A,Newton N,Partridge JC,Glidden DV,Vigneron DB,Barkovich AJ

更新日期：2002-02-26 00:00:00

abstract：:Four patients with presumed Tolosa-Hunt syndrome ultimately proved to have a parasellar tumor. All four had manifestations of a cavernous sinus syndrome, normal radiologic and medical investigations, and response to steroid therapy. The Tolosa-Hunt syndrome is a diagnosis of exclusion; many other lesions can simulate ...

journal_title：Neurology

authors： Spector RH,Fiandaca MS

更新日期：1986-02-01 00:00:00

abstract：OBJECTIVE:To validate a neuropsychological algorithm for dementia diagnosis. METHODS:We developed a neuropsychological algorithm in a sample of 1,023 elderly residents of Cache County, UT. We compared algorithmic and clinical dementia diagnoses both based on DSM-III-R criteria. The algorithm diagnosed dementia when th...

journal_title：Neurology

authors： Tschanz JT,Welsh-Bohmer KA,Skoog I,West N,Norton MC,Wyse BW,Nickles R,Breitner JC

更新日期：2000-03-28 00:00:00

abstract：OBJECTIVE:To investigate the relationship between the presence of a circadian body temperature rhythm and behaviorally assessed consciousness levels in patients with disorders of consciousness (DOC; i.e., vegetative state/unresponsive wakefulness syndrome or minimally conscious state). METHODS:In a cross-sectional stu...

journal_title：Neurology

authors： Blume C,Lechinger J,Santhi N,del Giudice R,Gnjezda MT,Pichler G,Scarpatetti M,Donis J,Michitsch G,Schabus M

更新日期：2017-05-16 00:00:00

abstract：OBJECTIVE:Among the rare causes of myelopathies is primary intramedullary spinal cord lymphoma (PISCL). As PISCL is often underrecognized, delaying appropriate treatment, we sought to describe its presentation, imaging characteristics, and outcomes. METHODS:Mayo Clinic medical records, lymphoma database, and autopsies...

journal_title：Neurology

authors： Flanagan EP,O'Neill BP,Porter AB,Lanzino G,Haberman TM,Keegan BM

更新日期：2011-08-23 00:00:00

abstract：OBJECTIVE:Bevacizumab has been shown to be effective in the treatment of recurrent glioblastoma in combination with chemotherapy compared with historic controls but not in randomized trials. METHODS:We conducted a retrospective analysis of patients treated for recurrent glioblastoma with bevacizumab vs a control group...

journal_title：Neurology

authors： Nghiemphu PL,Liu W,Lee Y,Than T,Graham C,Lai A,Green RM,Pope WB,Liau LM,Mischel PS,Nelson SF,Elashoff R,Cloughesy TF

更新日期：2009-04-07 00:00:00

abstract：:We identified the cytokines interleukin-1 beta (IL-1 beta), tumor necrosis factor (TNF), and interleukin-6 (IL-6) by specific radioimmunoassays in the CSF of patients with multiple sclerosis (MS) and other neurologic diseases (OND). There was a high incidence of detectable IL-1 beta in patients with active MS compared...

journal_title：Neurology

authors： Hauser SL,Doolittle TH,Lincoln R,Brown RH,Dinarello CA

更新日期：1990-11-01 00:00:00

abstract：OBJECTIVE:To study the accuracy of the ABCD2 score in predicting early stroke risk following TIA and to model post-test probability of stroke for varying cutoff scores and baseline stroke risk. METHODS:Medline, PubMed, Embase, conference proceedings, and manuscript references up to October 2010 were searched for studi...

journal_title：Neurology

authors： Sanders LM,Srikanth VK,Blacker DJ,Jolley DJ,Cooper KA,Phan TG

更新日期：2012-09-04 00:00:00

abstract：BACKGROUND:Photophobia is an abnormal sensitivity to light experienced by migraineurs during attacks. The pathophysiology of photophobia is poorly understood. Nevertheless, 2 facts appear to have a link with photophobia: visual cortex hyperexcitability on the one hand and interactions between visual pathway and trigemi...

journal_title：Neurology

authors： Denuelle M,Boulloche N,Payoux P,Fabre N,Trotter Y,Géraud G

更新日期：2011-01-18 00:00:00

abstract：OBJECTIVE:To evaluate the effectiveness of opicapone as add-on to levodopa and the effects of switching from entacapone over 1 year of treatment in patients with fluctuating Parkinson disease. METHODS:After completion of a placebo- and entacapone-controlled double-blind study of opicapone (5, 25, or 50 mg), 495 patien...

journal_title：Neurology

authors： Ferreira JJ,Lees AJ,Poewe W,Rascol O,Rocha JF,Keller B,Soares-da-Silva P

更新日期：2018-05-22 00:00:00

abstract：:In the current medical climate, medical education is at risk of being de-emphasized, leading to less financial support and compensation for faculty. A rise in compensation plans that reward clinical or research productivity fails to incentivize and threatens to erode the educational missions of our academic institutio...

journal_title：Neurology

authors： Weber D,Sarva H,Weaver J,Wang F,Chou J,Cornes S,Nickels K,Safdieh JE,Poncelet A,Stern BJ

更新日期：2019-07-02 00:00:00

abstract：:We initiated a double-blind, placebo-controlled trial to test the efficacy and safety of branched-chain amino acids (BCAA) (L-leucine 12 g, L-isoleucine 6 g, and L-valine 6 g daily) in amyotrophic lateral sclerosis (ALS) patients. There was an excess mortality in subjects randomized to active treatment (24 BCAA, 13 pl...

journal_title：Neurology

authors：

更新日期：1993-12-01 00:00:00

abstract：:We studied 15 dystonic patients with positron emission tomography (PET) and (18F)-2-fluoro-2-deoxy-D-glucose (FDG). The group comprised patients with focal (n = 5), multifocal (n = 1), and generalized (n = 4) dystonia as well as patients with hemidystonia (n = 5). The age at onset was during childhood in four, during ...

journal_title：Neurology

authors： Karbe H,Holthoff VA,Rudolf J,Herholz K,Heiss WD

更新日期：1992-08-01 00:00:00

abstract：:A 3-year old, previously well child developed paroxysms of left thigh pain. Evaluation was unremarkable except for interictal and postictal EEG epileptiform activity in the right parietal and posterior temporal regions. The painful spells were controlled with anticonvulsant medication. Episodes of paroxysmal, unexplai...

journal_title：Neurology

authors： Trevathan E,Cascino GD

更新日期：1988-02-01 00:00:00